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Product Name: 4-HO-MPT
IUPAC Name: 3-[2-(Methylpropylamino)ethyl]-4-indolol
Other Names: 4-HO-MPT, Meprocin
Molecular Formula: None
Molar Mass: 237.26 g·mol−1
Effect: stimulant, psychedelic
Purity of the substance: 99.9%
Physical properties: Crystals, Powder
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Table of Contents:

  1. Introduction
  2. Summary
  3. Chemistry
  4. Dosage
  5. Pharmacology
  6. Subjective Effects
  7. Physical and Visual Effects
  8. Cognitive Effects
  9. Toxicity and Harm Potential
    1. Further Information
    2. Lack of Scientific Study
    3. Tolerance and Addiction Potential
    4. Dangerous Interactions
    5. Legal Status
  10. FAQ (Frequently Asked Questions)


4-Hydroxy-N-methyl-N-propyltryptamine, commonly known as 4-HO-MPT or Meprocin, is a synthetic psychedelic substance belonging to the tryptamine chemical class. This novel compound exhibits psychedelic effects upon administration, closely resembling the structural analog of 4-HO-DMT (Psilocin) and other potent hallucinogenic tryptamines.


4-HO-MPT, with the chemical formula 4-hydroxy-N,N-methylpropyltryptamine, is a synthetic indole molecule within the tryptamine class. Tryptamines share a foundational structure characterized by a bicyclic indole heterocycle attached at R3 to an amino group through an ethyl side chain. In the case of 4-HO-MPT, a hydroxyl functional group OH− is substituted at R4 of its indole heterocycle. Additionally, it features a propyl and ethyl chain bound to the terminal amine RN of its tryptamine backbone (MPT).

Pharmacology, Metabolism, and Toxicity

Despite its intriguing psychedelic properties, there is a notable scarcity of data regarding the pharmacological properties, metabolism, and toxicity of 4-HO-MPT. The limited information available has led to its categorization as a research chemical, available for purchase online since 2016. The synthesis and description of 4-HO-MPT were documented by Alexander Shulgin in his 1994 book TiHKAL.

This dearth of comprehensive data emphasizes the importance of further research to unravel the intricacies of 4-HO-MPT's effects on the human body and mind. As a synthetic psychedelic substance, it beckons exploration into its potential therapeutic applications, as well as a thorough understanding of its safety profile and potential risks.



  • 5 mg


  • 10 - 20 mg


  • 20 - 30 mg


  • 30 - 50 mg


  • 50 mg +



4-HO-MPT is a psychedelic drug classified within the tryptamine class of chemical compounds. As a higher homologue of the naturally occurring substituted tryptamine psilocin and the 4-hydroxyl analog of MPT, it shares structural similarities with other potent psychedelics.

Mechanism of Action

Like many psychedelic tryptamines, 4-HO-MPT is believed to primarily act as a 5-HT2A partial agonist. The psychedelic effects associated with its use are thought to stem from its binding efficacy at the 5-HT2A receptors. However, the specific role of these interactions and how they contribute to the overall psychedelic experience remain elusive and require further exploration.

Understanding the dosage ranges is crucial for users and researchers alike, providing a framework for the potential effects at different levels. The threshold, light, common, strong, and heavy dosage categories offer a spectrum that individuals can refer to for a more informed and safer usage of 4-HO-MPT. Additionally, the pharmacological insights highlight the need for continued research to unravel the intricate mechanisms underlying the psychedelic effects of this compound.

Subjective Effects


The effects outlined below are based on the Subjective Effect Index (SEI), a compilation of anecdotal user reports and personal analyses from contributors to PsychonautWiki. It is essential to approach these effects with a healthy degree of skepticism, considering the subjective and variable nature of individual experiences.

It is crucial to note that the occurrence of these effects is not necessarily predictable or reliable, with higher doses being more likely to induce the full spectrum of effects. Additionally, adverse effects become increasingly likely with higher doses and may include addiction, severe injury, or even death.


