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Table of Contents

1. Introduction
2. Chemistry of PCE
3. Pharmacology of PCE
4. Subjective Effects of PCE
5. Dosage Guidelines
6. Toxicity and Harm Potential
7. Tolerance and Addiction Potential
8. Psychosis Risk
9. Urinary Tract Effects
10. Dangerous Interactions
11. Legal Status of PCE

The Evolution of PCE: From Pharmaceutical Anesthetic to Recreational Drug

Historical Background

Phencyclidine (PCP), initially introduced in the 1950s as an anesthetic pharmaceutical drug under the brand name Sernyl, garnered attention for its potent analgesic properties. However, its use was short-lived as it was withdrawn from the market in 1965 due to the prevalence of dissociative hallucinogenic side effects that overshadowed its medical benefits. During this time, Eticyclidine (PCE), a structural analog of PCP, was also discovered to produce similar dissociative, anesthetic, and hallucinogenic effects.

Pharmacological Properties

PCE, belonging to the arylcyclohexylamine chemical class, primarily acts as an NMDA receptor antagonist, much like its predecessor PCP. Through noncompetitive binding, it blocks the activity of the NMDA receptor, resulting in dissociative experiences.

Transition to Recreational Use

In the wake of PCP's removal from pharmaceutical use, researchers at Parke-Davis Pharmaceuticals discovered ketamine, a derivative deemed more tolerable for medical purposes. However, the allure of PCP-like effects persisted in the recreational drug scene, leading to the emergence of synthetic derivatives, including PCE.

Contemporary Usage

Today, PCE is predominantly consumed as a recreational drug, occasionally sought for entheogenic purposes alongside its popular counterparts, such as 3-MeO-PCP and 3-MeO-PCE. Users may ingest PCE orally, smoke it, insufflate it, or inject it.

Characteristics and Effects

PCE is renowned for its potency, diverse effects, prolonged duration, and potential for abuse. Compared to PCP, it exhibits slightly greater potency but is less favored due to its unpleasant taste and propensity to induce nausea. Consequently, PCE remains relatively obscure within the realm of recreational drugs, despite its similarities to its predecessor.

The Chemistry of PCE

Structure

PCE, also known as Eticyclidine, belongs to the synthetic dissociative category of the arylcyclohexylamine class. Its chemical structure comprises a cyclohexane ring, a six-member saturated ring, bonded to another ring and an -ethyl group at R1. One of these rings is a piperidine ring, a nitrogenous six-member ring, bonded at its nitrogen group. Unlike PCP, the other constituent at the nitrogen is not a complete cyclohexane ring but an ethyl group. PCE derives its name from the initial letters of its three constituent rings: phenyl, cyclohexane, and ethyl.

Pharmacology of PCE

Mechanism of Action

NMDA receptors, a subtype of receptors for glutamate, serve as the primary excitatory neurotransmitters in the nervous system. These receptors facilitate the transmission of electrical signals between nerve cells in the brain and spinal column. For these signals to propagate, the receptor must be open. NMDA receptor antagonists, like PCE, disrupt this signaling process by blocking these receptors. Consequently, this disruption in information flow within the nervous system leads to effects such as loss of sensation (anesthesia), motor discoordination, and a distinct "hole"-like state akin to that induced by ketamine, albeit with qualitative differences.

Additional Pharmacological Effects

Apart from its NMDA receptor blocking activity, PCE also functions as a dopamine-noradrenaline reuptake inhibitor and a serotonin reuptake inhibitor. Moreover, it is suspected to possess affinity for µ-opioid receptors. These pharmacological properties contribute to PCE's euphoric and often stimulating effects.

Potency and Effects

PCE exhibits slightly greater potency than PCP and elicits similar effects. However, its unpleasant taste and propensity to induce nausea have limited its acceptance among users. Despite its potency and efficacy, these factors have rendered PCE relatively less popular in comparison to other dissociative substances.

Subjective Effects of PCE

Disclaimer: The following effects are based on anecdotal user reports and the analysis from the Subjective Effect Index (SEI). While informative, these effects should be approached with caution and skepticism. Higher doses are more likely to induce the full spectrum of effects, and adverse effects, including addiction and severe injury, become increasingly likely with higher doses, potentially leading to death.

Physical Effects

• Spontaneous Physical Sensations
• Tactile Suppression
• Physical Autonomy
• Loss of Motor Control
• Physical Euphoria
• Perception of Bodily Lightness
• Dizziness
• Nausea

Disconnective Effects

• Tactile Disconnection
• Visual Disconnection: This may culminate in PCE's equivalent of the "k-hole," characterized by holes, spaces, and voids alongside structures. Unlike ketamine, PCE does not immobilize users at this level, potentially leading to unpredictable psychotic behavior.
• Consciousness Disconnection

Visual Effects

• Suppression
• Visual Acuity Suppression
• Double Vision
• Pattern Recognition Suppression
• Frame Rate Suppression
• Distortions
• Perspective Distortions
• Environmental Cubism
• Environmental Orbism
• Scenery Slicing
• Geometry
• Hallucinatory States: At high doses, PCE can induce a range of high-level hallucinatory states, albeit less consistently than many other psychedelics. These may include external and internal hallucinations.

