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Table of Contents

1. Introduction
2. Chemistry of STS-135
3. Pharmacology of STS-135
4. Dosage Recommendations for STS-135
5. Physical Effects of STS-135
6. Cognitive Effects of STS-135
7. Toxicity and Harm Potential of STS-135
   • Lack of Scientific Study
   • Risks for Vulnerable Individuals
   • Harm Reduction Practices
8. Tolerance and Addiction Potential of STS-135
   • Addiction Potential
   • Tolerance Development
9. Dangerous Interactions
   • Warning
   • Examples of Dangerous Interactions
10. Legal Status of STS-135

• Legal Status in Various Countries

STS-135: A Synthetic Cannabinoid with Potent Effects

Introduction to STS-135

STS-135, also known as N-(adamantan-1-yl)-1-(5-fluoropentyl)-1H-indole-3-carboxamide or 5F-APICA, belongs to the class of synthetic cannabinoids. This compound acts as a potent agonist for the cannabinoid receptors, inducing subjective effects akin to those of cannabis. However, it is characterized by a shorter duration and a heightened emphasis on intense physical sensations.

Pharmacology and Availability

Despite its prevalence in certain circles, there exists minimal information regarding the pharmacology of STS-135 within the scientific literature. Nevertheless, this substance is readily available for purchase as a grey area research chemical through online vendors.

Method of Consumption

Cannabinoids, including STS-135, are often consumed through smoking or vaporization to achieve rapid onset of effects and quick offset. However, STS-135 exhibits oral activity when dissolved in a lipid, leading to a significant increase in duration. While insoluble in water, it dissolves effectively in ethanol and lipids.

Health Considerations

It is crucial to note that chronic abuse of synthetic cannabinoids, including STS-135, has been linked to numerous fatalities and heightened risks of adverse effects and toxicity. Consequently, prolonged usage or excessive doses of this substance are strongly discouraged due to associated health hazards.

In conclusion, STS-135 presents as a potent synthetic cannabinoid with distinct pharmacological properties, availability, and associated health risks. Understanding its effects and exercising caution in its usage is paramount to mitigating potential harm.

Chemistry of STS-135

Molecular Structure

STS-135, scientifically known as N-(adamantan-1-yl)-1-(5-fluoropentyl)-1H-indole-3-carboxamide, is classified as a synthetic cannabinoid. It contains a substituted indole group, wherein the indole moiety is substituted at R1 with a fluoropentyl chain, a characteristic shared with compounds such as 5F-PB-22, THJ-2201, and 5F-AKB48. Moreover, the indole is substituted at R3 with a carboxamide group, and this carboxamide group is N-substituted at its terminal amine group with an adamantane group, forming a unique diamondoid structure composed of four fused cyclohexane rings. STS-135 is essentially an analog of 5F-AKB48, wherein the core indazole structure is substituted with an indole base.

Pharmacology of STS-135

Binding Profile and In Vivo Properties

While formal studies on STS-135 are lacking, structural analysis suggests that it likely shares a binding profile similar to other cannabinoids and exhibits many in vivo properties akin to Δ9-THC. Formal research indicates that STS-135 acts as a potent cannabinoid receptor agonist in vitro, with an EC50 of 51 nM for human CB2 receptors and 13 nM for human CB1 receptors. In animal studies, doses of 1-10 mg/kg of STS-135 have been shown to induce bradycardia and hypothermia in rats, indicative of cannabinoid-like activity. However, the precise mechanisms underlying these interactions and their role in producing the subjective "high" experience remain largely unexplored.

Subjective Effects of STS-135

Disclaimer: The following effects are based on anecdotal user reports and the analyses of the Subjective Effect Index (SEI). They should be interpreted with caution and skepticism.

It's important to note that the effects listed may not occur predictably or reliably, with higher doses potentially leading to a wider range of effects. Furthermore, higher doses increase the likelihood of adverse effects, which can include addiction, severe injury, or even death.

Chemistry of STS-135

Overview

STS-135, also known chemically as N-(adamantan-1-yl)-1-(5-fluoropentyl)-1H-indole-3-carboxamide, is classified as a synthetic cannabinoid drug. It possesses a substituted indole group as its core structure, featuring various substituents at different positions.

