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Table of Contents

1. Introduction to Allylescaline
2. Chemistry of Allylescaline
3. Pharmacology Insights
4. Dosage Guidelines
5. Physical, Visual, and Cognitive Effects
6. Auditory Effects
7. Experience Reports
8. Toxicity and Harm Potential
9. Tolerance and Addiction Potential
10. Legal Status
11. FAQ (Frequently Asked Questions)

Exploring Allylescaline: A Lesser-Known Phenethylamine Psychedelic

Introduction to Allylescaline

4-Allyloxy-3,5-dimethoxyphenethylamine, commonly known as allylescaline, stands as a lesser-known member within the phenethylamine class of psychedelic substances. Structurally, it bears resemblance to mescaline and shares connections with escaline and methallylescaline. Despite its intriguing structural profile, allylescaline remains relatively uncommon in usage, boasting little to no historical footprint in human consumption.

Understanding Effects and Dosage

The initial documentation of allylescaline's effects surfaced through Alexander Shulgin's seminal work, PiHKAL: A Chemical Love Story. Shulgin's findings outlined a dosage range spanning 20 to 35 mg when administered orally, with an anticipated duration of action ranging between 8 to 12 hours[1]. This dosage range serves as a foundational guide for individuals venturing into the exploration of allylescaline's psychoactive properties.

Limited Pharmacological Insights and Safety Considerations

Despite its presence in scientific literature, allylescaline remains shrouded in a veil of limited data concerning its pharmacological attributes, metabolic pathways, and potential toxicity profiles. Given the dearth of empirical knowledge, individuals contemplating the use of allylescaline are strongly urged to adhere to stringent harm reduction practices. Such cautionary measures aim to mitigate potential risks associated with its consumption, offering a semblance of safety amidst the unknown realms of its psychedelic effects.

Exploring Allylescaline: Unraveling Its Chemistry and Pharmacology

Chemistry of Allylescaline

Allylescaline, also known as 4-allyloxy-3,5-dimethoxyphenethylamine, represents a substituted phenethylamine characterized by a phenyl ring tethered to an amino (-NH2) group via an ethyl chain. Within its molecular structure, allylescaline features two methoxy functional groups (CH3O-) linked to carbons R3 and R5, alongside an additional allyloxy group at carbon R4 of the phenyl ring. This arrangement renders allylescaline as the 4-allyloxy analog of mescaline.

Chemical Properties

• IUPAC Name: 4-Allyloxy-3,5-dimethoxyphenethylamine
• Molecular Formula: C13H19NO3
• Molecular Weight: 237.29 g/mol
• Average Mass: 237.294998 Da
• Monoisotopic Mass: 237.136002 Da

Pharmacology Insights

Allylescaline exerts its effects primarily as a 5-HT2A partial agonist, operating within the realm of serotonergic psychedelics. The psychedelic manifestations attributed to allylescaline are postulated to stem from its affinity for 5-HT2A receptors. However, the precise mechanisms underlying these interactions and their contribution to the psychedelic experience remain enigmatic.

Being the 4O-allyl homolog of mescaline, allylescaline shares a binding pattern akin to serotonin receptors. Notably, it exhibits a notably heightened potency by weight, with reported human active doses ranging between 20 to 40 mg, as opposed to the 300 to 400 mg required for mescaline.

Safety and Limited Data

Allylescaline's status as a relatively uncommon research compound translates into a scarcity of historical usage data among human populations. Consequently, the pharmacological properties, metabolic pathways, and potential toxicity of allylescaline remain shrouded in uncertainty. The elucidation of its effects was initially chronicled by Alexander Shulgin in his seminal work, PiHKAL: A Chemical Love Story. Given the paucity of empirical insights, cautious approaches and stringent harm reduction practices are strongly advocated for individuals contemplating the exploration of allylescaline's psychoactive realms.

Navigating Allylescaline Dosage: Understanding Thresholds and Intensity

Threshold Dosage

Allylescaline manifests its effects even at minimal doses, with the threshold typically set at 15 mg. At this threshold, users may begin to perceive subtle alterations in perception and cognition.

Light Dosage Range

For those seeking a gentle introduction to allylescaline's effects, doses ranging between 20 to 30 mg are considered light. Within this range, users may experience mild psychedelic effects characterized by enhanced sensory perception and mood elevation.

Common Dosage Spectrum

The common dosage spectrum of allylescaline spans between 30 to 40 mg. At these doses, the psychedelic experience becomes more pronounced, with intensified visual distortions, heightened introspection, and a deeper sense of connectivity with one's surroundings.

Strong Dosage Bracket

Entering the realm of potency, doses ranging from 40 to 60 mg are categorized as strong. Within this bracket, users can anticipate profound alterations in consciousness, vivid hallucinations, and a profound restructuring of thought patterns and perceptions.

Heavy Dosage Threshold

Doses exceeding 60 mg are deemed heavy, representing an intense and potentially overwhelming psychedelic experience. At these high doses, users may encounter extreme visual and auditory hallucinations, profound ego dissolution, and a profound shift in their sense of self and reality.

