Buy MXE for sale online - USA vendor

Table of Contents

• Introduction
• Development and History
• Market Presence
• Safety and Harm Reduction
• Chemical Structure and Properties
• Pharmacology

Introduction

Methoxetamine, commonly referred to as 3-MeO-2'-Oxo-PCE, MXE, or Mexxy, is a dissociative substance belonging to the arylcyclohexylamine class. This compound is notable for its ability to produce dissociative effects similar to those of ketamine upon administration. Structurally, MXE is closely related to ketamine, PCE (Phencyclidine), and 3-MeO-PCP (3-Methoxyphencyclidine).

Development and History

MXE was initially developed using intelligent drug design techniques aimed at creating potential treatments for various ailments, including Phantom Limb Syndrome. The development focused on exploring its therapeutic applications, but the substance has since garnered attention for its recreational use.

The European Monitoring Centre for Drugs and Drug Addiction first identified MXE in November 2010, marking its entry into the awareness of substance use. By July 2011, a significant market for the compound emerged, with 58 online vendors offering it at prices ranging from 145 to 195 euros for 10 grams. However, despite its initial popularity, MXE has largely disappeared from the online research chemical market, primarily due to global bans.

Market Presence

The rapid rise and fall of MXE in the market reflect a complex interplay of demand, regulatory responses, and public health considerations. Once a widely sought-after compound, its availability has diminished significantly, leading to its current status as largely extinct in the online marketplace.

Safety and Harm Reduction

Due to the limited research on the pharmacological properties, metabolism, and toxicity of MXE in humans, caution is advised for users. The substance has a sparse history of human usage, and individuals are encouraged to practice harm reduction strategies when considering its use.

Chemical Structure and Properties

Methoxetamine, scientifically known as (RS)2-(3-methoxyphenyl)-2-(ethylamino)cyclohexanone, is classified as an arylcyclohexylamine. The nomenclature reflects its structural characteristics, which include a cyclohexane ring connected to an aromatic ring, in addition to an amine group.

The chemical structure of MXE features a phenyl ring that has a methoxy (CH3-O-) substituent at the R3 position. This phenyl ring is bonded to a cyclohexane ring that has an oxo group (cyclohexanone) at the R2 position. An ethylamine chain (-N-CH2CH3) is attached to the same location (R1) of the cyclohexanone ring.

As a chiral molecule, MXE is frequently synthesized as a racemic mixture, although some batches containing stereo-exclusive isomers have occasionally been produced and distributed.

Pharmacology

In terms of pharmacological action, MXE functions primarily as a non-competitive antagonist of the NMDA (N-Methyl-D-Aspartate) receptor and as a serotonin reuptake inhibitor. NMDA receptors are crucial for the transmission of electrical signals between neurons in the brain and spinal cord; for these signals to be effectively transmitted, the receptor must be open. Dissociative agents like MXE work by closing NMDA receptors, which effectively disrupts neuronal connectivity, leading to sensations of detachment, immobility, and experiences akin to the well-known "k-hole" associated with ketamine use.

Reports indicate that MXE may produce effects similar to those of ketamine, but users often describe it as being more potent and having a longer duration of action. Despite some claims suggesting that MXE may possess opioid-like properties due to its structural resemblance to 3-HO-PCP, these assertions lack substantial empirical support. Instead, studies indicate that MXE exhibits only minimal affinity for the μ-opioid receptor, although metabolites generated in vivo could potentially yield different pharmacological effects.

Subjective Effects

Methoxetamine (MXE) produces a variety of subjective effects that can be categorized into several distinct areas. Users often report a combination of physical, disconnective, visual, and cognitive effects.

Physical Effects

The physical effects of MXE include:

• Sedation: Many users experience a calming sedation that can affect their overall energy levels.
• Spontaneous Bodily Sensations: Users frequently report a sharp, pleasurable tingling sensation often localized in the hands, feet, and head, commonly referred to as the "body high."
• Perception of Bodily Lightness: At low to moderate doses, individuals may feel as if their bodies are floating, leading to an energizing effect that encourages physical activity.
• Motor Control Loss: Higher doses result in significant impairment of gross and fine motor skills, as well as balance and coordination. It is advised to remain seated during use to prevent injury from falls.
• Spatial Disorientation: Users often find it challenging to perceive their physical surroundings accurately.
• Tactile Suppression: MXE can lead to partial or complete numbness in the extremities, contributing to its anesthetic properties.
• Pain Relief: Many report experiencing relief from physical pain.
• Physical Autonomy: A heightened sense of control over one’s body may occur, despite other impairments.
• Dizziness: While less common, some users report dizziness while under the influence of MXE.
• Nausea: At high doses, users may experience nausea and vomiting, though many find this less unpleasant than anticipated due to the dissociative effects.
• Optical Sliding: Users may perceive visual changes that alter their environment's appearance.
• Orgasm Suppression & Enhancement: Some individuals report both suppression and enhancement of orgasms, although these effects can vary widely.

