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Product Name: 5-MeO-DiPT
IUPAC Name: [2-(5-Methoxy-1H-indol-3-yl)ethyl]bis(propan-2-yl)amine
Other Names: 5-MeO-DiPT, Foxy Methoxy, Foxy
Molecular Formula: None
Molar Mass: 237.26 g·mol−1
Effect: stimulant, psychedelic
Purity of the substance: 99.9%
Physical properties: Crystals, Powder
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Table of Contents

  1. Chemistry
  2. Pharmacology
  3. Subjective Effects
  4. Physical Effects
  5. Cognitive Effects
  6. Toxicity and Harm Potential
  7. Legal Status


5-Methoxy-N,N-diisopropyltryptamine (commonly known as 5-MeO-DiPT, Foxy, and Foxy Methoxy) belongs to the tryptamine class of psychedelic substances. It induces psychedelic effects upon administration and shares structural similarities with DiPT and 5-MeO-MiPT.

Historical Background

The initial human trials of 5-MeO-DiPT were conducted by Alexander Shulgin in 1975. Subsequently, Shulgin co-authored and published a paper outlining the synthesis and human psychopharmacology of this compound in 1981. Further details regarding synthesis and reports of human use were included in Shulgin's 1997 book TiHKAL ("Tryptamines I Have Known And Loved").

Effects and User Reports

Anecdotal reports suggest that the effects of 5-MeO-DiPT are highly stimulating and mildly entactogenic, with a notable absence of typical psychedelic visual distortions. Users commonly report intense physical and tactile sensations, often enhancing libido and sexual pleasure. However, higher dosages may lead to an unpleasant body load. Some users also report sound distortion, a phenomenon shared with the related compound, DiPT.

Pharmacological Properties and Safety

There is limited knowledge regarding the pharmacological properties, metabolism, and toxicity of 5-MeO-DiPT. Due to its relative obscurity and limited history of human use, comprehensive research on its safety profile is lacking. It has been marketed and sold online as a research chemical, emphasizing the importance of harm reduction practices for individuals considering its use.

In conclusion, 5-MeO-DiPT presents intriguing yet poorly understood effects within the realm of psychedelics. Further research is warranted to elucidate its pharmacological properties and potential risks associated with its use.



5-MeO-DiPT, or 5-methoxy-N,N-diisopropyltryptamine, belongs to the synthetic indole alkaloid molecule of the tryptamine class. Tryptamines share a core structure comprising a bicyclic indole heterocycle attached at R3 to an amino group via an ethyl side chain. 5-MeO-DiPT is substituted at R5 of its indole heterocycle with a methoxy (MeO) functional group CH3O−; it also contains two isopropyl chains bound to the terminal amine RN of its tryptamine backbone (DiPT).

Relationship to Other Compounds

5-MeO-DiPT is the N-substituted diisopropyl homolog of 5-MeO-MiPT.


Mechanism of Action

The purported hallucinogenic and entheogenic effects of 5-MeO-DiPT are primarily attributed to its agonism at the 5-HT2A receptor, a subtype of serotonin receptor. Additional mechanisms of action, such as monoamine oxidase inhibition (MAOI), may also be involved. Notably, 5-MeO-DiPT exhibits strong receptor binding affinity for the 5-HT1A receptor. However, the exact role of these interactions and how they contribute to the psychedelic experience remain unclear.


  • Threshold: 3 mg
  • Light: 3 - 10 mg
  • Common: 10 - 15 mg
  • Strong: 15 - 20 mg
  • Heavy: 20 mg +

Subjective Effects


The effects described below are based on anecdotal user reports and the personal analyses of contributors to the Subjective Effect Index (SEI). As such, they should be approached with caution and skepticism.

It is important to note that individual experiences may vary, and these effects may not occur reliably or predictably for all users. Additionally, higher doses increase the likelihood of experiencing the full spectrum of effects, including potential adverse reactions.

Potential Effects

  • Psychedelic: Users may experience alterations in perception, thought patterns, and consciousness. This can include visual distortions, enhanced introspection, and a sense of interconnectedness.
  • Entactogenic: Some users report heightened empathy, emotional openness, and feelings of closeness to others.
  • Stimulation: 5-MeO-DiPT is often described as stimulating, leading to increased energy, alertness, and physical activity.
  • Physical and Tactile Sensations: Users commonly report intense physical sensations, such as enhanced tactile sensitivity and a heightened awareness of bodily sensations.
  • Libido Enhancement: Many users note an increase in libido and sexual pleasure while under the influence of 5-MeO-DiPT.
  • Sound Distortion: Some users may experience alterations in auditory perception, including sound distortion.
  • Body Load: Higher doses of 5-MeO-DiPT may lead to an unpleasant physical sensation known as body load, which can include discomfort, tension, and nausea.