The subjective effects of 4-HO-MPT, as reported by users, provide insights into the range of experiences associated with its psychedelic properties. These effects may vary widely among individuals, emphasizing the importance of responsible and informed use.

Commonly Reported Effects

  • Visual Distortions: Users may experience alterations in visual perception, such as distortions, color enhancements, or pattern recognition.

  • Emotional Enhancement: Some users report heightened emotional states, ranging from increased empathy to intense feelings of joy or sadness.

  • Mindfulness: 4-HO-MPT may induce a sense of mindfulness or a heightened awareness of the present moment.

Variable Effects

  • Euphoria: While some users report feelings of euphoria, others may not experience this effect or may encounter a range of emotional states.

  • Auditory Effects: Auditory perceptions may be altered, with users reporting changes in sound intensity or clarity.

Adverse Effects

It is essential to acknowledge the potential risks associated with 4-HO-MPT use, especially at higher doses. Adverse effects may include:

  • Addiction: Higher doses increase the risk of developing addictive behaviors.

  • Severe Injury: Users may be susceptible to accidents or injuries due to impaired judgment and altered perception.

  • Death: In extreme cases, the misuse of 4-HO-MPT, particularly at high doses, can lead to fatal outcomes.

Understanding the subjective effects, along with the associated risks, contributes to a more informed and responsible approach to the use of 4-HO-MPT. Individuals should exercise caution, adhere to recommended dosage guidelines, and be mindful of their own susceptibility to the reported effects.

Physical and Visual Effects

Physical Effects

Spontaneous Physical Sensations

Users of 4-HO-MPT may experience spontaneous physical sensations, contributing to the overall psychedelic experience. These sensations can vary among individuals and may include tactile distortions, tingling, or a general feeling of body warmth.

Increased Heart Rate

One of the physiological responses associated with 4-HO-MPT use is an increase in heart rate. Users may notice a heightened awareness of their heartbeat, potentially accompanied by a sense of excitement or anxiety.


Nausea is a reported physical side effect of 4-HO-MPT use. Some individuals may experience a queasy or uneasy feeling, especially during the initial stages of the psychedelic experience.

Pupil Dilation

Pupil dilation is a common occurrence with the use of psychedelic substances, including 4-HO-MPT. The dilation of pupils may contribute to altered visual perceptions.

Visual Effects


  • Colour Enhancement: Users may perceive intensified or enhanced colors, leading to a vibrant and visually stimulating experience.

  • Pattern Recognition Enhancement: 4-HO-MPT can enhance the recognition of patterns, potentially leading to intricate and detailed visual experiences.

  • Visual Acuity Enhancement: Users may report an increased sharpness and clarity in their visual perception.


  • Drifting (Melting, Breathing, Morphing, and Flowing): Visual elements may appear to move, melt, morph, or flow, contributing to a dynamic and ever-changing visual landscape.

  • Colour Shifting: Colors may undergo dynamic shifts, creating a visually dynamic and immersive environment.

  • Depth Perception Distortions: Users may perceive alterations in the depth of their visual field, leading to a sense of three-dimensional distortions.

  • Perspective Distortions: Changes in perspective may occur, altering the way objects and surroundings are perceived.

  • Symmetrical Texture Repetition: Visual textures may exhibit symmetrical repetitions, adding complexity to the overall visual experience.

  • Tracers: Moving objects may leave lingering trails or tracers, enhancing the perception of motion.

  • After Images: Retained images may linger in the visual field after the removal of a stimulus.

  • Brightness Alteration: Users may perceive changes in the brightness or intensity of visual stimuli.

  • Diffraction: Visual stimuli may diffract, creating a prismatic or rainbow-like effect.


  • Hallucinatory States: Users may experience vivid geometric patterns, enhancing the overall visual experience.

  • Transformations: Objects and shapes may undergo transformative changes, leading to a visually dynamic and evolving hallucinatory state.

