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Specification
Product Name: 4-AcO-DET
IUPAC Name: 3-(2-(Diethylamino)ethyl)-1H-indol-4-yl acetate
Other Names: 4-AcO-DET, 4-Acetoxy-DET, Ethacetin
Molecular Formula: None
Molar Mass: 237.26 g·mol−1
Effect: stimulant, psychedelic
Purity of the substance: 99.9%
Physical properties: Crystals, Powder
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Table of Contents

  1. Overview of 4-AcO-DET

    • Overview of 4-AcO-DET
    • Usage and Acquisition
  2. Chemistry

    • Unraveling the Molecular Structure
    • Relationship to Psilocin and Analogous Compounds
  3. Dosage

    • Navigating the Dose Spectrum
    • Threshold, Light, Common, Strong, and Heavy Dosages
  4. Pharmacology

    • Understanding the Pharmacology of 4-AcO-DET
    • Prodrug Hypothesis and Receptor Interaction
    • Subjective Effects
      • Physical Effects
      • Visual Effects
      • Hallucinatory States
      • Cognitive Effects
      • Auditory Effects
  5. Toxicity and Harm Potential

    • Assessing Toxicity and Harm Potential
    • Limited Research on Toxicity
    • Anecdotal Reports and Harm Reduction
    • Tolerance and Addiction Potential
    • Dangerous Interactions
  6. Legal Status

    • Navigating Legal Status
    • Varied Legal Status Worldwide

Overview of 4-AcO-DET

4-AcO-DET, also known as 4-Acetoxy-N,N-diethyltryptamine or ethacetin, belongs to the fascinating family of novel psychedelic substances within the tryptamine class. This compound is chemically akin to psilocin and is part of a series of substituted tryptamines, including 4-AcO-MET and 4-AcO-DMT.

Usage and Acquisition

In contemporary settings, 4-AcO-DET finds application both as a recreational designer drug and as an entheogenic compound. Its availability predominantly hinges on online research chemical vendors. Users are cautioned to exercise caution and adhere to harm reduction practices due to the limited data on its human pharmacology and toxicity.

Chemistry of 4-AcO-DET

Delving into the molecular structure, 4-AcO-DET is a synthetic indole alkaloid falling under the tryptamine class. Tryptamines share a foundational structure characterized by a bicylic indole heterocycle attached at R3 to an amino group via an ethyl side chain. In the case of 4-AcO-DET, substitution at R4 of its indole heterocycle involves an acetoxy (AcO) functional group (CH3COO−). Additionally, it features two ethyl chains bound to the terminal amine RN of its tryptamine backbone (DET).

Relationship to Psilocin and Analogous Compounds

Crucially, 4-AcO-DET is the N-substituted diethyl homolog of 4-HO-DMT (psilocin). It serves as the acetate ester analog of DET and represents the N-substituted diethyl analog of 4-AcO-DMT. Positioned as a higher homolog in the series, it shares connections with 4-AcO-DMT and 4-AcO-MET.

In conclusion, while 4-AcO-DET remains relatively rare and lacks a comprehensive documented history of human usage, its emergence in the realm of psychedelic compounds prompts a need for further exploration. The limited data available underlines the importance of cautious use and a commitment to harm reduction principles in any encounters with this intriguing substance.

Navigating 4-AcO-DET Dosage: A Comprehensive Guide

Threshold Dosage

The threshold dosage for 4-AcO-DET is reported to be 5 mg. This represents the minimum amount required for users to perceive any noticeable effects.

Light Dosage

For those seeking a milder experience, a light dosage of 10 - 15 mg is suggested. This range is intended to induce subtle effects without overwhelming the user.

Common Dosage

A common dosage of 15 - 20 mg is identified for users aiming for a balanced and typical psychedelic experience with 4-AcO-DET. This range is expected to offer a moderate level of effects.

Strong Dosage

Stepping into a more intense realm, a strong dosage of 20 - 35 mg is advised. Users opting for this dosage range should be prepared for heightened and potentially more profound psychedelic effects.

Heavy Dosage

For those seeking an immersive and potent experience, a heavy dosage of 35 mg and beyond is recommended. It's crucial for individuals considering this dosage to be well-versed in psychedelic experiences and to approach it with caution due to the potential intensity of effects.

In summary, understanding the dosage spectrum of 4-AcO-DET is paramount for users to tailor their experiences according to their preferences and tolerance levels. Adhering to these suggested dosage ranges enhances safety and facilitates a more controlled exploration of the psychedelic effects associated with this compound.

Pharmacology of 4-AcO-DET

Prodrug Hypothesis and Receptor Interaction

The pharmacology of 4-AcO-DET, along with its counterparts like 4-AcO-MET and 4-AcO-DMT, is grounded in the prodrug hypothesis. This theory proposes that these 4-substituted acetylated tryptamines primarily function as prodrugs for their hydrolyzed counterparts, such as 4-HO-DMT and 4-HO-MET. While it is theorized that they remain inactive until deacetylated in the body, ongoing discussions question whether they might possess intrinsic activity of their own.

5-HT2A Receptor Agonism

Similar to most psychedelic tryptamines, 4-AcO-DET is thought to primarily act as a 5-HT2A partial agonist. The psychedelic effects are believed to stem from its binding efficacy at the 5-HT2A receptors. However, the specific role of these interactions and their contribution to the psychedelic experience remains elusive and warrants further exploration.

Subjective Effects

The effects of 4-AcO-DET, as outlined by the Subjective Effect Index (SEI), encompass a range of experiences reported by users. It is crucial to approach these effects with skepticism, as they may not occur predictably or reliably. Higher doses are more likely to induce the full spectrum of effects, with adverse effects becoming increasingly probable, including addiction, severe injury, or even death.

