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Intruduction
APINACA (AKB48, N-(1-adamantyl)-1-pentyl-1H-indazole-3-carboxamide) is a synthetic cannabinoid receptor agonist of moderate potency. It has a Ki of 304.5 nM and an EC50 of 585 nM at CB1, making it a potent activator of human receptors. In March 2012, Japanese labs identified APINACA as a component of synthetic cannabis smoking mixtures with APICA, a similar chemical. Despite its recent discovery, it has not been documented in the scientific or patent literature, making it a novel and emergent material of concern.
The Structure of APINACA
APINACA shares structural similarities with cannabinoid chemicals, which have been studied and researched for decades. A simple pentyl chain at the 1-indazole position distinguishes it from other cannabinoid compounds. This structural difference comes within the claims of a University of Connecticut patent (WO 2003/035005), although it was not included as an illustration in the patent.
The Discovery of APINACA
In March 2012, Japanese labs found APINACA as a component in synthetic cannabis smoking mixtures with the similar chemical APICA. Synthetic cannabinoids, such as APINACA, have been utilized as substitutes for natural cannabis since they are inexpensive to create, widely accessible, and frequently marketed legally. Due to the absence of APINACA in the scientific or patent literature, it is a novel and emergent material of concern.
How Does APINACA Work?
APINACA is an agonist for the cannabinoid receptors in the human body, which means that it stimulates these receptors and generates effects comparable to those of natural cannabinoids. The Ki value of 304.5nM and the EC50 value of 585nM for CB1 show that APINACA is an effective drug for activating the body's receptors.
Concerns Surrounding APINACA
The effects of the synthetic medication APINACA on the human body are not fully known. Due to its recent discovery and lack of understanding of its effects, this chemical is cause for concern. In addition, the frequency with which it is offered legally and used as a replacement for cannabis raises the danger of its use and addiction.
Questions asked frequently
What exactly is APINACA?
APINACA is a synthetic agonist for cannabis receptors with moderate potency.
Where was APINACA found initially?
In March 2012, Japanese labs identified APINACA as a chemical in synthetic cannabis smoking mixtures.
What is the APINACA structure?
APINACA is structurally similar to cannabis compounds, but its simple pentyl chain at the 1-indazole position sets it apart.
How does APINACA work?
APINACA is an agonist for the cannabinoid receptors in the human body, activating these receptors and providing effects comparable to those of natural cannabinoids.
Exist any complaints with APINACA?
Yes, APINACA is a synthetic medicine with unknown effects on the human body. Due to its recent discovery and lack of understanding of its effects, this chemical is cause for concern. In addition, the frequency with which it is offered legally and used as a replacement for cannabis raises the danger of its use and addiction.
