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Table of Contents
Introduction
History and Market Emergence
Chemistry of 1P-LSD
Structural Characteristics
Pharmacology
Mechanism of Action
Metabolism and Toxicity
Subjective Effects
Harm Reduction Considerations
- Subjective Effects
- Comparison with Other Psychedelics
- Physical Effects
- Stimulation
- Spontaneous Bodily Sensations
- Physical Euphoria
- Tactile Enhancement
- Stamina Enhancement
- Other Physical Effects
- Visual Effects
- Enhancements
- Distortions
- Geometry
- Hallucinatory States
- Cognitive Effects
- Toxicity and Harm Potential
- Overdose
- Legal Status
- FAQs
Introduction
Propionyl-d-lysergic acid diethylamide, commonly known as 1P-LSD, is a novel psychedelic compound belonging to the lysergamide class. Its structure is closely related to that of LSD and other contemporary lysergamides such as 1cP-LSD, 1B-LSD, and 1V-LSD. Although the precise mechanism through which 1P-LSD exerts its effects remains undetermined, it is believed to act primarily by stimulating serotonin receptors in the brain.
History and Market Emergence
1P-LSD first appeared on the online research chemical market in January 2015. Its original synthesis date is unknown, and it does not have any documented presence in scientific literature prior to its introduction as a research chemical. It was marketed as a legal alternative to LSD, alongside other new lysergamides like ALD-52, ETH-LAD, and AL-LAD. By 2019, 1P-LSD became the subject of interest for studies conducted by the French laboratory Caulredaitens, though specific details regarding these studies are limited.
Chemistry of 1P-LSD
1P-LSD is classified as a semisynthetic compound from the lysergamide family. Its unique characteristics stem from the propionyl group attached to the nitrogen of the polycyclic indole structure found in LSD.
Structural Characteristics
1P-LSD is homologous to ALD-52, differing primarily in that it features a propionyl group bound to the nitrogen atom, while ALD-52 has an acetyl group in the same position. The overall structure includes a polycyclic arrangement, comprising a bicyclic hexahydroindole linked to a bicyclic quinoline group. An N,N-diethyl carboxamide group is attached at the 8th carbon of the quinoline ring.
Pharmacology
Given its structural similarities to LSD, it is hypothesized that 1P-LSD functions as a partial agonist at the 5-HT2A serotonin receptor. This receptor activity is thought to be the primary contributor to its psychedelic effects.
Mechanism of Action
1P-LSD is theorized to exhibit binding activity across a spectrum of monoamine receptors, which may include dopamine and norepinephrine receptors. However, there is currently a lack of experimental data to confirm these interactions.
Research suggests that 1P-LSD may act as a prodrug for LSD. Despite exhibiting only 38% of the potency of LSD in mouse models, studies have shown that LSD is detectable via liquid chromatography-mass spectrometry (LC-MS) when 1P-LSD is introduced into human serum. Further studies are ongoing to compare the binding affinity and selectivity of both LSD and 1P-LSD at serotonin receptors, particularly to clarify whether 1P-LSD is converted to LSD in vivo.
Subjective Effects
Users report that the effects of 1P-LSD include a variety of subjective experiences, such as geometric visual hallucinations, alterations in the perception of time, enhanced introspection, conceptual thinking, feelings of euphoria, and instances of ego dissolution. Anecdotal evidence suggests that the subjective effects of 1P-LSD closely mirror those of LSD, leading to speculation that the two may produce nearly identical experience profiles, differing mainly in the speed of absorption and duration of effects.
Harm Reduction Considerations
The limited data available regarding the pharmacological properties, metabolism, and toxicity of 1P-LSD necessitates caution. It is presumed to carry a similar toxicity and risk profile to LSD; however, no formal studies have definitively established this comparison. Therefore, it is crucial for users to employ harm reduction practices when considering the use of 1P-LSD.
Subjective Effects
Comparison with Other Psychedelics
User experiences suggest that the subjective effects of 1P-LSD closely mirror those of LSD, making them virtually indistinguishable. Compared to other psychedelics like psilocybin, LSA, and ayahuasca, 1P-LSD is recognized for its stimulating and fast-paced effects.
