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Specification
Product Name: 4-HO-DET
IUPAC Name: 3-(2-diethylaminoethyl)-1H-indol-4-ol
Other Names: 4-HO-DET, Ethocin, CZ-74
Molecular Formula: None
Molar Mass: 237.26 g·mol−1
Effect: stimulant, psychedelic
Purity of the substance: 99.9%
Physical properties: Crystals, Powder
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Table of Contents

  1. Chemistry
  2. Dosage
    • Threshold
    • Light
    • Common
    • Strong
    • Heavy
    • Subjective effects
  3. Physical Effects
  4. Visual Effects
  5. Cognitive Effects
  6. Auditory Effects
  7. Toxicity and Harm Potential
    • Overview
    • Harm Reduction Practices
    • Tolerance and Addiction Potential
    • Dangerous Interactions
    • Legal Status

The Psychedelic Symphony of 4-HO-DET

4-Hydroxy-N,N-diethyltryptamine, also recognized as 4-HO-DET, CZ-74, and Ethocin, emerges as a clandestine synthetic psychedelic within the tryptamine chemical realm. This compound, when administered, manifests psychedelic effects reminiscent of psilocin, the primary psychoactive constituent found in magic mushrooms. Noteworthy for its structural and functional affinity with psilocin, 4-HO-DET introduces subtle variations in duration, as well as visual, cognitive, and bodily effects.

Roots in Psychedelic Exploration

The roots of 4-HO-DET trace back to the late 1950s when Albert Hofmann and Franz Troxler made its inaugural discovery. Their exploration focused on a spectrum of psychedelic compounds sharing structural and chemical kinship with the key components extracted from magic mushrooms, namely psilocybin (4-PO-DMT) and psilocin (4-HO-DMT). In subsequent human clinical trials during the 1960s, German researchers Hanscarl Leuner and G. Baer delved into the substance, alongside its phosphoryloxy-analog, 4-PO-DET[citation needed].

A Limited Odyssey

Despite its inception, 4-HO-DET has maintained a low profile, with scant documentation of human usage. In comparison to more conventional psychedelics like psilocybin and psilocin from magic mushrooms, or the contemporary 4-AcO-DMT, 4-HO-DET remains relatively uncommon. Its application spans the realms of recreational use and entheogenic exploration, yet it lacks a street-level presence, primarily procured through online research chemical vendors

Chemistry

4-HO-DET: A Synthetic Tryptamine Alkaloid

4-Hydroxy-N,N-diethyltryptamine (4-HO-DET), also known as CZ-74 and Ethocin, belongs to the tryptamine chemical class, characterized by a core structure comprising a bicyclic indole heterocycle linked to an amino group via an ethyl side chain at R3. This synthetic indole alkaloid stands out for its molecular structure, featuring a hydroxyl functional group (OH−) at R4 of the indole heterocycle and two ethyl chains attached to the terminal amine RN of its tryptamine backbone (DET).

Chemical Composition

4-HO-DET shares close structural and functional similarities with psilocin (4-HO-DMT), the primary psychoactive component in magic mushrooms. It is the lower homolog of 4-AcO-DET, the N-substituted diethyl homolog of 4-HO-DMT, and the 4-hydroxy analog of DET.

Pharmacology

Exploring Psychedelic Effects

As a member of the tryptamine class, 4-HO-DET primarily functions as a 5-HT2A partial agonist, playing a key role in the manifestation of its psychedelic effects. The exact nature of these interactions and how they contribute to the psychedelic experience, however, remains a subject of ongoing scientific exploration.

Historical Roots and Clinical Trials

4-HO-DET was first discovered in the late 1950s by Albert Hofmann and Franz Troxler during their investigations into psychedelic compounds related to the active components in magic mushrooms—psilocybin and psilocin. Notably, it was used in conjunction with its phosphoryloxy-analog, 4-PO-DET, in human clinical trials in the 1960s by German researchers Hanscarl Leuner and G. Baer.

