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Product Name: 3-MeO-PCE
IUPAC Name: N-Ethyl-1-(3-methoxyphenyl)cyclohexan-1-amine
Other Names: 3-MeO-PCE, Methoxyeticyclidine
Molecular Formula: None
Molar Mass: 237.26 g·mol−1
Effect: stimulant, psychedelic
Purity of the substance: 99.9%
Physical properties: Crystals, Powder
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Table of Contents

  1. Introduction
  2. Chemistry
  3. Pharmacology
  4. Dosage
  5. Physical Effects
  6. Cognitive Effects
  7. Visual Effects
  8. Toxicity and Harm Potential
  9. Tolerance and Addiction Potential
  10. Urinary Tract Effects
  11. Dangerous Interactions
  12. Legal Status

3-Methoxyeticyclidine (also known as Methoxieticyclidine and 3-MeO-PCE) stands as a novel dissociative substance belonging to the arylcyclohexylamine class. It elicits dissociative and hallucinogenic effects upon administration and serves as a structural analog of PCE.

Emergence and Popularity

Inception and Rise

The popularity of 3-MeO-PCE initiated around 2010 [2], gaining traction particularly within the online grey area research chemical market. It was marketed as a legal alternative to substances such as PCP or ketamine [3][4][5].

Lack of Comprehensive Data

Limited Information

Despite its increasing usage, there exists a dearth of comprehensive data regarding the pharmacological properties, metabolism, and toxicity of 3-MeO-PCE. Moreover, its history of human usage remains relatively brief.

Cautionary Note

Given the limited understanding surrounding this substance, it is strongly advised to adhere to harm reduction practices when considering its usage.


Structural Composition

3-MeO-PCE, also referred to as N-Ethyl-1-(3-methoxyphenyl)cyclohexan-1-amine, belongs to the arylcyclohexylamine drug class. This classification stems from its structural features, characterized by a cyclohexane ring fused to an aromatic ring alongside an amine group. Specifically, 3-MeO-PCE comprises a phenyl ring with a methoxy (CH3-O-) substituent at R3 attached to a cyclohexane ring. Additionally, an amino ethyl chain (-NCH2CH3) is bonded to the same carbon (R1) of the cyclohexanone ring. Notably, 3-MeO-PCE shares similarities with MXE, featuring an amino ethyl chain rather than the amino methyl chain found in DCK and ketamine. While analogous to MXE, 3-MeO-PCE lacks an R2 substituted ketone. It is also homologous to 3-MeO-PCP but lacks the additional carbons necessary to complete a piperidine ring.


Mechanism of Action

3-MeO-PCE primarily functions as an NMDA receptor antagonist. NMDA receptors facilitate the transmission of electrical signals between neurons in the brain and spinal cord, necessitating receptor openness for signal passage. Dissociatives like 3-MeO-PCE obstruct NMDA receptors, effectively closing them. This interruption of neuronal connectivity results in sensations of numbness, impaired movement, and an experience commonly likened to the "k-hole."

Receptor Affinities

The substance exhibits Ki values as follows:

  • NMDA receptor: 61 nM
  • Dopamine transporter: 743 nM
  • Histamine H2 receptor: 2097 nM
  • Alpha-2A adrenergic receptor: 964 nM
  • Serotonin transporter: 115 nM
  • σ1 receptor: 4519 nM
  • σ2 receptor: 525 nM [6]

Subjective Effects

Comparisons and Potential Risks

3-MeO-PCE shares significant similarities with 3-MeO-PCP, albeit potentially carrying a higher risk of inducing states of mania, delusions, and psychosis due to heightened euphoric stimulation and compulsive redosing tendencies. Nonetheless, as dosage increases, the effects reportedly converge with those of 3-MeO-PCP, with dissociative effects becoming predominant.

Stimulating Properties

Reports suggest that 3-MeO-PCE may be more stimulating and less sedating compared to other dissociatives such as ketamine or MXE. Moreover, it is perceived as more comfortable than compounds like O-PCE, MXP, and diphenidine, which act as noradrenaline reuptake inhibitors. This observation hints at a potential higher affinity for dopamine or serotonin, although empirical evidence is lacking.

Disclaimer: The subjective effects listed are based on the Subjective Effect Index (SEI), derived from anecdotal user reports and personal analyses by PsychonautWiki contributors. Caution is advised, as these effects may not occur predictably or reliably. Higher doses increase the likelihood of experiencing the full spectrum of effects, with adverse outcomes including addiction, severe injury, or fatality becoming more probable.

