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Product Name: [3-[2-[Isopropyl(methyl)amino]ethyl]-1H-indol-4-yl] acetate
IUPAC Name: 4-AcO-MiPT
Other Names: 4-AcO-MiPT, Mipracetin, O-Acetylmiprocin
Molecular Formula: None
Molar Mass: 237.26 g·mol−1
Effect: stimulant, psychedelic
Purity of the substance: 99.9%
Physical properties: Crystals, Powder
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Table of Contents

  1. Overview of 4-AcO-MiPT

    • Background
    • Chemical Structure
    • Pharmacology
  2. Physical and Cognitive Effects

    • Physical Effects
    • Cognitive Effects
    • Auditory and Multi-sensory Effects
    • Dosage Guidelines
  3. Toxicity and Harm Potential

    • Lack of Scientific Study
    • Anecdotal Evidence
    • Harm Reduction Practices
    • Tolerance and Addiction Potential
    • Dangerous Interactions
    • Legal Status


4-Acetoxy-N-methyl-N-isopropyltryptamine, commonly abbreviated as 4-AcO-MiPT and also known by the name mipracetin, is a synthetic psychedelic tryptamine. This compound is the acetylated derivative of 4-HO-MiPT, also known as miprocin. It belongs to the same class as 4-AcO-DMT, 4-AcO-MET, and 4-AcO-DET, with ongoing debates regarding their potential innate activity versus functioning primarily as prodrugs for their hydroxylated counterparts, such as 4-HO-DMT.

Human Pharmacology and Toxicity

Despite the limited availability of information on the human pharmacology and toxicity of 4-AcO-MiPT, various analytical methods have been developed for its detection. The substance is utilized either recreationally or as an entheogenic agent and is typically obtained through online research chemical vendors. Its usage is relatively uncommon, and it has a sparse history of human consumption.

Chemistry of 4-AcO-MiPT

Molecular Structure

4-AcO-MiPT, or 4-Acetoxy-N-isopropyl-N-methyltryptamine, is a synthetic indole alkaloid belonging to the tryptamine class. Tryptamines share a common core structure, featuring a bicyclic indole heterocycle attached to an amino group via an ethyl side chain at R3. At R4 of its indole heterocycle, 4-AcO-MiPT is substituted with an acetoxy (AcO) functional group (CH3COO−). Additionally, it includes isopropyl and methyl chains bound to the terminal amine RN of its tryptamine backbone (MiPT).

4-AcO-MiPT serves as the N-substituted methisopropyl homologue of 4-HO-DMT (psilocin), the acetate ester analog of MiPT, and the N-substituted methisopropyl analog of 4-AcO-DMT.


Mechanism of Action

Similar to most psychedelic tryptamines, 4-AcO-MiPT is believed to act primarily as a 5-HT2A partial agonist. The psychedelic effects associated with 4-AcO-MiPT are thought to result from its binding efficacy at the 5-HT2A receptors. However, the exact role of these interactions in inducing the psychedelic experience remains elusive.

Dosage Guidelines for 4-AcO-MiPT

Threshold Dosage

5 mg

The threshold dosage for 4-AcO-MiPT, the minimum amount required to produce noticeable effects, is reported to be around 5 mg. At this level, users may begin to perceive subtle alterations in perception and mood.

Light Dosage

10 - 15 mg

A light dosage of 4-AcO-MiPT typically ranges between 10 and 15 mg. At this level, users can expect mild to moderate effects, with an increase in sensory perception and a gentle alteration of cognitive functions.

Common Dosage

15 - 20 mg

For a common dosage of 4-AcO-MiPT, users are advised to consume between 15 and 20 mg. This range often results in a more pronounced psychedelic experience, including heightened sensory perception, cognitive alterations, and potential visual effects.

Strong Dosage

20 - 35 mg

A strong dosage of 4-AcO-MiPT falls within the range of 20 to 35 mg. At this level, users may experience intense psychedelic effects, with significant alterations in perception, profound cognitive shifts, and potential visual hallucinations.

Heavy Dosage

35 mg +

A heavy dosage of 4-AcO-MiPT is considered to be 35 mg or higher. This level of consumption can lead to extremely intense and immersive psychedelic experiences, including potent visual hallucinations, profound alterations in thought patterns, and an extended duration of effects. It is crucial for users to approach heavy dosages with caution due to the increased likelihood of intense and unpredictable effects.

Subjective Effects and Disclaimer


The following subjective effects are derived from the Subjective Effect Index (SEI), based on anecdotal user reports and analyses by PsychonautWiki contributors. These effects should be approached with a degree of skepticism, as they may not occur predictably or reliably. Higher doses are more likely to induce the full spectrum of effects, and adverse effects, including addiction, severe injury, or death, become increasingly likely at higher doses.

