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Table of Contents

1. Introduction

   • Overview of Diethyltryptamine (DET)
   • Historical Context and Transmethylation Hypothesis

2. Chemistry

   • Unveiling the Molecular Structure of DET
   • Analogues and Synthesis

3. Subjective Effects

   • Exploring the Psychedelic Experience with DET
   • Physical and Visual Perceptions Altered

4. Cognitive Effects

   • Understanding DET's Impact on Cognition
   • Emotional Enhancements, Memory Dynamics, and Altered Thought Patterns

5. Toxicity and Harm Potential

   • Assessing Risks and Health Implications
   • Anecdotal Insights, Tolerance, Dangerous Interactions, and Legal Status

UNVEILING THE ORIGINS AND PROPERTIES

Diethyltryptamine (DET), also recognized as N,N-DET or DET, stands as a synthetic psychedelic tryptamine closely related to Dimethyltryptamine (DMT). Despite its structural proximity to DMT, DET remains an exceedingly rare compound with minimal recorded instances of human usage.

THE TRANSMETHYLATION HYPOTHESIS AND DET IN THE 1950S

In the 1950s, scientific inquiry delved into the possibility of endogenous production of psychoactive agents, offering a potential explanation for hallucinatory symptoms observed in some psychiatric diseases. This phenomenon was coined as the transmethylation hypothesis. DET emerged as a focal point in early studies, along with other psychedelics, as researchers aimed to unravel their psychotomimetic properties.

THEORETICAL FRAMEWORK: DET AND MENTAL DISORDERS

Early investigations centered on the conjecture that abnormal metabolites of endogenous chemicals like tryptamine, serotonin, and tryptophan could elucidate mental disorders such as schizophrenia or psychosis. DET, with its unique structure, became a subject of interest in unraveling the complexities of these psychedelic compounds and their potential impact on mental health.

Retaining the essence of the original article, this rewritten piece provides a detailed exploration of Diethyltryptamine, shedding light on its synthetic nature, historical context, and the theoretical frameworks that surrounded its early studies.

CHEMISTRY OF DIETHYLTRYPTAMINE (DET)

THE TRYPTAMINE FOUNDATION: STRUCTURE AND ANALOGS

Diethyltryptamine (DET), also known as N,N-diethyltryptamine, stands as a synthetic indole alkaloid within the tryptamine class of molecules. Tryptamines, characterized by a bicyclic indole heterocycle attached to an amino group via an ethyl side chain at R3, share a core structure. DMT, a closely related compound, possesses two ethyl groups (CH2CH3-) bound to the terminal amine RN of its tryptamine backbone. DET, being an analogue of DMT, has numerous substituted counterparts, including the well-known 4-HO-DET, also recognized as "ethocin."

DET'S SYNTHESIS AND ANALOGOUS COMPOUNDS

While DET is a synthetic compound without natural sources, it has been strategically employed in conjunction with the mycelium of Psilocybe cubensis to produce synthetic chemicals like 4-PO-DET (Ethocybin) and 4-HO-DET (Ethocin). These synthetic variants stand in contrast to naturally occurring compounds like 4-PO-DMT (Psilocybin) and 4-HO-DMT (Psilocin). The isolation process of the alkaloids has yielded notable quantities of 3.3% 4-HO-DET and 0.01-0.8% 4-PO-DET.

NAVIGATING THE PHARMACOLOGICAL LANDSCAPE OF DET

INSIGHTS INTO DET'S PHARMACOLOGY

Despite a scarcity of research on DET, discussions on its pharmacology are rooted in its structure and subjective effects, drawing parallels with other tryptamine psychedelics like psilocin and DMT. It is hypothesized that DET acts as a 5-HT2A partial agonist. Notably, the presence of ethyl groups shields DET from the monoamine oxidase enzyme system, rendering it orally active—a distinction from DMT, which lacks this characteristic.

