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MPHP (4'-methyl-α-pyrrolidinohexiophenone) is a stimulant compound and has been reported as a novel designer drug. It is closely related to pyrovalerone, simply its chain-lengthened homolog. In the pyrrolidinophenone series, stimulant activity is maintained so long as the positions of the aryl, ketone and pyrrolidinyl groups are held constant. At the same time, their alkyl backbone can vary between three and as many as seven carbons. The highest potency is usually seen with the pentyl or isohexyl backbone, and various substituents are tolerated on the aromatic ring.
The pyrrolidinophenone series of stimulants include 4'-Methyl-α-pyrrolidinohexiophenone (MPHP), which has been reported as a novel designer drug. It is closely related to pyrovalerone, simply its chain-lengthened homolog. In the pyrrolidinophenone series, stimulant activity is maintained so long as the positions of the aryl, ketone and pyrrolidinyl groups are held constant. At the same time, the alkyl backbone can be varied anywhere between three and as many as seven carbons, with the highest potency usually seen with the pentyl or isohexyl backbone.
MPHP, also known as 4'-Methyl-α-pyrrolidinohexiophenone (MPHP), is a stimulant compound reported as a novel designer drug.
MPHP is a stimulant compound related to pyrovalerone and pyrrolidinophenones. It has been reported as a novel designer drug. It is closely related to pyrovalerone, which is its chain-lengthened homolog.MPHP is an analog of pyrovalerone and a close relative of pyrophenidone, but with a much longer alkyl side chain. It has been found in medicines typically prescribed for asthma and various types of cough. MPHP has also been detected in ecstasy pills and powders made in China that were sold as amphetamines.
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MPHP can cause serious damage to the liver and kidneys. In some cases, it is life-threatening. The long-term effects of using MPHP are unknown, but use may result in a build-up of MPHP in the body.
MPHP (4'-Methyl-α-pyrrolidinohexiophenone), a stimulant compound, has been reported as a modern designer drug. MPHP is closely related to pyrovalerone because it is its chain-lengthened homolog. In addition to being structurally similar to other potent stimulants such as pyrovalerone and pentylone, MPHP also shares their pharmacokinetic profile of large Cmax and exposure at both therapeutic and toxic dosages.
MPHP ranks as one of the most potent pyrrolidinophenone stimulants currently available. It is similar to pyrovalerone in structure but has a ketone substitution on the aromatic ring. It is also related to α-PHP and a-PHPP, analogs used in research for studying the dopamine transporter but have since been added to schedule I of the Controlled Substances Act.
Amphetamine-like stimulant related to pyrovalerone. Closely related to α-PHP and α-PVP but with a longer alkyl chain on the pyrrolidine group. Unlike α-PHP and α-PVP, MPHP is not dependent on selegiline for metabolism in human liver microsomes.
MPHP is a pyrovalerone derivative structurally similar to mephedrone but with a long chain attached. This results in a less lipophilic drug that is more potent. In the same vein as mephedrone and other drugs, it was initially thought to be an NMDA receptor antagonist. Still, later studies have shown that MPHP acts instead as a triple reuptake inhibitor and causes dopamine release in the nucleus accumbens.