  • Internal Hallucination (Autonomous Entities; Settings, Sceneries, and Landscapes; Perspective Hallucinations and Scenarios and Plots): Users may encounter complex internal hallucinations, ranging from autonomous entities to intricate landscapes and scenarios.

Understanding the comprehensive range of physical and visual effects associated with 4-HO-MPT contributes to a more informed and prepared approach to its use. Users should be aware of the potential variability in experiences and exercise caution, especially in higher dosage scenarios.

Cognitive Effects

Conceptual Thinking

4-HO-MPT users may experience alterations in conceptual thinking, leading to enhanced creativity, abstract thought, and a novel perspective on familiar ideas.

Cognitive Euphoria

A sense of cognitive euphoria is reported, characterized by heightened mental well-being, positivity, and a general feeling of elation.


Delusional thinking may occur, involving beliefs or interpretations that deviate from reality. Users should be mindful of potential delusions during the psychedelic experience.

Emotion Enhancement

4-HO-MPT is associated with emotion enhancement, intensifying emotional states and fostering a deeper connection with one's feelings.

Immersion Enhancement

Users may feel a heightened sense of immersion in their surroundings, leading to a more profound engagement with the environment and experiences.

Increased Music Appreciation

Music may be experienced with heightened appreciation, with auditory stimuli taking on a richer and more emotionally resonant quality.

Memory Suppression

The drug may induce memory suppression, potentially affecting the recall of events during the psychedelic experience.

Ego Death

Some users may report a dissolution of the ego, leading to a profound sense of interconnectedness with the external world.

Novelty Enhancement

4-HO-MPT can enhance the perception of novelty, making routine or familiar stimuli appear fresh and intriguing.

Personal Bias Suppression

Users may experience a reduction in personal biases, allowing for a more objective and unbiased perspective on thoughts and experiences.

Thought Loops

Cognitive effects may include the occurrence of thought loops, where a sequence of thoughts repeats, creating a loop-like pattern.

Time Distortion

Time perception may be distorted, with moments feeling elongated or compressed, contributing to an altered sense of temporal reality.

Auditory Effects


  • Auditory stimuli may be enhanced, leading to a heightened sensitivity to sound and music.


  • Auditory distortions may occur, altering the perception of pitch, tone, or intensity of sounds.


  • Users may experience auditory hallucinations, ranging from subtle distortions to vivid and complex auditory perceptions.


4-HO-MPT can induce transpersonal experiences, involving a sense of connection beyond the individual self, potentially leading to spiritual or metaphysical insights.

Unity and Interconnectedness

A profound sense of unity and interconnectedness with the universe may be experienced, contributing to a broader understanding of existence.

Understanding the cognitive and auditory effects of 4-HO-MPT is essential for users to navigate the psychedelic experience responsibly. These effects, while providing unique and potentially positive experiences, also carry the potential for challenging and unpredictable outcomes. Users should exercise caution, be aware of their mental state, and consider the potential variability in individual responses to the substance.

Toxicity and Harm Potential

Further Information

For additional information on toxicity and harm potential, readers are encouraged to refer to the sections on Research Chemicals under Toxicity and Harm Potential and Responsible Use under Hallucinogens.

Lack of Scientific Study

The toxicity and long-term health effects associated with recreational 4-HO-MPT use have not been extensively studied within a scientific context. The precise toxic dose remains unknown due to the limited history of human usage of this research chemical.

Anecdotal evidence from the community suggests that, when used alone and at low to moderate doses, 4-HO-MPT may not result in negative health effects. However, caution is necessary, and individual reactions can vary. Independent research is imperative to ensure the safety of combining 4-HO-MPT with other substances.

It is strongly recommended to incorporate harm reduction practices when using this substance, emphasizing responsible and informed use.

