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Specification
Product Name: 4-AcO-MET
IUPAC Name: 3-(2-Ethyl(methyl)aminoethyl)-1H-indol-4-yl acetate
Other Names: 4-AcO-MET, 4-Acetoxy-MET, Metacetin, O-Acetylmetocin
Molecular Formula: None
Molar Mass: 237.26 g·mol−1
Effect: stimulant, psychedelic
Purity of the substance: 99.9%
Physical properties: Crystals, Powder
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Table of Contents

  • Introduction

    • Overview of 4-Acetoxy-N-methyl-N-ethyltryptamine (4-AcO-MET)
    • Structural Affinities
  • Chemistry

    • Generic Structure of a Tryptamine Molecule
    • Acetoxy Substitution
    • Structural Relationships
  • Pharmacology

    • Serotonergic Psychedelic Properties
    • Metabolism and Hydrolysis
  • Street Presence

    • Occasional Presence in Northern Switzerland
    • Street Names: "Acomet" or "Azomet"
  • Dosage Guidelines

    • Threshold, Light, Common, Strong, Heavy
  • Physical Effects

    • Sedation, Physical Sensations, Muscle Contractions
    • Excessive Yawning, Visual and Auditory Effects
  • Cognitive Effects

    • Relaxing yet Fast-Paced Cognitive Style
    • Analysis Enhancement, Thought Acceleration, Hallucinatory States
  • Visual Effects

    • Enhancements, Distortions, Drifting
    • Colour Shifting, Visual Geometry, Hallucinatory States
  • Toxicity and Harm Potential

    • Lack of Scientific Study
    • Anecdotal Insights and Harm Reduction
    • Tolerance, Addiction Potential, and Dangerous Interactions
    • Legal Status in Different Countries
  • FAQ (Frequently Asked Questions)

    • What is the typical dosage for 4-AcO-MET?
    • Are there any known dangerous interactions with 4-AcO-MET?
    • How long does it take for tolerance to reset after using 4-AcO-MET?
    • Is 4-AcO-MET habit-forming?
    • What are the potential long-term health effects of using 4-AcO-MET?
    • What is the legal status of 4-AcO-MET in different countries?

Introduction

4-Acetoxy-N-methyl-N-ethyltryptamine, commonly known as 4-AcO-MET, Metacetin, or Azomet, stands as a lesser-known member of the novel psychedelic substances within the tryptamine class. Similar to its counterparts, this compound induces psilocybin-like psychedelic effects upon administration, making it a subject of interest for researchers and enthusiasts alike.

Structural Affinities

Belonging to the tryptamine class, 4-AcO-MET shares structural similarities with other psychedelic tryptamines such as 4-AcO-DMT, 4-AcO-DET, and 4-AcO-MiPT. Its structural relationship with 4-HO-MET suggests that it may act as a prodrug for the latter.

Street Presence in Northern Switzerland

Interestingly, 4-AcO-MET has been identified in pressed pills circulating on the streets of northern Switzerland, often sold under the names "Acomet" or "Azomet." However, it is crucial to note that these claims require citation for verification.

Limited Data on Pharmacology and Toxicity

Despite its intriguing properties, there is a scarcity of information regarding the pharmacological properties, metabolism, and toxicity of 4-AcO-MET. The compound has minimal historical usage in humans, contributing to the limited available data.

Availability as a Research Chemical

4-AcO-MET is predominantly available as a research chemical through online platforms. Researchers interested in exploring its properties can procure it for scientific investigations.

Cautionary Measures

Given the lack of comprehensive data on 4-AcO-MET, it is paramount to exercise caution and employ harm reduction practices when handling or using this substance. As with any novel psychedelic, responsible and informed usage is crucial to mitigate potential risks and ensure a safer research environment.

In conclusion, the enigmatic nature of 4-AcO-MET, coupled with its limited research history, underscores the importance of approaching its exploration with prudence and a commitment to ethical research practices.

Chemistry: Decoding the Molecular Structure

Tryptamine Framework

At the heart of 4-AcO-MET lies a synthetic indole alkaloid molecule classified within the tryptamine class. Tryptamines, sharing a common core structure, feature a bicyclic indole heterocycle connected at R3 to an amino group through an ethyl side chain.