Understanding and respecting these dosage guidelines is crucial for ensuring a safe and rewarding allylescaline experience. It is imperative to approach higher dosage ranges with caution and mindfulness, prioritizing harm reduction practices to mitigate potential risks and ensure a positive outcome.

Unraveling the Physical, Visual, and Cognitive Effects of Allylescaline

Physical Effects

• Spontaneous Tactile Sensations
• Increased Heart Rate
• Nausea
• Pupil Dilation

Visual Effects

• Enhancements
  • Colour Enhancement
  • Pattern Recognition Enhancement
  • Visual Acuity Enhancement
• Distortions
  • Drifting (Melting, Breathing, Morphing, and Flowing)
  • Colour Shifting
  • Depth Perception Distortions
  • Perspective Distortions
  • Symmetrical Texture Repetition
  • Tracers
  • After Images
  • Brightness Alteration
  • Diffraction
  • Geometry
• Hallucinatory States
  • Transformations
  • Internal Hallucination (Autonomous Entities; Settings, Sceneries, and Landscapes; Perspective Hallucinations and Scenarios and Plots)

Cognitive Effects

• Conceptual Thinking
• Cognitive Euphoria
• Delusion
• Emotion Enhancement
• Immersion Enhancement
• Increased Music Appreciation
• Memory Suppression
• Ego Death
• Novelty Enhancement
• Personal Bias Suppression
• Thought Loops
• Time Distortion
• Unity and Interconnectedness

Auditory Effects

• Enhancements
• Distortions
• Hallucinations

Experience Reports

Currently, there are no anecdotal reports within our experience index detailing the effects of allylescaline. Additional experience reports may be found on platforms such as Erowid Experience Vaults: Allylescaline.

Toxicity and Harm Potential

The toxicity and long-term health effects of recreational allylescaline use remain largely unstudied within scientific contexts. Due to its status as a research chemical with minimal human usage history, the exact toxic dose remains unknown. Anecdotal evidence from the psychonaut community suggests that at low to moderate doses used sparingly, allylescaline exhibits no negative health effects. However, comprehensive research and caution are advised before consuming allylescaline or combining it with other substances.

Tolerance and Addiction Potential

Allylescaline is not considered habit-forming, and the desire to use it may diminish with continued use. Tolerance to allylescaline's effects develops rapidly post-ingestion, taking approximately 3 days to reduce to half and 7 days to return to baseline in the absence of further consumption. Cross-tolerance with all psychedelics is observed after allylescaline consumption, leading to a reduced effect of other psychedelics.

Legal Issues

Germany

Allylescaline is classified under Anlage I BtMG (Narcotics Act, Schedule I) as of February 1, 1997, making it illegal to manufacture, possess, import, export, buy, sell, procure, or dispense without a license.

Japan

Allylescaline is a controlled substance in Japan effective March 25th, 2015.

Sweden

As of January 2016, allylescaline is illegal in Sweden.

Switzerland

Allylescaline is specifically named under Verzeichnis E as a controlled substance.

United Kingdom

Under the Psychoactive Substance Act effective May 26th, 2016, it is illegal to produce, supply, or import allylescaline in the United Kingdom.

FAQ (Frequently Asked Questions)

Q1: What is allylescaline?

A: Allylescaline, also known as 4-allyloxy-3,5-dimethoxyphenethylamine, is a lesser-known psychedelic substance belonging to the phenethylamine class. It is structurally related to mescaline and exhibits psychedelic effects.

Q2: What are the common dosage ranges for allylescaline?

A: Common dosage ranges for allylescaline include:

• Threshold: 15 mg
• Light: 20 - 30 mg
• Common: 30 - 40 mg
• Strong: 40 - 60 mg
• Heavy: 60 mg and above

Q3: What are the physical, visual, and cognitive effects of allylescaline?

A: Allylescaline can induce various physical effects such as increased heart rate, pupil dilation, and spontaneous tactile sensations. Visual effects include enhancements, distortions, and hallucinatory states. Cognitive effects may include conceptual thinking, cognitive euphoria, and time distortion.

Q4: Is allylescaline associated with any potential health risks?

A: The long-term health effects and toxicity of allylescaline remain largely unstudied. However, anecdotal evidence suggests that at low to moderate doses used sparingly, allylescaline may not exhibit significant negative health effects. Caution and thorough research are advised before consumption.

Q5: Is allylescaline addictive?

A: Allylescaline is not considered habit-forming, and the desire to use it may decrease with continued use. However, tolerance to its effects can develop rapidly, leading to reduced efficacy with frequent use.

Q6: What is the legal status of allylescaline?

A: The legal status of allylescaline varies by country. For example, it is illegal in Germany, Sweden, and the United Kingdom, while in other countries, it may be controlled or unregulated. It is essential to be aware of local laws and regulations before possessing or using allylescaline.