Understanding 3-MeO-PCE Dosage Guidelines

Dosage Ranges


  • Threshold Dose: 1 mg


  • Light Dose Range: 3 - 6 mg


  • Common Dose Range: 6 - 12 mg


  • Strong Dose Range: 12 - 20 mg


  • Heavy Dose: 20 mg and above

Potential Risks

Heavy doses of 3-MeO-PCE carry the potential risk of inducing psychosis and mania.

Exploring the Physical Effects of 3-MeO-PCE


  • Stimulation: 3-MeO-PCE exhibits pronounced stimulation compared to other dissociatives such as ketamine, MXE, or DCK. This stimulation is characterized by its cleanliness and comfort, resembling that of 3-MeO-PCP more closely than O-PCE.

Perception Alterations

  • Perception of Bodily Lightness
  • Restless Legs
  • Spontaneous Physical Sensations: The body high induced by 3-MeO-PCE encompasses motionless, sharp, and euphoric sensations across the body. These sensations, resembling those of 3-MeO-PCP and O-PCE, diminish at higher doses due to the compound's disconnecting and anesthetic effects.

Euphoria and Bodily Sensations

  • Physical Euphoria: At lower to moderate doses, 3-MeO-PCE generates feelings of physical comfort, warmth, and euphoria throughout the body. However, at higher doses, this sensation may become neutral or uncomfortable.
  • Bodily Control Enhancement: Initially, the compound enhances bodily control, but at higher doses, it leads to gross and fine motor control impairment.
  • Tactile Enhancement & Suppression: At lower doses, tactile sensations may be enhanced, while higher doses lead to suppression and anesthesia.
  • Motor Control Loss: Similar to bodily control enhancement, motor control enhancement at lower doses shifts to loss at higher doses.
  • Changes in Felt Gravity
  • Appetite Suppression
  • Nausea Suppression
  • Pain Relief
  • Increased Blood Pressure: Typically observed at higher doses.
  • Increased Heart Rate: Higher doses may result in an uncomfortably elevated heart rate, more pronounced than other dissociatives like DCK or ketamine, particularly towards the trip's end.
  • Respiratory Depression: Reported at heavier dosage levels.
  • Physical Autonomy
  • Olfactory Hallucinations
  • Optical Sliding
  • Spatial Disorientation
  • Dizziness
  • Increased Perspiration
  • Dehydration
  • Difficulty Urinating
  • Seizure

Disconnective Effects

  • Tactile Disconnection
  • Visual Disconnection: Leading to experiences akin to the "k-hole," featuring holes, spaces, and voids alongside structures.
  • Consciousness Disconnection

Auditory Effects

  • Suppression
  • Distortions
  • Hallucinations

Multi-sensory Effects

  • Synaesthesia

Transpersonal Effects

  • Unity and Interconnectedness

Exploring the Cognitive and Visual Effects of 3-MeO-PCE

Cognitive Effects

Anxiety Suppression



  • Occurrence: More common on 3-MeO-PCE compared to most other dissociatives. Typically arises during the trip's offset but can manifest during the onset and come-up phases as well.
  • Cognitive Euphoria
  • Depersonalization
  • Derealization


  • Frequency: More common on 3-MeO-PCE compared to most other dissociatives.

Delusions of Sobriety

Compulsive Redosing

  • Prominence: More pronounced based on the route of administration. Particularly evident when smoked or vaporized due to the substance's rapid entry and exit from the bloodstream.
  • Conceptual Thinking
  • Creativity Enhancement
  • Déjà Vu
  • Memory Suppression
  • Ego Death
  • Amnesia
  • Immersion Enhancement
  • Increased Music Appreciation
  • Analysis Suppression
  • Introspection
  • Time Distortion
  • Thought Deceleration


  • Occurrence: More common on 3-MeO-PCE compared to most other dissociatives.

Visual Effects


  • Acuity Enhancement: Especially notable at low dosages.
  • Color Enhancement


  • Double Vision
  • Frame Rate Suppression
  • Pattern Recognition Suppression
  • Visual Acuity Suppression


  • Environmental Cubism
  • Perspective Distortions
  • Scenery Slicing


  • The visual geometry induced by 3-MeO-PCE is characterized as dark and bland compared to ketamine or DXM. It often comprises interlocking and woven lines, not extending beyond level 4 complexity. Described as simplistic, algorithmic, and synthetic, with dim lighting, multicolored schemes, glossy shading, soft edges, small size, slow speed, smooth motion, and immersive depth.