Physical Effects

  • Sedation and Stimulation
  • Spontaneous Physical Sensations
  • Appetite Suppression
  • Bodily Pressures
  • Pupil Dilation
  • Runny Nose
  • Watery Eyes
  • Abnormal Heartbeat
  • Dehydration
  • Difficulty or Frequent Urination
  • Dizziness
  • Headaches
  • Increased Bodily Temperature
  • Muscle Contractions
  • Nausea
  • Restless Leg Syndrome
  • Stomach Bloating
  • Stomach Cramps
  • Teeth Grinding

Visual Effects

  • Enhancements
  • Colour Enhancement
  • Pattern Recognition Enhancement
  • Visual Acuity Enhancement
  • Distortions
  • Drifting
  • Colour Shifting
  • Depth Perception Distortions
  • Perspective Distortions
  • Symmetrical Texture Repetition
  • Tracers
  • After Images
  • Brightness Alteration
  • Diffraction
  • Geometry

Hallucinatory States

  • Transformations
  • Internal Hallucination

Cognitive Effects

  • Analysis Enhancement
  • Conceptual Thinking
  • Delusion
  • Autonomous Voice Communication
  • Déjà Vu
  • Emotion Enhancement
  • Enhancement and Suppression Cycles
  • Feelings of Interdependent Opposites
  • Perception of Predeterminism
  • Immersion Enhancement
  • Increased Music Appreciation
  • Memory Suppression
  • Ego Death
  • Novelty Enhancement
  • Personal Bias Suppression
  • Thought Connectivity
  • Thought Loops
  • Time Distortion
  • Unity and Interconnectedness
  • Wakefulness

Auditory Effects

  • Enhancements
  • Distortions
  • Hallucinations

Toxicity and Harm Potential

Limited Research on Toxicity

The toxicity and long-term health effects of recreational 4-AcO-DET remain largely unstudied in a scientific context. The exact toxic dose is unknown, adding to the complexity of its safety profile. Given its status as a research chemical with limited human usage history, assumptions are made based on its structural similarity to psilocybin.

Anecdotal Reports and Harm Reduction

Anecdotal reports from individuals who have experimented with 4-AcO-DET suggest no immediate negative health effects at low to moderate doses used sparingly. However, caution is emphasized, and independent research is encouraged to ensure safety, especially when combining with other substances. Strong recommendations for harm reduction practices accompany any use of this substance.

Tolerance and Addiction Potential

While no formal studies on addiction potential exist, it is generally believed that 4-AcO-DET is not habit-forming. Tolerance builds almost immediately after ingestion, with a gradual reduction to half after 3 days and a return to baseline after 7 days. Cross-tolerance with other psychedelics is noted, diminishing their effects.

Dangerous Interactions

Caution is urged regarding potential dangerous interactions, as certain combinations with other substances can escalate risks. Examples include lithium, cannabis, stimulants, and tramadol. Independent research is crucial to ensure the safety of combining substances.

Legal Status

Varied Legal Status Worldwide

The legal status of 4-AcO-DET varies across countries:

  • Unscheduled: Most countries, due to its relative obscurity.
  • Controlled: In Germany, Japan, Switzerland, Sweden, and Turkey, where specific regulations or prohibitions exist.
  • Class A: In the United Kingdom, classified as such due to its relation to the Class A drug 4-HO-DET.

Unscheduled in the United States: However, caution is advised as it may be considered an analogue of psilocin under the Federal Analogue Act. 

FAQ (Frequently Asked Questions)

Q1: What is 4-AcO-DET, and how is it related to psilocin?

A: 4-AcO-DET, or ethacetin, is a novel psychedelic tryptamine related to psilocin. It shares a chemical lineage with psilocin and is part of a series that includes 4-AcO-MET and 4-AcO-DMT.

Q2: How is 4-AcO-DET typically used?

A: 4-AcO-DET is used recreationally as a designer drug or as an entheogenic compound. It is often acquired through online research chemical vendors.

Q3: Is there a recommended dosage for 4-AcO-DET?

A: Dosages vary, with threshold at 5mg, light at 10-15mg, common at 15-20mg, strong at 20-35mg, and heavy at 35mg or more.

Q4: What is the pharmacology of 4-AcO-DET?

A: 4-AcO-DET is hypothesized to act as a prodrug, with 5-HT2A receptor agonism thought to be responsible for its psychedelic effects. However, the precise mechanisms are not fully understood.

Q5: Are there potential health risks associated with 4-AcO-DET use?

A: Limited research on toxicity exists, and anecdotal reports suggest no immediate negative effects at low to moderate doses. However, harm reduction practices are strongly recommended.

Q6: Can 4-AcO-DET lead to addiction?

A: While no formal studies exist, it is generally believed that 4-AcO-DET is not habit-forming, and tolerance develops almost immediately after ingestion.

Q7: Are there dangerous interactions with 4-AcO-DET?

A: Caution is advised, especially when combining with substances like lithium, cannabis, stimulants, or tramadol. Independent research on potential interactions is crucial.

Q8: What is the legal status of 4-AcO-DET worldwide?

A: The legal status varies, with many countries considering it unscheduled, while others, like Germany and the United Kingdom, have specific regulations or prohibitions in place. Always check local laws.

Q9: How should 4-AcO-DET be approached for safe use?

A: Approach with caution, follow harm reduction practices, conduct independent research, and adhere to recommended dosages. Individual reactions may vary, so start with lower doses.


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