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Specification
Product Name: Ayahuasca
IUPAC Name: None
Other Names: Ayahuasca, Aya, Caapi, Cipó, Hoasca, Vegetal, Yagé, Yajé, Natem, Shori
Molecular Formula: None
Molar Mass: 237.26 g·mol−1
Effect: stimulant, psychedelic
Purity of the substance: 99.9%
Physical properties: Crystals, Powder
100g
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Table of Contents

  1. Introduction
  2. History and Culture
  3. Understanding Ayahuasca
    • Mechanism of Action
    • Cultural and Historical Context
    • Psychological Effects and Considerations
  4. Exploring the Physical Effects of Ayahuasca
    • Energy Levels: Stimulation or Sedation
    • Bodily Sensations and Perceptions
    • Nausea and Purging
    • Other Physical Effects
  5. Visual Effects Induced by Ayahuasca
    • Enhancements and Distortions
    • Visual Geometry and Hallucinatory States
  6. Cognitive Effects and Perceptions
  7. Preparing Ayahuasca: Methods and Considerations
    • Traditional Preparation
    • Reversible and Irreversible MAOIs
    • Exploring Alternatives: Changa and Pharmahuasca
    • Recipes and Dosage Recommendations
  8. Exploring Ayahuasca's Therapeutic Potential
    • Antidepressant Effects
    • Mechanisms of Action
  9. Assessing Toxicity and Harm Potential
    • Safety Profile
    • Lethal Dosage and Tolerance
    • Dangerous Interactions
  10. Legal Status and Regulatory Considerations
  • International Regulations
  • Regional Legislation

Introduction to Ayahuasca

Ayahuasca, also known as Yagé, encompasses a broad spectrum of traditional and contemporary concoctions derived from natural plant sources, renowned for their profound psychoactive and hallucinogenic properties. Primarily, ayahuasca compositions feature a blend of a DMT-containing plant alongside one rich in MAOI or RIMA compounds, commonly utilizing plants like the B. caapi vine or Syrian rue. This combination results in uniquely potent psychedelic effects, often perceived as medicinal in nature.

Mechanism of Action

The pivotal role of an MAOI agent in ayahuasca consumption stems from the inherent properties of the DMT molecule. DMT, a monoamine akin to serotonin, faces near-total inactivation when ingested in isolation, owing to the presence of monoamine oxidase enzymes in the stomach, which swiftly degrade it.

Cultural and Historical Context

Ayahuasca holds deep cultural significance as a traditional spiritual medicine within the ceremonial practices of Indigenous peoples residing in Amazonian Peru. Many of these communities claim to have received guidance on its utilization directly from the plant entities themselves. The first documented encounters with ayahuasca outside Indigenous circles trace back to the early 1950s, when Harvard ethnobotanist Richard Evans Schultes shed light on its role in divination and healing rituals among Native populations.

Psychological Effects and Considerations

Contrary to popular misconceptions, ayahuasca and psychedelics, in general, are not deemed to be habit-forming or addictive by scientific and medical communities. However, the experience can unpredictably induce adverse reactions such as anxiety, paranoia, delusions, or psychotic episodes, especially among individuals predisposed to psychiatric conditions. While inadequate preparation or inexperienced usage often underlie such negative episodes, even seasoned users are not immune to spontaneous "bad trips." Therefore, despite scientific evidence suggesting minimal physical and neurotoxic risks, exercising caution and adhering to harm reduction practices remains imperative when engaging with this potent and capricious hallucinogenic substance.

Unveiling the History and Culture of Ayahuasca

Archaeological Insights

A profound glimpse into the historical roots of ayahuasca emerged from a discovery in Bolivia's rock shelter, revealing a 1000-year-old assortment of drug paraphernalia. Among the artifacts were traces of five psychoactive substances, including cocaine and elements integral to ayahuasca, encapsulating its ancient lineage and cultural significance.[5]

Ayahuasca Ceremonies: Traditions and Pitfalls

While ayahuasca ceremonies offer a conduit to spiritual enlightenment and healing, documented cases have surfaced, highlighting avoidable fatalities stemming from fraudulent individuals posing as shamans. The inclusion of brugmansia, a particular ingredient notorious for adverse reactions when co-administered with an MAOI, has been implicated in such tragic incidents. Contrary to popular belief, crafting a potent ayahuasca brew necessitates nothing more than a suitable DMT source (such as mimosa or acacia) paired with a reversible inhibitor of monoamine oxidase A (RIMA or MAOI). Mixing additional components can pose potential dangers, mandating thorough research into potential interactions before ingestion.[6][7][8]

Cultural Perceptions and Misconceptions

The mysticism and pseudoscience woven into centuries-old mythological rituals have birthed a culture steeped in singular narratives, fostering a bias tethered to a singular cultural paradigm. The irrational notion that ayahuasca's efficacy hinges solely on its consumption within the confines of the Amazon rainforest, under the guidance of a shaman, perpetuates a restrictive mindset. Such beliefs discourage exploration beyond this environment, devoid of logical foundation, thereby impeding broader understanding and safe utilization of ayahuasca.[8]

Exploring Ayahuasca's Pharmacology

Ayahuasca's psychedelic potency stems from its interaction with the 5-HT2A receptor as a partial agonist, orchestrating the kaleidoscopic tapestry of its effects. However, the intricacies of these interactions and their orchestration of the psychedelic experience continue to elude complete scientific comprehension.

