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Specification
Product Name: 5-MeO-MiPT
IUPAC Name: N-[2-(5-Methoxy-1H-indol-3-yl)ethyl]-N-methylpropan-2-amine
Other Names: 5-MeO-MiPT, Moxy
Molecular Formula: None
Molar Mass: 237.26 g·mol−1
Effect: stimulant, psychedelic
Purity of the substance: 99.9%
Physical properties: Crystals, Powder
100g
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Table of Contents

  1. Introduction
  2. Chemistry
  3. Pharmacology
  4. Effects
    • Physical Effects
    • Visual Effects
    • Cognitive Effects
    • Auditory Effects
  5. Reagent Results
  6. Toxicity and Harm Potential
  7. Tolerance and Addiction Potential
  8. Dangerous Interactions
  9. Legal Status

Introduction

5-Methoxy-N-methyl-N-isopropyltryptamine, commonly referred to as 5-MeO-MiPT or moxy, belongs to the tryptamine class of psychedelic substances. While not as well-known as other tryptamines like 5-MeO-DMT and 5-MeO-DiPT, 5-MeO-MiPT exerts its psychoactive effects by interacting with serotonin receptors in the brain.

Synthesis and Pharmacology

The synthesis and pharmacology of 5-MeO-MiPT were initially elucidated by David Repke and Alexander Shulgin in 1985. Alexander Shulgin documented its effects on humans in his seminal work, "TiHKAL" ("Tryptamines I Have Known and Loved").

Effects

Anecdotal reports suggest that 5-MeO-MiPT induces highly stimulating effects with mild entactogenic properties, often devoid of typical psychedelic visual distortions. Users frequently describe pronounced physical and tactile sensations that heighten libido and sexual pleasure. However, common to high doses, individuals may experience an uncomfortable "body load," characterized by muscle tension and nausea.

Pharmacological Properties and Human Use

Despite its intriguing effects, there remains a dearth of knowledge regarding the pharmacological properties, metabolism, and toxicity of 5-MeO-MiPT. Additionally, its history of human use is relatively limited. Sold primarily as a research chemical online, caution is strongly advised when handling this substance.

Chemistry

Structure and Composition

5-MeO-MiPT, known scientifically as 5-methoxy-N-methyl-N-isopropyltryptamine, belongs to the synthetic indole alkaloid class within the larger category of tryptamines. Tryptamines share a fundamental structure characterized by a bicyclic indole heterocycle linked at R3 to an amino group via an ethyl side chain. In the case of 5-MeO-MiPT, it is substituted at R5 of its indole heterocycle with a methoxy (MeO) functional group (CH3O−). Additionally, it contains a methyl group and an isopropyl chain bound to the terminal amine RN of its tryptamine backbone (MiPT).

5-MeO-MiPT serves as the N-substituted isopropyl homologue of 5-MeO-DMT.

Pharmacology

Mechanism of Action

5-MeO-MiPT's psychedelic effects primarily stem from its activity at the 5-HT2A receptor, where it acts as a partial agonist. Additionally, there have been speculations about other mechanisms of action such as the inhibition of monoamine oxidase (MAO), particularly in the digestive enzymes of the stomach, although scientific confirmation is lacking. Despite its strongest affinity for 5-HT1A receptors, 5-MeO-MiPT also exhibits notable binding affinity to the serotonin transporter (SERT) and norepinephrine transporter (NET), effectively functioning as a moderate serotonin-norepinephrine reuptake inhibitor. These actions may elucidate the anecdotal reports of antidepressant and anxiolytic effects observed at moderate doses, akin to medications like venlafaxine and buspirone which target similar receptors.

Subjective Effects

Modes of Administration and Experience

5-MeO-MiPT can be administered orally or smoked, with each route eliciting distinct effects. Orally ingested doses tend to amplify visual and sensory experiences. The subjective experience is often divided into two stages: the initial phase characterized by stimulation and entactogenic qualities, followed by a later phase resembling the effects of traditional tryptamine psychedelics such as psilocybin mushrooms or LSD. Smoking 5-MeO-MiPT accentuates its physically and cognitively stimulating effects.

Disclaimer: The following effects are derived from anecdotal user reports and the analyses of PsychonautWiki contributors. They should be interpreted with caution, as individual responses may vary. Higher doses increase the likelihood of experiencing the full spectrum of effects, including potential adverse reactions such as addiction, severe injury, or fatality.

Dosage

Threshold

The threshold dose of 5-MeO-MiPT is typically around 3 milligrams (mg).

Light

A light dose ranges from 3 to 7 milligrams (mg).

