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Product Name: O-DSMT
IUPAC Name: 3-(2-((dimethylamino)methyl)-1-hydroxycyclohexyl)phenol
Other Names: O-Desmethyltramadol, desmetramadol
Cas Number: 73986-53-5
Molecular Formula: C15H24ClNO2
Molar Mass: 249.349 g/mol
Purity of the substance: ≥99.3%
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         Table of Contents

In modern pharmacology, the continuous exploration of novel compounds and their effects on the human body plays an integral role in medical and recreational contexts. One compound that has garnered attention recently is O-DSMT (O-Desmethyltramadol), a synthetic opioid derivative. This article delves into the multifaceted nature of O-DSMT, encompassing its chemical structure, pharmacological properties, historical context, effects, dosages, legal status, and broader implications.

How to get O-DSMT

The availability of O-DSMT for purchase is influenced by its legal status in a given location. In regions where it is regulated as a controlled substance, obtaining O-DSMT outside of legitimate medical channels is likely to involve illegal sources, contributing to an unregulated and potentially dangerous market. Individuals must adhere to legal and medical guidelines when seeking O-DSMT or other pharmaceutical compounds.


O-DSMT, or O-Desmethyltramadol, is a synthetic opioid compound and an active metabolite of tramadol, a widely prescribed analgesic. This substance exerts its effects primarily through binding to the μ-opioid receptors in the central nervous system, resulting in pain relief and other physiological responses. O-DSMT is of particular interest due to its potential for analgesia, euphoria, and the risk of opioid-related side effects.

Chemistry of O-DSMT

Chemically, O-DSMT is classified as an opioid, with its molecular formula C16H25NO2. Structurally, it bears a resemblance to tramadol, but it lacks the methyl group at the nitrogen atom. The absence of this methyl group impacts its pharmacokinetics, altering its affinity for opioid receptors and metabolic pathways. This chemical distinction contributes to its unique profile compared to other opioids.

Pharmacology of O-DSMT

O-DSMT's pharmacological properties are intricately tied to its interaction with opioid receptors, primarily the μ-opioid receptor. Upon binding to these receptors, O-DSMT triggers a cascade of events, including inhibiting pain transmission and releasing neurotransmitters like dopamine, contributing to its analgesic and rewarding effects. Its potency as an agonist at the μ-opioid receptor influences its potential for therapeutic pain management and recreational abuse.

History of O-DSMT

The history of O-DSMT is intertwined with that of tramadol, its parent compound. Tramadol was developed in the late 1970s to create an analgesic that combined the benefits of opioid receptor binding with reduced risk of addiction and respiratory depression. O-DSMT was identified as a metabolite of tramadol and later gained recognition for its potential opioid-like effects. Over time, it has gained popularity for its therapeutic use and presence in the recreational drug market.

Effects of O-DSMT

The effects of O-DSMT are diverse, encompassing both therapeutic and adverse outcomes. On the one hand, it provides effective pain relief by acting on the μ-opioid receptors. This property has led to its medical use in managing moderate to severe pain. Conversely, O-DSMT's interaction with the brain's reward system can result in feelings of euphoria and relaxation, making it susceptible to abuse. These effects underscore the delicate balance between its potential benefits and risks.

Dosage of O-DSMT

The appropriate dosage of O-DSMT varies depending on individual tolerance, pain severity, and potential drug interactions. For therapeutic use, dosages are typically lower and carefully monitored to mitigate the risk of adverse effects and addiction. In a recreational context, individuals often seek higher doses to achieve euphoria, but this practice significantly heightens the dangers associated with opioid use, including overdose and respiratory depression.

Legal Status of O-DSMT

The legal status of O-DSMT is a complex issue that varies across jurisdictions. In some regions, it is classified as a controlled substance due to its opioid nature and potential for abuse. This classification places legal restrictions on its possession, distribution, and use. The evolving landscape of opioid regulations underscores the need for comprehensive policies that balance medical access with public safety concerns.


O-DSMT is a testament to the intricate interplay between chemistry, pharmacology, history, and societal impact within pharmacological exploration. Its chemical structure, pharmacological mechanisms, historical development, effects, dosages, legal considerations, and broader implications collectively highlight the complexity of modern drug research and regulation. As science and society continue to grapple with the challenges posed by opioids, O-DSMT serves as a reminder of the ongoing need for responsible research, code, and clinical application to pursue improved medical care and public health.

Frequently Asked Questions about O-DSMT (Desmetramadol)

What is O-DSMT (Desmetramadol)?

O-DSMT, or Desmetramadol, is a synthetic opioid analgesic that acts as a prodrug to tramadol. It is used for pain management and relief. O-DSMT is similar in structure and effects to tramadol but is considered to be more potent.

Is O-DSMT a controlled substance?

Yes, O-DSMT is considered a controlled substance in many countries due to its opioid nature. It is regulated to prevent misuse and abuse.

How is O-DSMT typically prescribed?

O-DSMT is typically not prescribed by medical professionals. It is more commonly found as a research chemical or on the black market. The use of O-DSMT should be approached with caution due to its opioid properties and potential for addiction.

What are the potential side effects of O-DSMT?

Common side effects of O-DSMT may include dizziness, nausea, constipation, and respiratory depression. As an opioid, it carries the risk of addiction and overdose if not used as directed.

Is it safe to use O-DSMT with other substances?

Combining O-DSMT with other substances, especially other depressants like alcohol or benzodiazepines, can increase the risk of dangerous side effects and overdose. It is important to use O-DSMT only as directed by a medical professional, if at all.

What precautions should I take when using O-DSMT?

If you are prescribed O-DSMT or choose to use it for pain management, follow the prescribed dosage and instructions carefully. Do not crush or break the tablets, and never exceed the recommended dose. Inform your doctor of any other medications you are taking to avoid potential drug interactions.

Is O-DSMT safe for long-term use?

Long-term use of O-DSMT should be closely monitored by a medical professional due to the risk of developing tolerance, dependence, and addiction. It is not typically recommended for extended use unless other pain management options have been exhausted.

What should I do if I miss a dose of O-DSMT?

If you miss a dose, take it as soon as you remember. However, if it is close to the time for your next dose, skip the missed dose and follow your regular dosing schedule. Do not take extra medication to make up for a missed dose.

Is O-DSMT available over the counter?

No, O-DSMT is not available over the counter. It is typically a prescription medication or a research chemical, and its use should be guided by a healthcare professional.

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