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Rose Bengal: A Versatile Stain and Beyond
Rose bengal, a prominent member of the xanthene class, is a multifaceted stain. Its sodium salt is widely employed in ophthalmology to highlight damaged conjunctival and corneal cells, facilitating the identification of ocular damage. Moreover, in the realm of microscopy, it aids in distinguishing between live and deceased Foraminifera specimens.
Exploring Therapeutic Frontiers
Rose bengal is under scrutiny for potential therapeutic applications in the realms of oncology and dermatology. PV-10, a cancer formulation derived from rose bengal, is currently undergoing clinical trials for melanoma, breast cancer, and neuroendocrine tumors. Likewise, rose bengal-based drug PV-10 is in clinical trials for eczema and psoriasis treatment.
Unearthing Historical Roots
This remarkable compound traces its origin to 1882 when Swiss chemist Robert Ghnem synthesized it as a fluorescein analog. Initially, it found use as a wool dye, a far cry from its contemporary applications in medicine and research.
Beyond its staining properties, rose bengal plays a pivotal role in synthetic chemistry. It can generate singlet oxygen from triplet oxygen, fostering various valuable reactions, particularly [2 + 2] cycloadditions with alkenes and similar compounds.
Derivatives and Salts
Rose bengal derivatives, such as RB2, have paved the way for sonosensitive but photoinsensitive compounds. These innovations offer potential in cancer treatment, particularly when combined with high-intensity focused ultrasound. Furthermore, rose bengal salts, notably the sodium salt, boast unique properties and applications.
Applications in Medicine
PV-10, an injectable form of rose bengal, has exhibited promise in melanoma treatment, showing tumor response and locoregional disease control. It even triggers a "bystander effect." Additionally, rose bengal has demonstrated efficacy in combating ovarian and colon cancer, contributing to immunogenic cell death and protective immune responses.
Rose bengal extends its utility to biomedical research, specifically in ischemic stroke models and the diagnosis of liver and eye cancer. Its ocular staining capabilities are instrumental in diagnosing various eye disorders, including conjunctival and lid issues.
Innovations in Healing
Researchers are exploring rose bengal's potential in nano sutures, where it seals wounds when illuminated with intense light, hastening healing and reducing infection risk. In microbiology, it curbs bacterial growth in several media, including Cooke's rose bengal agar.
Aiding Microbiology and Photodynamic Therapy
Since the 1950s, rose bengal acetate has been pivotal in differentiating between live and deceased microorganisms, such as Foraminifera. Moreover, it shows promise in photodynamic therapy for certain cancers.