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Product Name: PARGY-LAD
IUPAC Name: none
Other Names: PARGY-LAD
Cas Number: none
Molecular Formula: none
Molar Mass: none g•mol-1
Effect: psychedelic, hallucinogen
Purity of the substance: 99.9%
Physical properties: liquid, blotters
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Table of Contents

  1. Introduction

    • Overview of PARGY-LAD
    • Historical Context
  2. Chemistry

    • Structural Characteristics
    • Core Polycyclic Structure
    • Comparison with LSD
  3. Dosage Guidelines

    • Threshold, Light, Common, Strong, Heavy
    • Subjective Effects Disclaimer
  4. Subjective Effects

    • Physical Effects
    • Cognitive Effects
    • Auditory and Multi-sensory Effects
    • Transpersonal Effects
  5. Combinations with PARGY-LAD

    • Cannabis
    • Dissociatives
    • Alcohol
    • Benzodiazepines
    • Psychedelics
  6. Toxicity and Harm Potential

    • Research Status
    • Anecdotal Evidence
    • Harm Reduction Practices
  7. Tolerance and Addiction Potential

    • Habit-forming Speculation
    • Tolerance Build-up
    • Cross-tolerance with Psychedelics
  8. Dangerous Interactions

    • Lithium
    • Cannabis
    • Stimulants
    • Tramadol
  9. Legal Status

    • Germany
    • Latvia
    • Switzerland
    • United Kingdom


6-Propynyl-6-nor-Lysergic Acid Diethylamide (PARGY-LAD), also known as N-Propynylnorlysergic acid N,N-diethylamide, is an emerging synthetic psychedelic substance belonging to the lysergamide chemical class. Although it shares structural similarities with LSD, it is distinct in its effects and features. PARGY-LAD gained attention due to its mention in Alexander Shulgin's book TiHKAL and is recognized for its relative obscurity and limited distinguishing characteristics.

History and Pharmacology

PARGY-LAD was initially acknowledged as an LSD analog in Shulgin's TiHKAL. Reported to be less potent than LSD, it exhibits some activity at 160 μg and full activity at 500 micrograms. Despite being part of the lysergamide family, limited data exists on its pharmacological properties, metabolism, and toxicity. Its recent appearance in the market as a legal alternative to LSD, alongside compounds like AL-LAD and ETH-LAD, raises concerns about its safety and usage.


As a synthetic alkaloid, PARGY-LAD shares a core polycyclic structure with lysergic acid, featuring an N,N-diethylamide functional group. It is classified as an ergoline derivative, containing a bicyclic hexahydroindole fused to a bicyclic quinoline group (nor-lysergic acid). Unlike LSD, PARGY-LAD substitutes the R6 position with a propynyl group.

Dosage Guidelines

Understanding PARGY-LAD dosage is crucial for users to navigate its effects safely. Threshold doses begin at 50 µg, with a light experience ranging from 125 to 275 µg. Common doses fall between 275 and 500 µg, while strong and heavy doses are categorized at 500-700 µg and 700 µg and above, respectively.

Subjective Effects

Caution is advised when using PARGY-LAD due to the limited research on its effects. Physical effects include spontaneous sensations, euphoria, stimulation, and potential side effects like headaches and nausea. Cognitive effects encompass enhanced analysis, anxiety, novelty, introspection, and time distortion. Auditory and multi-sensory enhancements, along with transpersonal effects like spirituality enhancement and unity, may occur.

Combinations with PARGY-LAD


When combined with cannabis, PARGY-LAD's visual and cognitive effects may intensify and prolong. Caution is advised, especially for inexperienced users, as the combination can lead to a significantly more intense visual trip. The use of THC concentrates, such as hashish, has been reported to enhance effects but may also amplify anxiety, confusion, and psychosis. Extreme caution is recommended when combining PARGY-LAD with cannabis.


Combining PARGY-LAD with dissociatives enhances geometric patterns, euphoria, dissociation, and hallucinatory effects. The synergy results in more vivid visuals, internal hallucinations, and confusion compared to dissociatives alone. Users should exercise caution due to the potential for intensified experiences and unpredictable effects.