Physical Effects
Stimulation
1P-LSD is widely perceived as energetic and stimulating. Users often feel compelled to engage in physical activities such as running, walking, climbing, or dancing, contrasting with the more sedating effects of other psychedelics like psilocybin.
Spontaneous Bodily Sensations
The physical sensations associated with 1P-LSD can be intense, often described as euphoric, sharp, and location-specific tingling. These sensations can appear unpredictably throughout the experience but typically rise in intensity as the peak approaches. In moderate to high doses, this "body high" can become overwhelming.
Physical Euphoria
While physical euphoria may occur, it is less predictable than with stimulants or entactogens. In some instances, it may result in discomfort instead.
Tactile Enhancement
Users frequently report enhanced tactile sensations during 1P-LSD experiences. At higher levels, this can culminate in a heightened awareness of nerve endings throughout the body.
Stamina Enhancement
Stamina enhancement is noted but tends to be milder than that produced by traditional stimulants.
Other Physical Effects
- Appetite suppression
- Bodily control enhancement
- Difficulty urinating
- Excessive yawning: less pronounced than with psilocybin
- Nausea: mild nausea can occur, usually subsiding after vomiting or as the peak diminishes
- Physiological responses:
- Increased blood pressure
- Increased heart rate
- Increased perspiration
- Muscle contractions and spasms
- Pupil dilation
- Increased salivation
- Vasoconstriction, possibly leading to cold extremities
- Seizures: rare, primarily a concern for those with a genetic predisposition, particularly under physically taxing conditions
Visual Effects
Enhancements
Users report several visual enhancements, including:
- Colour enhancement: often described as brighter than other psychedelics
- Pattern recognition enhancement
- Visual acuity enhancement
Distortions
Common visual distortions include:
- Drifting: includes effects like melting, breathing, and morphing
- Colour shifting
- Tracers
- Afterimages
- Depth and perspective distortions
- Recursion and symmetrical texture repetition
- Scenery slicing
Geometry
The visual geometry associated with 1P-LSD resembles that of 2C-B or 2C-I, characterized by intricate complexity, brightly lit colors, synthetic feels, and sharp edges. It tends to be fast-moving and non-immersive.
Hallucinatory States
1P-LSD can induce hallucinatory states, although these are less consistent compared to tryptamines like DMT or psilocybin. Possible hallucinations include:
- Transformations
- Machinescapes: rare and generally observed at high doses
- Internal and external hallucinations: these can range from interactive experiences to realistic landscapes but occur less frequently than in other psychedelics
Cognitive Effects
Cognitive enhancements reported with 1P-LSD include:
- Analysis enhancement
- Creativity enhancement
- Emotion and novelty enhancement
- Increased focus: experienced primarily at lower doses
- Cognitive euphoria: less consistent than with substances like psilocybin
- Delusions, ego replacement, increased libido
- Increased music appreciation
- Memory suppression
- Time distortion and wakefulness
Toxicity and Harm Potential
Currently, the long-term health effects of 1P-LSD remain largely unstudied, as it is a research chemical with minimal historical use. Anecdotal evidence indicates that low to moderate doses may not produce negative health outcomes, but caution is advised. It is believed that 1P-LSD has low toxicity relative to its dose, akin to LSD.
Overdose
There is no known toxic dose for 1P-LSD, but higher doses may lead to adverse psychological reactions, including anxiety and panic attacks. Severe cases may require medical intervention, especially if combined with other substances.
Legal Status
The legal status of 1P-LSD varies by country, often residing in a grey area:
- Austria: potentially illegal under NPSG as an analogue of LSD
- Canada: not specifically mentioned in controlled substances legislation
- Czech Republic: classified as a controlled substance
- Denmark: specifically illegal as of August 2015
- Germany: controlled under the NpSG since July 2019
- United Kingdom: illegal under the Psychoactive Substance Act since May 2016
- United States: unscheduled, which may lead to legal challenges under the Federal Analogue Act
In other countries, 1P-LSD may be illegal or controlled due to its structural relation to LSD.
