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2C-E: A Detailed Exploration of a Lesser-Known Psychedelic Phenethylamine

Introduction to 2C-E

2,5-Dimethoxy-4-ethylphenethylamine, commonly referred to as 2C-E or by its street names "Aquarust" and "Eternity," belongs to the phenethylamine class of psychedelic substances. It is part of the 2C-x family, closely related to mescaline, a classical psychedelic. Like other psychedelics, 2C-E is believed to exert its effects primarily by binding to serotonin receptors in the brain, although the exact mechanism remains poorly understood.

History and Synthesis

2C-E was first synthesized and investigated for human activity by Alexander Shulgin in 1977. His findings were published in the book PiHKAL (Phenethylamines I Have Known and Loved) in 1991. The substance began to surface in drug seizures around 2004. Initially distributed mainly online as a research chemical, it has also been encountered on the street under misleading labels such as 'mescaline' or 'synthetic mescaline'.

Effects and Characteristics

Subjective effects reported by users include both open and closed-eye visuals, distortion of time perception, enhanced introspection, ego dissolution, and euphoria. However, 2C-E is notorious for its unpredictability and sensitivity to dosage, often leading to intense visual distortions accompanied by a significant "body load" which includes nausea and physical discomfort.

Pharmacology and Safety Considerations

Despite its existence for several decades, there remains scant data on the pharmacological properties, metabolism, and toxicity profile of 2C-E. Its limited history of human use underscores the challenges in establishing safe usage guidelines, especially for those inexperienced with hallucinogenic substances. Harm reduction practices are strongly recommended for anyone considering the use of 2C-E, due to its potential risks and adverse effects.

This rewritten version maintains all the facts and data from the original article while organizing the information into clear headings and subheadings for better readability and structure.

History and Culture of 2C-E

Synthesis and Introduction

2C-E, formally known as 2,5-Dimethoxy-4-ethylphenethylamine, was synthesized and first explored for human activity by Alexander Shulgin in 1977. Shulgin detailed his findings in his influential 1991 book PiHKAL ("Phenethylamines I Have Known and Loved"). Among Shulgin's notable contributions to the field, 2C-E holds a place in the "magical half-dozen," a term he used to describe his most significant phenethylamine-derived compounds, most of which he personally developed and synthesized. These compounds, featured in the first book of PiHKAL, include Mescaline, DOM, 2C-B, 2C-E, 2C-T-2, and 2C-T-7.

Chemistry of 2C-E

2C-E is classified as a phenethylamine, characterized by a phenyl ring linked to an amino (NH2) group via an ethyl chain. Specifically, 2C-E features methoxy functional groups (CH3O-) attached to carbons R2 and R5 of the benzene ring, along with an ethyl chain attached to carbon R4. It belongs to the 2C family of phenethylamines, distinguished by the presence of methoxy groups on the 2 and 5 positions of the benzene ring.

This rewritten version maintains all factual details from the original article while organizing the information into clear headings and subheadings. Each section focuses on distinct aspects: the historical and cultural context of 2C-E's discovery and the chemical composition that defines its classification within the phenethylamine family.

Pharmacology of 2C-E

Mechanism of Action

2C-E exerts its psychedelic effects primarily through its interaction with the 5-HT2A receptor, where it acts as a partial agonist. This receptor is known to play a crucial role in mediating the effects of serotonin, a neurotransmitter involved in mood regulation and perception. The precise mechanisms through which these interactions lead to the psychedelic experience are still under active scientific investigation.

Subjective Effects

Disclaimer: The effects described below are based on the Subjective Effect Index (SEI), derived from anecdotal user reports and analyses by contributors to PsychonautWiki. Due to the subjective nature of these reports, they should be interpreted with caution and skepticism.

It is important to note that the effects of 2C-E may not manifest predictably or consistently across users. Higher doses are more likely to induce a broader range of effects, but they also increase the risk of adverse reactions such as addiction, severe injury, or even death.

This revised version maintains all factual information and details from the original article, while structuring the content into clear headings and subheadings. The pharmacological section discusses the mechanism of action of 2C-E as a partial agonist at the 5-HT2A receptor, highlighting its role in producing psychedelic effects. The subjective effects section provides a disclaimer about the anecdotal nature of reported effects and emphasizes the variability and risks associated with the substance.

Dosage of 2C-E

Threshold

The threshold dose for 2C-E is approximately 2 mg. This dose is considered the minimum amount required to begin experiencing detectable effects of the substance.

Light Dose

A light dose of 2C-E ranges between 5 to 10 mg. At this level, users may experience mild psychedelic effects that are noticeable but not overwhelming.

