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Product Name: 5F-PB-22
IUPAC Name: 1-pentyfluoro-1H-indole-3-carboxylic acid 8-quinolinyl ester
Other Names: 5F-PB-22
Molecular Formula: None
Molar Mass: 237.26 g·mol−1
Effect: stimulant, psychedelic
Purity of the substance: 99.9%
Physical properties: Crystals, Powder
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Table of Contents

  1. Introduction
  2. Chemistry of 5F-PB-22
  3. Pharmacology of 5F-PB-22
  4. Subjective Effects of 5F-PB-22
    • Physical Effects
    • Cognitive Effects
    • Combinational Effects
  5. Toxicity and Harm Potential
  6. Tolerance and Addiction Potential
  7. Dangerous Interactions
  8. Legal Status
  9. FAQ

Understanding 5F-PB-22: A Synthetic Cannabinoid

Introduction to 5F-PB-22

5F-PB-22, also referred to as 1-pentyfluoro-1H-indole-3-carboxylic acid 8-quinolinyl ester or 5F-QUPIC, is categorized as a synthetic cannabinoid. This compound acts as an agonist of the cannabinoid receptors, eliciting effects that are predominantly sedating and somewhat akin to those of cannabis. Despite its pharmacological properties, there exists a scarcity of information regarding its specific actions within scientific literature. Nonetheless, it has gained prominence as a grey area research chemical, being distributed through online vendors.

Pharmacological Characteristics

Cannabinoids are commonly consumed via smoking or vaporization, allowing for a rapid onset of effects and quick offset. Notably, 5F-PB-22 demonstrates oral activity when dissolved in a lipid medium, potentially extending its duration of action. Similar to other cannabinoids, it exhibits insolubility in water but can be dissolved in ethanol and lipids, facilitating various administration methods.

Safety Concerns and Risks

In contrast to natural cannabis, the chronic abuse of synthetic cannabinoids has been linked to severe adverse effects, including fatalities. Specifically, the use of 5F-PB-22 has been implicated in five deaths in the United States alone. Consequently, caution is strongly advised against prolonged consumption or excessive dosages of this substance, given its potential for toxicity and associated dangers.

Understanding 5F-PB-22: Chemistry, Pharmacology, and Subjective Effects

Chemistry of 5F-PB-22

5F-PB-22, formally known as quinolin-8-yl 1-pentyfluoro-1H-indole-3-8-carboxylate, belongs to the synthetic indolecarboxylate class due to its substituted core indole structure. This indole core is a common feature shared with other cannabinoid compounds such as PB-22, JWH-018, and AM2201. Structurally, 5F-PB-22 is an ether (R-O-R') molecule, composed of two sub-units linked through an oxygen bridge. Specifically, its indole group is substituted at R5 with a fluoropentyl chain, a characteristic also observed in 5F-AKB48. Additionally, the indole core bears a carboxylic acid group at R3, with its terminal oxygen forming an ether bond to a quinoline group located at R8 of the heterocycle.

Pharmacology of 5F-PB-22

While formal studies on 5F-PB-22's pharmacology are lacking, structural analysis suggests similarities in binding profiles with other cannabinoids, exhibiting comparable in vivo properties to Δ9-THC. However, the precise mechanisms underlying these interactions and their contribution to the cannabinoid high experience remain poorly understood.

Subjective Effects of 5F-PB-22

Disclaimer: The effects mentioned below are sourced from the Subjective Effect Index (SEI), which relies on anecdotal user reports and personal analyses by PsychonautWiki contributors. Readers are advised to approach these effects with caution and skepticism. It should be noted that individual responses to 5F-PB-22 may vary, and the occurrence of these effects is not guaranteed or predictable. Higher doses increase the likelihood of experiencing the full spectrum of effects, which may include adverse outcomes such as addiction, severe injury, or even death.