Tolerance and Addiction Potential

4-HO-MPT is generally considered non-habit-forming, with a reported decrease in the desire to use it with regular consumption. Similar to most psychedelics, it is often perceived as self-regulating.

Tolerance to 4-HO-MPT develops almost immediately after ingestion, with a half-life reduction in about 3 days and a return to baseline within 7 days (in the absence of further consumption). Cross-tolerance with other psychedelics exists, diminishing their effects after 4-HO-MPT use.

Dangerous Interactions


Combining psychoactive substances can lead to dangerous and life-threatening situations. Conduct independent research, including online searches and consulting reputable sources, to ensure the safety of combining substances. Some known dangerous interactions are outlined below, but this list may not be exhaustive.

  • Lithium: Combining 4-HO-MPT with lithium, commonly prescribed for bipolar disorder, may significantly increase the risk of psychosis and seizures.

  • Cannabis: There is a potential for unexpected and strong synergy between cannabis and 4-HO-MPT, increasing the risk of adverse psychological reactions.

  • Stimulants: Substances like amphetamine, cocaine, or methylphenidate, when combined with 4-HO-MPT, may elevate the risk of anxiety, paranoia, panic attacks, and thought loops.

  • Tramadol: The combination of tramadol and psychedelics may lower the seizure threshold, potentially triggering seizures in susceptible individuals.

Legal Status

The legal status of 4-HO-MPT varies across countries:

  • Germany: Controlled under the NpSG (New Psychoactive Substances Act) since July 18, 2019.

  • Switzerland: Not controlled under Buchstabe A, B, C, and D, possibly considered legal.

  • United Kingdom: Classified as a Class A drug due to the tryptamine catch-all clause.

  • United States: Unscheduled, but may be considered an analogue of psilocin (4-HO-DMT), a Schedule I drug. Sale or use for non-medical or illicit purposes could be prosecuted under the Federal Analogue Act.

FAQ (Frequently Asked Questions):

  1. Q: What is 4-HO-MPT?

    • A: 4-HO-MPT, also known as Meprocin, is a synthetic psychedelic substance belonging to the tryptamine chemical class.
  2. Q: How is 4-HO-MPT related to other psychedelics?

    • A: It is a closely related structural analog of 4-HO-DMT (Psilocin) and shares similarities with other hallucinogenic tryptamines.
  3. Q: What are the recommended dosage ranges for 4-HO-MPT?

    • A: Dosage ranges include Threshold, Light, Common, Strong, and Heavy, with specific amounts detailed for each category.
  4. Q: What are the subjective effects of 4-HO-MPT?

    • A: Subjective effects encompass a range of experiences, including visual distortions, emotional enhancement, and altered mindfulness.
  5. Q: What are the physical and visual effects associated with 4-HO-MPT use?

    • A: Physical effects may include spontaneous sensations, increased heart rate, nausea, and pupil dilation. Visual effects cover enhancements, distortions, and hallucinatory states.
  6. Q: Is 4-HO-MPT habit-forming?

    • A: 4-HO-MPT is generally considered not habit-forming, and the desire to use it may decrease with regular consumption.
  7. Q: What is the legal status of 4-HO-MPT in different countries?

    • A: Legal status varies; for example, in the United Kingdom, it is classified as a Class A drug, while in the United States, it is unscheduled but may be considered an analogue of psilocin.
  8. Q: Are there dangerous interactions with 4-HO-MPT?

    • A: Yes, combining 4-HO-MPT with certain substances, such as lithium, cannabis, stimulants, and tramadol, can lead to dangerous and life-threatening situations.
  9. Q: Are there long-term health effects studied for 4-HO-MPT?

    • A: No extensive scientific studies exist on the long-term health effects of recreational 4-HO-MPT use, emphasizing the need for caution and responsible use.
  10. Q: What harm reduction practices are recommended when using 4-HO-MPT?

  • A: It is strongly recommended to exercise harm reduction practices, conduct independent research, and approach its use responsibly to mitigate potential risks.

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