Table of Contents

• 1P-ETH-LAD Overview 1.1 Chemistry
  1.2 Dosage
  1.3 Pharmacology

• Subjective Effects 2.1 Physical Effects
  2.2 Cognitive Effects
  2.3 Auditory Effects
  2.4 Visual Effects

• Geometry 3.1 Visual Geometry
  3.2 Hallucinatory States

• Toxicity and Harm Potential 4.1 Limited Studies
  4.2 Anecdotal Reports
  4.3 Harm Reduction Practices
  4.4 Dangerous Interactions

• Tolerance and Addiction Potential

Chemistry

1P-ETH-LAD, also known as 1-propionyl-6-ethyl-6-nor-lysergic acid diethylamide, belongs to the lysergamide family—a semisynthetic psychedelic substance. Structurally analogous to lysergic acid, it features an N, N-diethylamide functional group, creating a core polycyclic structure with tryptamine and phenethylamine groups. Its unique structure includes a bicyclic hexahydro indole fused to a bicyclic quinoline group (nor-lysergic acid). Notably, it lacks a methyl group at R6 of its nor-lysergic acid skeleton, being substituted with an ethyl group at R6 and a propionyl group at R1. Additionally, a diethyl carboxamide is bound at carbon 8 of the quinoline. This chiral compound has two stereocenters at R5 and R8, with the active configuration being (5R, 8R).

Dosage

• Threshold: 25 µg
• Light: 30 - 60 µg
• Common: 60 - 100 µg
• Strong: 100 - 200 µg
• Heavy: 200 µg +

Pharmacology

1P-ETH-LAD likely acts as a 5-HT2A partial agonist, exerting psychedelic effects through its efficacy at the 5-HT2A receptors. Comparable in potency to LSD, it shares similarities in mechanism, albeit with a compressed progression and duration of effects, making it qualitatively less intense and more manageable. Research indicates its conversion to ETH-LAD in human serum, suggesting a pro-drug function.

Subjective Effects

Physical Effects

• Stimulation: Energetic and encouraging of physical activities.
• Spontaneous Bodily Sensations: Intense tingling, euphoric and fast-moving.
• Bodily Control Enhancement
• Increased Heart Rate
• Nausea: Mild, occasionally reported in moderate to high dosages.
• Pupil Dilation
• Tactile Enhancement: Consistent and moderate throughout trips.
• Teeth Grinding
• Temperature Regulation Suppression

Cognitive Effects

• Analysis Enhancement
• Conceptual Thinking
• Delusion
• Déjà Vu
• Emotion Enhancement
• Immersion Enhancement
• Increased Music Appreciation
• Laughter
• Memory Suppression
• Ego Death
• Motivation Enhancement
• Novelty Enhancement
• Personal Bias Suppression
• Thought Acceleration
• Thought Loops
• Time Distortion
• Wakefulness

Auditory Effects

• Distortions
• Enhancements
• Hallucinations

Transpersonal Effects

• Existential Self-Realization
• Unity and Interconnectedness

Visual Effects

• Enhancements
• Colour Enhancement
• Pattern Recognition Enhancement
• Visual Acuity Enhancement
• Distortions
• Drifting (Melting, Breathing, Morphing, and Flowing): Highly detailed yet cartoon-like.
• After Images
• Colour Shifting
• Depth Perception Distortions
• Diffraction
• Scenery Slicing
• Symmetrical Texture Repetition
• Tracers

Geometry

1P-ETH-LAD visual geometry is akin to LSD, 2C-B, or 2C-I, displaying intricate, algorithmic, brightly lit, colorful, and organic patterns. At higher dosages, it leans towards level 8B visual geometry over level 8A. Compared to LSD, its geometry is slightly softer in edges and corners.

Hallucinatory States

1P-ETH-LAD induces a range of low and high-level hallucinatory states, with hallucinations resembling those of 4-AcO-DMT, especially at higher dosages. These include transformations and internal hallucinations.

Toxicity and Harm Potential

Limited scientific studies exist on the toxicity and long-term health effects of 1P-ETH-LAD. Anecdotal reports suggest no negative health effects at low to moderate doses. Harm reduction practices are strongly recommended, and caution should be exercised regarding potential dangerous interactions.

Tolerance and Addiction Potential

1P-ETH-LAD is not habit-forming, with decreasing desire for use over time. Immediate physiological tolerance builds after ingestion, taking about 3 days to reduce by half and 7 days to return to baseline. Cross-tolerance with other psychedelics, especially tryptamines and lysergamides, is observed.

Dangerous Interactions

Combining 1P-ETH-LAD with certain substances, such as lithium, cannabis, and stimulants, may pose risks of psychosis, seizures, anxiety, and panic attacks. Caution and independent research are advised.

Legal Status

Legal status varies globally, with considerations in Canada, Germany, Switzerland, Turkey, the United States, and the United Kingdom. Users are advised to be aware of local regulations to avoid legal issues

FAQ (Frequently Asked Questions)

Q1: What is 1P-ETH-LAD?

A1: 1P-ETH-LAD is a semisynthetic psychedelic substance of the lysergamide class, often considered a designer drug analog to ETH-LAD.

Q2: How does 1P-ETH-LAD compare to LSD?

A2: Anecdotal reports suggest similarities in psychedelic effects but note differences such as increased visual and synaesthetic experiences and a less emotionally-charged headspace.

Q3: What are the recommended dosages for 1P-ETH-LAD?

A3: Dosages range from threshold (25 µg) to heavy (200 µg+), with effects intensifying at higher doses.

Q4: What are the physical and cognitive effects of 1P-ETH-LAD?

A4: Physical effects include stimulation, spontaneous bodily sensations, and increased heart rate. Cognitive effects range from analysis enhancement to time distortion.

Q5: How does 1P-ETH-LAD impact visual perception?

A5: Visual effects include enhancements, color shifting, and drifting, resembling LSD but with a slightly softer appearance.

Q6: Is 1P-ETH-LAD habit-forming?

A6: No, it is not habit-forming, and the desire to use may decrease with continued use.

Q7: What is the legal status of 1P-ETH-LAD?

A7: Legal status varies globally, with considerations in Canada, Germany, Switzerland, Turkey, the United States, and the United Kingdom.

Q8: Are there dangerous interactions with 1P-ETH-LAD?

A8: Yes, interactions with substances like lithium, cannabis, and stimulants can pose risks, requiring caution and independent research.

Q9: How long does tolerance to 1P-ETH-LAD last?

A9: Physiological tolerance builds immediately, taking about 3 days to reduce by half and 7 days to return to baseline. Mental tolerance may take two weeks or more.

Q10: Are there harm reduction practices for using 1P-ETH-LAD?

A10: Yes, harm reduction practices are strongly recommended, including awareness of dosage, set, and setting, and avoiding risky combinations.