Acetoxy Substitution

Specifically, 4-AcO-MET is distinguished by the substitution at R4 of its indole heterocycle, where an acetoxy (AcO) functional group (CH3COO−) is attached. Additionally, it incorporates a methyl group and an ethyl chain linked to the terminal amine RN of its tryptamine backbone, earning it the designation of MET. Notably, it serves as the acetate ester analog of 4-HO-MET and the N-substituted ethyl homolog of 4-AcO-DMT.

Pharmacology: Unraveling the Mysteries

It has been postulated that 4-AcO-MET undergoes rapid hydrolysis into the free phenolic 4-HO-MET through the action of serum esterases. However, a deficiency in human studies pertaining to the metabolic fate of this compound leaves this hypothesis unconfirmed.

The psychedelic effects attributed to 4-AcO-MET are believed to stem from its interaction with the 5-HT2A receptor, acting as a partial agonist. Despite this understanding, the intricacies of these interactions and how they contribute to the overall psychedelic experience remain elusive.

Furthermore, there is a hypothesis suggesting the swift conversion of 4-AcO-MET into the free phenolic 4-HO-MET, mirroring the metabolic pathway observed in 4-AcO-DMT. This potential transformation could explain the similarity in subjective effects between the two compounds during human experiences.

Subjective Effects: Anecdotal Insights

Disclaimer: The following subjective effects are derived from the Subjective Effect Index (SEI), relying on anecdotal user reports and analyses by PsychonautWiki contributors. It is essential to approach these insights with a critical perspective.

It is crucial to note that the manifestation of these effects may not occur predictably or reliably. Higher doses are more likely to induce the full spectrum of effects, while adverse effects become increasingly probable with elevated doses. These adverse effects may include addiction, severe injury, or even death. Responsible and cautious exploration of 4-AcO-MET is paramount to ensure a safe and informed experience.

Dosage Guidelines: A Crucial Consideration

Threshold Dose: 5 mg

Commencing with the minimal effective dose, the threshold for 4-AcO-MET is reported to be 5 mg. This represents the point at which subtle effects may become perceptible, marking the initiation of the compound's influence.

Light Dose Range: 10 - 20 mg

Moving into the light dosage range, users typically administer between 10 to 20 mg of 4-AcO-MET. Within this bracket, individuals may experience a more noticeable impact, characterized by mild to moderate effects that do not overwhelm the user.

Common Dose Range: 20 - 30 mg

For those seeking a more pronounced experience, a common dosage falls within the range of 20 to 30 mg. This level of intake often elicits a well-defined psychedelic encounter, with users encountering more intense visuals and altered perceptions.

Strong Dose Range: 30 - 50 mg

Venturing into the strong dose range, users consuming 30 to 50 mg of 4-AcO-MET can anticipate a significantly heightened psychedelic experience. This dosage may lead to intensified visuals, altered thought patterns, and a deeper connection with the psychedelic realm.

Heavy Dose: 50 mg and Beyond

At doses exceeding 50 mg, users enter the heavy dosage territory. This level of ingestion is associated with a profound and potentially overwhelming psychedelic experience. Caution is paramount at this level, as the effects can be intense and may lead to challenges in managing the experience.

Critical Considerations

It is imperative for individuals experimenting with 4-AcO-MET to approach dosage with the utmost care and responsibility. Variability in individual responses, potential adverse reactions, and the risk of overdose emphasize the need for adherence to these guidelines. Always err on the side of caution, especially when exploring higher dosage ranges, to ensure a safe and controlled psychedelic journey.

Physical Manifestations: A Comprehensive Overview

Sedation: A Relaxing Journey

4-AcO-MET is widely regarded for its relaxing and stoning qualities, accompanied by a mild sedative effect. Users often experience compulsive yawning, indicative of the substance's sedative nature. It's noteworthy, however, that the sedation produced by 4-AcO-MET is generally perceived as less intense compared to related compounds such as psilocin and 4-AcO-DMT.

Spontaneous Physical Sensations: The "Body High"

The "body high" induced by 4-AcO-MET is characterized by a pleasurable, warm, soft, and enveloping tingling sensation. This sensation maintains a consistent presence, gradually intensifying from onset until it reaches its peak during the psychedelic experience.