Limited Human Usage and Contemporary Trends

Despite its early discovery and inclusion in clinical trials, 4-HO-DET has remained relatively uncommon in human usage. The psychedelic community predominantly favors more traditional psychedelics like psilocybin and psilocin found in magic mushrooms or, more recently, substances like 4-AcO-DMT. Today, 4-HO-DET is primarily obtained through online research chemical vendors, serving either as a recreational substance or an entheogen. Its scarcity in documented street sales underscores its niche status in the realm of psychedelics.

Dosage

Threshold

The threshold dose for 4-HO-DET is reported to be 5 mg, indicating the minimum amount needed for subtle effects to become perceptible.

Light

For a light experience, users are recommended to take a dosage ranging from 10 to 15 mg. At this level, mild psychedelic effects can be expected without delving into more intense states of consciousness.

Common

A common dose falls within the range of 20 to 30 mg. This dosage level induces a moderate and balanced psychedelic experience, allowing users to explore the compound's effects more deeply.

Strong

A strong dose is considered to be in the range of 30 to 45 mg. At this level, users can anticipate more pronounced and immersive psychedelic effects, potentially leading to a profound alteration of perception and consciousness.

Heavy

A heavy dose, exceeding 45 mg, is recommended for experienced users seeking an intense and potentially overwhelming psychedelic encounter. Caution is advised at this level, as effects may be potent and challenging.

Comparison with Other Tryptamines

In comparison to other isolated synthetic tryptamine compounds such as 4-AcO-DMT and 4-HO-DMT, 4-HO-DET has been reported as being similar in terms of its visual, cognitive, and physical effects. Notably, it possesses a slightly longer duration, fewer bodily effects, and visuals described as more "synthetic" or "algorithmic" in style.

Disclaimer: The effects listed below cite the Subjective Effect Index (SEI), an open research literature based on anecdotal user reports and the personal analyses of PsychonautWiki contributors. As a result, they should be viewed with a healthy degree of skepticism. It is also worth noting that these effects will not necessarily occur in a predictable or reliable manner, although higher doses are more liable to induce the full spectrum of effects. L

ikewise, adverse effects become increasingly likely with higher doses and may include addiction, severe injury, or death.

Physical Effects

Spontaneous physical sensations

  • Tactile enhancement
  • Stimulation
  • Temperature regulation suppression
  • Bodily control enhancement
  • Increased heart rate
  • Excessive yawning - Particularly pronounced with psilocin and related tryptamines, occurring to a lesser degree on LSD and very rarely on psychedelic phenethylamines like mescaline. Often accompanied by watery eyes, though reports suggest it may be less noticeable compared to other psychedelics.
  • Watery eyes
  • Frequent urination
  • Muscle contractions
  • Olfactory hallucination
  • Pupil dilation
  • Runny nose

Visual Effects

  • Enhancements
  • Colour enhancement
  • Pattern recognition enhancement
  • Visual acuity enhancement
  • Distortions
  • Drifting (melting, breathing, morphing, and flowing)
  • Tracers
  • Colour tinting
  • Colour shifting
  • Depth perception distortions
  • Perspective distortions
  • Symmetrical texture repetition
  • Geometry

The visual geometry associated with 4-HO-DET is akin to that of psilocin, ayahuasca, and 2C-T-7 rather than LSD or 2C-B. It is intricate, abstract, mostly synthetic in style, unstructured, dimly lit, monotone, glossy, sharp-edged, large, slow, smooth, with both rounded and angular corners. At higher dosages, it is more likely to result in Level 8B visual geometry.

  • Hallucinatory states
    • Machinescapes
    • Transformations
    • Internal hallucination (autonomous entities; settings, sceneries, and landscapes; perspective hallucinations, scenarios, and plots)

External hallucination (autonomous entities; settings, sceneries, and landscapes; perspective hallucinations, scenarios, and plots).