Disconnective Effects

MXE also induces several disconnective effects, including:

• Tactile Disconnection: A diminished connection to one's sense of touch.
• Visual Disconnection: Users may experience a state similar to the "k-hole," characterized by feelings of emptiness and detachment from visual stimuli.
• Consciousness Disconnection: A sense of separation from one’s thoughts and awareness.

Visual Effects

The visual effects of MXE encompass a range of phenomena:

Suppression

• Visual Acuity Suppression: The ability to see clearly may be reduced.
• Double Vision: Common at moderate to high doses, making reading difficult.
• Pattern Recognition Suppression: At higher doses, users may struggle to interpret visual information.
• Frame Rate Suppression: Slower perception of moving images.

Distortions

• Perspective Distortions: Changes in how users perceive spatial relationships.
• Environmental Cubism: A fragmented view of the environment, reminiscent of cubist art.
• Environmental Orbism: Curvilinear visual perceptions of the environment.
• Scenery Slicing: The experience of visual landscapes being cut into sections.

Geometry

The visual geometry experienced with MXE is described as darker and more simplistic compared to that of other dissociatives like ketamine. Visual patterns typically consist of interlocking lines that create a synthetic and algorithmic feel, lacking in complexity but rich in color and texture. At high doses, users may experience glowing visuals akin to those produced by ketamine.

Hallucinatory States

At elevated doses, MXE can induce hallucinatory experiences, though they may be less consistent than those produced by traditional psychedelics. Users might encounter:

• Internal Hallucinations: These may include visions of autonomous entities, imagined settings, or complex narratives, but they are less common compared to similar effects found with psychedelics.
• External Hallucinations: These are rare but can involve perceiving nonexistent entities or landscapes, often characterized by a sense of interaction with absent friends.

Cognitive Effects

Cognitive experiences under the influence of MXE are often marked by a euphoric and clear-headed state. Specific cognitive effects include:

• Amnesia: Short-term memory may be impaired.
• Anxiety Suppression: Users often report reduced feelings of anxiety.
• Cognitive Euphoria: A heightened sense of well-being and joy.
• Compulsive Redosing: Some users may feel compelled to take more of the substance.
• Conceptual Thinking: Enhanced ability to think abstractly.
• Creativity Enhancement: Users often report improved creative thinking.
• Decreased Libido: Some experience reduced sexual desire, although increased libido can also occur at lower doses.
• Déjà Vu: A common feeling of familiarity with new experiences.
• Depersonalization: A sense of detachment from oneself.
• Derealization: A feeling of unreality concerning one’s surroundings.
• Disinhibition: Reduced social inhibitions and increased sociability.
• Dream Potentiation: Vivid dreams may be more accessible.
• Ego Death: A profound loss of the sense of self.
• Immersion Enhancement: Increased engagement with experiences or activities.
• Increased Music Appreciation: Music may be experienced more intensely.
• Analysis Suppression: Reduced critical thinking and analysis.
• Introspection: Heightened self-reflection and awareness.
• Mania: Potentially occurring with frequent high-dose use, though less common than with other stimulants.
• Memory Suppression: Difficulty recalling memories.
• Personal Meaning Enhancement: Experiences may feel more significant or meaningful.
• Thought Deceleration: Slower cognitive processing.
• Time Distortion: A skewed perception of time.

Toxicity and Harm Potential

The toxicity and long-term health effects of MXE use have not been extensively studied in scientific literature, leaving the exact toxic dosage unknown. As a research chemical with limited history of human usage, reports from users suggest that low to moderate doses do not typically result in negative health effects when used sparingly. However, it is crucial to conduct independent research to ensure safety, especially when considering combining MXE with other substances.