Risk of Adverse Effects

It is crucial to acknowledge the potential risks associated with the use of 5-MeO-DiPT. Higher doses increase the likelihood of adverse reactions, which may include addiction, severe injury, or even death. Users should exercise caution and prioritize harm reduction practices when experimenting with this substance.

Physical Effects


  • Increased Energy: Users commonly experience a boost in energy levels and heightened alertness.
  • Spontaneous Physical Sensations: Sensations such as tingling, warmth, or shivers may occur without external stimuli.
  • Bodily Pressures: Some users report sensations of pressure or discomfort in various parts of the body.
  • Nausea: Nausea is a common side effect, particularly at higher dosages.
  • Abnormal Heartbeat: Some anecdotal reports suggest changes in heart rhythm, although citations are needed to confirm this effect.
  • Increased Heart Rate: Users may experience a faster heart rate after consuming 5-MeO-DiPT, although citations are needed to verify this effect.
  • Increased Blood Pressure: Anecdotal reports suggest that 5-MeO-DiPT can lead to elevated blood pressure, although citations are needed for confirmation.
  • Headaches: Headaches may occur as a side effect, particularly at higher dosages. Citations are needed to validate this effect.
  • Stomach Bloating: Higher doses of 5-MeO-DiPT can induce severe stomach bloating in susceptible individuals. This effect can be mitigated, at least partially, through the use of antacids.
  • Vasoconstriction: Constriction of blood vessels may occur, potentially leading to discomfort or other complications.
  • Diarrhea: Some users may experience diarrhea as a side effect.
  • Dehydration: Increased fluid loss due to sweating or other factors may lead to dehydration.
  • Pupil Dilation: Dilated pupils are a common physical response to the ingestion of psychedelics.

Visual Effects


  • Color Enhancement: Colors may appear brighter, more vivid, or more intense than usual.
  • Pattern Recognition Enhancement: Users may notice patterns and details that are not usually apparent.
  • Visual Acuity Enhancement: Vision may become sharper and more focused.


  • Drifting: Visual stimuli may appear to shift, melt, breathe, morph, or flow.
  • Color Shifting: Colors may change or shift in hue, saturation, or intensity.
  • Depth Perception Distortions: Perception of depth and distance may be altered.
  • Perspective Distortions: Objects may appear distorted or skewed from certain viewpoints.
  • Symmetrical Texture Repetition: Patterns or textures may repeat symmetrically across surfaces.
  • Tracers: Moving objects may leave trails or "tracers" behind them.
  • Afterimages: Images may persist after the removal of the stimulus.
  • Brightness Alteration: Brightness levels may fluctuate or seem exaggerated.
  • Diffraction: Light may appear to bend or spread out around objects.
  • Geometry: Users may perceive geometric shapes or patterns, sometimes with intricate detail.

Hallucinatory States

  • Transformations: Objects or scenery may undergo dramatic transformations.
  • Internal Hallucination: Users may experience vivid hallucinations, including autonomous entities, landscapes, and scenarios.

Cognitive Effects

Conceptual Thinking

  • Abstract Thinking: Users may engage in more abstract or philosophical thoughts.
  • Creativity: Enhanced creativity and imaginative thinking may occur.

Cognitive Euphoria

  • Euphoria: Feelings of happiness, contentment, and general well-being may be experienced.


  • Altered Beliefs: Users may experience temporary delusions or distortions in their beliefs or perceptions.

Emotion Enhancement

  • Emotional Intensity: Emotions may become more intense and profound.

Immersion Enhancement

  • Deep Engagement: Users may feel deeply immersed in their thoughts, activities, or surroundings.

Increased Music Appreciation

  • Enhanced Enjoyment: Music may sound more vibrant, emotionally resonant, or profound.

Memory Suppression

  • Memory Loss: Users may experience difficulty recalling past events or forming new memories.

Ego Death

  • Loss of Self: Users may experience a dissolution of the sense of self or ego.

Novelty Enhancement

  • Fascination with Novelty: Everyday experiences may become more novel and interesting.

Personal Bias Suppression

  • Reduced Bias: Users may become more open-minded and less influenced by personal biases or prejudices.

Thought Loops

  • Repetitive Thoughts: Users may get caught in cyclical patterns of thinking, where the same thoughts repeat.

