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Specification

Product Name: 5-MeO-DMT

IUPAC Name: 2-(5-Methoxy-1H-indol-3-yl)-N,N-dimethylethanamine

Other Names: MXE; 3-MeO-2'-oxo-PCE

Cas Number: 1239943-76-0

Molecular Formula: C15H21NO2

Molar Mass: 247.33 g/mol

Effect: Psychedelics

Purity of the substance: 99.9%

Physical properties: Crystalline powder

100g

$840

200g

$1070

300g

$1350

500g

$1700

2000g

$3900

1000g

$2400

5000g

$6800

10000g

$12000

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Introduction
How to get 5-MeO-DMT

Historical Context
Chemical Structure and Properties
- Chemical Composition
- Endogenous Presence
Pharmacology
Effects of 5-MeO-DMT
- Subjective Effects
- Side Effects
Safety Profile and Harm Reduction

Subjective Effects

Physical Effects
Visual Effects
Cognitive Effects

Routes of Administration

Vaporization
Oral

Dosage

Toxicity and Harm Potential

Legal Status

FAQs

How to get 5-MeO-DMT

The availability of 5-MeO-DMT has expanded over the years, with various sources offering the compound through different channels. It can be obtained from natural sources, such as the secretion of the Colorado River toad (Bufo alvarius), and through synthetic means in research laboratories. However, due to its powerful effects and legal status in many regions, sourcing 5-MeO-DMT can be challenging and often exists in a legal gray area. Caution, research, and a commitment to safety are paramount for those interested in acquiring and experiencing this substance.

Introduction

5-Methoxy-N,N-dimethyltryptamine, commonly known as 5-MeO-DMT, is a naturally occurring psychedelic compound classified within the tryptamine family. Structurally, it is closely related to both DMT (N,N-Dimethyltryptamine) and bufotenin (5-HO-DMT). Renowned for inducing extremely powerful psychedelic experiences, 5-MeO-DMT is noted for its intense and often overwhelming effects. It primarily interacts with serotonin receptors in the brain, although the exact mechanisms remain largely unexplored.

Historical Context

5-MeO-DMT is found in a variety of plant species and notably in the venom of the Sonoran Desert toad (Incilius alvarius). Although its historical use is not well documented, it is believed to have been utilized in shamanic rituals throughout South America for centuries. In contemporary contexts, both toad venom extracts and synthetic powder forms of 5-MeO-DMT are commonly consumed, typically through vaporization.

The first comprehensive documentation of 5-MeO-DMT's synthesis and psychoactive effects was provided by chemist Alexander Shulgin in his influential 1997 book, TiHKAL (Tryptamines I Have Known and Loved). Recent scientific investigations have highlighted its potential to elicit profound mystical experiences, leading to increased interest in its therapeutic applications.

Chemical Structure and Properties

Chemical Composition

5-MeO-DMT is a ring-substituted indole alkaloid. Tryptamines are characterized by a core structure that includes a bicyclic indole heterocycle, which connects to a terminal amine group via an ethyl side chain. In the case of 5-MeO-DMT, a methoxy (MeO) functional group is located at the R5 position of the indole heterocycle, while two methyl groups are attached to the terminal amine (N) in its tryptamine backbone.

Endogenous Presence

Research indicates that 5-MeO-DMT is produced in trace amounts within the human body, although its biological significance remains largely unknown.

Pharmacology

The psychedelic effects of 5-MeO-DMT are primarily attributed to its role as a partial agonist at the 5-HT1A serotonin receptor, where it exhibits a high binding affinity. In contrast, its affinity for the 5-HT2A receptor is relatively low. Given that many traditional psychedelics exert their effects mainly through 5-HT2A receptor activity, the precise relationship between 5-MeO-DMT's binding profile and its psychedelic experiences continues to be an area of investigation.

Additionally, 5-MeO-DMT may inhibit the reuptake of various neurotransmitters, including serotonin, noradrenaline, and dopamine. This interaction can lead to heightened toxicity when combined with monoamine oxidase inhibitors (MAOIs), reversible inhibitors of monoamine oxidase A (RIMAs), selective serotonin reuptake inhibitors (SSRIs), stimulants, or any substances that function as releasing agents or reuptake inhibitors of monoamine neurotransmitters.

Furthermore, 5-MeO-DMT is metabolized in the body by the polymorphic enzyme cytochrome P450 2D6 (CYP2D6) into an active metabolite known as bufotenin.