Cognitive Effects

The cognitive effects of 4-HO-DET are mildly stimulating and lucid compared to similar psychedelics like psilocybin or 2C-C, which tend to be more sedating. It is characterized by a "neutral," "analytical" headspace with minimal memory disruptions or emotional confusion compared to psilocybin mushrooms. Prominent effects include:

  • Analysis enhancement
  • Conceptual thinking
  • Immersion enhancement
  • Increased music appreciation
  • Increased sense of humor
  • Laughter fits
  • Memory suppression
  • Ego death
  • Novelty enhancement
  • Personal bias suppression
  • Thought acceleration
  • Thought connectivity
  • Thought loops
  • Time distortion
  • Wakefulness

Auditory Effects

  • Enhancements
  • Distortions
  • Hallucinations

Toxicity and Harm Potential

Overview

The toxicity and long-term health effects of recreational 4-HO-DET use have not been studied in any scientific context, and the exact toxic dose remains unknown. As a research chemical with minimal history of human usage, anecdotal evidence from the psychonaut community suggests that trying 4-HO-DET at low to moderate doses, and using it sparingly, does not appear to lead to negative health effects. However, caution is advised, and independent research is crucial to ensure the safety of combining 4-HO-DET with other substances.

Harm Reduction Practices

It is strongly recommended to employ harm reduction practices when using 4-HO-DET. Users should be aware of the potential risks and take necessary precautions to minimize harm.

Tolerance and Addiction Potential

4-HO-DET is not habit-forming, and the desire to use it may decrease with continued use. Tolerance to its effects develops almost immediately after ingestion, taking about 3 days for tolerance to be reduced by half and 7 days to return to baseline (in the absence of further consumption). Cross-tolerance with all psychedelics is observed, meaning that consumption of 4-HO-DET reduces the effectiveness of other psychedelics.

Dangerous Interactions

Warning: Many psychoactive substances that are reasonably safe on their own can become dangerous, even life-threatening, when combined with certain other substances. Some known dangerous interactions include:

Lithium: Combining lithium with psychedelics increases the risk of psychosis and seizures, and this combination is strongly discouraged.

Cannabis: There may be a strong and unpredictable synergy with the effects of 4-HO-DET, increasing the risk of adverse psychological reactions. Caution is advised, and users are recommended to start with a fraction of their normal cannabis dose.

Stimulants: Combining stimulants with 4-HO-DET may increase the risk of anxiety, paranoia, panic attacks, and thought loops. It may also elevate the risk of mania and psychosis.

Tramadol: Tramadol's lowering of the seizure threshold combined with psychedelics may trigger seizures in susceptible individuals.

Legal Status

This legality section is a stub. As such, it may contain incomplete or inaccurate information. Your contribution to expanding it would be valuable.

Germany: Controlled under Anlage I BtMG (Narcotics Act, Schedule I), making it illegal to manufacture, possess, import, export, buy, sell, procure, or dispense without a license.

Sweden: Classified as a health hazard, making it illegal to sell or possess.

Switzerland: A controlled substance specifically named under Verzeichnis E.

United Kingdom: Classified as a Class A drug.

United States: Unscheduled, but may be considered an analogue of psilocin (4-HO-DMT), a Schedule I drug. Sale or use for illicit non-medical or industrial purposes could be prosecuted under the Federal Analogue Act.

FAQ (Frequently Asked Questions)

Q1: What is the threshold dose for 4-HO-DET?

A: The threshold dose for 4-HO-DET is reported to be 5 mg, indicating the minimum amount needed for subtle effects to become perceptible.

Q2: Is 4-HO-DET habit-forming?

A: No, 4-HO-DET is not habit-forming, and the desire to use it may decrease with continued use.

Q3: How long does it take for tolerance to 4-HO-DET to diminish?

A: Tolerance to 4-HO-DET develops almost immediately after ingestion. It takes about 3 days for tolerance to be reduced by half and 7 days to return to baseline in the absence of further consumption.

Q4: Are there dangerous interactions with 4-HO-DET?

A: Yes, there can be dangerous interactions, including combining it with lithium, cannabis, stimulants, or tramadol. Caution is advised, and independent research is crucial to ensure safety.

Q5: What is the legal status of 4-HO-DET in the United States?

A: 4-HO-DET is unscheduled in the United States. However, it may be considered an analogue of psilocin (4-HO-DMT), a Schedule I drug. Sale or use for illicit non-medical or industrial purposes could be prosecuted under the Federal Analogue Act.


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