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Table of Contents

1. Summary

   • 1.1 N,N-Dimethyltryptamine Overview
   • 1.2 History and Cultural Significance

2. Chemistry

   • 2.1 Tryptamine Family Structure
   • 2.2 Homologs and Analogs
   • 2.3 Pure DMT: Characteristics and Dosages

3. Pharmacology

   • 3.1 Serotonergic Psychedelic Effects
   • 3.2 Sigma Receptor and Ongoing Research
   • 3.3 Subjective Effects and Experiences

4. Physical Effects

   • 4.1 Neurogenesis
   • 4.2 Bodily Sensations and Euphoria
   • 4.3 Changes in Gravity and Spatial Disorientation

5. Cognitive Effects

   • 5.1 Analysis Enhancement and Anxiety
   • 5.2 Memory Suppression and Mindfulness
   • 5.3 Novelty Enhancement and Autonomous Voice Communication

6. Visual Effects

   • 6.1 Enhancements and Distortions
   • 6.2 Drifting and Visual Geometry
   • 6.3 Hallucinatory States and Machinescapes

7. Auditory Effects

   • 7.1 Enhancements and Hallucinations
   • 7.2 Synaesthesia and Spirituality Enhancement

8. Progressive Stages

   • 8.1 Breaking Through
   • 8.2 The Waiting Room
   • 8.3 The Other Side
   • 8.4 Drifting Down

9. Toxicity and Harm Potential

   • 9.1 Non-addictive Nature and Safety Profile
   • 9.2 Potential Triggers for Underlying Psychiatric Conditions
   • 9.3 Caution and Harm Reduction Practices

10. Legal Status

    • 10.1 International Classification and Regulations
    • 10.2 Country-specific Legal Status

Summary

N,N-Dimethyltryptamine, commonly known as DMT or "The Spirit Molecule," is a classical psychedelic belonging to the tryptamine class. Renowned for its ability to induce short-lived yet intense visionary states and complete hallucinations, DMT interacts with serotonin receptors in the brain, although the precise mechanism remains elusive.

DMT in Nature

With a presence in over 65 plant species, DMT is not only a constituent of human metabolism but also an endogenous neurotransmitter in certain rodents. Widely distributed in the plant kingdom, the neurobiological function of DMT is yet to be fully understood despite various postulated theories.

Modes of Consumption

When vaporized or smoked, DMT engenders rapid and short-lived effects, often likened to an "inconceivably high-speed rollercoaster ride." When combined with a MAOI or RIMA agent, it becomes orally active, leading to longer-lasting, immersive, and interactive experiences, a combination commonly known as ayahuasca. South American cultures have traditionally used ayahuasca brews since at least 1500.

Safety Considerations

In contrast to many prohibited substances, DMT has not demonstrated addictive properties or physiological toxicity. However, caution is advised, as adverse reactions such as severe anxiety, delusions, and psychosis can occur, especially in individuals predisposed to mental disorders. Harm reduction practices are strongly recommended for those using this substance.

History and Culture

DMT's synthesis dates back to 1931 by German chemist Richard Helmuth Fredrick Manske. Its recognition as a natural product is credited to Brazilian chemist Oswaldo Gonçalves de Lima, who isolated the alkaloid nigerina from the root bark of jurema preta (Mimosa tenuiflora) in 1946. In 1959, American chemists identified DMT in Mimosa tenuiflora, and in 1955, it was isolated from the seeds and pods of Anadenanthera peregrina.

Since then, DMT has been discovered in numerous organisms, including at least fifty plant species across ten families and four animal species, encompassing a gorgonian and three mammalian species. The enigmatic history and diverse cultural applications of DMT contribute to its status as a fascinating and complex substance.

Chemistry

Substitutive Structure of Tryptamine Molecule

DMT, scientifically known as N,N-dimethyltryptamine, belongs to the tryptamine family, a group of organic compounds characterized by a core structure. This structure consists of a bicyclic indole heterocycle attached at R3 to an amino group via an ethyl side chain. In the case of DMT, two methyl groups (CH3-) are bound to the terminal amine RN at the end of this chain.

Tryptamines exhibit a rich diversity with numerous homologs and analogs. From base tryptamines like MET and DPT to more complex variants like 4-PO-DMT (psilocybin), 4-AcO-DMT (psilacetin), 5-HO-DMT (bufotenin), and 5-MeO-DMT, the family showcases a spectrum of chemical structures.

Physical Properties of DMT

Pure DMT manifests as a white, crystalline solid, often noted for its distinctive rubber-like smell. While it shows moderate solubility in water, it is readily soluble in organic solvents and aqueous acids.

Dosage

Understanding the dosage of DMT is crucial for safe consumption. Here are the general thresholds:

• Threshold: 2 mg
• Light: 10 - 20 mg
• Common: 20 - 40 mg
• Strong: 40 - 60 mg
• Heavy: 60+ mg

These dosage ranges provide a framework for users to gauge their DMT experience, with effects intensifying as dosage increases. Precise measurement and adherence to these thresholds are essential for managing the profound psychoactive effects associated with DMT consumption.