While not typically recommended, low doses of alcohol may reduce the intensity of a PARGY-LAD trip. However, moderate to high doses of alcohol can cause dehydration, nausea, and physical fatigue, negatively impacting the psychedelic experience. Caution is advised, and responsible use is recommended when considering this combination.


Combining PARGY-LAD with benzodiazepines can reduce the cognitive, physical, and visual effects of the trip, depending on the dosage. Benzodiazepines are effective in stopping bad trips but come with the cost of amnesia and reduced trip intensity. Caution is emphasized due to the high addiction potential of benzodiazepines.


When combined with other psychedelics, PARGY-LAD intensifies the effects of each substance, creating a strong and unpredictable synergy. This combination is generally not advised, and if users choose to combine psychedelics, starting with lower dosages than when taken individually is recommended.

Toxicity and Harm Potential

The toxicity and long-term health effects of PARGY-LAD remain largely unstudied, given its status as a research chemical with minimal human usage history. Anecdotal evidence suggests no negative health effects at low to moderate doses used sparingly. Independent research is crucial to ensuring the safety of combining PARGY-LAD with other substances, and harm reduction practices are strongly recommended.

Tolerance and Addiction Potential

While no formal studies on addiction potential have been conducted, PARGY-LAD is speculated to be non-habit forming. Tolerance builds rapidly after ingestion, with a reduction to half within 5-7 days and a return to baseline within 14 days. Cross-tolerance with other psychedelics is present, diminishing their effects.

Dangerous Interactions

Certain combinations with PARGY-LAD can be dangerous. Caution is advised, and independent research should be conducted to ensure safety. Some known dangerous interactions include:

  • Lithium: Increases the risk of psychosis and seizures.
  • Cannabis: Unpredictable synergy, increasing the risk of adverse psychological reactions.
  • Stimulants: Elevates the risk of anxiety, paranoia, panic attacks, and thought loops.
  • Tramadol: Lowers the seizure threshold, potentially triggering seizures.

Legal Status

The legal status of PARGY-LAD varies:

    • Germany: Controlled under the NpSG (New Psychoactive Substances Act).
    • Latvia: Illegal due to LSD structural analog classification.
    • Switzerland: Not specifically controlled, potentially legal.
    • United Kingdom: Classified as a Class A drug under the Misuse of Drugs Act.

Frequently Asked Questions (FAQ)

Q1: What is PARGY-LAD?

A1: PARGY-LAD, or 6-Propynyl-6-nor-Lysergic Acid Diethylamide, is a synthetic psychedelic substance in the lysergamide class, known for its structural similarities to LSD.

Q2: How does PARGY-LAD compare to LSD?

A2: PARGY-LAD is a close structural homolog of LSD but is reported to be less potent. It lacks distinguishing features and has gained attention as a legal alternative to LSD.

Q3: Are there known combinations with PARGY-LAD?

A3: Yes, caution is advised when combining PARGY-LAD with cannabis, dissociatives, alcohol, benzodiazepines, or other psychedelics. Effects can be intensified, and unpredictable synergies may occur.

Q4: Is PARGY-LAD habit-forming?

A4: While no formal studies have been conducted, it is speculated that PARGY-LAD is not habit-forming. Tolerance builds rapidly, and cross-tolerance with other psychedelics is present.

Q5: What is the legal status of PARGY-LAD?

A5: Legal status varies by country. It is controlled in Germany, illegal in Latvia, potentially legal in Switzerland, and classified as a Class A drug in the United Kingdom.

Q6: Are there dangerous interactions with PARGY-LAD?

A6: Yes, interactions with substances like lithium, cannabis, stimulants, and tramadol can be dangerous. Independent research is crucial to ensure safety.

Q7: What harm reduction practices should be followed?

A7: Users are strongly advised to approach PARGY-LAD with caution, conduct independent research, and adhere to harm reduction practices to minimize risks and adverse effects.

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