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Buy Zopiclone for sale online - USA vendor

Product Name: Zopiclone
IUPAC Name: (RS)-6-(5-Chloropyridin-2-yl)-7-oxo-6,7-dihydro-5H-pyrrolo[3,4-b]pyrazin-5-yl 4-methylpiperazine-1-carboxylate
Other Names: Zimovane, Imovane
Molecular Formula: None
Molar Mass: 237.26 g·mol−1
Effect: stimulant, psychedelic
Purity of the substance: 99.9%
Physical properties: Crystals, Powder
Buy Zopiclone for sale online - USA vendor
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Table of Contents

  1. Introduction
  2. Chemistry
  3. Pharmacology
  4. Subjective Effects
  5. Dosage
  6. Physical Effects
  7. Visual Effects
  8. Cognitive Effects
  9. Auditory Effects
  10. Toxicity and Harm Potential
    • Overview
    • Dependence and Abuse Potential
    • Dangerous Interactions
  11. Legal Status


Zopiclone, recognized under trade names such as Zimovane and Imovane, belongs to the cyclopyrrolone class of non-benzodiazepine hypnotic substances. It falls within the category of "Z-drugs," alongside zaleplon (Sonata) and zolpidem (Ambien and AmbienCR). These drugs exhibit benzodiazepine-like activity on GABA receptors, contributing to their sedative effects.

Misuse Potential and Usage Recommendations

Initially perceived to have lower misuse potential than benzodiazepines, recent observations of addiction and habituation have altered this perspective. Zopiclone, like other "Z-drugs," is typically prescribed for short-term use, usually not exceeding a week, to mitigate the risks of dependence.


Zopiclone is a nonbenzodiazepine hypnotic drug featuring a cyclopyrrolone structure. It shares similarity with its stereoisomer, zopiclone (Lunesta), and is distinguished by its pyrrolone core and a pyrazine ring, along with other functional groups.

The drug's composition includes a pyrrolone core with a ketone group at R5, fused with a pyrazine ring at R3 and R4, and attached to a substituted pyridine ring at R6. Furthermore, it incorporates a piperazine ring linked to the pyrrolone core through a carboxylate group at R7.


Despite structural disparities, zopiclone mirrors benzodiazepines in its pharmacological actions. It binds to GABAA receptors similarly to benzodiazepines, acting as a full agonist, thereby enhancing GABA binding and resulting in sedative and anxiolytic effects. Additionally, it exhibits barbiturate-like properties and acts as a noncompetitive antagonist at nicotinic acetylcholine receptors.

Its metabolite, desmethylzopiclone, displays anxiolytic properties and partial agonist activity on α1 and α5 GABAA receptor subunits. However, it is generally considered non-selective in its binding to α1, α2, α3, and α5 GABAA benzodiazepine receptor complexes.

Subjective Effects

Compared to benzodiazepines, zopiclone often induces more pronounced amnesic and disinhibiting effects, akin to alcohol. It's important to note that individual responses may vary, and higher doses increase the likelihood of experiencing the drug's full range of effects, including potential adverse reactions such as addiction and severe impairment.

In conclusion, while zopiclone serves as a valuable treatment for insomnia, its usage warrants careful consideration and adherence to prescribed guidelines to mitigate potential risks and ensure its therapeutic benefits.

Understanding Zopiclone Dosage: A Detailed Analysis


Zopiclone is typically administered orally in tablet form. Its dosage varies depending on the severity of insomnia and individual response. Understanding the dosage guidelines is crucial to ensure safe and effective use.


The bioavailability of zopiclone, the proportion of the drug that enters circulation when introduced into the body, ranges between 52% to 59% [citation needed]. This factor influences the drug's effectiveness and duration of action.

Dosage Thresholds

Zopiclone exhibits a range of dosage thresholds, indicating the minimum amount required to produce discernible effects.

  • Threshold: 2 mg
  • Light: 3.5 - 5 mg
  • Common: 5 - 7.5 mg
  • Strong: 7.5 - 15 mg
  • Heavy: 15 mg and above

These thresholds serve as reference points for users and healthcare professionals to gauge dosage adequacy and potential risk levels. It's important to adhere to prescribed dosages and avoid exceeding recommended limits to prevent adverse effects and complications.

Physical Effects

Zopiclone exerts a range of physical effects on users, which can vary in intensity based on dosage.

  • Sedation: Zopiclone induces profound sedation, often leading users into an overwhelmingly lethargic state. Higher doses can intensify this effect, causing users to feel extremely sleep deprived and on the brink of passing out.
  • Respiratory Depression: Zopiclone can depress respiratory function, particularly at higher doses, posing risks to individuals with compromised respiratory health.
  • Muscle Relaxation: Users may experience muscle relaxation, contributing to feelings of physical heaviness and relaxation.
  • Dizziness: Zopiclone can induce dizziness, leading to impaired balance and coordination.
  • Motor Control Loss: Similar to alcohol intoxication, zopiclone can impair motor function, resulting in stumbling and difficulty walking straight. To mitigate injury risks, users should avoid activities requiring precise motor skills, such as walking or using stairs.
  • Gustatory Hallucination: Some users report experiencing a metallic taste in their mouth after consuming zopiclone.

Visual Effects

Zopiclone can induce various visual effects, which may manifest at different dosage levels.

  • Shadow People: At high doses, users may perceive shadowy figures or shapes, a phenomenon commonly referred to as shadow people.
  • Acuity Suppression: Zopiclone can suppress visual acuity, leading to blurred vision or difficulty focusing.
  • Drifting: Visual drifting effects, characterized by distortions in perception such as melting, breathing, or morphing of objects, are common. These effects may be more pronounced in low lighting conditions and can occur at strong doses.
  • External Hallucinations: In rare cases, zopiclone may induce external hallucinations, though they are typically less intense than those experienced with deliriants.
  • Tracers: Users may perceive trailing or lingering visual images, known as tracers, particularly at high doses.

