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Table of Contents

1. Introduction
2. Chemistry of Methallylescaline
   • Structural Composition
   • Pharmacological Profile
3. Dosage Guidelines
   • Threshold
   • Light Dosage
   • Common Dosage
   • Strong Dosage
   • Heavy Dosage
4. Physical Effects
   • Stimulation
   • Spontaneous Bodily Sensations
   • Perception of Bodily Lightness
   • Physical Euphoria
   • Nausea
   • Muscle Cramps
   • Tactile Enhancement
   • Appetite Suppression
   • Other Physical Effects
5. Visual Effects
   • Enhancements
   • Distortions
   • Geometry
   • Hallucinatory States
6. Cognitive Effects
   • Conceptual Thinking
   • Cognitive Euphoria
   • Delusion
   • Emotion Enhancement
   • Immersion Enhancement
   • Increased Music Appreciation
   • Memory Suppression
   • Ego Death
   • Novelty Enhancement
   • Personal Bias Suppression
   • Thought Acceleration
   • Thought Loops
   • Time Distortion
7. Auditory Effects
   • Enhancements
   • Distortions
   • Hallucinations
8. Experience Reports
9. Toxicity and Harm Potential
10. Tolerance and Addiction Potential
11. Legal Status
12. FAQ

4-Methallyloxy-3,5-dimethoxyphenethylamine (MAL): A Synthetic Phenethylamine

Overview of Methallylescaline (MAL)

4-Methallyloxy-3,5-dimethoxyphenethylamine, commonly referred to as methallylescaline or MAL, belongs to the synthetic psychedelic phenethylamine class. Similar to other mescaline analogs such as allylescaline, proscaline, and escaline, MAL is known to induce hallucinogenic and stimulant effects upon administration.

Pharmacological Profile and Effects

The effects of methallylescaline were first documented by Alexander Shulgin in his influential book PiHKAL. According to Shulgin, the typical oral dosage ranges from 40mg to 60mg, with a duration of action lasting 8 to 12 hours [1]. Anecdotal reports suggest that methallylescaline shares many similarities with mescaline, albeit higher doses may lead to a pronounced body load.

Considerations and Safety

Despite its psychedelic properties, there is scant information available regarding the pharmacology, metabolism, and toxicity profile of methallylescaline. Furthermore, its history of human usage is limited. Consequently, caution and adherence to harm reduction practices are strongly recommended for individuals considering the use of this substance.

Chemistry of Methallylescaline

Structural Composition

Methallylescaline, scientifically known as 4-methallyloxy-3,5-dimethoxyphenethylamine, belongs to the substituted phenethylamine class. Its molecular structure features a phenyl ring linked to an amino group (NH2) via an ethyl chain. The phenyl ring is substituted with two methoxy groups (CH3O-) at carbons R3 and R5.

At R4, methallylescaline is substituted with a methallyloxy chain. This chain consists of three carbons, including a methyl-substituted allyl group with a double bond on the terminal carbon. This chain connects to the phenyl ring at R4 through an ether (oxygen) bridge.

Pharmacology of Methallylescaline

Mechanism of Action

Methallylescaline is thought to act primarily as a partial agonist at serotonin 5-HT2A receptors, which are known to play a key role in mediating psychedelic effects. However, the precise mechanisms through which these interactions lead to the full spectrum of psychedelic experiences are not yet fully understood.

Subjective Effects

The subjective effects of methallylescaline are still under investigation and are largely based on anecdotal reports. Users report a range of psychedelic experiences, though these effects can vary widely and are not guaranteed to manifest consistently or predictably. Higher doses are typically associated with a greater likelihood of experiencing the full spectrum of effects, including potential adverse effects such as addiction, severe injury, or even death.

Dosage Guidelines for Methallylescaline

Threshold

The threshold dose of methallylescaline, where effects may first become perceptible, is typically around 5 mg.

Light Dosage

A light dose of methallylescaline ranges from 15 to 25 mg. At this level, users may experience mild psychedelic effects.

Common Dosage

A common dose of methallylescaline falls between 25 and 40 mg. This range is associated with moderate psychedelic effects and is often used by those seeking a balanced experience.

Strong Dosage

A strong dose of methallylescaline is considered to be between 40 and 60 mg. At this level, users can expect pronounced psychedelic effects, including potentially intense visual and sensory alterations.

Heavy Dosage

A heavy dose of methallylescaline exceeds 60 mg. This dosage level is characterized by very potent and potentially overwhelming psychedelic effects, including a significant body load and profound alterations in perception.