Time Distortion

  • Subjective Time Alterations: Users may perceive time as passing more slowly or quickly than usual.

Unity and Interconnectedness

  • Sense of Connection: Users may feel a profound sense of unity with others, nature, or the universe as a whole.

Auditory Effects


  • Increased Sensitivity: Users may notice subtleties in sound that they would not typically perceive.
  • Enhanced Music Appreciation: Music may sound richer, fuller, or more immersive.


  • Altered Perception: Sounds may be distorted or seem different from reality.


  • Auditory Hallucinations: Users may perceive sounds or voices that are not present in their environment.

Toxicity and Harm Potential

The long-term health effects of recreational 5-MeO-DiPT use have not been extensively studied in scientific contexts, and the exact toxic dose remains unknown. This is primarily due to its classification as a research chemical with limited human usage history. Neurotoxic effects have been studied in rats.

Anecdotal reports suggest that trying 5-MeO-DiPT by itself at low to moderate doses or using it sparingly does not typically result in negative health effects. However, caution should always be exercised, and independent research should be conducted to ensure the safety of combining it with other substances.

It is strongly recommended to practice harm reduction measures when using 5-MeO-DiPT.


Excessive doses of 5-MeO-DiPT have been associated with various adverse effects, including nausea, vomiting, agitation, decreased blood pressure, pupil dilation, increased heart rate, and hallucinations. Severe cases have resulted in rhabdomyolysis, renal failure, and even death. Instances of fatal overdose have been reported, including cases of rectal administration.

Tolerance and Addiction Potential

5-MeO-DiPT, like other serotonergic psychedelics, is not considered habit-forming. However, tolerance to its effects can develop rapidly after ingestion. It takes approximately three days for tolerance to be halved and around seven days to return to baseline in the absence of further consumption. Cross-tolerance with other psychedelics is also observed, leading to a diminished response to those substances.

Dangerous Interactions

Combining 5-MeO-DiPT with certain substances can be potentially dangerous and even life-threatening. Some of the known dangerous interactions include:

  • 2C-T-X
  • 2C-X
  • Cannabis
  • DOx
  • MDMA
  • Mescaline
  • NBOMe
  • Amphetamines
  • Cocaine
  • DXM
  • Tramadol
  • aMT
  • MAOIs
  • PCP

Legal Status

The legal status of 5-MeO-DiPT varies by country:

  • In Brazil, China, Denmark, Greece, Japan, Latvia, Singapore, and Sweden, it is illegal.
  • In Germany, it is controlled under narcotics laws.
  • In New Zealand, it is considered a Class C controlled drug.
  • In Switzerland, it is a controlled substance.
  • In the United Kingdom, it is a Class A drug.
  • In the United States, it is classified as a Schedule I controlled substance.

Frequently Asked Questions (FAQ)

1. What is 5-MeO-DiPT?

5-MeO-DiPT, or 5-methoxy-N,N-diisopropyltryptamine, is a synthetic indole alkaloid molecule of the tryptamine class. It is known for its psychedelic effects when administered.

2. How does 5-MeO-DiPT work?

The mechanism behind the psychedelic effects of 5-MeO-DiPT is primarily attributed to its agonism at the 5-HT2A receptor, a subtype of serotonin receptor. Additional mechanisms, such as monoamine oxidase inhibition (MAOI), may also play a role.

3. What are the effects of 5-MeO-DiPT?

The effects of 5-MeO-DiPT include psychedelic, entactogenic, stimulating, and physical sensations such as enhanced tactile sensitivity and increased libido. Visual distortions, emotional enhancements, and alterations in cognition are also commonly reported.

4. Is 5-MeO-DiPT safe to use?

The safety of 5-MeO-DiPT has not been extensively studied, and there are potential risks associated with its use. Adverse effects such as nausea, vomiting, and hallucinations have been reported, particularly at higher doses. It is strongly recommended to practice harm reduction measures and conduct thorough research before using this substance.

5. Can 5-MeO-DiPT lead to addiction?

5-MeO-DiPT is not considered habit-forming, but tolerance to its effects can develop rapidly. It is important to use this substance responsibly and avoid frequent use to mitigate the risk of tolerance and potential addiction.

6. What are the legal implications of using 5-MeO-DiPT?

The legal status of 5-MeO-DiPT varies by country, with some countries prohibiting its possession, production, and sale. It is classified as a Schedule I controlled substance in the United States and a Class A drug in the United Kingdom, among other legal designations in different jurisdictions.

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