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Specification
Product Name: 2-Fluorodeschloroketamine
IUPAC Name: (R/S)-2-(2-fluorophenyl)-2-(methylamino)cyclohexanone
Other Names: 2-Fluoroketamine, Fluoroketamine, 2-FK, 2-FDCK
Molecular Formula: None
Molar Mass: 237.26 g·mol−1
Effect: stimulant, psychedelic
Purity of the substance: 99.9%
Physical properties: Crystals, Powder
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Table of Contents

  1. Introduction
  2. Chemistry
  3. Pharmacology
  4. Subjective Effects
  5. Physical Effects
  6. Visual Effects
  7. Cognitive Effects
  8. Dosage
  9. Toxicity and Harm Potential
  10. Dangerous Interactions
  11. Legal Status

2-Fl-2'-Oxo-PCM (2-Fluorodeschloroketamine, 2-FDCK): An Overview

2-Fl-2'-Oxo-PCM, commonly known as 2-Fluorodeschloroketamine or 2-FDCK, belongs to the arylcyclohexylamine class of dissociative substances. Chemically akin to ketamine and deschloroketamine (DCK), it is purported to function as an antagonist of NMDA receptors, although extensive research on its mechanism of action is lacking.

Origins and Availability

The precise origins of 2F-DCK are not well-documented. It emerged on the online research chemical market circa 2017, marketed initially as a legal alternative to ketamine. Its introduction followed the success of deschloroketamine, another analog of ketamine.

Subjective Effects

Subjective effects attributed to 2F-DCK encompass a range of sensations including sedation, loss of motor control, pain relief, internal hallucinations, conceptual thinking, euphoria, and dissociation. Dissociation, characterized by perceptual distortions and feelings of detachment from one's environment and self, is a prominent feature of its effects. Notably, the reported effects of 2F-DCK closely mirror those of ketamine. Its effects are highly dose-dependent, with lower doses resembling alcohol-like intoxication and higher doses precipitating hallucinogenic states often referred to as a "k-hole."

Limited Research

Despite its presence in online markets and anecdotal reports of its effects, there is a paucity of data regarding the pharmacology, metabolism, and toxicity of 2-FDCK. Its history of human use is exceedingly brief, underscoring the need for caution and harm reduction practices when experimenting with this substance.

In conclusion, 2-Fl-2'-Oxo-PCM, or 2-FDCK, represents a novel dissociative compound with effects reminiscent of ketamine. Its emergence in online markets underscores the importance of further research into its properties and potential risks. Users are strongly advised to exercise caution and employ harm reduction strategies if considering the use of this substance.

Chemistry

2-Fluorodeschloroketamine (2-FDCK), also known as 2-(2-Fluorophenyl)-2-methylamino-cyclohexanone, falls within the arylcyclohexylamine drug class. This class is characterized by structures comprising a cyclohexane ring attached to an aromatic ring along with an amine group. Specifically, 2-FDCK features a phenyl ring bonded to a cyclohexane ring substituted with a ketone group (cyclohexanone). An amino methyl chain (-N-CH3) is bound to the adjacent alpha carbon (R2) of the cyclohexanone ring. Furthermore, the phenyl ring is substituted at R2 with a fluorine group.

2-Fluorodeschloroketamine is a chiral molecule and is often synthesized as a racemate. The prefix "des-" in chemistry denotes the absence of a functional group (in this case "chloro"), hence 2-FDCK is named for containing a fluorine substitution at its phenyl ring instead of the chlorine found in ketamine.

Pharmacology

Due to limited research on 2-Fluorodeschloroketamine, discussions on its pharmacology are speculative and based primarily on its structural similarity to other arylcyclohexylamine dissociatives like DCK and ketamine. It is hypothesized to function as an NMDA receptor antagonist.

NMDA receptors facilitate the transmission of electrical signals between neurons in the brain and spinal column. For these signals to propagate, the receptors must remain open. Dissociatives such as 2-FDCK act by blocking NMDA receptors, leading to a disconnection of neurons, resulting in sensations of numbness, impaired movement, and potentially inducing the "K-hole" experience associated with this substance.

Subjective Effects

The effects described below are based on anecdotal user reports and the analyses of contributors to the Subjective Effect Index (SEI). It's important to approach these effects with skepticism as they may not occur predictably or reliably. Additionally, higher doses are more likely to induce the full spectrum of effects, which may include addiction, severe injury, or death.

Physical Effects

2-Fluorodeschloroketamine (2-FDCK) induces a variety of physical effects, ranging from pain relief to dissociative sensations. Here is a breakdown of the physical effects associated with its use:

Pain Relief

Users commonly report experiencing relief from physical discomfort while under the influence of 2-FDCK.

Spontaneous Physical Sensations

Sensations such as tingling, warmth, or pressure may manifest spontaneously throughout the body.

Physical Euphoria

Feelings of pleasure and well-being may be experienced on a physical level.

Dizziness

Dizziness or vertigo may occur, affecting balance and coordination.

Motor Control Loss

Users often experience impaired motor function, resulting in difficulties with movement and coordination.