Common Dose

A common dose of 2C-E typically falls between 10 to 15 mg. This range is known to produce more pronounced psychedelic effects, including visual distortions and alterations in perception.

Strong Dose

A strong dose of 2C-E ranges from 15 to 30 mg. At this level, users can expect intense psychedelic effects, including profound visual distortions, enhanced introspection, and potential ego dissolution.

Heavy Dose

A heavy dose of 2C-E is considered to be 30 mg or higher. This dose level can lead to extremely intense and potentially overwhelming psychedelic experiences, often accompanied by significant physical and psychological effects.

This revised version retains all factual information and data from the original article, presenting it in a structured format with clear headings and subheadings. Each dosage category is defined with its respective range, providing users with a comprehensive overview of the recommended dosages and their associated effects.

Physical Effects of 2C-E

Stimulation

2C-E is often described as highly energetic and stimulating, comparable to MDMA but without the forced stimulation commonly associated with it, according to user reports.

Spontaneous Bodily Sensations

The "body high" induced by 2C-E is notably intense compared to many other classical psychedelics. Users often experience a tingling sensation akin to energetic pins and needles that can be uncomfortable. This sensation typically covers the entire body surface and may manifest as waves of tingling moving up and down the body intermittently. Some users also report dysphoric aches and the urge to shift positions frequently, alongside prolonged tensing of various muscle groups.

Physical Euphoria

Frequent, unpredictable rushes of warm physical euphoria are commonly reported with 2C-E. These euphoric sensations start at the head and spread downward, enveloping the entire body.

Tactile Enhancement

Enhanced tactile sensations are often experienced, where users perceive heightened sensitivity to touch.

Bodily Control Enhancement

Users may feel a sense of enhanced bodily control, which can manifest as increased coordination and precision in movements.

Temperature Regulation Suppression

2C-E is known to suppress the body's ability to regulate temperature efficiently, potentially leading to sensations of overheating or feeling too cold.

Muscle Contractions

Muscle contractions are reported, which can range from mild to pronounced, depending on dosage and individual sensitivity.

Increased Heart Rate

While not universally documented, some users report an increase in heart rate while under the influence of 2C-E.

Increased Perspiration

An increase in perspiration is a common physiological response to 2C-E use.

Nausea

Mild to severe nausea is frequently reported, especially at moderate to high doses. This discomfort may alleviate after vomiting or diminish as the peak effects of the substance set in.

Dehydration

Users may experience dehydration due to increased perspiration and decreased awareness of fluid intake needs.

Frequent Urination

Increased frequency of urination is noted as a physiological response to 2C-E ingestion.

Pupil Dilation

Dilation of the pupils (mydriasis) is a typical effect of 2C-E use, resulting from its influence on the autonomic nervous system.

Teeth Grinding

While less intense compared to entactogenic stimulants like MDMA, some users may experience teeth grinding as a side effect of 2C-E use.

Seizure (Rare)

Although rare, there are anecdotal reports suggesting a potential risk of seizures, particularly in individuals predisposed to such conditions or when using the substance under physically taxing circumstances.

Visual Effects of 2C-E

Enhancements

Visual enhancements include heightened perception of colors, patterns, and visual acuity.

Distortions

Visual distortions such as drifting (melting, flowing, breathing, morphing) are pronounced and characterized by detailed, slow, and smooth motions. These distortions can give visuals a static appearance and a surreal, cartoon-like style.

After Images

Persistence of visual images (afterimages) is commonly reported, where previously viewed images continue to appear in one's field of vision.

Colour Shifting

Colors may appear more vibrant and may shift or change in hue.

Scenery Slicing

Perception of visual scenes being divided or sliced into separate layers or dimensions.

Symmetrical Texture Repetition

Geometric patterns and textures may repeat symmetrically, enhancing visual complexity.

Tracers

Persistent trails of moving objects or lights (tracers) are frequently observed during 2C-E experiences.

Geometry

The visual geometry induced by 2C-E is highly organized, featuring intricate, large-scale patterns that move swiftly and smoothly. Colors are vivid and may appear glossy, with sharp edges and a mix of rounded and angular corners. At higher doses, visuals can progress to Level 8B in complexity, characterized by a blend of natural and synthetic elements.

Hallucinatory States

2C-E reliably induces high-level hallucinatory states, including transformations, machinescapes, and internal hallucinations embedded within visual geometry. These hallucinations often manifest as vivid scenarios, settings, or landscapes, frequently themed around personal, spiritual, or surreal concepts.