Unveiling Harmala Alkaloids

Central to ayahuasca's pharmacological profile are harmala alkaloids, notably found in the B. caapi vine. Harmine and harmaline emerge as selective and reversible inhibitors of monoamine oxidase A (MAO-A), while tetrahydroharmine exhibits a modest serotonin reuptake inhibition (SRI) effect. This inhibition of MAO-A crucially permits the unhindered diffusion of DMT past gastrointestinal barriers, facilitating its journey across the blood-brain barrier to activate key receptor sites in the brain. Without the presence of RIMAs or MAOIs, DMT succumbs to oxidation by monoamine oxidase enzymes in the digestive tract, rendering it biologically inert.[10][11]

Navigating the Subjective Realm: Effects of Ayahuasca

(Disclaimer: The effects below are based on the Subjective Effect Index (SEI), a compilation of anecdotal user reports and analyses from PsychonautWiki contributors. Exercise caution and skepticism when interpreting these effects, as their occurrence may vary unpredictably. Higher doses may intensify these effects, potentially leading to adverse outcomes such as addiction, severe injury, or death.)

Exploring the Physical Effects of Ayahuasca

Energy Levels: Stimulation or Sedation

Ayahuasca's impact on physical energy levels varies significantly depending on the setting. In socially dynamic environments with fast-paced music or engaging activities like running or dancing, it can induce stimulation and heightened energy. Conversely, in tranquil settings characterized by subdued lighting and comfortable seating, it often promotes relaxation and sedation.

Bodily Sensations and Perceptions

  • Perception of Bodily Heaviness: Users may experience a sensation of increased bodily weight or groundedness.
  • Perception of Bodily Lightness: Conversely, some users report feelings of weightlessness or buoyancy.
  • Spontaneous Physical Sensations: Often described as a warm, pleasurable glow, the "body high" of ayahuasca manifests unpredictably throughout the experience, offering a sense of enveloping comfort and warmth.

Nausea and Purging

Ayahuasca's traditional form is renowned for its purgative properties, which can induce nausea, vomiting, diarrhea, and cold flashes—a phenomenon known as "la purga" or "the purge." While some view these effects as integral to the healing process, others find them discomforting. Research indicates that the purging process may serve to expel parasites from the body, supported by the presence of harmala alkaloids known to expel intestinal parasites.

Other Physical Effects

  • Changes in Felt Bodily Form
  • Muscle Relaxation or Tension
  • Motor Control and Autonomy
  • Appetite Suppression
  • Dehydration and Stomach Discomfort

Visual Effects Induced by Ayahuasca

Enhancements and Distortions

  • Enhanced Visual Acuity and Color Perception
  • Pattern Recognition and Magnification
  • Distortions such as Drifting and Tracers

Visual Geometry and Hallucinatory States

The visual geometry experienced during an ayahuasca trip resembles that induced by psilocybin mushrooms, characterized by intricate, organic forms with vibrant colors. At higher doses, the intensity and complexity of geometric patterns may escalate, accompanied by hallucinatory experiences such as machinescapes and transformations.

Cognitive Effects and Perceptions

Clear-headedness and Mindfulness

Ayahuasca is often described as inducing a clear-headed and sober cognitive state despite its potent psychedelic effects. Users commonly report sustained mindfulness, which can persist for days, weeks, or even months post-experience, fostering therapeutic benefits for psychological well-being.

Emotional and Cognitive Enhancements

  • Addiction Suppression
  • Analysis Enhancement
  • Creativity and Conceptual Thinking
  • Empathy and Sociability Enhancement

Ego Dissolution and Perception Alterations

Ayahuasca can lead to ego dissolution, wherein the boundaries between self and surroundings blur, fostering feelings of unity and interconnectedness. Users may also experience alterations in time perception, enhanced music appreciation, and increased sense of humor.

Auditory and Multi-sensory Effects

Auditory Perception

Users may perceive auditory enhancements, distortions, and hallucinations, enriching the overall sensory experience of the trip.

Synaesthesia and Transpersonal Experiences

Ayahuasca-induced synaesthesia may intertwine sensory modalities, while transpersonal effects such as spirituality enhancement and existential self-realization offer profound insights into the nature of consciousness and existence.

Preparing Ayahuasca: Methods and Considerations

Traditional Preparation

Traditional ayahuasca is crafted by brewing the Banisteriopsis caapi vine, rich in MAOIs, with a DMT-containing plant like Psychotria viridis. This blend forms the foundation of ayahuasca ceremonies among Indigenous communities.