These dosage guidelines are based on anecdotal reports and may vary depending on individual tolerance, sensitivity, and other factors. It is crucial to approach higher doses with caution due to the potential for increased intensity and risks associated with psychedelic substances.

Physical Effects of Methallylescaline

Stimulation

Methallylescaline is noted for its significant stimulation of physical energy levels. Users often find themselves motivated to engage in activities such as running, walking, dancing, or climbing. This contrasts with the sedating effects typically associated with other psychedelics like psilocin.

Spontaneous Bodily Sensations

The "body high" induced by methallylescaline is characterized by intense sensations that can vary in nature. Users commonly report a warm, soft glow that spreads throughout the body, leading to profound physical euphoria akin to substances like MDMA. Additionally, there may be sharp, cold electric tingling sensations reminiscent of mescaline, as well as an energetic pins-and-needles sensation similar to 2C-I, though less consistent.

Perception of Bodily Lightness

Users may experience a sensation of bodily lightness, which can contribute to feelings of euphoria and physical comfort during the methallylescaline experience.

Physical Euphoria

Relative to other psychedelics, methallylescaline is known for its physically euphoric effects, reminiscent of phenethylamines such as MDA.

Nausea

Nausea is a common side effect, particularly at moderate to high doses of methallylescaline. It may either pass quickly after vomiting or gradually fade as the peak effects set in.

Muscle Cramps

While uncommon, muscle cramps may occur, especially in individuals who are malnourished, dehydrated, or engaging in strenuous physical activity.

Tactile Enhancement

Enhanced tactile sensations are frequently reported during methallylescaline experiences, with users describing heightened sensitivity and awareness of touch.

Appetite Suppression

Users often experience reduced appetite while under the influence of methallylescaline.

Other Physical Effects

Additional physical effects include frequent urination, increased heart rate, increased libido, muscle contractions, pupil dilation, excessive yawning, and visual changes.

Visual Effects of Methallylescaline

Enhancements

Methallylescaline enhances visual perception in several ways, including increased brightness, color enhancement, pattern recognition, and visual acuity.

Distortions

Visual distortions commonly observed include drifting (melting, breathing, morphing), color shifting, depth perception distortions, perspective distortions, symmetrical texture repetition, tracers, afterimages, brightness alteration, diffraction, and geometric patterns.

Geometry

The visual geometry induced by methallylescaline is often described as organic, structured, and intricate, similar to ayahuasca or psilocin. It features a bright color palette and sharp edges reminiscent of LSD, 2C-B, and 2C-I. The geometry can vary in size, speed, and complexity, with multicolored, glossy patterns and sharp angular corners.

Hallucinatory States

At higher doses, methallylescaline can induce internal hallucinations, including autonomous entities, vivid landscapes, and intricate scenarios.

These effects are based on anecdotal reports and may vary widely among individuals. Caution and responsible use are advised due to the substance's potential intensity and variability in effects.

FAQ

Q: What is methallylescaline?

Methallylescaline, also known as MAL, is a synthetic psychedelic substance belonging to the phenethylamine class. It is structurally related to mescaline and known for its hallucinogenic effects.

Q: How does methallylescaline affect the body?

Methallylescaline primarily acts as a partial agonist at serotonin 5-HT2A receptors, resulting in profound psychedelic experiences characterized by visual and cognitive alterations.

Q: What are the typical doses of methallylescaline?

The dosage of methallylescaline can vary:

• Threshold: around 5 mg
• Light: 15 - 25 mg
• Common: 25 - 40 mg
• Strong: 40 - 60 mg
• Heavy: 60 mg and above

Q: What are the physical effects of methallylescaline?

Physical effects include stimulation, spontaneous bodily sensations (e.g., warmth, tingling), perception of bodily lightness, physical euphoria, nausea (at higher doses), muscle cramps (rare), tactile enhancement, appetite suppression, and increased heart rate.

Q: What visual effects does methallylescaline induce?

Visual effects include enhancements in brightness, color, pattern recognition, and visual acuity. Distortions such as drifting, color shifting, and geometric patterns are common, along with complex and structured visual geometry resembling natural and organic forms.

Q: Is methallylescaline addictive?

Methallylescaline is not considered to be habit-forming, and tolerance develops rapidly after ingestion. It presents cross-tolerance with other psychedelics, meaning repeated use diminishes its effects over time.

Q: What is the legal status of methallylescaline?

Legal status varies by country. For example, it is unscheduled in the United States but may be regulated as an analogue of mescaline under certain circumstances. In countries like the United Kingdom and Germany, it is controlled under specific legislation governing psychoactive substances.

These FAQs provide a brief overview of methallylescaline's effects, dosing, safety considerations, and legal status, based on current knowledge and anecdotal reports.