FAQs
What is 1P-LSD?
1P-LSD is a psychedelic compound closely related to LSD (lysergic acid diethylamide). It is known for producing similar effects, including visual and auditory hallucinations, altered perception, and enhanced sensory experiences.
How does 1P-LSD work?
1P-LSD primarily interacts with serotonin receptors in the brain, particularly the 5-HT2A receptor. This interaction is responsible for its psychedelic effects, including altered mood, perception, and cognition.
What are the effects of 1P-LSD?
Users typically report effects such as enhanced sensory perception, visual distortions, euphoria, increased energy, and altered thought patterns. Effects can vary based on dosage and individual sensitivity.
Is 1P-LSD legal?
The legal status of 1P-LSD varies by country. It exists in a legal grey area in many places, meaning it is not specifically scheduled, but may still be subject to analogue laws.
How long do the effects of 1P-LSD last?
The effects of 1P-LSD usually last between 6 to 12 hours, depending on the dosage and individual metabolism.
What is the typical dosage for 1P-LSD?
Typical dosages for 1P-LSD range from 50 to 200 micrograms, with individual sensitivity influencing the appropriate amount.
Can I overdose on 1P-LSD?
There is no known toxic dose for 1P-LSD, but taking excessively high doses can increase the risk of negative psychological reactions, such as anxiety or panic attacks.
What are the risks associated with 1P-LSD?
Potential risks include anxiety, paranoia, psychotic episodes, and exacerbation of underlying mental health issues. Users with a history of mental illness should exercise caution.
How does 1P-LSD compare to LSD?
1P-LSD is chemically similar to LSD and produces similar effects; however, users often report that 1P-LSD has a slightly different onset and duration of effects.
Can 1P-LSD cause addiction?
There is currently no evidence to suggest that 1P-LSD has addictive properties. However, habitual use of psychedelics can lead to psychological dependence in some individuals.
What should I do if I have a bad trip on 1P-LSD?
If experiencing a bad trip, try to remain calm and change your environment if possible. Surround yourself with supportive people and consider using calming techniques. If the situation escalates, medical help may be necessary.
Can 1P-LSD be mixed with other substances?
Combining 1P-LSD with other substances, especially stimulants or depressants, can increase the risk of adverse effects. Users should exercise caution and be informed about potential interactions.
What is the onset time for 1P-LSD?
The onset time for 1P-LSD is typically between 30 minutes to 2 hours after ingestion, depending on the method of consumption (e.g., oral, sublingual).
Does 1P-LSD have any physical side effects?
Physical side effects may include nausea, increased heart rate, pupil dilation, and muscle tension. These effects vary by individual and dosage.
How should 1P-LSD be stored?
1P-LSD should be stored in a cool, dark place, away from direct sunlight and moisture, to maintain its potency.
Is 1P-LSD safe for everyone?
1P-LSD may not be safe for individuals with a history of mental health disorders or those taking certain medications. It's crucial to consult with a healthcare professional before use.
Can I drive after taking 1P-LSD?
Driving or operating heavy machinery after taking 1P-LSD is not recommended, as the substance can impair judgment and reaction times.
What are some common experiences reported by users?
Common experiences include heightened emotions, enhanced creativity, introspection, and, in some cases, profound spiritual insights. However, experiences can vary widely.
Can 1P-LSD cause long-term effects?
Research on the long-term effects of 1P-LSD is limited, but prolonged use of psychedelics can lead to persistent changes in perception and mental state in some users.
How can I ensure a safer experience with 1P-LSD?
To ensure a safer experience, consider using 1P-LSD in a controlled, comfortable environment with trusted individuals. Start with a low dose and be mindful of your mental state and surroundings.
FAQs about 1P-LSD
Q1: What is 1P-LSD?
A1: 1P-LSD (1-Propionyl-lysergic acid diethylamide) is a novel psychedelic compound that is chemically similar to LSD (lysergic acid diethylamide). It is often considered a prodrug, meaning it is converted into LSD in the body after ingestion.
Q2: How does 1P-LSD differ from LSD?