Cognitive Effects

The cognitive effects of PCE are often described as particularly stimulating, euphoric, and clear-headed compared to other dissociatives like DXM and ketamine. These effects include:

• Anxiety Suppression
• Disinhibition
• Conceptual Thinking
• Thought Acceleration
• Thought Disorganization
• Immersion Enhancement
• Delusion
• Depersonalization & Derealization
• Memory Suppression
• Ego Death
• Amnesia
• Analysis Suppression
• Time Distortion
• Cognitive Euphoria
• Introspection
• Déjà Vu
• Compulsive Redosing
• Feelings of Impending Doom
• Creativity Enhancement
• Psychosis: This effect is more common with PCE than other dissociatives.

Auditory Effects

• Suppression
• Distortions
• Hallucinations

Experience Reports

There are currently no anecdotal reports describing the effects of PCE within our experience index. Additional experience reports may be found on Erowid Experience Vaults: PCE.

Dosage of PCE

Threshold

• Threshold: 1 mg

Light

• Light: 3 - 5 mg

Common

• Common: 5 - 10 mg

Strong

• Strong: 10 - 15 mg

Heavy

• Heavy: 15 mg and above

Note: Heavy doses of PCE may lead to psychosis and mania.

Toxicity and Harm Potential of PCE

Long-Term Effects

• Long-term use of PCE may lead to:

  • Schizophrenia-like psychotic episodes
  • Severe lasting memory loss
  • Disorganized thinking
  • Depression
  • Weight loss
  • Liver abnormalities
  • Rhabdomyolysis (skeletal muscle breakdown)

• PCE can cause brain damage known as Olney's lesions in rats, similar to other NMDA receptor antagonists. However, studies on Olney's lesions have only been conducted on non-human animals and may not directly apply to humans.

• PCE has been shown to cause schizophrenia-like changes in N-acetylaspartate and N-acetylaspartylglutamate levels in the rat brain, which are detectable both in living rats and upon necropsy examination of brain tissue. It also induces symptoms in humans that mimic schizophrenia.

Tolerance and Addiction Potential

• Chronic use of PCE can be highly addictive with a high potential for adverse side effects such as psychosis.
• PCE is reported to cause psychosis and mania at a significantly higher rate than other dissociatives.
• Compulsive redosing and addiction can lead to severe adverse effects.
• Tolerance to PCE develops with prolonged use, requiring increasingly larger doses to achieve the same effects.

Urinary Tract Effects

• Repeated and excessive use of PCE can lead to severe bladder and urinary tract problems, similar to other arylcyclohexylamines like ketamine or PCP.
• Symptoms include urinary frequency, urgency, pressure, pelvic and bladder pain, hematuria, and incontinence.

Dangerous Interactions

• Combining PCE with other substances, especially psychedelics, stimulants, or depressants, can lead to extreme psychological disturbances, respiratory depression, and other life-threatening effects.
• Users should conduct independent research to ensure the safety of combining substances.

Legal Status

• Internationally, PCE is classified as a Schedule I substance under the Convention on Psychotropic Substances.
• Legal status varies by country, with PCE being controlled or illegal in many jurisdictions, including the United States, Canada, Germany, New Zealand, Poland, Portugal, Switzerland, and the United Kingdom.

Frequently Asked Questions (FAQ)

1. What is PCE?

PCE, also known as Eticyclidine, is a synthetic dissociative substance belonging to the arylcyclohexylamine chemical class.

2. How does PCE affect the body?

PCE primarily acts as an NMDA receptor antagonist, disrupting signaling in the nervous system and leading to effects such as anesthesia, motor discoordination, and dissociation.

3. What are the common subjective effects of PCE?

Common subjective effects of PCE include physical sensations, disconnective effects, visual distortions, cognitive alterations, and auditory distortions.

4. What are the recommended dosage guidelines for PCE?

Threshold: 1 mg Light: 3 - 5 mg Common: 5 - 10 mg Strong: 10 - 15 mg Heavy: 15 mg and above

5. Are there any long-term health risks associated with PCE use?

Yes, long-term use of PCE may lead to schizophrenia-like psychotic episodes, memory loss, disorganized thinking, depression, weight loss, liver abnormalities, and urinary tract problems.

6. Is PCE addictive?

Yes, chronic use of PCE can lead to addiction, with users experiencing tolerance and requiring increasingly larger doses to achieve the same effects.

7. What is the risk of psychosis with PCE use?

PCE has been reported to cause psychosis and mania at a higher rate than other dissociatives. Extreme caution and harm reduction practices are recommended.

8. Are there any dangerous interactions with PCE?

Yes, combining PCE with other substances, especially psychedelics, stimulants, or depressants, can lead to extreme psychological disturbances and life-threatening effects.

9. What is the legal status of PCE?

PCE is classified as a Schedule I substance under the Convention on Psychotropic Substances and is controlled or illegal in many countries, including the United States, Canada, Germany, and the United Kingdom.