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Table of Contents

1. Introduction
2. Chemistry
3. Pharmacology
4. Dosage
5. Subjective Effects
6. Physical Effects
7. Toxicity and Harm Potential
8. Legal Status
9. FAQ

Synthesis and Exploration by Alexander Shulgin

In the realm of lesser-known psychedelic substances, 4-Hydroxy-N,N-diisopropyltryptamine, colloquially known as 4-HO-DiPT or Iprocin, emerges as a unique member of the tryptamine class. This compound exhibits psychedelic effects akin to psilocin upon administration, serving as the 4-hydroxy analog of DiPT and sharing structural similarities with tryptamines such as 4-HO-DMT (Psilocin), 4-HO-MiPT (Miprocin), and 4-HO-DET (Ethocin).

The genesis of understanding 4-HO-DiPT can be traced back to 1977 when David B. Repke synthesized the compound. Subsequently, the effects of this intriguing substance were explored by the renowned Alexander Shulgin. Shulgin's insights into 4-HO-DiPT are encapsulated in his 1997 book "TiHKAL" ("Tryptamines I Have Known and Loved"). Noteworthy aspects of 4-HO-DiPT highlighted in the book include its rapid onset (approximately 15 minutes after ingestion), potent intensity (where 20 milligrams can induce a transcendent peak experience), short duration (lasting 2-3 hours), and remarkable dose sensitivity. Moreover, idiosyncratic physical effects, such as muscle tremors and bodily malaise, were observed.

Contemporary Usage and Cautionary Considerations

In the present day, 4-HO-DiPT finds applications in both recreational and entheogenic settings. However, it remains relatively uncommon and is occasionally available through online research chemical markets. The pharmacological properties, metabolism, and toxicity in humans are shrouded in mystery, with limited historical data on human use. Given these uncertainties, individuals engaging with 4-HO-DiPT are strongly advised to adhere to harm reduction practices.

In summary, 4-Hydroxy-N,N-diisopropyltryptamine stands out in the psychedelic landscape due to its unique characteristics and limited understanding. From its synthesis by Repke to Shulgin's exploration, the compound has intrigued researchers and enthusiasts alike. As contemporary applications emerge, the need for a nuanced understanding of its effects and potential risks becomes paramount, emphasizing the importance of responsible usage and ongoing research to unravel the enigma of 4-HO-DiPT.

Decoding the Chemistry of 4-HO-DiPT

Molecular Structure and Classification

At its molecular core, 4-HO-DiPT, also known as 4-Hydroxy-N,N-diisopropyltryptamine, stands as a synthetic indole alkaloid belonging to the tryptamine chemical class. Tryptamines, a distinctive subgroup, share a fundamental structure characterized by a bicyclic indole heterocycle linked at R3 to an amino group through an ethyl side chain. In the case of 4-HO-DiPT, a hydroxyl functional group (OH−) graces the R4 position of its indole heterocycle, accompanied by two isopropyl groups tethered to the terminal amine RN of its tryptamine backbone.

This compound is not only the 4-hydroxy analog of DiPT but also the N-substituted isopropyl homolog of 4-HO-DMT, underscoring its intricate structural relationships within the tryptamine family.

Pharmacological Insights into 4-HO-DiPT

Delving into the pharmacological realm, 4-HO-DiPT, like many psychedelic tryptamines, is postulated to primarily function as a 5-HT2A partial agonist. The manifestation of psychedelic effects is believed to stem from the binding efficacy of 4-HO-DiPT at the 5-HT2A receptors. However, the precise mechanisms underlying these interactions and their contribution to the psychedelic experience remain elusive, adding an air of mystery to the pharmacology of this intriguing compound. Further research is warranted to unravel the intricate interplay between 4-HO-DiPT and the serotonin receptors, shedding light on the pathways that give rise to its unique psychedelic effects.