DET VS. DMT: ORAL ADMINISTRATION ADVANTAGE

One notable advantage of DET over DMT is its oral bioavailability, attributed to the protective effect of ethyl groups against the monoamine oxidase enzyme system. Unlike DMT, which requires alternative administration methods to bypass enzymatic degradation, DET can be taken orally. This characteristic has contributed to the preference for DET in certain contexts.

DOSAGE GUIDELINES FOR DET

Understanding the dosage parameters for DET is crucial for responsible use. The following dosage ranges provide insights into the effects associated with varying quantities:

• Threshold: 10 mg
• Light: 20 - 40 mg
• Common: 40 - 70 mg
• Strong: 70 - 100 mg
• Heavy: 100 mg and beyond

These dosage guidelines serve as a reference for individuals navigating the realm of DET, aiding in safe and informed consumption.

SUBJECTIVE EFFECTS OF DIETHYLTRYPTAMINE (DET)

SUBJECTIVE EFFECT INDEX (SEI) INSIGHTS

Disclaimer: The effects listed below are derived from the Subjective Effect Index (SEI), an open research literature based on anecdotal user reports and the personal analyses of PsychonautWiki contributors. It is essential to approach these findings with a healthy degree of skepticism.

It is crucial to note that the occurrence of these effects is not necessarily predictable or reliable, though higher doses are more likely to induce the full spectrum. Furthermore, adverse effects become increasingly probable with higher doses, including the risk of addiction, severe injury, or even death.

PHYSICAL MANIFESTATIONS OF DET

STIMULATING THE SENSES

• Stimulation: DET is reported to induce a sense of stimulation in users.
• Spontaneous Physical Sensations: Users may experience spontaneous physical sensations.
• Increased Heart Rate: Anecdotal evidence suggests DET may lead to an increase in heart rate.
• Increased Blood Pressure: Reports also mention a potential elevation in blood pressure.
• Nausea: Some users report feelings of nausea as a physical side effect.
• Pupil Dilation: DET use may result in the dilation of pupils.

VISUAL PERCEPTIONS UNDER DET

ENHANCEMENTS AND DISTORTIONS

• Enhancements: Users may perceive enhancements in their visual experience.

  • Colour Enhancement: DET has been associated with intensified perception of colors.
  • Pattern Recognition Enhancement: Users may experience heightened pattern recognition.
  • Visual Acuity Enhancement: Reports suggest an improvement in visual acuity.

• Distortions: DET induces various distortions in visual perception.

  • Drifting: Visual elements may appear to melt, breathe, morph, or flow.
  • Colour Shifting: Colors may undergo dynamic changes.
  • Depth Perception Distortions: Users might experience alterations in depth perception.
  • Perspective Distortions: DET can lead to changes in the perception of perspective.
  • Symmetrical Texture Repetition: Symmetry in textures may be repetitively perceived.
  • Tracers: Visual trails or tracers may follow moving objects.
  • After Images: Persistent images may linger after the removal of a visual stimulus.
  • Brightness Alteration: Changes in brightness perception may occur.
  • Diffraction: Users may witness light diffraction phenomena.

• Geometry: DET can evoke geometric patterns in the visual field.

• Hallucinatory States: Users may enter hallucinatory states.

  • Transformations: Visual elements and surroundings may undergo transformative changes.

• Internal Hallucination: DET may induce internal hallucinations, including autonomous entities, diverse settings, sceneries, landscapes, perspective hallucinations, scenarios, and plots.

Understanding these subjective effects is essential for individuals considering the use of DET, emphasizing the need for caution and responsible decision-making due to potential risks associated with varying doses.

COGNITIVE EFFECTS OF DIETHYLTRYPTAMINE (DET)

COGNITIVE LANDSCAPE EXPLORED

Delving into the cognitive effects of Diethyltryptamine (DET) provides a comprehensive view of the impact it has on various mental faculties.

CONCEPTUAL THINKING AND EUPHORIA

THE COGNITIVE SPECTRUM

• Conceptual Thinking: DET users may experience alterations in conceptual thinking, potentially leading to novel ideas and perspectives.

