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Specification
IUPAC Name: 5-[2-ethoxy-5-(4-methylpiperazin-1-yl)sulfonylphenyl]-1-methyl-3-propyl-4H-pyrazolo[4,3-d]pyrimidin-7-one
Cas Number: 139755-83-2
Molecular Formula: C22H30N6O4S
Molar Mass: 474.5 g/mol
Effect: stimulant
Physical properties: pills
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Table of Contents

How to get Viagra (Sildenafil)

Sildenafil, commonly known as Viagra, is available through various channels. It can be obtained with a prescription from licensed medical professionals. In many countries, it is also available through online pharmacies, though caution should be exercised to ensure the authenticity and safety of the source.

What is Viagra (Sildenafil)

Sildenafil is a potent and selective inhibitor of cyclic guanosine monophosphate (cGMP)-specific phosphodiesterase type 5 (PDE5). PDE5 is an enzyme primarily located in the smooth muscle cells of the corpus cavernosum in the penis and other tissues, such as the lungs. Its inhibition by Sildenafil leads to increased levels of cGMP, a second messenger molecule responsible for vasodilation and relaxation of smooth muscle cells. This mechanism forms the basis of Sildenafil's primary application in treating erectile dysfunction (ED) and pulmonary arterial hypertension (PAH).

The History of Sildenafil

The history of Sildenafil dates back to the 1980s when pharmaceutical researchers were exploring the potential of PDE5 inhibition for cardiovascular conditions. Initially developed as a candidate for angina treatment, clinical trials revealed unexpected but profound effects on male erectile function. This serendipitous discovery led to the approval of Sildenafil by the U.S. Food and Drug Administration (FDA) in 1998 for treating ED, revolutionizing the field of sexual medicine.

Effects of Sildenafil

Its influence on the cGMP-PDE5 pathway primarily mediates the effects of Sildenafil. In individuals with ED, the drug enhances penile erection by promoting increased blood flow to the erectile tissues upon sexual stimulation. This effect occurs due to the relaxation of smooth muscles in the corpus cavernosum, allowing for improved arterial inflow and reduced venous outflow. Additionally, Sildenafil has been found to exert vasodilatory effects in the pulmonary arteries, making it a valuable therapeutic option for PAH patients.

Dosage of Sildenafil

The appropriate dosage of Sildenafil varies depending on the individual's condition and needs. The typical starting dose for ED is 50 mg, with adjustments made based on efficacy and tolerance. The drug usually takes about 30 minutes to an hour before sexual activity. The dosage for PAH ranges from 20 mg to 80 mg, administered thrice daily. As with any medication, healthcare providers are crucial in determining the most suitable dosage to achieve optimal therapeutic outcomes while minimizing potential side effects.

Legal Status of Sildenafil

Sildenafil's legal status is subject to regulations that vary across different jurisdictions. In many countries, Sildenafil is available only with a valid prescription from a licensed healthcare provider. This regulation aims to ensure the safe and appropriate use of the drug and prevent potential misuse or adverse reactions. However, the digital age has brought about online availability through unregulated sources, necessitating caution to avoid counterfeit or substandard products.

Pharmacology of Sildenafil

The pharmacology of Sildenafil revolves around its role as a PDE5 inhibitor. PDE5 enzymes are crucial regulators of cyclic nucleotide signalling pathways, particularly the cGMP pathway. By inhibiting PDE5, Sildenafil increases the cGMP concentration, promoting vasodilation and smooth muscle relaxation. In the context of ED, this translates to improved blood flow to the erectile tissues, facilitating the physiological mechanisms of penile erection. Furthermore, Sildenafil's effect on pulmonary arteries offers a therapeutic avenue for managing PAH, characterized by elevated pulmonary artery pressure.

Chemistry of Sildenafil

The chemical structure of Sildenafil is characterized by a pyrazolo[4,3-d]pyrimidin-7-one core, which serves as the scaffold for its pharmacological activity. The compound's systematic name is 1-[[3-(6,7-dihydro-1-methyl-7-oxo-3-propyl-1H-pyrazolo[4,3-d]pyrimidin-5-yl)-4-ethoxyphenyl]sulfonyl]-4-methyl piperazine citrate. This intricate arrangement of atoms contributes to its high specificity for PDE5 inhibition and underscores the importance of molecular design in drug development.

Conclusion

Sildenafil is a testament to scientific discovery's unpredictable yet remarkable nature. From its humble beginnings as a cardiovascular candidate to its transformative impact on sexual medicine, Sildenafil has enriched our understanding of molecular pharmacology and its potential applications. As we navigate the landscape of pharmaceuticals, Sildenafil's journey reminds us that even unintended outcomes can lead to groundbreaking advancements with far-reaching implications for human health and well-being.

FAQ

What is Viagra (Sildenafil)?

Viagra, also known by its generic name Sildenafil, is a medication used to treat erectile dysfunction (ED). It belongs to a class of drugs called phosphodiesterase type 5 (PDE5) inhibitors.

How does Viagra work?

Viagra works by relaxing the blood vessels in the penis, allowing for increased blood flow when a man is sexually aroused. This improved blood flow helps men with ED to achieve and maintain an erection.

Is Viagra safe for everyone?

Viagra may not be safe for everyone. It is essential to consult with a healthcare professional before taking Viagra, as it can interact with other medications and may not be suitable for people with certain medical conditions.

What are the common side effects of Viagra?

Common side effects of Viagra may include headache, flushing, upset stomach, nasal congestion, vision changes, and dizziness. These side effects are usually mild and temporary.

Is Viagra addictive?

No, Viagra is not addictive. It is not associated with physical or psychological dependence.

How should I take Viagra?

Viagra should be taken as prescribed by a healthcare provider. It is typically taken about 30 minutes to an hour before sexual activity. It should not be taken more than once a day.

Can women take Viagra?

Viagra is specifically designed to treat erectile dysfunction in men and is not approved for use by women. Women should not take Viagra, and there are other medications available for female sexual health concerns.

What should I do if I experience an erection lasting more than four hours?

An erection lasting more than four hours, known as priapism, is a medical emergency. Seek immediate medical attention if this occurs, as it can damage the penis if not treated promptly.

Where can I get more information about Viagra?

For more information about Viagra, its uses, and potential side effects, consult with a healthcare professional or refer to reputable sources such as the medication's official website or medical literature.


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