Physical and Cognitive Functions

Physical Effects

Excessive Yawning

One of the notable physical effects associated with 4-AcO-MiPT is excessive yawning. Users commonly report an uncontrollable urge to yawn during the experience.


In terms of its impact on physical energy levels, 4-AcO-MiPT is generally considered to be relaxing, stoning, and mildly sedating. This sense of sedation often coincides with a relaxing state and is frequently accompanied by uncontrollable yawning.

Spontaneous Tactile Sensations

Described as the "body high," 4-AcO-MiPT induces pleasurable, warm, soft, and all-encompassing tingling sensations. These sensations maintain a consistent presence, steadily intensifying with the onset and reaching their peak during the psychedelic experience.

Pupil Dilation

Users may experience pupil dilation as a physical manifestation of the substance's effects.

Runny Nose and Watery Eyes

Another physical effect includes a runny nose and watery eyes, which are reported by individuals under the influence of 4-AcO-MiPT.

Cognitive Effects

Relaxing and Complex Cognitive State

Similar to its counterpart 4-HO-MiPT, 4-AcO-MiPT induces cognitive effects that are often described as extremely relaxing, complex, and stoning in style. This distinguishes it from other commonly used psychedelics like LSD or 2C-B, which are typically characterized as energetic and stimulating.

Analysis Enhancement

Users may experience heightened analytical abilities, allowing for a deeper understanding of concepts and ideas.

Conceptual Thinking

The substance induces a state of conceptual thinking, potentially leading to profound insights and connections between ideas.


Delusional thinking may occur, altering the user's perception of reality during the psychedelic experience.

Autonomous Voice Communication

Some users report a phenomenon of autonomous voice communication, where internal thoughts or voices are perceived as independent entities.

Déjà Vu

A sense of familiarity with current experiences, known as déjà vu, is a cognitive effect associated with 4-AcO-MiPT.

Enhancement and Suppression Cycles

The cognitive experience involves constant waves of extremely stimulated and profound thinking, cyclically interspersed with waves of general thought suppression and mental intoxication. These cycles typically occur every 20 to 60 minutes.

Immersion Enhancement

Users may feel a heightened sense of immersion in their surroundings or activities.

Increased Music Appreciation

The substance is known to enhance the appreciation of music, making auditory experiences more profound and enjoyable.

Memory Suppression

Temporary suppression of memory recall may occur during the psychedelic experience.

Ego Death

A profound loss of the sense of self, known as ego death, can be a part of the cognitive effects induced by 4-AcO-MiPT.

Novelty Enhancement

The substance may amplify the perception of novelty, making ordinary experiences seem fresh and extraordinary.

Personal Bias Suppression

Users may experience a reduction in personal biases, leading to more objective and unbiased thinking.

Thought Connectivity and Loops

Thought connectivity and loops involve an interconnected flow of thoughts and the potential for repetitive thought patterns.

Time Distortion

A distortion of time perception is a common cognitive effect, altering the subjective experience of time passage.


Despite its sedative physical effects, 4-AcO-MiPT is reported to maintain a level of wakefulness in users.

Auditory and Multi-sensory Effects of 4-AcO-MiPT

Auditory Effects

Auditory Enhancement

One of the perceptual alterations induced by 4-AcO-MiPT is auditory enhancement. Users may experience an intensification of auditory perceptions, leading to a heightened appreciation of sounds.

Auditory Distortion

Individuals under the influence of 4-AcO-MiPT may encounter auditory distortion, where sounds are altered or perceived differently than usual.

Auditory Hallucination

Auditory hallucinations can occur, involving the perception of sounds that are not present in the external environment.

Multi-sensory Effects


In its fullest manifestation, synaesthesia is a rare and non-reproducible effect associated with 4-AcO-MiPT. Increasing the dosage may elevate the likelihood of experiencing synaesthesia, but it appears to be more prevalent among individuals already predisposed to synaesthetic states. Synaesthesia involves the blending of sensory experiences, such as hearing colors or tasting sounds.

Transpersonal Effects

Note on Reliability

It is important to note that transpersonal effects with 4-AcO-MiPT are reported to occur less reliably and impactfully compared to substances like psilocybin or 4-AcO-DMT. These effects generally necessitate heavier doses to manifest.

Spirituality Enhancement

Users may report an enhancement of spirituality, with a heightened sense of connection to the transcendent or divine.

Existential Self-Realization

Existential self-realization is a transpersonal effect associated with 4-AcO-MiPT, involving profound insights into one's existence and purpose.

Unity and Interconnectedness

A sense of unity and interconnectedness, either with others, the universe, or a higher consciousness, can be experienced as part of the transpersonal effects induced by 4-AcO-MiPT.