Cognitive Effects

Zopiclone influences cognitive function, often resulting in a range of effects that intensify with dosage.

  • Amnesia: Zopiclone can induce amnesia, with users potentially experiencing memory gaps, even at moderate doses. This effect may be less intense compared to other drugs like zolpidem.
  • Anxiety Suppression: The drug can suppress feelings of anxiety, promoting a sense of calmness and relaxation.
  • Thought Deceleration: Zopiclone may slow down cognitive processing, leading to a reduction in thought speed and clarity.
  • Disinhibition: Users may experience a loss of inhibitions, which can lead to impulsive behavior and decreased self-control.
  • Delusion and Delirium: In rare cases, zopiclone may induce delusional thinking or delirium, characterized by confusion and disorientation.
  • Analysis Suppression: Zopiclone can impair logical reasoning and analytical thinking.
  • Euphoria: Some users report feelings of euphoria, particularly during the onset of the experience, though this effect is usually short-lived.
  • Emotion Suppression: Zopiclone may suppress various emotions, including anxiety, although it can also dampen other emotions, similar to antipsychotic drugs.
  • Time Compression: Users may perceive time as passing more quickly than usual, especially at higher doses.
  • Irritability: Zopiclone, combined with disinhibiting effects, can lead to irritability and potentially aggressive behavior towards others or oneself.
  • Increased Music Appreciation: Users may experience heightened enjoyment and appreciation of music while under the influence of zopiclone.
  • Compulsive Redosing: Some users may feel compelled to take additional doses of zopiclone, leading to a pattern of compulsive redosing.

Auditory Effects

Zopiclone can also influence auditory perception, with potential effects including:

  • Auditory Hallucinations: At higher doses, users may experience auditory hallucinations, often in the form of voices. Sleep deprivation can exacerbate this effect.

Understanding these effects is essential for safe and informed use of zopiclone, highlighting the importance of adhering to prescribed dosages and precautions to minimize risks and ensure well-being.

Toxicity and Harm Potential


Zopiclone is generally considered to have a low toxicity relative to dosage. However, caution is warranted, as it can be potentially lethal when combined with other depressants such as benzodiazepines, alcohol, or opioids. Mixing zopiclone with these substances significantly increases the risk of blackouts, where users may have little to no memory of events while under the influence. Some individuals have reported using zopiclone in combination with alcohol to manage hangovers, with varying degrees of success. It's crucial to exercise harm reduction practices and conduct independent research before using this substance.

Dependence and Abuse Potential

Addiction Potential

Zopiclone is highly addictive both physically and psychologically, with a potential for addiction even greater than benzodiazepines. Tolerance to its sedative-hypnotic effects can develop within a few weeks of regular use. Upon cessation, tolerance typically returns to baseline within 7 to 14 days. Abrupt discontinuation after steady dosing may lead to withdrawal or rebound symptoms, necessitating a gradual tapering of dosage. Zopiclone also exhibits cross-tolerance with benzodiazepines and other GABAergic depressants, reducing the effectiveness of these substances.

Dangerous Interactions


Combining zopiclone with certain substances can result in dangerous or life-threatening interactions. It's essential to conduct thorough research to ensure the safety of combining substances. Here are some known dangerous interactions:

  • Depressants: Mixing zopiclone with substances like alcohol, opioids, or barbiturates can lead to severe respiratory depression, muscle relaxation, sedation, and amnesia, potentially resulting in loss of consciousness or suffocation. If unconsciousness occurs, users should be placed in the recovery position to prevent suffocation from vomiting.
  • Dissociatives: Combining zopiclone with dissociative substances can increase the risk of vomiting during unconsciousness and suffocation. Users should be monitored and placed in the recovery position if necessary.

Legal Status


The legal status of zopiclone varies by country:

  • Canada: Zopiclone is available by prescription only.
  • Germany: Classified as a prescription medicine according to Anlage 1 AMVV.
  • Norway: Available by prescription.
  • Switzerland: Listed as a pharmaceutical requiring a prescription.

Expanding upon and verifying this information is essential due to the potential legal ramifications of possessing or distributing zopiclone.

Frequently Asked Questions (FAQ)

Q1: Is zopiclone safe to use?

A1: Zopiclone is generally considered safe when used as prescribed by healthcare professionals for the treatment of insomnia. However, caution should be exercised, especially when combining it with other substances such as alcohol or opioids, as this can increase the risk of adverse effects.

Q2: Can zopiclone be addictive?

A2: Yes, zopiclone can be addictive, both physically and psychologically. Tolerance to its effects can develop with regular use, leading to dependence and withdrawal symptoms upon cessation. It's essential to use zopiclone only as directed by a healthcare provider and to avoid prolonged or excessive use.

Q3: What are the potential side effects of zopiclone?

A3: Zopiclone can cause a range of side effects, including sedation, dizziness, muscle relaxation, cognitive impairment, and respiratory depression. Visual and auditory disturbances may also occur, especially at higher doses or when combined with other substances.

Q4: How should I use zopiclone responsibly?

A4: It's crucial to use zopiclone only as prescribed by a healthcare provider and to follow dosage instructions carefully. Avoid combining it with alcohol or other depressants, as this can increase the risk of adverse effects. Additionally, refrain from activities requiring alertness, such as driving, while under the influence of zopiclone.

Q5: Is zopiclone legal to use?

A5: The legal status of zopiclone varies by country. In many countries, including Canada, Germany, and Norway, it is available by prescription only. It's important to be aware of and adhere to local laws and regulations regarding the use of zopiclone.

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