Changes in Felt Bodily Form: A Seamless Connection

Often occurring around or directly after the peak, users may perceive changes in their felt bodily form. This effect is accompanied by a sense of warmth and may lead to the feeling of being physically connected or conjoined with other objects in a seamless continuity. Reports describe this sensation as comfortable, tranquil, and mindful, though it can occasionally manifest as bodily tension.

Muscle Contractions: Transient and Benign

Muscle contractions associated with 4-AcO-MET are typically transient and benign compared to many other tryptamines, phenethylamines, and lysergamides. Users may experience mild muscle contractions, contributing to the overall physical experience.

Muscle Relaxation: A Soothing Presence

In tandem with its sedative qualities, 4-AcO-MET often induces muscle relaxation, enhancing the overall sense of tranquility and comfort during the psychedelic journey.

Excessive Yawning: A Unique Phenomenon

Excessive yawning is a pronounced effect associated with 4-AcO-MET, a characteristic that is notably distinct among psilocin and related tryptamines. While it can occur to a lesser degree with LSD and very rarely with psychedelic phenethylamines like mescaline, it is often more prominent with 4-AcO-MET and is commonly coupled with watery eyes.

Additional Physical Effects:

  • Watery eyes
  • Olfactory hallucination
  • Pupil dilation
  • Runny nose
  • Increased salivation
  • Teeth grinding (less intense compared to substances like MDMA)
  • Nausea

Understanding these diverse physical effects is crucial for individuals embarking on a journey with 4-AcO-MET, ensuring a prepared and informed approach to the psychedelic encounter.

Physical Sensations: A Symphony of Experience

Sedation

Most users describe 4-AcO-MET as inducing a relaxing, stoning, and mildly sedating effect. The sense of sedation is often accompanied by compulsive yawning, although it is generally perceived as less intense than that experienced with related compounds such as psilocin and 4-AcO-DMT.

Spontaneous Physical Sensations

The "body high" associated with 4-AcO-MET is characterized by a pleasurable, warm, soft, and all-encompassing tingling sensation. This sensation steadily intensifies from the onset and reaches its peak during the height of the experience.

Changes in Felt Bodily Form

Users may experience alterations in their perceived bodily form, often accompanied by a sense of warmth. This phenomenon is commonly reported around or after the peak of the experience, with individuals feeling physically connected or conjoined with objects in a seamless continuity. The manifestation of this effect varies, ranging from comfort and tranquility to potential bodily tension.

Muscle Contractions and Relaxation

Muscle contractions induced by 4-AcO-MET are typically transient and benign, differing from the more intense experiences associated with many other tryptamines, phenethylamines, and lysergamides. The drug also induces muscle relaxation.

Excessive Yawning and Other Effects

Notably, excessive yawning is pronounced with 4-AcO-MET, a phenomenon unique to psilocin and related tryptamines. Additionally, users may experience watery eyes, olfactory hallucinations, pupil dilation, runny nose, increased salivation, and teeth grinding, although the latter is less intense compared to substances like MDMA.

Nausea

Nausea is a reported physical effect, suggesting the importance of considering potential gastrointestinal discomfort when using 4-AcO-MET.

Cognitive Harmony: Relaxation with Speed

Overview

The cognitive effects of 4-AcO-MET are often described as somewhat relaxing yet fast-paced, bearing similarities to psychedelics such as LSD or 2C-B, known for their cognitive energy and stimulation. This compound elicits a range of both typical and unique psychedelic cognitive effects.