Hallucinatory States

  • Internal Hallucination: Includes autonomous entities, settings, sceneries, landscapes, perspective hallucinations, scenarios, and plots.

Investigating Toxicity and Harm Potential of 3-MeO-PCE

Lack of Scientific Research

The toxicity and long-term health effects of recreational 3-MeO-PCE use have not been extensively studied in scientific contexts, primarily due to its limited history of human usage. Consequently, the exact toxic dosage remains unknown.


3-MeO-PCE has been associated with a higher incidence of psychosis, delusions, and mania compared to other dissociatives like ketamine, diphenidine, or MXE. Numerous online experience reports describe states of "psychotic delirium, amnesia, mania, and other serious consequences" following substance abuse.

Harm Reduction Practices

It is strongly recommended to exercise extreme caution and adopt harm reduction practices when using 3-MeO-PCE:

  • Avoid consecutive daily usage or developing addiction, as these behaviors heighten the risk of severe adverse effects.
  • Adhere to recommended dosage ranges to mitigate the potential for triggering adverse effects.
  • Initiate usage with extremely low doses and gradually increase, preferably utilizing volumetric liquid dosing due to the substance's potency.
  • Discourage compulsive redosing, particularly before fully sobering up, to prevent accidental overdosing.
  • Refrain from combining 3-MeO-PCE with other substances, especially stimulants, psychedelics, or other dissociatives, to minimize the risk of psychosis.

Tolerance and Addiction Potential

Chronic use of 3-MeO-PCE is considered highly addictive, with a heightened potential for adverse side effects, including psychosis. Reports suggest it is more habit-forming than MXE, diphenidine, ephenidine, and ketamine. Users may experience cravings and withdrawal effects upon sudden cessation of usage. Exercise caution and thoughtful consideration before trying this substance to avoid potential addiction.

Urinary Tract Effects

Repeated and excessive usage of 3-MeO-PCE may lead to bladder and urinary tract issues similar to those observed with ketamine, albeit to a lesser extent due to 3-MeO-PCE's potency. Symptoms include urinary frequency, urgency, pressure, pelvic and bladder pain, hematuria, and incontinence. These effects can be avoided by limiting usage frequency.

Dangerous Interactions

Combining 3-MeO-PCE with certain substances can result in dangerous and life-threatening interactions:

  • Psychedelics: Risk of extreme psychological disturbances like psychosis and mania.
  • Stimulants: Increased risk of adverse psychological reactions such as anxiety, delusions, and psychosis.
  • Depressants: Enhanced respiratory depression, potentially leading to unconsciousness, vomiting, and suffocation.

Legal Status

3-MeO-PCE is subject to legal restrictions in various countries:

  • Germany: Controlled under the NpSG (New Psychoactive Substances Act).
  • Switzerland: Classified as a controlled substance under Verzeichnis E.
  • Turkey: Illegal to possess, produce, supply, or import.
  • United Kingdom: Class B drug, illegal to possess, produce, supply, or import under the Misuse of Drugs Act.

Frequently Asked Questions (FAQ)

1. What is 3-MeO-PCE?

3-Methoxyeticyclidine (3-MeO-PCE), also known as Methoxieticyclidine, is a novel dissociative substance belonging to the arylcyclohexylamine class. It produces dissociative and hallucinogenic effects similar to substances like PCP or ketamine.

2. Is 3-MeO-PCE legal?

The legal status of 3-MeO-PCE varies by country. For example, it is classified as a controlled substance in Germany and the United Kingdom. Users should research their local laws before purchasing or using 3-MeO-PCE.

3. What are the potential risks of using 3-MeO-PCE?

3-MeO-PCE usage may lead to adverse effects such as psychosis, mania, and urinary tract issues. It is highly addictive, and users may develop tolerance with prolonged use. Combining 3-MeO-PCE with other substances can result in dangerous interactions.

4. How should I use 3-MeO-PCE safely?

To use 3-MeO-PCE safely, it is recommended to start with extremely low doses and gradually increase, adhering to recommended dosage ranges. Users should avoid consecutive daily usage, compulsive redosing, and combining 3-MeO-PCE with other substances. Harm reduction practices such as volumetric dosing and research into safe combinations are essential.

5. What are the long-term effects of 3-MeO-PCE usage?

Long-term usage of 3-MeO-PCE may lead to addiction, tolerance, and urinary tract issues similar to those observed with ketamine. Users may experience withdrawal effects upon cessation of usage. It is crucial to exercise caution and moderation when using 3-MeO-PCE to minimize the risk of adverse health effects.

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