Understanding 5F-PB-22 Dosage Guidelines

Dosage Ranges

When considering the consumption of 5F-PB-22, it's crucial to understand the dosage thresholds and associated effects. The following dosage ranges are provided as general guidelines, but individual responses may vary:

  • Threshold: Onset of effects may be observed at doses as low as 1 mg.

  • Light: Typically, doses ranging from 1 to 3 mg may produce mild effects.

  • Common: Effects become more pronounced within the range of 3 to 5 mg.

  • Strong: Doses between 5 to 8 mg may elicit intense effects.

  • Heavy: Consumption exceeding 8 mg is considered heavy and may lead to overwhelming experiences.

It's essential to approach dosing with caution, starting at the lower end of the spectrum and gradually increasing as needed while closely monitoring individual reactions. Additionally, factors such as tolerance, body weight, and overall health should be taken into consideration when determining appropriate dosage levels.

Exploring the Physical Effects of 5F-PB-22

Spontaneous Physical Sensations

The "body high" induced by 5F-PB-22 is characterized by a warm, soft, and pleasurable tingling sensation that envelops the entire body. This sensation emerges swiftly upon onset, reaching its peak intensity before gradually subsiding.


Users commonly experience significant sedation with 5F-PB-22, often prompting relaxation, reclining, and, at higher doses, sleep. Its sedative effects are notably potent, comparable to substances like JWH-018 and more pronounced than THC, JWH-073, THJ-018, AM-2201, or 5F-UR-144, albeit less intense than 5F-AKB48.

Motor Control Loss

Consumption of 5F-PB-22 can lead to partial to moderate suppression of motor control, escalating with dose but seldom resulting in complete immobilization.

Appetite Enhancement

Similar to many other cannabinoids, 5F-PB-22 triggers an increase in appetite, commonly referred to as "the munchies." Clinical studies and survey data indicate that cannabinoids enhance food enjoyment and stimulate interest in food, likely attributed to the activation of cannabinoid receptors responsible for regulating food intake.

Dehydration and Vasodilation

Users may experience dehydration, colloquially known as "cotton mouth," alongside vasodilation, resulting in decreased blood pressure and increased heart rate.

Pain Relief and Perception Changes

Clinical evidence suggests that cannabinoids, including synthetic agonists like 5F-PB-22, provide pain relief by activating cannabinoid receptors CB1 and CB2. Users may also perceive changes in bodily heaviness or lightness, along with alterations in gravity perception.

Increased Heart Rate and Visual Effects

Consumption of 5F-PB-22 can lead to increased heart rate and various visual effects, including color enhancement, acuity suppression, and geometric patterns. At moderate doses, it may induce closed-eye visuals and visual distortions, resembling ripples and mild geometric patterns. However, these effects are typically milder compared to other synthetic cannabinoids like JWH-018 or JWH-073.

Exploring Cognitive Effects of 5F-PB-22

Emotion Enhancement

5F-PB-22 demonstrates a significant ability to amplify existing emotions in users, proportionate to dosage. This effect can lead to euphoria, intense laughter, heightened immersion in tasks, or conversely, anxiety and paranoia, depending on the individual's mental state.


Users may experience pronounced euphoria with 5F-PB-22, although it is typically less intense compared to substances like JWH-073 but more so than THJ-018, AM-2201, and 5F-UR-144.

Thought Connectivity and Anxiety

Consumption of 5F-PB-22 can promote fluid and abstract thinking, enhancing thought connectivity while potentially inducing anxiety, albeit less so than with Δ9-THC, THJ-018, AM-2201, or 5F-UR-144, but more than JWH-073 or JWH-018.

Paranoia and Other Cognitive Effects

Paranoia is a potential side effect of 5F-PB-22, particularly at high doses or with chronic use. Other cognitive effects may include thought deceleration, conceptual thinking, mindfulness, analysis suppression, dream suppression, and immersion enhancement.

Psychosis Risk

Prolonged usage of synthetic cannabinoids like 5F-PB-22 may elevate the risk of psychosis, especially in individuals with predisposing factors such as a personal or family history of schizophrenia.