Effects of 5-MeO-DMT

Subjective Effects

Users of 5-MeO-DMT often report a profound sense of unity and interconnectedness, significant time distortion, enhanced conceptual thinking, intense euphoria, and a marked sense of ego dissolution. Many describe the psychedelic experience induced by 5-MeO-DMT as extremely intense, comparable to DMT, but with notable differences in visual effects and physical sensations. Unlike DMT, 5-MeO-DMT typically does not elicit the same visual geometries and instead tends to produce a more pronounced sense of physical euphoria and transpersonal experiences.

Side Effects

While 5-MeO-DMT can lead to remarkable experiences, it is also associated with both mental and physical side effects. Users frequently report experiences of anxiety and dysphoria, along with nausea and bodily discomfort. Many describe these adverse effects as challenging or overwhelming, which can detract from the overall experience.

Safety Profile and Harm Reduction

The safety profile of 5-MeO-DMT is less established compared to that of DMT, with a limited number of fatalities reported in connection with its use. These incidents appear to be associated with physical overdose. Some users have raised concerns about the potential for serotonin toxicity when 5-MeO-DMT is combined with certain substances, particularly MAOIs. Additionally, there are suggestions that 5-MeO-DMT may possess cardiotoxic properties.

Given the potency of 5-MeO-DMT, anecdotal evidence suggests that it is best suited for individuals with significant experience using powerful psychedelics, such as DMT, ayahuasca, or DPT. Users are strongly encouraged to adhere to harm reduction practices when using this substance.

Subjective Effects

The subjective effects of 5-MeO-DMT are marked by intense and often overwhelming experiences. In contrast to the relatively mild cognitive and visual effects that accompany some other psychedelics, the physical sensations associated with 5-MeO-DMT are uniquely pronounced. These sensations can be perceived as either highly pleasurable or uncomfortable, depending on the individual's experience.

Physical Effects

The physical effects of 5-MeO-DMT are complex and can manifest in various ways:

Spontaneous Bodily Sensations: Perhaps the most distinctive sensation reported during the 5-MeO-DMT experience is an overwhelming intensification of physical sensations. Users may experience full-body sensations akin to sustained orgasms, impacting every nerve ending. This heightened state can create a perception of difficulty in maintaining normal breathing patterns, though it is not considered dangerous or indicative of respiratory depression.
Physical Euphoria: A profound sense of euphoria can pervade the experience, enhancing overall well-being.
Tactile Enhancement: The ability to feel textures and sensations becomes heightened, contributing to a rich sensory experience.
Perception of Bodily Heaviness: Users may feel an increased sense of heaviness in their bodies.
Bodily Control Enhancement: Some individuals report enhanced control over bodily movements.
Bodily Pressures: Users may experience various pressures throughout the body.
Changes in Felt Bodily Form: Users might perceive alterations in the shape or form of their body.
Changes in Felt Gravity: There can be a notable alteration in the perception of gravitational forces.
Physical Autonomy: Users may experience a sense of autonomy over their physical body.
Muscle Contractions, Spasms, and Tremors: Some users report involuntary muscle contractions or spasms during their experience.
Motor Control Loss: Users might experience temporary loss of motor control.
Respiratory Depression: While some users report breathing difficulties, these do not usually indicate genuine respiratory issues.
Nausea: Nausea appears to be a common effect of 5-MeO-DMT, often more pronounced than with other psychedelics. It is not unusual for users to vomit, particularly when in an unconscious or semi-conscious state, making supervised usage advisable. However, some individuals report only minimal nausea that typically resolves after the initial phase of the experience.
Pupil Dilation: A common physiological effect during the experience.
Skin Flushing: Users may experience reddening of the skin.
Spatial Disorientation: Altered perception of space and surroundings is common.
Temperature Regulation Suppression: Users may have difficulty regulating their body temperature.

Visual Effects

The visual effects of 5-MeO-DMT are often less pronounced than its physical and cognitive effects. However, they can still vary in intensity based on dosage:

Visual Acuity Enhancement or Suppression: 5-MeO-DMT can both enhance and diminish visual acuity, with the effect being somewhat random and largely influenced by the user's setting.
Drifting Effects: Similar to DMT, users may experience detailed, smooth motions resembling morphing or melting visuals.
Color Shifting: Colors may appear to shift and change in intensity.
Environmental Orbism: A perceptual effect where environments seem to become orb-like or fluid.
Recursion: Users may perceive repetitive patterns or images.
Geometry: Visual geometry is typically less extensive than that seen with DMT, rarely exceeding level 7 in intensity. While some users report non-visual experiences at level 8b, the geometry of 5-MeO-DMT is generally smaller and more likely to manifest in darkness or low-distraction environments. The visual patterns can be described as intricate, abstract, both organic and digital, bright, multicolored, glossy, sharp and soft, rounded and angular, immersive, and consistent in intensity.

