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Phenethylamine: The Influential Trace Amine
Phenethylamine (PEA), also known as β-phenylethylamine, β-phenethylamine, or benzeneethanamine, is a trace amine known for its influence on various neurotransmitters, including dopamine and serotonin. It plays a vital role in the brain but is not commonly used as a supplement due to its rapid breakdown into inactive components before it can effectively reach and cross the blood-brain barrier.
Neuromodulator and Neurotransmitter
Phenylethylamine serves as a monoaminergic neuromodulator and, to a lesser extent, as a neurotransmitter in the human central nervous system. Beyond mammals, it's present in various organisms and foods, such as chocolate. This molecule plays a role in feelings of affection, contributing to its ability to enhance empathy, affection, and sociability.
When combined with a monoamine oxidase inhibitor (MAOI) like hordenine, phenethylamine can produce profound entactogenic effects similar to MDMA. However, these effects are notably shorter-lived and may come with more severe side effects. The comprehensive study of 179 phenethylamine compounds was documented by Ann and Alexander Shulgin in their work "PiHKAL."
Phenethylamine consists of a benzene ring attached to a monoamine group via an ethyl side-chain. When orally ingested without an MAOI, it undergoes significant first-pass metabolism by monoamine oxidase B (MAO-B) and aldehyde dehydrogenase (ALDH), metabolizing it into phenylacetic acid. This process prevents significant concentrations from reaching the brain at low doses. In the body, it is biosynthesized from the amino acid L-phenylalanine through enzymatic decarboxylation via the enzyme aromatic L-amino acid decarboxylase.
Hydrogen atoms around the structure can be replaced with other functional groups to produce drugs with varying potency, affinity, efficacy, and half-life.
Phenethylamine brings about various physical effects, including:
- Physical Euphoria
- Tactile Enhancement
- Spontaneous Physical Sensations: Described as a euphoric, warm tingling sensation that can become overwhelmingly pleasurable at higher doses.
- Increased Perspiration
- Temporary Erectile Dysfunction
- Increased Heart Rate
- Increased Blood Pressure
Visual effects are typically subtle and manifest at higher doses, encompassing:
- Visual Acuity Enhancement
- Color Enhancement
- Visual Haze
Cognitive effects of phenethylamine intensify with dosage and are characterized by a sense of euphoria, love, and empathy. Notable cognitive effects include:
- Anxiety or Anxiety Suppression
- Cognitive Euphoria: Strong emotional euphoria stemming from serotonin release.
- Empathy, Affection, and Sociability Enhancement: Pronounced and therapeutic, akin to MDMA or 2C-B.
- Thought Acceleration
- Immersion Enhancement
- Novelty Enhancement
- Focus Enhancement
- Increased Libido