• Cognitive Euphoria: Reports suggest that DET induces cognitive euphoria, enhancing overall mental well-being.

EMOTIONAL AND COGNITIVE ENHANCEMENTS

AFFECTING EMOTIONS AND IMMERSION

• Emotion Enhancement: DET is associated with heightened emotional states, potentially intensifying feelings and reactions.

• Immersion Enhancement: Users may feel a heightened sense of immersion, deepening their engagement with their surroundings or activities.

• Increased Music Appreciation: Anecdotal evidence points towards an increased appreciation for music under the influence of DET.

MEMORY AND EGO DYNAMICS

MANIPULATING MEMORY AND EGO

• Memory Suppression: DET may lead to temporary memory suppression, affecting the recall of recent events.

• Ego Death: Some users report experiencing ego death, a phenomenon where one loses the sense of self or individual identity.

COGNITIVE PERCEPTIONS ALTERED

NOVELTY, BIAS, AND THOUGHT PATTERNS

• Novelty Enhancement: DET may contribute to perceiving ordinary things or concepts as novel and extraordinary.

• Personal Bias Suppression: Users may find a suppression of personal biases, allowing for more objective thought processes.

• Thought Loops: DET has been associated with thought loops, where a sequence of thoughts repeats, sometimes leading to introspective challenges.

TEMPORAL AND AUDITORY DISTORTIONS

TIME PERCEPTION AND AUDITORY EFFECTS

• Time Distortion: Users may experience alterations in time perception, where time seems to pass differently than usual.

AUDITORY EXPERIENCES UNDER DET

AUDITORY ENHANCEMENTS, DISTORTIONS, AND HALLUCINATIONS

• Auditory Enhancements: DET may enhance the perception of auditory stimuli.

• Auditory Distortions: Users may encounter distortions in the perception of sounds.

• Auditory Hallucinations: In some instances, DET can lead to auditory hallucinations, where users perceive sounds that are not present in reality.

TRANSPERSONAL COGNITIVE STATES

INFINITY, UNITY, AND INTERCONNECTEDNESS

• Transpersonal Effects: DET can induce transpersonal states, including feelings of infinity, unity, and interconnectedness with the broader universe.

Understanding these cognitive effects provides crucial insights for those considering the use of DET, emphasizing the diverse mental experiences that may arise and the need for careful consideration of potential risks associated with its consumption.

TOXICITY AND HARM POTENTIAL OF DIETHYLTRYPTAMINE (DET)

UNVEILING THE RESEARCH GAP

The toxicity and long-term health effects of recreational Diethyltryptamine (DET) remain largely unexplored within the realm of scientific investigation. The absence of formal studies in a scientific context, coupled with the limited history of human usage, contributes to the uncertainty surrounding its exact toxic dose. Notably, DET falls into the category of research chemicals, further complicating the understanding of its potential risks.

COMPARING DET TO DMT

Despite the lack of specific studies on DET, assumptions about its toxicity profile draw parallels with DMT, given their structural similarities. Both substances belong to the tryptamine class, prompting a presumption that DET may exhibit a toxicity profile akin to DMT.

ANECDOTAL INSIGHTS AND CAUTIONARY MEASURES

USER REPORTS AND HARM REDUCTION

Anecdotal reports from individuals who have experimented with DET suggest that, at low to moderate doses and when used sparingly, there are no immediately apparent negative health effects. However, it is crucial to approach these reports with caution, as the substance's limited history leaves room for uncertainties. Independent research becomes imperative, especially when considering combinations with other substances, emphasizing the need for harm reduction practices.

TOLERANCE, ADDICTION, AND CROSS-TOLERANCE

Formal studies on the addiction potential of DET are absent, and current beliefs posit that DET is not habit-forming. Interestingly, there is a suggestion that the desire to use DET may decrease with continued usage. Tolerance to DET builds rapidly, with effects diminishing almost immediately after ingestion. Cross-tolerance with other psychedelics is notable, potentially impacting the efficacy of similar substances.