Increased Music Appreciation and Auditory Enhancements

Users may notice heightened music appreciation and auditory enhancements while under the influence of 5F-PB-22, adding to the overall sensory experience.

Understanding Combinational Effects of 5F-PB-22

Interaction with Other Substances


Combining cannabinoids with psychedelics can intensify and prolong both visual and cognitive effects. However, caution is advised, especially for inexperienced users.


When used alongside dissociatives, cannabinoids can enhance effects such as geometry, euphoria, dissociation, and hallucinations.


Mixing cannabinoids with alcohol may lead to extreme nausea, dizziness, and changes in gravity. It's recommended to consume cannabinoids before drinking, rather than the reverse, unless exercising extreme caution.

Toxicity and Harm Potential

The toxicity and long-term health effects of recreational 5F-PB-22 use remain poorly understood, with limited scientific research available. However, anecdotal reports suggest that overdose can cause physical discomfort, including heart palpitations, vertigo, and sedation. There have been numerous hospital reports and cases of post-mortem analysis linked to 5F-PB-22, with five deaths reported in the United States.

Mental Health Risks

Individuals with severe pre-existing mental conditions are advised against consuming 5F-PB-22 due to its potential to exacerbate current mental states. Prolonged usage of synthetic cannabinoids may increase the risk of mental illness and psychosis, particularly in vulnerable individuals with predisposing factors.

Tolerance and Addiction Potential

Chronic use of 5F-PB-22 can lead to psychological dependence and addiction, with users experiencing cravings and withdrawal symptoms upon cessation. Tolerance develops with prolonged use, necessitating higher doses to achieve desired effects. Cross-tolerance with other cannabinoids is also observed.

Dangerous Interactions

Combining 5F-PB-22 with certain substances, such as stimulants or psychedelics, can lead to dangerous interactions, increasing the risk of negative experiences and potential harm. Independent research is recommended to ensure the safety of combining multiple substances.

Legal Status

The legal status of 5F-PB-22 varies by country:

  • China: Controlled substance since October 2015.
  • Germany: Controlled under Narcotics Act as of December 13, 2014.
  • Latvia: Scheduled as a controlled substance.
  • Switzerland: Controlled substance.
  • United Kingdom: Class B controlled substance since December 14, 2016.
  • United States: Designated as a Schedule I controlled substance.

Frequently Asked Questions (FAQ) about 5F-PB-22

1. What is 5F-PB-22?

5F-PB-22 is a synthetic cannabinoid with agonistic properties towards cannabinoid receptors, producing effects similar to cannabis. It is often sold as a research chemical through online vendors.

2. Is 5F-PB-22 orally active?

Yes, 5F-PB-22 is orally active when dissolved in a lipid medium, which can extend its duration of action. However, like other cannabinoids, it is typically smoked or vaporized for faster onset and offset of effects.

3. What are the potential risks associated with 5F-PB-22?

The chronic use of 5F-PB-22 has been associated with adverse effects including nausea, dizziness, anxiety, paranoia, and even psychosis, particularly in individuals with predisposing mental health conditions. There have been reports of hospitalizations and fatalities linked to its use.

4. Can 5F-PB-22 be addictive?

Yes, chronic use of 5F-PB-22 can lead to psychological dependence and addiction, with users experiencing cravings and withdrawal symptoms upon cessation.

5. What precautions should be taken when using 5F-PB-22?

It is crucial to start with low doses and gradually increase while monitoring individual reactions. Avoid mixing 5F-PB-22 with other substances, especially alcohol or stimulants, as it can lead to dangerous interactions. Additionally, practicing harm reduction strategies and seeking professional help if needed is recommended.

6. Is 5F-PB-22 legal?

The legal status of 5F-PB-22 varies by country, with some nations having banned its possession, sale, or use, while others have not regulated it explicitly. It is important to research and understand the legal status in your specific region before acquiring or using 5F-PB-22.

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