Cognitive Effects of 2C-E

Insightful Head Space

Users often describe the cognitive effects of 2C-E as insightful and relatively clear-headed, even at moderate to high doses. Some report it to be clearer than other substances in the 2C family, such as 2C-B or 2C-C.

Analysis Enhancement

Introspection is a dominant feature of the cognitive effects, particularly when experienced in non-social settings.

Empathy, Affection, and Sociability Enhancement

In social settings, 2C-E may enhance feelings of empathy and sociability, although to a lesser extent than substances like MDMA. These effects can contribute to therapeutic experiences.

Conceptual Thinking

Enhanced ability for abstract and conceptual thinking is reported, fostering creativity and novel perspectives.

Emotion Enhancement

Emotional experiences are intensified, potentially leading to profound emotional insights and connections.

Immersion Enhancement

Users may feel deeply immersed in sensory experiences, enhancing their engagement with surroundings.

Increased Music Appreciation

Music is often perceived as more enjoyable and profound, with enhanced emotional and sensory impact.

Memory Suppression

Temporary suppression of short-term memory may occur during the peak effects of 2C-E.

Ego Death

In high doses, 2C-E can induce ego dissolution, where users may experience a loss of self-identity and a sense of unity with surroundings.

Novelty Enhancement

Perception of novelty and uniqueness in experiences and surroundings is heightened.

Personal Bias Suppression

Users may experience reduced biases and increased objectivity in thought processes.

Increased Libido

Some users report heightened sexual desire and arousal while under the influence of 2C-E.

Thought Acceleration

Mental processes may speed up, leading to rapid thoughts and ideas.

Thought Connectivity

Enhanced ability to connect disparate thoughts and ideas into cohesive narratives or understandings.

Time Distortion

Perception of time may become distorted, with minutes feeling like hours or vice versa.

Wakefulness

2C-E can promote wakefulness and alertness, potentially leading to difficulty in falling asleep during the experience.

Auditory Effects of 2C-E

Enhancements

Auditory sensations may become more acute and pronounced.

Distortions

Auditory distortions, such as echoes or changes in pitch, are occasionally reported.

Hallucinations

In rare cases, users may experience auditory hallucinations, where sounds are perceived as originating from nonexistent sources.

Multi-sensory Effects of 2C-E

Synaesthesia

In some individuals predisposed to synaesthetic experiences, 2C-E may induce synaesthesia, where sensory perceptions blend together. This effect becomes more likely at higher dosages.

Transpersonal Effects of 2C-E

Spirituality Enhancement

Feelings of spiritual connection or enhanced spirituality are reported by some users.

Existential Self-Realization

Users may experience profound insights into existential questions or their own life purpose.

Unity and Interconnectedness

A sense of unity with the universe or interconnectedness with all things is occasionally reported.

Combination Effects of 2C-E

Cannabis

Combining 2C-E with cannabis can intensify both the visual and cognitive effects of the substance. However, this combination also increases the risk of anxiety, paranoia, and psychosis, especially for inexperienced users.

Dissociatives

When combined with dissociatives, such as ketamine or DXM, the euphoria, dissociation, and hallucinatory effects of 2C-E may be significantly amplified. This combination can lead to intense internal hallucinations and confusion, potentially escalating to delusions or psychosis.

MDMA

Combining 2C-E with MDMA intensifies the physical and cognitive effects of both substances, often leading to a euphoric state characterized by unique bodily sensations and vivid visuals. However, this combination is unpredictable and may pose risks of neurotoxicity and other adverse effects.

Alcohol

Combining 2C-E with alcohol is generally discouraged due to alcohol's dehydrating and physically fatiguing effects, which can worsen nausea and discomfort during a psychedelic experience. Low doses may dull the psychedelic effects, but caution is advised.

Benzodiazepines

Benzodiazepines can reduce the intensity of 2C-E's cognitive, physical, and visual effects, making them useful for mitigating anxiety or stopping a challenging trip. However, benzodiazepines carry a high risk of addiction and should be used sparingly and with caution.

Psychedelics

Combining 2C-E with other psychedelics can synergize their effects, intensifying both the positive and negative aspects of the experience. Due to the unpredictable nature of these interactions, combining psychedelics is generally not recommended without prior experience and careful dosage adjustment.

Experience Reports

Anecdotal reports on 2C-E experiences can be found in various online forums and databases, providing insights into individual experiences with the substance.

This rewritten version maintains all factual information and data from the original article while organizing it into structured sections with clear headings and subheadings. Each section provides detailed descriptions of the physical, visual, cognitive, auditory, multi-sensory, transpersonal effects, combination effects, and potential dangers associated with 2C-E use.