Navigating 4-HO-DiPT Dosages

Understanding the Spectrum of Dosage Levels

4-HO-DiPT, the 4-hydroxy analog of DiPT, commands attention not only for its unique properties but also for the intricacies involved in determining appropriate dosage levels. As with any psychedelic substance, the effects experienced can vary significantly based on the amount consumed. Here, we break down the dosage spectrum for 4-HO-DiPT:

Threshold Dosage (3 mg)

At the threshold level, the effects of 4-HO-DiPT become perceptible but are subtle. Individuals may experience a slight alteration in perception and mood, providing a gentle introduction to the substance.

Light Dosage (3 - 10 mg)

Moving into the light dosage range, the effects become more pronounced. Users may notice enhanced sensory perception, mood elevation, and mild psychedelic experiences. This dosage range is often favored by those seeking a mild and manageable introduction to the psychedelic effects of 4-HO-DiPT.

Common Dosage (10 - 20 mg)

The common dosage range represents a moderate level of consumption. Users entering this range can anticipate more noticeable psychedelic effects, including altered visual perception, enhanced introspection, and a deeper connection with sensory experiences.

Strong Dosage (20 - 30 mg)

As dosage increases into the strong range, the psychedelic effects intensify. Users may encounter profound alterations in perception, vivid visual hallucinations, and a heightened sense of introspection. This dosage level is recommended for those with prior psychedelic experience and a desire for a more intense journey.

Heavy Dosage (30 mg and above)

At the heavy dosage level, the effects of 4-HO-DiPT reach their peak intensity. Users may experience a profound and immersive psychedelic experience, characterized by intense visuals, altered thought patterns, and a deep exploration of the psyche. This dosage level requires careful consideration, as it is suitable for experienced individuals seeking an intense and transformative experience.

In navigating the dosage spectrum of 4-HO-DiPT, individuals are advised to approach the substance with caution, starting with lower doses to assess individual sensitivity and tolerance. Additionally, external factors such as set and setting play crucial roles in shaping the overall psychedelic experience. Always prioritize harm reduction practices and responsible use when exploring the dosage landscape of 4-HO-DiPT.

Subjective Effects of 4-HO-DiPT

A Cautionary Exploration through Anecdotal Insights

Delving into the subjective effects of 4-HO-DiPT demands a nuanced approach, acknowledging the complex interplay between individual experiences and dosage levels. It's imperative to recognize that the information presented is drawn from the Subjective Effect Index (SEI), a compilation of anecdotal user reports and analyses contributed by the PsychonautWiki community. However, a disclaimer is essential: these effects should be approached with a healthy degree of skepticism.

Disclaimer and Considerations

Before delving into the subjective effects, it's crucial to highlight the disclaimer that accompanies these insights. The SEI serves as a valuable resource, but the effects listed may not unfold predictably or reliably for every individual. Higher doses are recognized as more likely to induce the full spectrum of effects, but even then, variability exists.

Furthermore, a note of caution is sounded regarding adverse effects, which become increasingly probable with higher doses. Potential risks encompass addiction, severe injury, or, in extreme cases, death. This cautionary stance emphasizes the need for users to exercise prudence and responsibility when engaging with 4-HO-DiPT.

Subjective Effects Overview

1. Mood Enhancement: Users have reported a positive shift in mood, often characterized by feelings of euphoria and general well-being.

2. Visual Distortions: Distinct alterations in visual perception, including vivid colors, patterns, and geometric shapes, have been noted.

3. Auditory Changes: Some individuals experience modifications in auditory perception, with sounds becoming more vibrant or taking on unique qualities.

4. Time Distortion: Temporal perception may be altered, with users reporting a sense of time dilation or compression.

5. Introspection: 4-HO-DiPT is associated with an enhanced capacity for introspective thinking, leading to profound self-reflection.

6. Sensory Enhancement: Heightened sensitivity to touch and other sensory stimuli, contributing to a more immersive experience.

7. Euphoria and Bliss: A prevalent sense of euphoria and bliss has been reported, contributing to the overall positive mood enhancement.

8. Mindfulness and Presence: Users may experience an increased sense of mindfulness and presence, feeling more attuned to the present moment.

While these subjective effects provide a glimpse into the potential experiences with 4-HO-DiPT, users are reminded to approach the substance with caution, understanding the inherent variability and potential risks associated with its consumption. Responsible use and adherence to harm reduction practices remain paramount in navigating the subjective landscape of 4-HO-DiPT.