Prominent Typical Effects

  • Analysis Enhancement: Improved ability for critical thinking and analysis.
  • Conceptual Thinking: Altered and abstract thought patterns.
  • Delusion: Possible distortion of reality leading to false beliefs.
  • Autonomous Voice Communication: Perception of voices independent of external stimuli.
  • Ego Death: Loss of the sense of self, often transformative.
  • Emotion Enhancement: Amplification of emotional experiences.
  • Perception of Interdependent Opposites: Recognition of paradoxical concepts.
  • Immersion Enhancement: Heightened engagement with surroundings.
  • Increased Music Appreciation: Enhanced enjoyment and understanding of music.
  • Memory Suppression: Impaired recall of certain details or events.
  • Novelty Enhancement: Heightened appreciation for novel stimuli.
  • Personal Bias Suppression: Reduced influence of personal biases.
  • Thought Acceleration: Accelerated thought processes.
  • Thought Connectivity: Enhanced associations between thoughts.
  • Thought Loops: Repetitive thought patterns.
  • Time Distortion: Altered perception of time passage.
  • Unity and Interconnectedness: Sense of oneness with the environment.
  • Wakefulness: Heightened alertness and wakeful state.
  • Brain Zaps: Sensations of electrical-like jolts in the brain.

Auditory Effects: Enhancements, Distortions, and Hallucinations

In the realm of auditory perception, users may encounter enhancements, distortions, and even hallucinations, contributing to the multi-faceted cognitive experience induced by 4-AcO-MET.

Visual Enhancements: A Kaleidoscope of Perception

Colour Enhancement

Engaging with 4-AcO-MET often results in heightened color perception, with users reporting a more vibrant and intense visual experience.

Pattern Recognition Enhancement

Users may find that patterns become more pronounced and intricate under the influence of 4-AcO-MET, enhancing the appreciation of visual stimuli.

Visual Acuity Enhancement

The drug is known to enhance visual acuity, sharpening the perception of details in the surrounding environment.

Visual Distortions: Shaping Perception

Drifting (Melting, Flowing, Breathing, and Morphing)

A distinctive visual distortion associated with 4-AcO-MET involves the perception of objects undergoing detailed, slow, and smooth motions, reminiscent of a cartoon-like style. This effect is static in appearance but dynamic in its detailed, flowing movements.

After Images

Objects may leave lingering images in the visual field after being observed, contributing to a unique and dynamic visual experience.

Colour Shifting

Colors may undergo dynamic and shifting changes, adding a dynamic and kaleidoscopic element to the visual landscape.

Environmental Patterning

Visual patterns within the environment may manifest more vividly, creating a visually rich and patterned surroundings.

Scenery Slicing

The perception of the environment may be altered, as if it is sliced or divided into distinct sections.

Symmetrical Texture Repetition

Textures in the visual field may exhibit symmetrical and repetitive patterns, further enhancing the visual complexity.

Tracers

Moving objects may leave a trail or "tracer" behind them, contributing to a sense of motion and fluidity in the visual field.

Geometry

The visual geometry induced by 4-AcO-MET is comparable to that of psilocin, 4-AcO-DMT, and 4-HO-MiPT. However, it carries stronger "synthetic" digital undertones, reminiscent of 2C-B. The visual experience is intricate, abstract, synthetic yet organic, brightly lit, multicolored, glossy, sharp-edged, large in size, fast in motion, angular in corners, and consistent in intensity. The visuals present a paradoxical blend of "synthetic" and "natural" sensations, reminiscent of both LSD and psilocybin, with higher dosages leaning towards level 8A visual geometry over level 8B.

Hallucinatory States: Unveiling the Sublime

Transformations

Under the influence of 4-AcO-MET, users may witness transformations in the perception of objects, adding a dynamic and surreal element to their visual experience.

Internal Hallucination

In dark environments and at appropriately high dosages, users may experience internal hallucinations. These can include autonomous entities, settings, sceneries, landscapes, perspective hallucinations, and scenarios and plots. The nature of these hallucinations is often lucid, interactive, new in content, autonomous, geometry-based, and predominantly of personal, religious, spiritual, science-fiction, fantasy, surreal, nonsensical, or transcendental themes.

Toxicity and Harm Potential of 4-Acetoxy-N-methyl-N-ethyltryptamine (4-AcO-MET)

Lack of Scientific Study

Scientific Void

The toxicity and long-term health effects associated with recreational use of 4-AcO-MET remain unexplored within a scientific context. The absence of empirical studies leaves the exact toxic dose unknown, primarily because 4-AcO-MET is categorized as a research chemical with minimal historical human usage.

