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3-MeO-2'-Oxo-PCE: A Dissociative Compound

3-MeO-2'-Oxo-PCE, commonly known as Methoxetamine (MXE), Mexxy, or by various other names, belongs to the arylcyclohexylamine class. When administered, it induces dissociative effects reminiscent of ketamine. Its structural relatives include ketamine, PCE, and 3-MeO-PCP.

A Brief History

MXE originated from intelligent drug design, initially explored as a potential remedy for Phantom Limb Syndrome and other medical conditions.

It wasn't until November 2010 that the European Monitoring Centre for Drugs and Drug Addiction identified MXE. By July 2011, 58 websites were selling it for 145–195 euros per 10 grams. While once highly popular, it has virtually disappeared from online research chemical markets due to a global ban on the substance.

Pharmacological Mysteries

Limited information is available regarding MXE's pharmacological properties, metabolism, and human toxicity. Given this scarcity of data and its limited history of human use, the utmost caution is advised when dealing with this compound, with a strong emphasis on harm reduction practices.

Unraveling the Chemistry

Methoxetamine, or (RS)2-(3-methoxyphenyl)-2-(ethylamino)cyclohexanone, falls under the category of arylcyclohexylamines. These compounds feature a cyclohexane ring fused to an aromatic ring, accompanied by an amine group.

MXE includes a phenyl ring with a methoxy (CH3-O-) group attached to R3, linked to a cyclohexane ring featuring an oxo group (cyclohexanone) at R2. Additionally, there's an amino ethyl chain (-N-CH2CH3) attached at R1 of the cyclohexanone ring.

MXE is a chiral molecule, primarily produced as a racemate, although stereo-exclusive isomers have occasionally been manufactured and distributed.

The Inner Workings

In terms of its pharmacology, MXE operates as a non-competitive NMDA receptor antagonist and a serotonin reuptake inhibitor. NMDA receptors facilitate the transmission of electrical signals between neurons in the brain and spinal column, but dissociatives like MXE shut these receptors by blocking them. This leads to a disconnection of neurons, resulting in a loss of sensation, impaired movement, and an experience similar to the renowned "k-hole."

Although MXE is often likened to ketamine, it's reported to be more potent and have a longer duration of action. Despite its structural resemblance to 3-HO-PCP, the belief that it possesses opioid properties is unfounded, as actual data indicates only minimal affinity for the µ-opioid receptor. However, it's worth noting that in-vivo metabolites may yield different effects.

Physical Effects of Methoxetamine (MXE)

Methoxetamine, commonly known as MXE, is associated with a range of distinctive physical effects:

• Sedation: A calming and relaxing influence.
• Spontaneous Bodily Sensations: This entails a pleasurable, location-specific tingling sensation in the hands, feet, and head.
• Perception of Bodily Lightness: Creates the sensation of weightlessness, which can encourage physical activities.
• Motor Control Loss: At higher doses, there's a significant reduction in gross and fine motor control, balance, and coordination.
• Spatial Disorientation: An altered sense of physical space.
• Tactile Suppression: Partial or complete numbing of the sense of touch, responsible for the anesthetic properties.
• Pain Relief: The compound may provide pain relief.
• Physical Autonomy: A sense of ease and lightness in body movements.
• Dizziness: Occasional reports of dizziness while under the influence.
• Nausea: High doses may lead to nausea and vomiting, often surprisingly tolerable due to reduced physical sensation.
• Optical Sliding: Distorted visual perception.
• Orgasm Suppression & Enhancement: Variable effects on sexual experiences, with both suppression and enhancement reported.

Disconnective Effects

MXE introduces a range of disconnective effects:

• Tactile Disconnection: A reduced sense of touch.
• Visual Disconnection: May lead to experiences akin to the "k-hole," featuring voids and altered structures.
• Consciousness Disconnection: A potential disconnection from one's usual state of awareness.

Visual Effects

The visual effects of MXE can be categorized into suppression, distortions, and hallucinations:

Suppression

• Visual Acuity Suppression: Impaired visual sharpness.
• Double Vision: Common at moderate to heavy doses, making reading difficult.
• Pattern Recognition Suppression: Inability to recognize and interpret visual data.
• Frame Rate Suppression: Visual frame rate may appear slower.

Distortions

• Perspective Distortions: Altered perception of depth and space.
• Environmental Cubism: The environment may appear fragmented and surreal.
• Environmental Orbism: Distorted environmental shapes and structures.
• Scenery Slicing: Visual scenes may seem segmented.

Geometry

The visual geometry of MXE is characterized by dark, intricate, interlocking lines. It's comparatively simpler than ketamine or DXM visuals, featuring dim lighting, multicolored schemes, and soft edges. High doses can induce white glow visual phenomena similar to ketamine.

Hallucinatory States

At high doses, MXE can produce hallucinatory states, though these are less consistent and reproducible compared to other psychedelics. Effects include:

• Internal Hallucination: These autonomous experiences include entities, settings, sceneries, and more.
• External Hallucination: Occasional experiences of seeing and conversing with absent friends.

Cognitive Effects

The cognitive effects of MXE are often described as euphoric and clear-headed compared to other dissociatives. These effects include:

• Amnesia: Impaired memory.
• Anxiety Suppression: Reduced feelings of anxiety.
• Cognitive Euphoria: An enhanced sense of mental well-being.
• Compulsive Redosing: A tendency to redose.
• Conceptual Thinking: Enhanced abstract thinking.
• Creativity Enhancement: Boosted creativity.
• Decreased Libido: Libido may decrease, though increased libido can occur at lower doses.
• Déjà Vu: A sensation of experiencing something previously.
• Depersonalization: Feeling disconnected from one's self.
• Derealization: A sense of unreality in one's surroundings.
• Disinhibition: Reduced inhibitions.
• Dream Potentiation: Enhanced dream vividness.
• Ego Death: A profound loss of the sense of self.
• Immersion Enhancement: Enhanced engagement in activities or experiences.
• Increased Music Appreciation: Amplified music enjoyment.
• Analysis Suppression: Reduced analytical thinking.
• Introspection: Enhanced self-reflection.
• Mania: Occasional mania, especially in heavy users.
• Memory Suppression: Impaired memory function.
• Personal Meaning Enhancement: An intensified sense of personal meaning.
• Thought Deceleration: Slowed thought processes.
• Time Distortion: A sense of time passing differently.

Auditory Effects

Auditory experiences with MXE include distortions, hallucinations, and suppression.

Transpersonal Effects

MXE may induce transpersonal experiences related to self-realization and interconnectedness.