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Diphenidine: A Lesser-Known Dissociative Compound

Diphenidine, also known as DPD, DND, 1,2-DEP, and DPH, is a lesser-known novel dissociative substance of the diarylethylamine class. It is structurally similar to methoxphenidine (MXP) and ephenidine and is classified as an NMDA receptor antagonist.

Early Synthesis and Availability

The initial synthesis of diphenidine dates back to 1924. However, it wasn't pursued further. Following the 2013 UK arylcyclohexylamine ban, diphenidine, along with the related compound methoxphenidine, surfaced on the grey market. In 2014, there were instances of diphenidine being sold alongside synthetic cannabinoids in Japanese herbal incense blends, one of which was associated with a fatal overdose.

Subjective Effects

Diphenidine is reported to induce subjective effects that encompass stimulation, motor control impairment, pain relief, internal hallucinations, conceptual thinking, euphoria, and dissociation. Dissociation, a complex mental state characterized by perceptual distortions and a sense of detachment from both the environment and self, is a notable outcome. Anecdotal accounts have described high doses of diphenidine resulting in "bizarre somatosensory phenomena and transient anterograde amnesia. The effects of diarylethylamines bear similarities to arylcyclohexylamines such as ketamine and phencyclidine (PCP) as well as dextromethorphan (DXM).

Pharmacological Insights and Safety Concerns

There exists limited data regarding the pharmacological properties, metabolism, and toxicity of diphenidine in humans, and its history of human usage is exceedingly restricted. Some reports suggest that it may pose distinct toxicity risks compared to conventional dissociatives. Furthermore, it is believed to carry moderate to high abuse potential, making it crucial for individuals using this substance to adhere to harm reduction practices.

History and Culture

The synthesis of diphenidine was initially documented in 1924 and involved a nitrile displacement reaction similar to the one used later to discover phencyclidine in 1956. Following the 2013 UK ban on arylcyclohexylamines, diphenidine and methoxphenidine became accessible on the grey market.

In 2014, two instances emerged where diphenidine was combined with synthetic cannabinoids in Japanese herbal incense blends. One such blend contained diphenidine and 5-fluoro-AB-PINACA at concentrations of 289 mg/g and 55.5 mg/g, respectively. Another product that included AB-CHMINACA, 5F-AMB, and diphenidine was implicated in a fatal overdose.

Chemistry

Diphenidine falls within the diarylethylamine class, characterized by a phenethylamine framework with a substituted Rα in the phenyl ring. It possesses an amino group attached through the phenethylamine chain at the termini of the piperidine ring, categorizing it as a piperidine dissociative compound. Diphenidine structurally resembles MXP but lacks a 2-methoxy substitution on one of its phenyl rings.

Pharmacology

Diphenidine functions as an NMDA receptor antagonist. NMDA receptors are crucial for transmitting electrical signals between neurons in the brain and spinal column, and to allow signal transmission, these receptors must remain open. Dissociatives, like diphenidine, obstruct NMDA receptors, leading to diminished sensation, impaired movement, and the characteristic "hole" experience.

While some vendors have suggested that diphenidine acts as a dopamine reuptake inhibitor and a serotonin reuptake inhibitor with µ-opioid affinity, delivering typical dissociative effects, no comprehensive assessment of its affinity at the dopamine transporter has been conducted. If this hypothesis holds true, it offers an explanation for the substance's euphoric and often stimulating effects.

Furthermore, diphenidine and related diarylethylamines have been researched in vitro as potential treatments for neurotoxic injury. In this context, diphenidine may exhibit stronger NMDA receptor antagonist properties for neurogenesis, neurological repair, and neuroprotection compared to more commonly known NMDA receptor antagonistic dissociatives such as ketamine, dextromethorphan, PCP analogs, Iboga, and methoxetamine.

Subjective Effects

The general headspace of diphenidine is often described as euphoric and clear-headed in comparison to that of ketamine and reminiscent of ephenidine at lower dosages. Moderate or higher dosages can sometimes unwillingly turn very confusing and dysphoric without any apparent cause.

