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What are 5F-CUMYL-P7AICA, CUMYL-PEGACLONE, and 5F-CUMYL-PINACA?
5F-CUMYL-P7AICA (CUMYL-5F-P7AICA or SGT-263) is a synthetic cannabinoid derived from pyrrolo[2,3-b]pyridine-3-carboxamide that has been offered as a designer drug. In February 2015, the European Monitoring Centre for Drugs and Drug Addiction (EMCDDA) recognized it for the first time.
CUMYL-PEGACLONE (SGT-151) is a synthetic cannabinoid derived from gamma-carboline that has been offered as a designer drug. CUMYL-PEGACLONE has a similar gamma-carboline core structure to other gamma-carboline cannabinoids revealed by Bristol-Myers Squibb in 2001.
5F-CUMYL-PINACA (also known as SGT-25 and occasionally offered as C-Liquid in electronic cigarette liquid form) is an indazole-3-carboxamide-based synthetic cannabinoid. It has been determined that it is a potent agonist for cannabinoid receptors, with an EC50 of 0.1 nM for human CB1 receptors and 0.37 nM for human CB2 receptors.
The Dangers of Synthetic Cannabinoids
Synthetic cannabinoids are frequently sold as legal and safe alternatives to marijuana, but this is not the case. The following compounds can have severe and life-threatening impacts on human health:
-Seizures and convulsions
-Rapid heart rate and high blood pressure
-Nausea and vomiting
-Severe anxiety and paranoia
-Psychotic episodes and hallucinations
-Kidney damage and failure
-Coma and death
As the intensity and composition of synthetic cannabinoids can vary widely, it is crucial to remember that these effects may be far more severe than those of regular marijuana. Furthermore, these drugs can be highly addictive and cause long-term harm to the brain and other organs.
Why are Synthetic Cannabinoids Dangerous?
Among the many reasons why synthetic cannabinoids are harmful are the following:
Lack of regulation: Since synthetic cannabinoids are not regulated, the composition and potency can vary significantly from batch to batch, making it impossible to predict the effects.
Lack of quality control: Synthetic cannabinoids are frequently manufactured in cloudy and uncontrolled conditions, which increases the risk of contamination and other harmful consequences.
Lack of medical information: There is minimal information available on the long-term effects of synthetic cannabinoids, making it difficult for medical professionals to treat the symptoms and adverse effects.