Structural Composition

The indole moiety in STS-135 is substituted at R1 with a fluoropentyl chain, a characteristic shared with other synthetic cannabinoids such as 5F-PB-22, THJ-2201, and 5F-AKB48. Additionally, at R3 of the indole, there is a carboxamide group. Notably, this carboxamide group is N-substituted at its terminal amine group with an adamantane group, consisting of four fused cyclohexane rings, forming a unique structural feature known as a diamondoid. STS-135 is essentially an analog of 5F-AKB48, with the core indazole structure substituted with an indole base.

Pharmacology of STS-135

Mechanism of Action

While formal studies on STS-135 are limited, analysis of its structure suggests similarities in binding profiles to other cannabinoids, particularly Δ9-THC. It is presumed to act as a potent cannabinoid receptor agonist.

In Vitro Studies

Formal studies have shown that STS-135 acts as a potent cannabinoid receptor agonist in vitro. It exhibits an EC50 of 51 nM for human CB2 receptors and 13 nM for human CB1 receptors. In animal models, such as rats, STS-135 induces bradycardia and hypothermia at doses ranging from 1 to 10 mg/kg, indicating cannabinoid-like activity.

Dosage Recommendations for STS-135

Threshold Dose

• Less than 0.5 mg

Light Dose

• 0.5 to 1.5 mg

Common Dose

• 1.5 to 2 mg

Strong Dose

• 2 to 4 mg

Heavy Dose

• 4 mg or more

These dosage ranges are indicative and should be approached with caution. Effects may vary between individuals, and higher doses can lead to increased likelihood of adverse effects, including addiction, severe injury, or even death.

Spontaneous Tactile Sensations

The ingestion of STS-135 can induce a distinct "body high" characterized by sharp, uncomfortable, all-encompassing electric tingling sensations that spread across the body. This sensation typically intensifies rapidly upon onset, reaching its peak before dissipating suddenly.

Motor Control Loss

STS-135 can lead to partial to moderate suppression of motor control, with the degree of impairment increasing proportionally to the dosage. However, it rarely results in a complete inability to walk or perform basic movements.

Appetite Enhancement

Similar to many other cannabinoids, STS-135 is associated with an increase in appetite, colloquially referred to as "the munchies." Clinical studies and survey data indicate that cannabinoids enhance food enjoyment and stimulate interest in food. This effect is believed to stem from the activation of cannabinoid receptors responsible for regulating food intake in the hypothalamus.

Pain Relief

Cannabinoids, including synthetic cannabinoid receptor agonists like STS-135, have been clinically shown to provide pain relief by agonizing cannabinoid receptors CB1 and CB2.

Perception of Bodily Sensations

Users may experience alterations in the perception of bodily sensations, including sensations of heaviness or lightness, as well as changes in perception related to gravity.

Dehydration

STS-135 can induce dehydration, commonly referred to as "cotton mouth" in popular American and British culture.

Vasodilation

Another physiological effect associated with STS-135 is vasodilation, which involves the widening of blood vessels, potentially leading to changes in blood pressure and circulation.

Cognitive Effects of STS-135

Anxiety and Paranoia

STS-135 is known to have a higher propensity for inducing feelings of anxiety and paranoia compared to other cannabinoids. Individuals who are prone to these states of mind should exercise caution when consuming this compound.

Emotion Enhancement

Users may experience heightened emotions while under the influence of STS-135.

Thought Connectivity and Deceleration

STS-135 can alter thought processes, leading to enhanced connectivity between thoughts as well as a deceleration of thought speed.

Conceptual Thinking and Mindfulness

Some individuals report changes in conceptual thinking and an increased sense of mindfulness while using STS-135.

Analysis Suppression and Dream Suppression

The compound may suppress analytical thinking and inhibit the ability to analyze situations or information. Additionally, it has been associated with a reduction in dream activity.

Psychosis

Prolonged usage of synthetic cannabinoids like STS-135 may elevate the risk of psychosis, particularly in individuals with predisposing factors such as a personal or family history of psychotic illnesses like schizophrenia.

Increased Music Appreciation

Users may experience heightened appreciation for music while under the influence of STS-135.

Auditory Effects of STS-135

Enhancements and Distortions

Auditory effects of STS-135 may include enhancements or distortions in the perception of sound volume and quality.