Nausea

Nausea is a potential side effect of 2-FDCK use.

Perception of Bodily Lightness

Some users report feeling a sense of lightness or weightlessness in their body.

Physical Autonomy

A sense of detachment from physical movements and actions may be experienced.

Spatial Disorientation

Distortions in perception of space and surroundings can lead to feelings of disorientation.

Tactile Suppression

Decreased sensitivity to tactile stimuli may occur.

Orgasm Suppression

The ability to achieve orgasm may be diminished while under the influence of 2-FDCK.

Disconnective Effects

Tactile Disconnection

Users may feel disconnected from their sense of touch.

Visual Disconnection

Visual disconnection may manifest as distortions and alterations in perception, eventually leading to the characteristic "k-hole" experience. This may include perceptions of holes, spaces, voids, and alterations in the structure of objects.

Consciousness Disconnection

A sense of detachment from one's consciousness and surroundings may be experienced.

Visual Effects

In addition to physical effects, 2-FDCK can induce a range of visual effects, altering perception and creating hallucinatory states:

Suppression

Visual suppression may result in decreased clarity and brightness of vision.

Double Vision

Perception of multiple overlapping images of the same object may occur.

Frame Rate Suppression

Visual perception may appear choppy or fragmented, resembling a decrease in frame rate.

Pattern Recognition Suppression

Ability to recognize patterns and shapes may be impaired.

Visual Acuity Suppression

Visual acuity may be diminished, affecting the sharpness and clarity of vision.

Distortions

Various distortions in visual perception may occur, altering the appearance of objects and surroundings.

Environmental Cubism

Perception of the environment may be fragmented or distorted, resembling the artistic style of cubism.

Environmental Orbism

Objects in the environment may appear spherical or orb-like.

Perspective Distortions

Distortions in perspective may lead to alterations in the perceived size and shape of objects.

Scenery Slicing

Perception of the environment may be fragmented or divided into distinct sections.

Geometry

Users may perceive geometric patterns or shapes overlaying their visual field.

Hallucinatory States

Internal hallucinations may occur, including autonomous entities, landscapes, and scenarios, contributing to the overall dissociative experience induced by 2-FDCK.

Cognitive Effects

The cognitive effects of 2-Fluorodeschloroketamine (2-FDCK) closely resemble those of ketamine, with some users finding them nearly indistinguishable. Here are the cognitive effects commonly associated with 2-FDCK use:

Anxiety Suppression

Feelings of anxiety may be diminished or alleviated while under the influence of 2-FDCK.

Compulsive Redosing

Some users may feel compelled to repeatedly dose 2-FDCK, leading to a pattern of compulsive redosing.

Conceptual Thinking

2-FDCK can enhance conceptual thinking, leading to abstract or philosophical thoughts.

Creativity Enhancement

Users may experience heightened creativity while on 2-FDCK.

Déjà Vu

The sensation of experiencing something familiar or having lived through the moment before may occur.

Depersonalization

Users may feel detached from their own thoughts, feelings, and identity.

Derealization

Perception of the external world may feel unreal or dreamlike.

Disinhibition

Inhibition may be reduced, leading to more impulsive behavior.

Dream Potentiation

Dream intensity and vividness may be enhanced, both during sleep and while awake.

Cognitive Euphoria

Feelings of intense pleasure and well-being may manifest on a cognitive level.

Immersion Enhancement

Users may feel deeply engrossed or absorbed in their surroundings or activities.

Analysis Suppression

Critical thinking and analysis may be impaired.

Introspection

2-FDCK can facilitate deep introspective experiences, allowing users to explore their thoughts and emotions.

Memory Suppression

Short-term memory may be impaired while under the influence of 2-FDCK.

Ego Death

The dissolution of the sense of self or ego may occur, leading to feelings of oneness with the universe.

Amnesia

Users may experience gaps in memory or difficulty recalling events that occurred while under the influence of 2-FDCK.

Time Distortion

Perception of time may be altered, leading to a sense of time dilation or contraction.

Thought Deceleration

The pace of thought may slow down, leading to a more contemplative state of mind.

Increased Music Appreciation

Users may experience heightened enjoyment and appreciation of music.

Auditory Effects

2-FDCK can also induce auditory effects, altering perception and creating hallucinatory experiences:

Distortions

Sounds may be distorted or altered in pitch and tone.

Hallucinations

Auditory hallucinations, such as voices or sounds, may occur.

Suppression

Auditory perception may be suppressed, leading to decreased sensitivity to sounds.

Dosage

The dosage of 2-Fluorodeschloroketamine (2-FDCK) can vary significantly depending on individual tolerance, body weight, and desired effects. Here are the commonly recognized dosage ranges:

Threshold

  • Threshold: 5 mg
    • At this dosage level, users may begin to perceive subtle effects of 2-FDCK, although they may not be fully pronounced.

Light

  • Light: 10 - 25 mg
    • Light doses of 2-FDCK typically induce mild effects, such as a slight alteration in perception and mood elevation.