Common

Common doses fall within the range of 7 to 15 milligrams (mg).

Strong

Strong doses range from 15 to 20 milligrams (mg).

Heavy

Heavy doses are considered to be 20 milligrams (mg) or higher.

Physical Effects

Stimulation

At doses below 10 to 15 milligrams (mg), 5-MeO-MiPT induces a level of stimulation comparable to that of LSD.

Spontaneous Bodily Sensations

The "body high" associated with 5-MeO-MiPT is often described as a pleasant, warm, soft, and all-encompassing glow. This sensation may be accompanied by a cold, sharp tingling feeling that arises unpredictably throughout the experience. For some individuals, this tingling sensation remains consistently present, intensifying as the effects peak.

Nausea

Nausea is a common side effect of 5-MeO-MiPT, occasionally leading to vomiting. However, it typically diminishes after the initial phase of the experience. Compared to 5-MeO-DiPT, this substance is less likely to cause unpleasant physical reactions.

Bodily Pressures

  • Abnormal heartbeat
  • Increased heart rate
  • Increased blood pressure
  • Headaches
  • Dehydration
  • Stomach bloating: At higher doses, 5-MeO-MiPT can cause severe stomach bloating in susceptible individuals. This effect can be partially or fully alleviated with the use of antacids.
  • Pupil dilation
  • Vasoconstriction
  • Diarrhea

Visual Effects

Enhancements

  • Colour enhancement
  • Pattern recognition enhancement
  • Visual acuity enhancement

Distortions

  • Drifting (Melting, Breathing, Warping, and Flowing): Characterized by highly detailed, slow, and smooth motions with a static appearance compared to other psychedelics.
  • Tracers
  • After images
  • Symmetrical texture repetition
  • Colour shifting
  • Scenery slicing

Geometry

The visual geometry induced by 5-MeO-MiPT resembles that of Psilocin, 4-AcO-DMT, or ayahuasca rather than LSD or 2C-B. It is intricate, abstract, organic, brightly lit, multicoloured, glossy, with blurred and sharp edges, large in size, fast in motion, smooth, with rounded and angular corners, lacking depth immersion, and intensifying at higher dosages, often resulting in level 8B visual geometry.

Hallucinatory States

5-MeO-MiPT induces a full spectrum of high-level hallucinatory states in a consistent and reproducible manner compared to many other psychedelics.

Transformations

  • Internal hallucinations: Including autonomous entities, settings, sceneries, landscapes, perspective alterations, and scenarios. These hallucinations are more prevalent in darkness and are characterized by their lucidity, interactivity, novelty, autonomy, geometry-based style, and themes ranging from personal, religious, spiritual, science-fiction, fantasy, surreal, nonsensical, to transcendental.

Cognitive Effects

Insight and Relaxation

At low to moderate doses, users often describe the cognitive effects of 5-MeO-MiPT as insightful, moderately relaxing, and occasionally stimulating. These effects are typical of many psychedelic substances and tend to intensify with higher dosages. However, at higher doses, the experience may become primarily sedating and impairing, often accompanied by depersonalization without any accompanying insights.

Analysis Enhancement

5-MeO-MiPT can enhance analytical thinking processes.

Empathy, Affection, and Sociability Enhancement

In social settings, 5-MeO-MiPT may enhance feelings of empathy, love, and sociability. While these effects are slightly weaker compared to substances like MDMA and 2C-B, they still offer significant therapeutic potential.

Depersonalization

Unlike most traditional psychedelics, 5-MeO-MiPT has the potential to induce extreme depersonalization and dissociation in some users throughout the experience.

Conceptual Thinking

Users may experience enhanced conceptual thinking.

Increased Music Appreciation

Music appreciation is often heightened under the influence of 5-MeO-MiPT.

Emotion Enhancement

Emotional experiences can be intensified.

Increased Libido

5-MeO-MiPT may enhance libido and sexual arousal.

Memory Suppression

There may be a suppression of memory recall during the experience.

Novelty Enhancement

Users may perceive ordinary experiences as novel or unique.

Personal Bias Suppression

The influence of personal biases may be reduced.

Thought Acceleration

Thought processes may speed up.

Thought Connectivity

Users may experience enhanced connectivity between thoughts.

Time Distortion

Perception of time may be altered.

Wakefulness

5-MeO-MiPT can promote wakefulness during the experience.

Auditory Effects

Enhancements

Auditory perceptions may be enhanced.

Distortions

Auditory perceptions may be distorted.

Hallucinations

Hallucinations involving sound may occur.