Legal Status

The legal status of methoxetamine varies significantly across different countries and jurisdictions:

• European Union: In September 2014, the European Council mandated that member states implement control measures for MXE by October 2, 2015.
• Austria: Illegal to possess, produce, or sell since June 26, 2019.
• Brazil: Listed as illegal under Portaria SVS/MS nº 344.
• Canada: Classified as a controlled substance and illegal to possess, produce, or sell.
• Cyprus: Listed as illegal in drug control laws since 2012.
• Denmark: Controlled under the Executive Order on Euphoriant Substances.
• France: Added to the list of illicit substances on August 5, 2013.
• Germany: Controlled under the BtMG Anlage I, making it illegal without a license.
• Italy: Illegal since 2016.
• Japan: Classified as a narcotic effective June 26, 2016.
• Netherlands: Illegal to possess, produce, transport, import, export, or sell.
• Russia: Illegal to possess, produce, or sell.
• Slovenia: Controlled substance under Official Gazette of RS No. 62/2013.
• Sweden: Controlled under the Narcotic Drugs Control Act.
• Switzerland: Specifically named as a controlled substance under Verzeichnis D.
• Turkey: Regulated under the Law on Control of Narcotics no. 2313.
• United Kingdom: Classified as a Class B drug.
• United States: Scheduled as a Schedule I controlled substance.

Methoxetamine (MXE) FAQ

1. What is Methoxetamine (MXE)?

Methoxetamine, commonly known as MXE, is a dissociative substance belonging to the arylcyclohexylamine class. It is chemically related to ketamine and is known for producing similar dissociative effects.

2. What effects does MXE produce?

Users report a variety of effects, including sedation, euphoria, sensory distortions, and altered perception of time and space. Common physical effects include a pleasurable body high, loss of motor control, and pain relief.

3. How is MXE consumed?

MXE can be consumed through several methods, including oral ingestion, insufflation (snorting), or intravenous injection. The method of use can affect the intensity and onset of effects.

4. What are the risks of using MXE?

Risks associated with MXE include loss of motor control, spatial disorientation, and potential for overdose, especially at higher doses. Long-term effects and toxicity are not well understood due to limited research.

5. Is MXE legal?

The legal status of MXE varies by country. It is classified as a controlled substance in many places, including the United States, Canada, and several European countries. Always check local laws before considering use.

6. How does MXE compare to ketamine?

MXE is structurally similar to ketamine and produces similar dissociative effects, but users often report that MXE has a longer duration and can be more intense than ketamine.

7. What is the typical dosage for MXE?

Dosing can vary significantly among users, but common doses range from 10 to 50 mg when insufflated. It’s crucial to start with a lower dose to gauge individual sensitivity.

8. Can MXE cause addiction?

While MXE is not as widely studied as other substances, there are reports of compulsive redosing and potential for psychological dependence. Caution is advised with frequent use.

9. Are there any withdrawal symptoms from MXE?

There is limited information on withdrawal symptoms due to the lack of extensive research on long-term use. Some users report mood changes or cravings upon cessation.

10. What should I do if I experience negative effects from MXE?

If negative effects occur, it is recommended to stay calm, find a safe and comfortable space, and have a sober friend nearby for support. If severe symptoms arise, seek medical attention.

11. Can MXE interact with other substances?

Yes, MXE can interact with other drugs, especially depressants like alcohol, benzodiazepines, or opioids, which can enhance sedative effects and increase the risk of overdose.

12. What is the mechanism of action of MXE?

MXE primarily acts as a non-competitive NMDA receptor antagonist, which means it blocks the activity of this receptor in the brain, leading to dissociative and anesthetic effects.

13. How long do the effects of MXE last?

The effects of MXE can last anywhere from 2 to 8 hours, depending on the dose and method of administration.

14. Can MXE cause hallucinations?

Yes, at higher doses, users may experience visual and auditory hallucinations, as well as altered perceptions of reality, which can be less predictable than those produced by traditional psychedelics.

15. Is MXE safe to use?

Due to limited research and potential risks, using MXE carries inherent dangers. It is crucial to practice harm reduction strategies if choosing to use this substance.

16. What are the long-term effects of MXE?

The long-term health effects of MXE use are not well studied. Anecdotal evidence suggests that there may be risks associated with prolonged use, including cognitive impairments and mental health issues.

17. Can MXE cause overdose?

Yes, overdose is possible, especially at high doses or when combined with other substances. Symptoms may include severe confusion, respiratory depression, and loss of consciousness.

18. What should I know about sourcing MXE?

Purchasing MXE from unregulated sources poses significant risks, including the potential for adulteration and inconsistent dosing. Always be cautious when acquiring substances from the internet.

19. Is there any therapeutic potential for MXE?

Some researchers speculate that MXE may have therapeutic applications, particularly in treating conditions like chronic pain or depression, but more research is needed to validate these claims.

20. Where can I find more information about MXE?

For reliable information on MXE, consider consulting harm reduction organizations, academic research articles, and reputable online resources focused on drug safety and research chemicals.