Physical Effects

• Stimulation
• Perception of bodily lightness - This creates the sensation that the body is floating and has become entirely weightless. This effect is strangely stimulating and encourages physical activities at low to moderate dosages by making the body feel light and effortless to move.
• Changes in felt bodily form
• Spatial disorientation
• Spontaneous bodily sensations - The diphenidine "body high" is a sharp, pleasurable tingling sensation which is location specific to the hands, feet and head.
• Tactile suppression - This partially to entirely suppresses one's own sense of touch, creating feelings of numbness within the extremities. It is responsible for the anaesthetic properties of this substance.
• Physical autonomy
• Increased salivation
• Increased heart rate
• Motor control loss - A loss of gross and fine motor control alongside of balance and coordination is prevalent within diphenidine and becomes especially strong at higher dosages. This means that one should be sitting down before the onset (unless one is experienced) in case of falling over and injuring oneself.
• Gait alteration
• Euphoria - This results in feelings of physical euphoria which range between mild pleasure to moderate all-encompassing bliss.
• Dizziness - Although uncommon, some people report dizziness under the influence of diphenidine.
• Nausea - It's worth noting that high dose diphenidine trips can sometimes result in nausea and vomiting at the peak of the trip. For most people, this is surprisingly not as unpleasant as they would initially expect due to the accompanying detachment from the physical senses.
• Orgasm suppression & Orgasm enhancement - Orgasm enhancement can sometimes also be present, even at higher doses, although this effect is not reliable.

Visual Effects

Suppression

• Visual acuity suppression
• Double vision - This component is prevalent at moderate to heavy dosages and makes reading impossible unless one closes an eye.
• Pattern recognition suppression - This effect generally occurs at higher dosages and makes one unable to recognize and interpret perceivable visual data.
• Frame rate suppression

Distortions

• Perspective distortions
• Environmental cubism
• Environmental orbism
• Scenery slicing

Geometry

The visual geometry produced by diphenidine can be described as very dark and bland when compared to that of ketamine or DXM and often consists of many tiny interlocking and woven lines. It does not extend beyond level 4 and can be comprehensively described through its variations as simplistic in complexity, algorithmic in style, synthetic in feel, unstructured in organization, dimly lit in lighting, multicoloured in scheme, glossy in shading, soft in edges, small in size, slow in speed, smooth in motion, equal in rounded and angular corners, immersive in depth and consistent in intensity.

Hallucinatory states

At high dosages, diphenidine can produce a full range of high level hallucinatory states in a fashion that is less consistent and reproducible than that of many other commonly used psychedelics. These effects include internal hallucination (autonomous entities; settings, sceneries, and landscapes; perspective hallucinations and scenarios and plots) - In comparison to other dissociatives, this effect can occur at heavy dosages, but is considerably less common than the same effect found within psychedelics and deliriants. It can be comprehensively described through its variations as delirious in believability, fixed in style, equal in new experiences and memory replays in content, autonomous in controllability and solid in style.

Cognitive Effects

The specific cognitive effects can be broken down into several separate subcomponents which are listed and described below:

• Anxiety suppression
• Disinhibition
• Depersonalization
• Derealization
• Creativity enhancement
• Dream potentiation
• Memory suppression
• Ego death
• Ego inflation
• Thought deceleration
• Increased music appreciation
• Analysis suppression
• Time distortion
• Cognitive euphoria
• Introspection
• Déjà vu
• Conceptual thinking
• Compulsive redosing
• Amnesia
• Increased libido - This is reported to be experienced at low to mid dosage ranges.

Disconnective Effects

• Tactile disconnection
• Consciousness disconnection
• Visual disconnection - This eventually results in the diphenidine's equivalent of the "K-hole" or more specifically, holes, spaces and voids alongside of structures.

Auditory Effects

• Auditory enhancement
• Auditory suppression
• Auditory distortion

Legal Status

Diphenidine is currently a legal grey area drug worldwide and is easily accessible through the use of online research chemical vendors. However, this does not guarantee anyone to be immune from legal prosecution should they be found in possession of this substance as the legality is likely to vary from country to country.

Canada: As of March 2016, MT-45 and its analogues, one of which being Diphenidine, are Schedule I controlled substances. Possession without legal authority can result in maximum 7 years imprisonment. Only those with a law enforcement agency, person with an exemption permit or institutions with Minister's authorization may possess the drug.

Switzerland: Diphenidine is a controlled substance specifically named under Verzeichnis E.

Turkey: Diphenidine is a classed as drug and is illegal to possess, produce, supply, or import.

Diphenidine FAQ: Top 20 Frequently Asked Questions

1. What is diphenidine?

Diphenidine is a dissociative research chemical that belongs to the diarylethylamine class of substances. It has dissociative, hallucinogenic, and anesthetic effects, acting primarily as an NMDA receptor antagonist. It is structurally similar to phencyclidine (PCP) and ketamine.

2. How does diphenidine work?

Diphenidine works by blocking the NMDA receptors in the brain, which are involved in pain perception, memory, and learning. This blockade results in dissociation, altered perception, and hallucinogenic effects.