Common

  • Common: 25 - 70 mg
    • Common doses of 2-FDCK are associated with more pronounced effects, including significant alterations in consciousness, dissociation, and sensory perception.

Strong

  • Strong: 70 - 140 mg
    • Strong doses of 2-FDCK can lead to intense dissociative experiences, profound alterations in perception, and a deep sense of detachment from reality.

Heavy

  • Heavy: 140 mg+
    • Heavy doses of 2-FDCK are associated with extreme dissociation, intense hallucinatory states, and a potential loss of awareness of one's surroundings. These doses are typically reserved for experienced users and should be approached with caution due to the increased risk of adverse effects and potential harm.

Toxicity and Harm Potential

Overview

The toxicity and long-term health effects of recreational 2-Fluorodeschloroketamine (2-FDCK) use have not been extensively studied in scientific contexts, primarily due to its limited history of human usage. However, anecdotal evidence suggests that low to moderate doses of 2-FDCK used sparingly do not typically result in negative health effects.

Harm Reduction

It is strongly recommended to practice harm reduction strategies when using 2-FDCK, including:

  • Educating oneself about the substance and its potential risks.
  • Starting with low doses and gradually titrating upwards to assess individual sensitivity.
  • Avoiding frequent or excessive use to mitigate the risk of dependence and other adverse effects.

Dependence and Abuse Potential

Chronic use of 2-FDCK, like other NMDA receptor antagonists, can lead to psychological dependence and a high potential for abuse. Users may develop tolerance, requiring increasingly larger doses to achieve desired effects. Abrupt cessation of use may result in cravings and withdrawal effects.

Urinary Tract Effects

Repetitive and excessive use of 2-FDCK can lead to bladder and urinary tract issues similar to those associated with ketamine use, albeit to a lesser extent. Symptoms may include urinary frequency, urgency, pressure, pelvic and bladder pain, hematuria, and incontinence. These effects can be mitigated by limiting use and avoiding daily or weekly consumption.

Dangerous Interactions

Combining 2-FDCK with certain substances can be dangerous and even life-threatening. Some known dangerous interactions include:

  • Benzodiazepines: Potentiate sedation and ataxia, increasing the risk of loss of consciousness and vomit aspiration.
  • MAOIs: May increase the potency of 2-FDCK, leading to unpredictable effects.
  • Alcohol, GHB, and GBL: Heighten ataxia and bring a high risk of vomiting and unconsciousness.
  • Opioids and Tramadol: Increase the risk of respiratory depression and unconsciousness.
  • Grapefruit: Enhances oral absorption of 2-FDCK, leading to higher concentrations and prolonged effects.

Legal Status

International

  • Austria: Illegal under the Neue-Psychoaktive-Substanzen-Gesetz Österreich (NPSG).
  • Canada: Not specifically listed but could be considered controlled under schedule I.
  • Germany: Controlled under the New Psychoactive Substances Act (NpSG).
  • Italy: Classified as a Schedule I controlled substance.
  • Latvia: Illegal.
  • Switzerland: Controlled under Verzeichnis E.
  • Turkey: Illegal to possess, produce, supply, or import.
  • United Kingdom: Class B drug, illegal to possess, produce, supply, or import. Covered by the Misuse of Drugs Act.

It's important to note that legal status may vary by country, and individuals should consult local laws and regulations before using or possessing 2-FDCK.

FAQ

Q: What is 2-Fluorodeschloroketamine (2-FDCK)?

A: 2-Fluorodeschloroketamine, also known as 2-FDCK, is a dissociative substance belonging to the arylcyclohexylamine class, similar to ketamine and deschloroketamine (DCK).

Q: How does 2-FDCK affect the body?

A: 2-FDCK can induce a range of effects, including dissociation, altered perception, cognitive changes, and physical sensations. Its effects are often compared to those of ketamine.

Q: What are the common dosage ranges for 2-FDCK?

A: Dosages of 2-FDCK can vary, but commonly recognized ranges include threshold (5 mg), light (10 - 25 mg), common (25 - 70 mg), strong (70 - 140 mg), and heavy (140 mg+).

Q: Is 2-FDCK toxic or harmful?

A: The long-term health effects and toxicity of 2-FDCK are not well-studied, but it is generally recommended to use harm reduction practices and avoid excessive use to minimize potential risks.

Q: Can 2-FDCK be addictive?

A: Chronic use of 2-FDCK can lead to psychological dependence and addiction, similar to other NMDA receptor antagonists. Tolerance may develop with prolonged use, requiring higher doses to achieve the same effects.

Q: What are the potential interactions of 2-FDCK with other substances?

A: Combining 2-FDCK with certain substances, such as benzodiazepines, alcohol, opioids, or MAOIs, can lead to dangerous interactions and increased risk of adverse effects.

Q: What is the legal status of 2-FDCK?

A: The legal status of 2-FDCK varies by country. It may be classified as a controlled substance in some jurisdictions, while in others, it may be unregulated or illegal to possess, produce, or distribute. It's important to research and adhere to local laws and regulations.


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