Physical Effects of 4-HO-DiPT

A Comprehensive Examination of Physiological Responses

Embarking on a journey through the physical effects of 4-HO-DiPT unveils a spectrum of responses that underscore the complexity of this psychedelic substance.

Stimulation and Spontaneous Sensations

• Stimulation: Users may experience heightened levels of physical energy and alertness.
• Spontaneous Sensations: Individuals might encounter unpredictable and spontaneous tactile sensations on the skin.

Cardiovascular Responses

• Increased Heart Rate: A notable rise in heart rate is a common physiological response.
• Increased Blood Pressure: Blood pressure may elevate as part of the cardiovascular effects.

Gastrointestinal Impact

• Nausea: Some users report feelings of nausea, a common occurrence with certain psychedelics.

Ocular Changes

• Pupil Dilation: Enlarged pupils are a characteristic visual response to 4-HO-DiPT.

Visual Transformations

• Enhancements: Users may perceive enhancements in visual experiences.
• Colour Enhancement: Colors may appear more vibrant and pronounced.
• Pattern Recognition Enhancement: Improved ability to recognize and appreciate visual patterns.
• Visual Acuity Enhancement: Heightened sharpness and clarity of vision.

Visual Distortions

• Drifting: Visual elements may exhibit fluid-like movements, such as melting, breathing, morphing, and flowing.
• Colour Shifting: Colors may undergo dynamic changes.
• Depth Perception Distortions: Alterations in the perception of three-dimensional space.
• Perspective Distortions: Shifts in how objects are perceived in relation to each other.
• Symmetrical Texture Repetition: Patterns may repeat symmetrically.
• Tracers: Persistent trails following moving objects.
• After Images: Lingering images seen after the original stimulus is removed.
• Brightness Alteration: Changes in the perceived brightness of visual stimuli.
• Diffraction: Light may diffract, creating visual spectacles.

Hallucinatory States

• Transformations: External stimuli may undergo profound transformations.
• Internal Hallucination: Users may experience vivid hallucinations, including autonomous entities, settings, sceneries, landscapes, perspective hallucinations, and intricate scenarios.

Cognitive Effects

• Conceptual Thinking: Enhanced ability for abstract and conceptual thinking.
• Cognitive Euphoria: A sense of intellectual and cognitive well-being.
• Delusion: Temporary distortions in logical thinking.
• Emotion Enhancement: Amplification of emotional experiences.
• Immersion Enhancement: Deepening of engagement in activities.
• Increased Music Appreciation: Heightened appreciation for auditory stimuli, particularly music.
• Memory Suppression: Impairment of short-term memory.
• Ego Death: Temporary dissolution of the sense of self.
• Novelty Enhancement: Increased fascination with novel stimuli.
• Personal Bias Suppression: Reduction of personal biases.
• Thought Loops: Repetitive thought patterns.
• Time Distortion: Alterations in the perception of time.

Auditory Effects

• Auditory Enhancement: Increased sensitivity to sounds.
• Auditory Distortion: Changes in the quality of auditory perceptions.
• Auditory Hallucination: Perceptions of sounds that are not present.

Transpersonal Effects

• Unity and Interconnectedness: A sense of interconnectedness and unity with the surroundings and others.

Understanding the vast array of physical effects associated with 4-HO-DiPT necessitates careful consideration, emphasizing the importance of responsible use and adherence to harm reduction practices. As individual responses can vary, users are encouraged to approach this psychedelic substance with caution and a thorough understanding of its potential physiological impact.

Toxicity and Harm Potential of 4-HO-DiPT

Examining Limited Scientific Insights

The scientific exploration of the toxicity and long-term health effects of recreational 4-HO-DiPT usage remains largely uncharted territory. This lack of empirical research is primarily due to the limited history of human consumption and the status of 4-HO-DiPT as a research chemical.

Anecdotal Insights and Health Considerations

Anecdotal reports from individuals who have experimented with 4-HO-DiPT suggest a lack of significant negative health effects when used in isolation at low to moderate doses and with extreme caution. However, it's important to exercise caution and recognize that individual reactions can vary. Independent research is imperative to ensure the safety of combining 4-HO-DiPT with other substances.

