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Discovery and Background

ALD-52 was originally discovered by Albert Hofmann while researching LSD analogs. It gained notoriety in the 1960s through Western youth counterculture. Notably, it was associated with "Orange Sunshine," later revealed to be LSD.

Effects and Comparisons

ALD-52 produces effects similar to LSD but may have less visual distortion and anxiety. Some reports find the two substances indistinguishable. It's not considered addictive or toxic by the scientific community, but adverse reactions can occur.

Chemical Structure

ALD-52 is a semisynthetic lysergamide, a derivative of lysergic acid. Its structure includes a bicyclic hexahydroindole fused to a bicyclic quinoline group. It contains an N,N-diethylcarboxamide functional group and a methyl group at carbon 6.

Pharmacology

ALD-52 acts as a partial agonist at serotonin receptors, especially 5-HT2A, 5-HT2C, and 5-HT1A. It is believed to metabolize into LSD and two other distinct metabolites, N-deethyl ALD-52 and N6-demethyl ALD-52 (nor-ALD-52).

History and Culture

In 1968 and 1969, a batch of LSD known as "Orange Sunshine" was synthesized and widely distributed. It was later revealed to be LSD, not ALD-52, in 2005 by Nick Sand and confirmed by Tim Scully in 2017.

Chemistry

ALD-52's chemical structure consists of a core ergoline derivative with tryptamine and phenethylamine structures. It differs from 1P-LSD in the substituent group at carbon 6.

Pharmacology

ALD-52 acts as a partial agonist at serotonin receptors, primarily 5-HT2A, 5-HT2C, and 5-HT1A. It may metabolize into LSD and two other metabolites, N-deethyl ALD-52 and N6-demethyl ALD-52.

Subjective Effects

Anecdotal reports suggest ALD-52's effects are virtually identical to LSD. It's more stimulating and fast-paced compared to other psychedelics, with a milder, less anxiety-inducing headspace but less depth.

Physical Effects

• Stimulation: Similar to LSD, providing increased energy.
• Spontaneous physical sensations: Intense, euphoric tingling.
• Tactile enhancement: Enhanced tactile sensations, reaching peak awareness of nerve endings.
• Changes in bodily form: Feeling part of or conjoined with objects.
• Perception of bodily lightness
• Nausea: Mild, occasional, usually passing or fading.
• Stamina enhancement: Mild increase in stamina.
• Bodily control enhancement
• Appetite suppression
• Increased blood pressure
• Increased heart rate
• Increased perspiration
• Muscle contractions
• Muscle spasms
• Difficulty urinating
• Excessive yawning: Less pronounced than with psilocybin.
• Pupil dilation
• Increased salivation
• Seizure risk: Believed to be low but exists for predisposed individuals.

Visual Effects

Enhancements include color, pattern recognition, and visual acuity. Distortions such as drifting, color shifting, and tracers. Geometry resembles 2C-B or 2C-I, and hallucinations are less consistent than other psychedelics.

Toxicity and Harm Potential

ALD-52's toxicity and long-term health effects haven't been studied scientifically. Anecdotal evidence suggests low to moderate doses have no negative health effects. Caution is advised when combining substances.

Physical side effects are minimal, and it's considered non-addictive with low toxicity. It may trigger underlying psychiatric conditions, so caution is recommended for those with a history of mental illness.

Legal Status

ALD-52's legal status varies by country:

• Austria: May fall under analog laws.
• Denmark: Not illegal, lysergamide class not banned.
• Germany: Controlled under New Psychoactive Substances Act.
• Latvia: Illegal due to LSD structural analog classification.
• Poland: NPS class drug, illegal.
• Singapore: Class A controlled substance.
• Switzerland: Controlled substance (Verzeichnis E).
• United Kingdom: Class A controlled substance.
• United States: Unscheduled but may be treated as an LSD analogue.

FAQ

What is ALD-52?

ALD-52, or 1-Acetyl-N,N-diethyllysergamide, is a lysergamide compound known for its psychedelic effects, often compared to LSD.

How do ALD-52 effects compare to LSD?

Anecdotal reports suggest ALD-52's effects are nearly identical to LSD, with a milder, less anxiety-inducing headspace and less visual intensity.

What are the physical effects of ALD-52?

Physical effects may include stimulation, spontaneous sensations, tactile enhancement, changes in bodily form, and mild side effects like nausea, increased heart rate, and muscle contractions.

What visual effects does ALD-52 produce?

Visual effects include enhancements in color, pattern recognition, and visual acuity, as well as distortions like drifting and tracers. The geometric patterns resemble 2C-B or 2C-I.

Is ALD-52 safe to use?

The safety of ALD-52 is not well-studied. Anecdotal evidence suggests low toxicity and non-addictive qualities. However, caution is advised, especially for those with a history of mental illness.

What is the legal status of ALD-52?

ALD-52's legal status varies by country. In some places, it may be unscheduled, while in others, it falls under analog laws or is considered a controlled substance.