Understanding Reversible and Irreversible MAOIs

It's crucial to differentiate between reversible and irreversible MAOIs when preparing ayahuasca. Irreversible MAOIs remain active in the body for an extended period, potentially leading to dangerous interactions with tyramine-rich foods and triggering hypertensive crises. Hence, employing reversible MAOIs or RIMAs is strongly recommended for safety and efficacy, aligning more closely with the Harmala alkaloids found in traditional ayahuasca.

Exploring Alternatives: Changa and Pharmahuasca

  • Changa: A smoking blend infused with DMT, Changa offers a convenient alternative to traditional ayahuasca consumption. It typically consists of DMT extracts blended with various herbs and ayahuasca components, delivering a smokeable form of the brew.

  • Pharmahuasca: Utilizing pharmaceutical-grade ingredients, pharmahuasca offers a precise and controlled approach to ayahuasca consumption. Combining specific dosages of DMT and harmaline or harmine in gelatin capsules, pharmahuasca minimizes nausea while maximizing the intensity of visionary experiences.

Recipes and Dosage Recommendations

Pharmahuasca typically involves the ingestion of 50 mg N,N-DMT and 100 mg harmaline per person. However, variations in dosage, such as 50 mg harmaline, 50 mg harmine, and 50 mg N,N-DMT, have also shown efficacy. The choice of ingredients influences the intensity of visions and the likelihood of experiencing nausea, emphasizing the importance of careful formulation.

Exploring Ayahuasca's Therapeutic Potential

Antidepressant Effects

Research indicates that ayahuasca exhibits rapid and significant antidepressant effects, offering promising alternatives to conventional antidepressants. Studies have reported substantial reductions in depressive scores following ayahuasca administration, suggesting its potential as a fast-acting anxiolytic and antidepressant agent.

Mechanisms of Action

While the precise mechanisms underlying ayahuasca's antidepressant effects remain unclear, hypotheses revolve around its MAOI and serotonin reuptake inhibition properties. Additionally, the subjective effects of 5-HT2A agonism contribute to its therapeutic potential, necessitating further research to elucidate its impact on depressive disorders.

Assessing Toxicity and Harm Potential

Safety Profile

Ayahuasca exhibits low toxicity relative to dosage and is non-addictive, with minimal risk of physical harm. Studies have demonstrated its safety in controlled contexts, highlighting its potential as a therapeutic tool with few adverse effects.

Lethal Dosage and Tolerance

Research attempting to establish the lethal dose of ayahuasca in rats failed due to the large quantities required, indicating its physical safety. Moreover, ayahuasca does not induce tolerance or cross-tolerance with other psychedelics, allowing for repeated usage without diminished effects.

Dangerous Interactions

Ayahuasca's MAOI effects elevate the risk of serotonin syndrome and neurotransmitter overload when combined with certain substances, including other MAOIs and stimulants. Awareness of potential interactions is crucial to mitigate risks and ensure safe consumption practices.

Legal Status and Regulatory Considerations

International Regulations

Internationally, DMT is classified as a Schedule I drug under the Convention on Psychotropic Substances. However, plants containing DMT are not subject to international control, offering a legal loophole for ayahuasca preparations.

Regional Legislation

  • Brazil: Religious use of ayahuasca is legal.
  • Peru: Traditional therapeutic use of ayahuasca is permitted.
  • United States: Legal status varies by state, with Louisiana prohibiting the cultivation and possession of ayahuasca plants for non-ornamental purposes.

Understanding regional laws and regulations is essential for individuals seeking to engage with ayahuasca in a legal and responsible manner.

Frequently Asked Questions (FAQ)

1. Is ayahuasca addictive?

Ayahuasca is not habit-forming and is most often self-regulating. The desire to use it can actually decrease with use.

2. What are the potential therapeutic applications of ayahuasca?

Research suggests that ayahuasca exhibits rapid antidepressant effects, with significant reductions in depressive scores reported following administration. Additionally, its acute and fast-acting effects show promise for the treatment of depression, offering alternatives to conventional antidepressants.

3. Is ayahuasca safe to use?

Ayahuasca exhibits low toxicity relative to dosage and is non-addictive. Studies have demonstrated its safety in controlled contexts, with minimal risk of physical harm.

4. Can ayahuasca interact with other substances?

Due to its MAOI effects, ayahuasca can interact dangerously with certain substances, including other MAOIs and stimulants. It is crucial to be aware of potential interactions to ensure safe consumption practices.

5. What is the legal status of ayahuasca?

Internationally, DMT is classified as a Schedule I drug, but plants containing DMT are not subject to international control. Regional legislation varies, with countries like Brazil and Peru permitting certain uses of ayahuasca, while others impose restrictions on its cultivation and possession. Understanding local laws and regulations is essential for responsible use.


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