Cognitive Effects

Cognitive effects associated with 5-MeO-DMT can include:

Amnesia: Users may experience temporary memory loss during or after the experience.
Enhanced Analysis: Cognitive function may be heightened, allowing for deeper analysis of thoughts and feelings.
Anxiety: Some users report heightened feelings of anxiety during their experience.
Conceptual Thinking: Enhanced ability to think conceptually or abstractly.
Catharsis: A release of emotional tension may occur.
Confusion and Delusion: Users might experience disorientation or distorted perceptions of reality.
Emotion Enhancement: Emotions can be amplified, both positive and negative.
Memory Suppression: Users may find their ability to recall memories temporarily diminished.
Ego Death: A common and pronounced effect on 5-MeO-DMT, often resulting in a profound loss of self-identity.
Mindfulness: A heightened awareness of the present moment can occur.
Rejuvenation: Users may feel revitalized or refreshed.
Autonomous Voice Communication: Some users report the experience of engaging in a dialogue with themselves or an external presence.
Thought Connectivity: Enhanced connections between thoughts can lead to insights.
Time Distortion: Perception of time may become distorted.
Wakefulness: Users often feel alert and awake throughout their experience.

Routes of Administration

Vaporization

When taken in its synthetic powder form, 5-MeO-DMT is most commonly vaporized. Although some users may choose to insufflate it, this method is discouraged due to potential discomfort. Vaporization allows users to feel effects at doses as low as 2 mg, with 5-MeO-DMT estimated to be approximately 4 to 5 times more potent than DMT.

Oral

5-MeO-DMT can also be consumed orally, particularly when combined with a monoamine oxidase inhibitor (MAOI). However, numerous reports indicate that this combination can produce a highly unpleasant experience characterized by a strong body load and potential risks of hypertensive symptoms and serotonin syndrome. Consequently, oral ingestion is generally advised against and is considered less safe than other administration methods.

Dosage

Dosage recommendations for 5-MeO-DMT, assuming that an average of at least 10% of toad venom contains the substance, are as follows:

Threshold: 10 - 20 mg
Light: 20 - 50 mg
Common: 50 - 100 mg
Strong: 100 - 200 mg

Toxicity and Harm Potential

The toxicity and long-term health effects of recreational use of 5-MeO-DMT have not been extensively studied in scientific contexts, and the precise toxic dose remains unknown. Due to its limited history of documented human usage, anecdotal evidence suggests that low to moderate doses used sparingly are unlikely to result in significant negative health effects. However, users are encouraged to conduct independent research to assess the safety of combining 5-MeO-DMT with other substances.

Legal Status

The legal status of 5-MeO-DMT varies across countries:

Australia: Classified as a Schedule 9 prohibited substance under the Poisons Standard.
Austria: Illegal to possess, produce, and sell under the SMG (Suchtmittelgesetz Österreich).
Brazil: Possession, production, and sale are illegal as it is listed in Portaria SVS/MS nº 344.
China: Classified as a controlled substance as of October 2015.
Czech Republic: Legal, as it is not listed in Government Regulation n. 463/2013.
Denmark: Restricted to medical or scientific purposes since December 2004.
Germany: Controlled under the Narcotics Act, illegal to manufacture, possess, import, export, or sell without a license since October 10, 2000.
Greece: Became a controlled substance on February 18, 2003.
Latvia: Classified as a Schedule I drug.
The Netherlands: Considered a controlled substance as an ether of bufotenin; available from online sellers.
New Zealand: Classified as Schedule I (Class A).
Romania: Illegal to produce and sell since February 2010 under the controlled substance analogue act.
Sweden: Classified as illegal under the "Act on the Prohibition of Certain Goods Dangerous to Health" since October 1, 2004.
Switzerland: Specifically named under Verzeichnis E as a controlled substance.
Turkey: Classified as a drug; illegal to possess, produce, supply, or import.
United Kingdom: A Class A drug, illegal due to its classification as an ether of 5-HO-DMT.
United States

FAQs about 5-MeO-DMT

Q1: What is 5-MeO-DMT?