Toxicity and Harm Potential of 4-AcO-MiPT

Lack of Scientific Study

The toxicity and long-term health effects of recreational 4-AcO-MiPT use have not been scientifically studied. This is mainly due to its classification as a research chemical with limited human usage history.

Anecdotal Evidence

Anecdotal evidence suggests that trying the drug by itself at low to moderate doses, used sparingly, does not seem to result in negative health effects. However, it is important to note that individual reactions may vary, and nothing can be completely guaranteed. Independent research is crucial to ensure the safety of consuming 4-AcO-MiPT, especially when combined with other substances.

Harm Reduction Practices

It is strongly recommended to employ harm reduction practices when using 4-AcO-MiPT to mitigate potential risks and ensure a safer experience.

Tolerance and Addiction Potential

4-AcO-MiPT is not considered habit-forming, and the desire to use it may decrease with regular consumption. Similar to most psychedelics, it is generally believed to be self-regulating.


Tolerance to the effects of 4-AcO-MiPT develops almost immediately after ingestion. It takes approximately 3 days for the tolerance to be reduced to half and around 7 days to return to baseline in the absence of further consumption. Additionally, 4-AcO-MiPT exhibits cross-tolerance with other psychedelics, meaning that the effects of all psychedelics may be diminished after consuming 4-AcO-MiPT.

Dangerous Interactions

Warning on Interactions

Combining psychoactive substances can lead to dangerous and life-threatening situations. It is crucial to conduct independent research to ensure the safety of combining two or more substances. Some known dangerous interactions include:

  1. Lithium

    • Lithium, commonly prescribed for bipolar disorder, significantly increases the risk of psychosis and seizures when combined with psychedelics. This combination is strongly discouraged.
  2. Cannabis

    • Cannabis may have an unpredictable synergy with 4-AcO-MiPT, increasing the risk of adverse psychological reactions. Caution is advised, and users should start with a fraction of their normal cannabis dose.
  3. Stimulants

    • Stimulants like amphetamine, cocaine, or methylphenidate, when combined with 4-AcO-MiPT, can elevate the risk of anxiety, paranoia, panic attacks, and thought loops. This combination may also increase the risk of mania and psychosis.
  4. Tramadol

    • Tramadol, known to lower the seizure threshold, combined with psychedelics may trigger seizures in susceptible individuals.

Legal Status

The legal status of 4-AcO-MiPT varies by country:

  • Germany: Controlled under the NpSG as of July 18, 2019.
  • Japan: Controlled substance effective March 25th, 2015.
  • Sweden: Classified as a "health hazard" and illegal to sell or possess.
  • Switzerland: Considered an ester analog and could be illegal.
  • United Kingdom: Class A drug due to the ester of 4-HO-MiPT.
  • United States: Unscheduled but may be considered an analogue of psilocin, subject to prosecution under the Federal Analogue Act.

Frequently Asked Questions (FAQ)

Q1: What is 4-AcO-MiPT?

  • A synthetic psychedelic tryptamine, acetylated form of 4-HO-MiPT, and a higher homolog of 4-AcO-DMT.

Q2: Are there known physical effects of 4-AcO-MiPT?

  • Yes, including excessive yawning, sedation, spontaneous tactile sensations, pupil dilation, runny nose, and watery eyes.

Q3: What are the cognitive effects of 4-AcO-MiPT?

  • Cognitive effects include analysis enhancement, conceptual thinking, delusion, autonomous voice communication, déjà vu, emotion enhancement, and more.

Q4: What is the recommended dosage of 4-AcO-MiPT?

  • Dosage varies, with threshold at 5 mg, light at 10-15 mg, common at 15-20 mg, strong at 20-35 mg, and heavy at 35 mg and above.

Q5: Is 4-AcO-MiPT habit-forming?

  • No, it is not habit-forming, and the desire to use it may decrease with regular consumption.

Q6: How long does tolerance to 4-AcO-MiPT last?

  • Tolerance is built almost immediately after ingestion, with a half-life of approximately 3 days and a return to baseline in 7 days.

Q7: Are there dangerous interactions with 4-AcO-MiPT?

  • Yes, interactions with substances like lithium, cannabis, stimulants, and tramadol can be dangerous and should be approached with caution.

Q8: What is the legal status of 4-AcO-MiPT?

  • Legal status varies by country, with some countries controlling its possession and sale.

Q9: Is 4-AcO-MiPT widely studied for its toxicity and long-term effects?

  • No, there is limited scientific study on the toxicity and long-term health effects due to its classification as a research chemical.

Q10: What precautions should be taken when using 4-AcO-MiPT?

  • It is strongly recommended to practice harm reduction, conduct independent research on substance combinations, and be cautious with dosage.

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1kg $1590

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1kg $1590

1kg $1590

1kg $1690

100g $390

100g $600