A2: While 1P-LSD and LSD have similar effects, 1P-LSD is structurally different due to the addition of a propionyl group. This slight modification may alter the onset, duration, and overall experience, although many users report effects similar to those of LSD.
Q3: What effects can I expect from 1P-LSD?
A3: Users commonly report a range of effects, including altered sensory perception, visual distortions, enhanced creativity, mood elevation, and deep introspective insights. The experience can vary widely depending on the dose and individual.
Q4: How is 1P-LSD consumed?
A4: 1P-LSD is usually consumed orally, often as blotter paper, microdots, or in liquid form. The effects typically take around 30 to 90 minutes to begin after ingestion.
Q5: Is 1P-LSD legal?
A5: The legal status of 1P-LSD varies by country. In some places, it may be legal or unregulated, while in others, it may be classified as a controlled substance. Always check local laws before purchasing or using.
Q6: How long do the effects of 1P-LSD last?
A6: The effects of 1P-LSD can last anywhere from 6 to 12 hours, depending on the dose and individual metabolism. The peak effects typically occur around 3 to 5 hours after ingestion.
Q7: What are the risks associated with using 1P-LSD?
A7: Potential risks include anxiety, paranoia, and confusion, especially in higher doses or in individuals with pre-existing mental health conditions. Like all psychedelics, the experience can be unpredictable.
Q8: Can 1P-LSD cause addiction?
A8: 1P-LSD is not considered physically addictive. However, some users may develop a psychological dependence on the substance, especially if used frequently.
Q9: Can 1P-LSD be detected in drug tests?
A9: Standard drug tests typically do not screen for 1P-LSD specifically. However, because it metabolizes into LSD, it could potentially be detected in tests that look for LSD.
Q10: Is 1P-LSD safe to use?
A10: While many users report positive experiences, the safety of 1P-LSD is not well established due to limited research. It is essential to approach its use with caution and be aware of potential psychological effects.
Q11: What should I do if I have a bad trip on 1P-LSD?
A11: If you experience a bad trip, find a safe and calming environment, focus on your breathing, and consider having a trusted friend present to provide reassurance. If needed, seek professional help.
Q12: How does 1P-LSD compare to other psychedelics?
A12: 1P-LSD is often compared to other psychedelics like psilocybin (magic mushrooms) and mescaline. Each has unique effects and experiences, but 1P-LSD is often noted for its longer duration and intense visual effects.
Q13: What are the potential therapeutic uses of 1P-LSD?
A13: Research into the therapeutic potential of 1P-LSD is limited, but it may have applications in treating conditions like anxiety, depression, and PTSD, similar to other psychedelics.
Q14: How should I prepare for a 1P-LSD experience?
A14: Preparation includes creating a safe and comfortable environment, setting intentions for the experience, and ensuring you are in a positive mental state. Having a sober trip sitter can also be beneficial.
Q15: Can I microdose 1P-LSD?
A15: Yes, many people report microdosing with 1P-LSD to enhance mood, creativity, and focus without experiencing significant psychedelic effects. A typical microdose is about 10-20 micrograms.
Q16: What are the signs of 1P-LSD overdose?
A16: While overdose is rare, taking excessive amounts may lead to severe anxiety, paranoia, agitation, or physical discomfort. In extreme cases, it may require medical attention.
Q17: Can I use 1P-LSD with other substances?
A17: Combining 1P-LSD with other substances can increase the risk of adverse effects. It's crucial to be cautious and aware of potential interactions, especially with other psychedelics or stimulants.
Q18: What should I do if I experience side effects from 1P-LSD?
A18: If you experience uncomfortable side effects, try to stay calm, hydrate, and find a safe environment. If the symptoms persist or worsen, seek medical help.
Q19: How can I store 1P-LSD safely?
A19: If legal, 1P-LSD should be stored in a cool, dark place, away from moisture and light, in an airtight container to maintain potency.
Q20: Where can I find more information about 1P-LSD?
A20: For more information, consult scientific literature, reputable health resources, or organizations focused on psychedelics and mental health. Online forums and communities may also provide personal insights and experiences.