NAVIGATING DANGEROUS INTERACTIONS

CAUTIONARY NOTES ON INTERACTIONS

Warning: The combination of psychoactive substances can pose significant risks, turning otherwise safe substances into potentially life-threatening concoctions. While the list provided may not encompass all potential interactions, it serves as a cautionary guide. Independent research, utilizing reputable sources such as Google, DuckDuckGo, and PubMed, is paramount to ensuring the safety of combining two or more substances.

• Lithium: Lithium, commonly used for bipolar disorder treatment, may intensify psychedelic effects and is linked with psychosis and seizures.

• Stimulants: Combining stimulants with psychedelics can lead to anxiety, panic, thought loops, and paranoia, elevating the risk of psychosis.

• Tramadol: Known to lower the seizure threshold, tramadol combined with psychedelics may act as triggers, especially in individuals predisposed to seizures.

LEGAL STATUS OF DET INTERNATIONALLY

REGULATORY FRAMEWORKS

Internationally, DET is classified as a Schedule I substance under the Convention on Psychotropic Substances. Its legal status varies across countries:

• Australia: Schedule 9 controlled substance.
• Germany: Controlled under Anlage I BtMG (Narcotics Act, Schedule I).
• Italy: Schedule I controlled substance.
• New Zealand: Class A controlled substance.
• Switzerland: Controlled under Verzeichnis D.
• United Kingdom: Class A controlled substance.
• United States: Schedule I controlled substance.

Understanding the legal context is crucial for individuals navigating the regulatory landscape associated with DET.

FAQ (FREQUENTLY ASKED QUESTIONS)

Q1: WHAT IS DIETHYLTRYPTAMINE (DET)?

• DET, also known as N,N-diethyltryptamine, is a synthetic indole alkaloid belonging to the tryptamine class of molecules.

Q2: HOW DOES DET COMPARE TO DMT?

• DET is a structural analogue of DMT (Dimethyltryptamine) with similarities in their chemical structure.

Q3: WHAT ARE THE SUBJECTIVE EFFECTS OF DET?

• The subjective effects encompass a range of physical and visual perceptions, alterations in cognition, and transpersonal experiences.

Q4: IS DET HABIT-FORMING?

• While formal studies are lacking, current beliefs suggest that DET is not habit-forming, and the desire to use it may decrease with continued usage.

Q5: ARE THERE DANGEROUS INTERACTIONS WITH DET?

• Yes, combining DET with certain substances, such as lithium or stimulants, can pose risks. Independent research is crucial to ensure safety.

Q6: WHAT IS THE LEGAL STATUS OF DET INTERNATIONALLY?

• DET is classified as a Schedule I substance in various countries, including the United States, the United Kingdom, Australia, Germany, Italy, New Zealand, and Switzerland.

Q7: HOW SHOULD DET BE USED RESPONSIBLY?

• Harm reduction practices, independent research, and caution when combining substances are strongly recommended for safe DET use.

Q8: HAS THE LONG-TERM HEALTH IMPACT OF DET BEEN STUDIED?

• No formal studies on the long-term health effects of recreational DET exist. Anecdotal reports suggest no immediate negative health effects at low to moderate doses, but caution is advised.

Q9: HOW DOES DET AFFECT COGNITION?

• DET can impact conceptual thinking, induce cognitive euphoria, enhance emotions, and alter thought patterns, among other cognitive effects.

Q10: WHAT IS THE TRANSMETHYLATION HYPOTHESIS MENTIONED IN THE ARTICLE?

• The transmethylation hypothesis, proposed in the 1950s, explored the potential endogenous production of psychoactive agents as an explanation for hallucinatory symptoms in psychiatric diseases.

These FAQs provide a concise overview of key aspects related to Diethyltryptamine (DET), addressing common queries and promoting a better understanding of the substance and its effects.