The product can not be sold in a country where it is illegal.

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Product Name: AM-2201
IUPAC Name: 1-[(5-Fluoropentyl)-1H-indol-3-yl]-(naphthalen-1-yl)methanone
Other Names: 1-(5-fluoropentyl)-3-(1-naphthoyl)indole
Cas Number: 335161-24-5
Molecular Formula: C24H22FNO
Molar Mass: 359.44 g/mol
Effect: stimulant, psychedelic
Purity of the substance: 99.9%
Physical properties: Crystals, Powder
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The realm of psychoactive substances continually evolves with the emergence of novel compounds that interact with the human nervous system. AM-2201 is a compound that has gained attention in recent years due to its psychoactive effects. This article delves into the multifaceted aspects of AM-2201, covering its chemistry, pharmacology, effects, dosages, history, legal status, and more.

How to get AM-2201

AM-2201 is not a substance readily available for legal purchase. Its production, distribution, and possession often fall under strict legal regulations, making it challenging to find through conventional means. Online black markets and illicit platforms have been known to facilitate its sale, but engaging in such activities poses serious legal and health risks.

What is AM-2201?

AM-2201, chemically known as 1-(5-fluorophenyl)-3-(1-naphthyl)indole, belongs to the class of synthetic cannabinoids. Synthetic cannabinoids are designed to mimic the effects of naturally occurring cannabinoids found in cannabis, primarily by binding to the cannabinoid receptors in the brain and peripheral tissues. AM-2201 is structurally related to the parent compound JWH-018, another synthetic cannabinoid.

The History of AM-2201

In 2201 was first synthesized by Alexandros Makriyannis and his research team at the University of Connecticut in 2008. It quickly gained popularity in recreational drug use due to its potent psychoactive effects. However, its rise was met with increasing concerns about its safety, legality, and potential health risks.

Effects of AM-2201

The effects of AM-2201 are primarily attributed to its interaction with the endocannabinoid system. This system regulates various physiological processes, including mood, appetite, pain perception, and immune response. AM-2201, as a synthetic cannabinoid, binds to cannabinoid receptors, particularly CB1 and CB2 receptors, leading to alterations in neurotransmitter signalling.

The reported effects of AM-2201 use can vary widely and may include the following:

  1. Euphoria: Users may experience feelings of intense happiness and pleasure.
  2. Altered Perception: Distortions in sensory perception, time perception, and visual experiences are shared.
  3. Relaxation: A sense of peace and reduced anxiety may be observed.
  4. Increased Heart Rate and Blood Pressure: AM-2201 can lead to physiological changes, including elevated heart rate and blood pressure.
  5. Cognitive Impairment: Impaired memory, concentration, and coordination are potential mental effects.
  6. Paranoia and Anxiety: Some individuals may experience heightened anxiety and paranoia, contributing to the compound's adverse psychological effects.

Dosage of AM-2201

Determining a safe and effective dosage of AM-2201 is challenging due to its high potency and unpredictable effects. It is often sold in powder form, and users might attempt to vaporize or smoke it. However, due to the variability in product purity and concentration, even minute variations in dosage can lead to drastically different outcomes. This lack of standardization significantly increases the risk of overdose, adverse reactions, and long-term health consequences.

Legal Status of AM-2201

The legal status of AM-2201 varies across jurisdictions. In many countries, AM-2201 and other synthetic cannabinoids are classified as controlled substances due to their potential for abuse and health risks. The compound's inclusion in regulatory schedules aims to restrict its production, distribution, and possession. This legal stance reflects the authorities' concern regarding its widespread recreational use and potential adverse effects on public health.

Pharmacology of AM-2201

AM-2201's pharmacological effects stem from its interactions with the endocannabinoid system. The compound binds to CB1 and CB2 receptors, primarily located in the central nervous system and peripheral tissues. Activation of CB1 receptors can lead to the release of neurotransmitters like dopamine and serotonin, contributing to the compound's psychoactive effects.

Furthermore, the high affinity of AM-2201 for these receptors contributes to its potency, often resulting in intense and unpredictable outcomes. The rapid and robust binding of synthetic cannabinoids like AM-2201 to cannabinoid receptors can disrupt the balance of neurotransmitter signalling, potentially leading to adverse physiological and psychological effects.

Chemistry of AM-2201

AM-2201's chemical structure is characterized by its indole core, a common motif in many synthetic cannabinoids. The compound's systematic name, 1-(5-fluorophenyl)-3-(1-naphthyl)indole, signifies the presence of a fluorophenyl chain and a naphthyl group attached to the indole ring. Introducing the fluorine atom and naphthyl moiety imparts unique properties to AM-2201, influencing its binding affinity, selectivity, and overall pharmacological profile. 


AM-2201 represents a striking example of the ongoing exploration of psychoactive compounds, their effects, and their potential risks. Its emergence in recreational drug use underscores the need for comprehensive research into its chemistry, pharmacology, and impact on human health. The compound's potent interactions with the endocannabinoid system result in a wide range of physiological and psychological effects, albeit often accompanied by significant risks and uncertainties. As legal regulations surrounding such compounds continue to evolve, understanding AM-2201's impact on individuals and society remains essential for scientific inquiry and public health considerations.


How does AM-2201 work?

AM-2201 acts on the endocannabinoid system, binding to cannabinoid receptors in the brain and producing psychoactive effects.

What are the effects of AM-2201?

AM-2201 effects can include relaxation, altered perception, euphoria, and increased heart rate. It may also have negative side effects and health risks.

Is AM-2201 safe to use?

The safety of AM-2201 is a subject of concern. It has been associated with adverse effects, and its long-term effects are not well understood. Its use should be approached with caution.

Is AM-2201 legal?

AM-2201's legal status varies by country and region. In many places, it is illegal due to its potential for misuse and health risks.

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