Reagent Results

Exposing compounds to reagents induces a color change indicative of the compound under test. The following test results are from ProTestKit:

Compound Marquis Mecke Mandelin Liebermann Ehrlich Hofmann Simon’s
Freebase Orange - brown Orange red Deep greenish brown Unknown Purple No reaction No reaction
HCl Orange - brown Red - brown Greenish brown Brown Violet - purple Green Unknown

Toxicity and Harm Potential

Almost nothing is known about the long-term effects of 5-MeO-MiPT, and the exact toxic dosage remains unknown due to its status as a research chemical with limited human use history.

A preliminary study on mice indicated that a normal dose of 5-MeO-MiPT (0.27 mg/kg) did not produce measurable toxic effects. However, doses significantly higher than normal (2.7 mg/kg) induced cell toxicity, resulting in programmed cell death in the brain, liver, and kidneys. The extent of damage in other bodily tissues and the underlying mechanisms are yet to be determined.

Anecdotal evidence from users suggests that low to moderate doses of 5-MeO-MiPT used sparingly may not lead to negative health effects. However, caution and independent research are advised, especially when combining with other substances.

Tolerance and Addiction Potential

5-MeO-MiPT is not considered habit-forming, and the desire to use it may decrease with continued use. Tolerance to its effects develops rapidly after ingestion, taking approximately 3 days to reduce to half and 7 days to return to baseline in the absence of further consumption. Cross-tolerance occurs with other psychedelics, leading to reduced effects after using 5-MeO-MiPT.

Dangerous Interactions

Combining 5-MeO-MiPT with certain substances can be dangerous, potentially leading to life-threatening situations. Some known dangerous interactions include:

  • 2C-T-X
  • 2C-X
  • Cannabis
  • DOx
  • MDMA
  • Mescaline
  • NBOMe
  • Amphetamines
  • Cocaine
  • DXM
  • Tramadol
  • aMT
  • MAOIs
  • PCP

Legal Status

  • Austria: Illegal
  • Brazil: Illegal
  • China: Illegal
  • Finland: Illegal
  • Germany: Controlled substance
  • Japan: Illegal
  • Latvia: Schedule I drug
  • Luxembourg: Legal
  • New Zealand: Class C controlled drug
  • Switzerland: Controlled substance
  • United Kingdom: Class A drug
  • United States: Unscheduled, potential prosecution under Federal Analogue Act
  • Florida: Schedule I drug
  • Louisiana: Schedule I drug
  • Minnesota: Banned

Conclusion

In conclusion, 5-Methoxy-N-methyl-N-isopropyltryptamine, or 5-MeO-MiPT, represents a lesser-known member of the tryptamine psychedelic family. While its effects have been documented anecdotally and its synthesis and pharmacology explored to some extent, there is still much to learn about its properties and potential risks. As with any psychedelic substance, harm reduction practices should be diligently followed to mitigate adverse effects and ensure safety.

Frequently Asked Questions (FAQ)

1. What is 5-MeO-MiPT?

5-Methoxy-N-methyl-N-isopropyltryptamine, commonly known as 5-MeO-MiPT or moxy, is a psychedelic substance belonging to the tryptamine class. It produces psychoactive effects by interacting with serotonin receptors in the brain.

2. What are the effects of 5-MeO-MiPT?

The effects of 5-MeO-MiPT include physical sensations such as stimulation, bodily pressures, and pupil dilation, as well as visual distortions like drifting and tracers. It also affects cognition, enhancing analytical thinking and empathy while potentially inducing depersonalization.

3. How is 5-MeO-MiPT tested using reagents?

Reagent tests induce a color change indicative of the compound being tested. Results for 5-MeO-MiPT vary depending on the type of reagent used, with colors ranging from orange to purple.

4. Is 5-MeO-MiPT toxic?

Long-term effects and toxic dosage of 5-MeO-MiPT remain largely unknown due to its status as a research chemical. Preliminary studies in mice suggest that high doses may induce cell toxicity, particularly in the brain, liver, and kidneys.

5. Is 5-MeO-MiPT addictive?

5-MeO-MiPT is not considered habit-forming, and tolerance to its effects develops rapidly after ingestion. Continued use may even decrease the desire to consume it.

6. What are the dangerous interactions of 5-MeO-MiPT?

Combining 5-MeO-MiPT with certain substances can be dangerous, potentially leading to life-threatening situations. Some known dangerous interactions include combinations with MDMA, cannabis, and MAOIs.

7. What is the legal status of 5-MeO-MiPT?

The legal status of 5-MeO-MiPT varies by country, with some nations classifying it as illegal while others have not yet regulated it. In the United States, it remains unscheduled but may be prosecuted under the Federal Analogue Act.


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