Toxicity and Harm Potential of STS-135

Lack of Scientific Study

The toxicity and long-term health effects of recreational STS-135 use have not been extensively studied in scientific contexts. Due to its limited history of human usage, the exact toxic dosage remains unknown. Anecdotal evidence from community members suggests that trying STS-135 at low to moderate doses, used sparingly, does not typically result in negative health effects. However, overdose can cause physical discomfort, including heart palpitations, vertigo, and sedation.

Risks for Vulnerable Individuals

Individuals with severe pre-existing mental conditions are advised against ingesting STS-135 due to its potential to strongly amplify current states of mind and emotions. Prolonged usage of synthetic cannabinoids, like STS-135, may also increase the risk of mental illness and psychosis, particularly in those with predisposing factors such as a personal or family history of schizophrenia.

Harm Reduction Practices

Given that synthetic cannabinoids are active in the milligram range, it is crucial to exercise caution and use proper precautions when dosing to avoid negative experiences. Harm reduction practices, such as starting with low doses, using with trusted individuals present, and avoiding mixing with other substances, are strongly recommended.

Tolerance and Addiction Potential

Addiction Potential

Chronic use of STS-135 can lead to psychological dependence and is considered moderately addictive with a high potential for abuse. Users may develop tolerance to the effects of STS-135 over time, requiring increasingly large doses to achieve the same effects. Withdrawal effects and cravings may occur if usage is suddenly stopped.

Tolerance Development

Tolerance to STS-135 effects develops with prolonged and repeated use, requiring users to administer larger doses for the same effects. It takes approximately 3 to 7 days for tolerance to reduce by half and 1 to 2 weeks to return to baseline in the absence of further consumption. STS-135 also presents cross-tolerance with all cannabinoids, meaning that consumption of STS-135 reduces the effects of other cannabinoids.

Dangerous Interactions

Warning

Combining STS-135 with certain substances can result in dangerous interactions, potentially leading to life-threatening situations. Stimulants, psychedelics, and other psychoactive substances may increase anxiety levels and the risk of negative experiences when used in combination with STS-135.

Examples of Dangerous Interactions

• Stimulants (e.g., amphetamines, cocaine)
• Psychedelics (e.g., LSD, mushrooms, DMT)
• Phenethylamines (e.g., 2C-T-x, 2C-x, 5-MeO-xxT)
• NBOMe compounds (e.g., 25x-NBOMe)
• Tryptamines (e.g., aMT)

Users are advised to conduct independent research to ensure the safety of combining STS-135 with other substances.

Legal Status of STS-135

STS-135 was developed as a response to drug prohibition laws targeting synthetic cannabinoids. While it remains legal in many parts of the world, individuals may face charges for possession under certain circumstances, such as analog laws or intent to sell or consume.

Legal Status in Various Countries

• China: Controlled substance as of October 2015.
• Germany: Controlled under Anlage II BtMG (Narcotics Act) as of December 13, 2014.
• Latvia: Schedule I controlled substance.
• Switzerland: Controlled substance under Verzeichnis E.
• United Kingdom: Class B controlled substance under the third-generation synthetic cannabinoids generic definition, illegal to possess, produce, supply, or import.

Frequently Asked Questions (FAQ)

1. Is STS-135 similar to cannabis in its effects?

STS-135 is a synthetic cannabinoid that produces effects somewhat similar to cannabis, but with notable differences in duration and intensity. It acts as a potent agonist for cannabinoid receptors, leading to effects such as euphoria, relaxation, and altered sensory perception.

2. What are the potential risks associated with STS-135 use?

While limited scientific research exists on the toxicity and long-term health effects of STS-135, anecdotal evidence suggests potential risks such as anxiety, paranoia, and physical discomfort at high doses. Prolonged usage may also increase the risk of mental illness and psychosis, particularly in vulnerable individuals.

3. How should STS-135 be dosed?

Dosage recommendations for STS-135 vary depending on the desired effects. It is crucial to start with a low dose and gradually increase as needed while being mindful of potential adverse reactions. Using proper precautions and harm reduction practices is essential to minimize risks.

4. Are there any dangerous interactions associated with STS-135?

Yes, combining STS-135 with certain substances, such as stimulants or psychedelics, can result in dangerous interactions that may lead to adverse effects or life-threatening situations. Users should conduct independent research and exercise caution when combining substances.

5. What is the legal status of STS-135?

The legal status of STS-135 varies by country. While it remains legal in some regions, it may be classified as a controlled substance in others. Users should be aware of local laws and regulations regarding its possession, sale, and consumption.