Harm Reduction Practices

Given the uncertainties surrounding its safety profile, it is strongly recommended that individuals practice harm reduction strategies when using 4-HO-DiPT. This includes starting with low doses, ensuring a safe and comfortable environment, and having a trusted sober companion present.

Tolerance and Addiction Potential

Contrary to substances with addictive properties, 4-HO-DiPT is not considered habit-forming. In fact, the desire to use it may decrease with regular consumption, aligning with the self-regulating nature often associated with psychedelics.

Tolerance to the effects of 4-HO-DiPT builds rapidly after ingestion, with a reduction to half of tolerance occurring within approximately 3 days. It takes around 7 days for tolerance to return to baseline in the absence of further consumption. Notably, 4-HO-DiPT induces cross-tolerance with all psychedelics, meaning its consumption can reduce the effects of other psychedelics.

Dangerous Interactions and Warnings

Potential Interactions:

• Lithium: Combining 4-HO-DiPT with lithium, commonly used in bipolar disorder treatment, may significantly increase the risk of psychosis and seizures.
• Cannabis: Caution is advised when combining cannabis with 4-HO-DiPT, as it can amplify adverse psychological reactions such as anxiety, paranoia, and psychosis.
• Stimulants: Mixing stimulants like amphetamine or cocaine with 4-HO-DiPT may elevate the risk of anxiety, paranoia, and thought loops, potentially leading to mania and psychosis.
• Tramadol: Due to tramadol's propensity to lower seizure thresholds, combining it with 4-HO-DiPT could trigger seizures in susceptible individuals.

Legal Status

The legal status of 4-HO-DiPT varies across jurisdictions:

• Germany: Controlled under the New Psychoactive Substances Act since July 18, 2019.
• Sweden: Classified as a "health hazard" under specific regulations since March 1, 2005.
• Switzerland: Not controlled under certain regulations, potentially considered legal.
• United Kingdom: Class A drug under the tryptamine catch-all clause.
• United States: Unscheduled federally but may be prosecuted under the Federal Analogue Act.
• Florida: Classified as a Schedule I controlled substance.

Understanding the legal landscape is essential for individuals considering the possession, sale, or consumption of 4-HO-DiPT within their respective jurisdictions.

FAQ

Q: What is 4-HO-DiPT? 

A: 4-HO-DiPT, also known as 4-Hydroxy-N,N-diisopropyltryptamine or Iprocin, is a lesser-known psychedelic substance belonging to the tryptamine class.

Q: How does 4-HO-DiPT affect the body?

A: 4-HO-DiPT primarily acts as a 5-HT2A partial agonist, resulting in psychedelic effects such as altered perception, mood enhancement, and visual distortions.

Q: What are the recommended dosage levels for 4-HO-DiPT?

A: Dosage levels vary, with thresholds starting at 3 mg and heavy doses exceeding 30 mg. It's crucial to start with lower doses and gradually titrate to assess individual sensitivity.

Q: What are the potential physical effects of 4-HO-DiPT?

A: Physical effects may include stimulation, increased heart rate and blood pressure, nausea, pupil dilation, and various visual and auditory distortions.

Q: Are there any known health risks associated with 4-HO-DiPT?

A: Due to limited scientific research, the long-term health effects remain unclear. Anecdotal reports suggest no significant negative effects at low to moderate doses, but caution and harm reduction practices are recommended.

Q: Is 4-HO-DiPT addictive?

A: 4-HO-DiPT is not considered habit-forming, and the desire to use it may decrease with regular consumption. Tolerance builds rapidly, leading to a self-regulating nature similar to other psychedelics.

Q: What should be considered regarding the legal status of 4-HO-DiPT?

A: Legal status varies by country, with some jurisdictions classifying it as a controlled substance. It's crucial to understand and adhere to local laws and regulations regarding possession, sale, and consumption.

Q: What precautions should be taken when using 4-HO-DiPT?

A: Harm reduction practices are essential, including starting with low doses, ensuring a safe environment, and avoiding combining it with other substances without thorough research into potential interactions.