A1: 5-MeO-DMT (5-Methoxy-N,N-Dimethyltryptamine) is a powerful psychedelic compound that belongs to the tryptamine family. It is found naturally in various plants and the secretions of certain toads, particularly the Bufo alvarius toad.

Q2: How does 5-MeO-DMT work in the body?

A2: 5-MeO-DMT primarily acts as an agonist at serotonin receptors, particularly the 5-HT2A receptor, leading to altered perception, intense visual experiences, and profound changes in consciousness.

Q3: What effects can users expect from 5-MeO-DMT?

A3: Users often report powerful experiences that can include ego dissolution, intense feelings of interconnectedness, altered sensory perception, and vivid visual or auditory hallucinations.

Q4: How is 5-MeO-DMT typically consumed?

A4: 5-MeO-DMT can be consumed in several forms, including vaporized or smoked, ingested as a brew, or taken as a synthetic powder. The method of consumption significantly influences the onset and intensity of effects.

Q5: Is 5-MeO-DMT legal?

A5: The legal status of 5-MeO-DMT varies by country. In some places, it is classified as a controlled substance, while in others, it may not be explicitly regulated. It's essential to check local laws.

Q6: What are the risks associated with using 5-MeO-DMT?

A6: Potential risks include intense psychological experiences that may lead to anxiety, confusion, or panic. There is also a risk of substance interactions, especially with other psychedelics or medications.

Q7: Can 5-MeO-DMT cause addiction?

A7: 5-MeO-DMT is not considered physically addictive. However, repeated use may lead to psychological dependence, particularly in individuals with predispositions to substance use disorders.

Q8: How long do the effects of 5-MeO-DMT last?

A8: The effects of 5-MeO-DMT are typically short-lived, lasting anywhere from 15 to 45 minutes when vaporized or smoked, although the subjective experience may feel much longer.

Q9: What should I do if I have a bad trip on 5-MeO-DMT?

A9: If you experience a bad trip, try to find a safe and comfortable environment. Grounding techniques, such as focusing on your breath, and having a trusted friend present can be helpful. In severe cases, seek professional help.

Q10: Is 5-MeO-DMT safe to use?

A10: While many users report positive experiences, the safety of 5-MeO-DMT is not well established, particularly due to the potential for intense psychological effects. Caution and preparation are advised.

Q11: Can 5-MeO-DMT be detected in drug tests?

A11: Standard drug tests typically do not screen for 5-MeO-DMT, but specialized tests may be able to detect its presence, particularly in research settings or specific medical contexts.

Q12: What is the difference between 5-MeO-DMT and DMT?

A12: While both compounds are tryptamines and share similar effects, 5-MeO-DMT is often described as having a more intense and less visual experience compared to DMT, which is typically more focused on visual hallucinations.

Q13: What are the potential therapeutic uses of 5-MeO-DMT?

A13: Research into the therapeutic potential of 5-MeO-DMT is in its early stages, but some studies suggest it may have benefits for treating anxiety, depression, and PTSD, similar to other psychedelics.

Q14: Can I use 5-MeO-DMT with other substances?

A14: Combining 5-MeO-DMT with other substances can increase the risk of adverse effects and unpredictable experiences. It is essential to exercise caution and consult a healthcare professional before combining substances.

Q15: How can I prepare for a 5-MeO-DMT experience?

A15: Preparation includes creating a safe and comfortable environment, setting a clear intention, and having a trusted friend or guide present. It's also crucial to be mentally prepared for the intensity of the experience.

Q16: What are the signs of 5-MeO-DMT overdose?

A16: While the risk of overdose is low, excessive doses can lead to overwhelming psychological experiences, severe agitation, confusion, or even cardiovascular complications. In such cases, seek medical help.

Q17: Is 5-MeO-DMT suitable for everyone?

A17: 5-MeO-DMT may not be suitable for individuals with certain mental health conditions or those taking specific medications. Consulting with a healthcare professional before use is recommended.

Q18: How should 5-MeO-DMT be stored?

A18: If legal, 5-MeO-DMT should be stored in a cool, dark place, away from light and moisture, in an airtight container to preserve its potency.

Q19: Where can I find more information about 5-MeO-DMT?

A19: For more information, consult scientific literature, reputable health resources, or organizations that focus on psychedelics and mental health.

Q20: Can I microdose with 5-MeO-DMT?

A20: Microdosing with 5-MeO-DMT is not well-studied, and the appropriate dosing protocols are unclear. Users should exercise caution and be aware of potential psychological effects, even at lower doses.

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