Anecdotal Insights

Anecdotal evidence suggests that trying the drug at low to moderate doses, and using it sparingly, does not appear to be linked to negative health effects. However, it is essential to recognize the limitations of anecdotal information, and caution is advised. Independent research is imperative to ensure the safety of combining 4-AcO-MET with other substances.

Harm Reduction Practices

Given the limited data, it is strongly recommended that harm reduction practices be employed when using 4-AcO-MET. Users should exercise caution and prioritize safety, especially when exploring uncharted territory with substances that lack an extensive research background.

Tolerance and Addiction Potential

Non-Habit Forming

4-AcO-MET is reported to be non-habit forming, with users experiencing a decreased desire to use the substance over time. The self-regulating nature of its usage contributes to a lower likelihood of developing addictive behaviors.

Tolerance Build-Up

Tolerance to the effects of 4-AcO-MET occurs almost immediately after ingestion. It takes approximately 3 days for the tolerance to decrease by half and 7 days to return to baseline, assuming no further consumption. Importantly, 4-AcO-MET presents cross-tolerance with all psychedelics, resulting in a reduced effect of other psychedelics after its consumption.

Dangerous Interactions

Vigilance Required

Warning users about potentially dangerous interactions is crucial. Many substances that are individually safe may become hazardous when combined with others. Independent research is paramount to ensure the safety of such combinations.

Specific Interactions

Lithium

The combination of lithium, commonly prescribed for bipolar disorder, with psychedelics, including 4-AcO-MET, may significantly increase the risk of psychosis and seizures. This combination is strongly discouraged.

Cannabis

Cannabis may exhibit unexpected and intense synergy with 4-AcO-MET, potentially leading to adverse psychological reactions such as anxiety, paranoia, panic attacks, and psychosis. Caution is advised, and users are recommended to start with a fraction of their normal cannabis dose and take breaks between hits.

Stimulants

Combining 4-AcO-MET with stimulants like amphetamine, cocaine, or methylphenidate may elevate the risk of anxiety, paranoia, panic attacks, and thought loops. Additionally, there is an increased risk of mania and psychosis.

Tramadol

The combination of tramadol with psychedelics may lower the seizure threshold, potentially leading to seizures in susceptible individuals.

Legal Status

Regional Regulations

Germany

Controlled under the NpSG (New Psychoactive Substances Act) as of July 18, 2019. Production, import with the intent to market, administration to others, placing it on the market, and trading are punishable offenses. Possession is illegal but not punishable.

Switzerland

4-AcO-MET is a controlled substance specifically named under Verzeichnis E.

United Kingdom

Classified as a Class A drug due to its status as an ester of 4-HO-MET, a Class A drug.

United States

Unscheduled, but its status as an analogue of psilocin (4-HO-DMT), a Schedule I drug, could lead to legal consequences under the Federal Analogue Act if sold for human consumption or used for illicit purposes.

FAQ (Frequently Asked Questions)

Q: What is the typical dosage for 4-AcO-MET?

A: Dosage can vary, but commonly ranges from 5 mg (threshold) to 50 mg or more for a heavy experience. Users are advised to start with lower doses and adjust cautiously.

Q: Are there any known dangerous interactions with 4-AcO-MET?

A: Yes, interactions with substances like lithium, cannabis, stimulants, and tramadol can be dangerous. Independent research is crucial to ensure the safety of combining substances with 4-AcO-MET.

Q: How long does it take for tolerance to reset after using 4-AcO-MET?

A: Tolerance builds almost immediately after ingestion, and it takes about 3 days for it to reduce by half. After 7 days of abstinence, tolerance typically returns to baseline.

Q: Is 4-AcO-MET habit-forming?

A: No, 4-AcO-MET is not considered habit-forming, and the desire to use it may decrease with repeated use. It is often self-regulating.

Q: What are the potential long-term health effects of using 4-AcO-MET?

A: The long-term health effects remain unknown due to limited scientific study. Anecdotal evidence suggests minimal negative effects at low to moderate doses, but caution and responsible use are advised.

Q: What is the legal status of 4-AcO-MET in different countries?

A: The legal status varies; it is controlled in Germany and Switzerland, classified as a Class A drug in the UK, and unscheduled in the United States with potential legal consequences under certain circumstances.


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