3. What are the effects of diphenidine?

Common effects of diphenidine include dissociation (feeling detached from one's body and surroundings), visual and auditory distortions, euphoria, time distortion, numbness, and altered thought patterns. At higher doses, users may experience profound dissociation and loss of motor control.

4. Is diphenidine safe?

Diphenidine has limited human research, so its long-term safety profile is not well understood. As a research chemical, it has not been approved for medical use, and it carries potential risks, especially when used at high doses or mixed with other substances. Adverse effects such as confusion, agitation, and anxiety are possible.

5. What is the usual dosage of diphenidine?

The typical dosage of diphenidine varies depending on the desired intensity of effects, but a common range for light effects is 30-50 mg, while stronger dissociative effects may require 100-150 mg. Doses above this are not recommended due to increased risks of adverse effects.

6. How long do the effects of diphenidine last?

The effects of diphenidine typically last between 4 to 8 hours, depending on the dose. The onset of effects usually occurs within 20-40 minutes after ingestion, with the peak effects occurring between 1 to 3 hours.

7. Can diphenidine cause addiction?

There is limited information on diphenidine's potential for addiction, but like other dissociatives, it may carry a risk of psychological dependence. Repeated use can lead to tolerance, meaning higher doses are needed to achieve the same effects.

8. What are the side effects of diphenidine?

Common side effects include confusion, motor impairment, dizziness, nausea, increased heart rate, and anxiety. Some users report difficulty focusing, memory issues, or paranoia. At higher doses, diphenidine can cause severe disorientation and loss of coordination.

9. Is diphenidine legal?

Diphenidine's legal status varies by country. In some places, it is classified as a controlled substance, while in others, it may be legal but unregulated. It is important to check local laws before purchasing or using diphenidine.

10. Can diphenidine be detected in a drug test?

Diphenidine is not commonly tested for in standard drug tests. However, specialized tests may be able to detect it, especially if its use is suspected. It is unclear how long it remains in the system.

11. What is the difference between diphenidine and ketamine?

Both diphenidine and ketamine are dissociatives that work by blocking NMDA receptors, but they differ in their chemical structures and effects. Ketamine is a medically used anesthetic with a more established safety profile, while diphenidine is a research chemical with less-known risks and a longer duration of action.

12. Can diphenidine cause hallucinations?

Yes, at higher doses, diphenidine can cause hallucinations. These can include both visual and auditory distortions, as well as out-of-body experiences and vivid, dream-like states.

13. How does diphenidine compare to MXE (methoxetamine)?

Diphenidine and methoxetamine (MXE) are both dissociatives, but MXE tends to be more euphoric and shorter-acting compared to diphenidine. Diphenidine is often described as being more "numb" or dissociative, with less pronounced euphoria than MXE.

14. Can you mix diphenidine with other substances?

Mixing diphenidine with other substances, particularly other depressants like alcohol or benzodiazepines, can be dangerous and increase the risk of severe side effects such as respiratory depression, loss of consciousness, or overdose. Combining diphenidine with stimulants may increase anxiety, confusion, and heart problems.

15. What are the risks of taking diphenidine?

Risks include confusion, agitation, severe dissociation, impaired motor function, and accidental injury due to disorientation. Higher doses may increase the risk of psychological distress, anxiety, paranoia, or psychosis. Its long-term health effects are unknown.

16. Can diphenidine cause brain damage?

There is no conclusive evidence that diphenidine causes brain damage, but due to its NMDA receptor-blocking properties, there is concern that long-term or heavy use could negatively affect cognitive function and memory, similar to other dissociatives like ketamine.

17. What happens if you overdose on diphenidine?

Overdosing on diphenidine can result in severe confusion, hallucinations, loss of motor control, respiratory depression, unconsciousness, and potentially life-threatening conditions. If an overdose is suspected, immediate medical attention is required.

18. What is the best way to take diphenidine?

Diphenidine is typically taken orally, but some users report insufflating (snorting) it. Oral ingestion tends to have a longer onset and duration, while insufflation may produce faster, more intense effects. However, insufflation can irritate nasal passages and may lead to more unpredictable dosing.

19. Can diphenidine cause tolerance?

Yes, tolerance to diphenidine can develop quickly with repeated use. Users may need to take higher doses to achieve the same effects over time. Cross-tolerance with other dissociatives, like ketamine or PCP, may also occur.

20. Is it safe to take diphenidine alone?

Due to its potent dissociative effects, it is generally advised not to take diphenidine alone. The disorienting nature of the drug can increase the risk of accidental injury or dangerous situations. If used, it is safer to have a sober "trip sitter" present who can monitor the user.