Pharmacology

Mechanism of Action

DMT, or N,N-dimethyltryptamine, induces psychedelic effects believed to stem from its interaction with the 5-HT2A receptor as a partial agonist. Despite this understanding, the precise role of these interactions and their contribution to the psychedelic experience remains a captivating enigma in the realm of pharmacology.

Furthermore, DMT is posited to function as an endogenous ligand for the sigma receptor. However, the significance of the sigma-1 receptor remains a subject of ongoing scientific exploration, adding a layer of complexity to our comprehension of DMT's pharmacological profile.

Subjective Effects

The effects of DMT are contingent on dosage and administration method, spanning from mild psychedelic states to intensely immersive, life-altering experiences. Users often describe these experiences as a profound departure from ordinary consciousness, reporting encounters with ineffable spiritual realms or alternate dimensions. Notably, high doses of DMT have been associated with reported interactions with mysterious 'beings' of unknown origin, a phenomenon studied and popularized by Terrence McKenna and Dr. Rick Strassman.

In its smokeable form, DMT is distinguished as one of the least mentally inebriating psychedelics. This clarity contributes to the perception of DMT as a genuine, tangible experience happening to the user. It's essential to recognize that smoked DMT, due to its short-acting nature, tends to produce fewer personal insights compared to orally active psychedelics like ayahuasca, LSD, and psilocybin.

Disclaimer on Effects

The subjective effects of DMT are cataloged through the Subjective Effect Index (SEI), derived from anecdotal user reports and personal analyses by contributors to PsychonautWiki. However, these effects should be approached with a healthy degree of skepticism, as they may not occur predictably or reliably.

It's crucial to note that higher doses are more likely to induce the full spectrum of effects, and with escalating doses, adverse effects become increasingly probable. These may include addiction, severe injury, or even death, underscoring the importance of responsible and informed use.

Physical Effects

Neurogenesis

DMT has been linked to neurogenesis, a process involving the growth and development of neurons in the brain.[19]

Spontaneous Bodily Sensations

The "body high" induced by DMT is characterized by a pleasurable, all-encompassing glow. This sensation intensifies swiftly with the onset of the experience, reaching its peak during the zenith and can persist for up to half an hour after the encounter concludes. At higher doses, this effect can become exceptionally potent.

Physical Euphoria

While DMT may produce physical euphoria, it is not as consistently experienced as with substances like stimulants or entactogens. In some cases, it can manifest as physical discomfort without apparent cause.

Changes in Felt Gravity

Higher breakthrough doses of DMT are associated with physical sensations of being propelled across vast distances at remarkable speeds, a phenomenon frequently reported by users.

Spatial Disorientation

DMT users may undergo spatial disorientation during their experience.

Changes in Felt Bodily Form

Alterations in the perception of one's bodily form are reported as part of the physical effects of DMT.

Physical Autonomy

A sense of physical autonomy can be experienced under the influence of DMT.

Nausea

While less common than with substances like 5-MeO-DMT or longer-lasting psychedelics such as psilocybin mushrooms or mescaline, nausea can still manifest spontaneously during a DMT experience and, in some instances, lead to sudden bouts of vomiting.

Pupil Dilation

Pupil dilation is a notable physical effect associated with DMT consumption.

Increased Heart Rate

DMT use is linked to an increase in heart rate.

Temperature Regulation Suppression

DMT may suppress the regulation of body temperature during its effects.

Seizure

Although an exceedingly rare occurrence, seizures have been reported in individuals predisposed to them, especially when conditions such as dehydration, fatigue, or malnourishment are present. This emphasizes the importance of caution, especially in physically demanding circumstances.

Cognitive Effects

Analysis Enhancement

DMT has been associated with enhancement in cognitive analysis.

Anxiety

Anxiety is a potential cognitive effect of DMT use.

Déjà Vu

Users may experience déjà vu during a DMT encounter.

Delusion

Delusional thinking can be part of the cognitive effects of DMT.

Ego Replacement

The phenomenon of ego replacement is reported as part of the cognitive experiences with DMT.

Emotion Enhancement

DMT may enhance emotional experiences during its effects.

Euthymia

When combined with psychotherapy, DMT has been noted to manifest acute euphoria, especially when used in a treatment program. Comparative meta-analyses suggest that psychedelic psychotherapy outperforms conventional "gold standard" treatments for several mental health issues.

Cognitive Euphoria

A sense of cognitive euphoria can be experienced under the influence of DMT.

Feelings of Impending Doom

Users may encounter feelings of impending doom during a DMT experience.

Increased Music Appreciation

At lower sub-breakthrough doses, DMT users may experience increased appreciation for music. However, this effect is not as pronounced as with longer-lasting psychedelics like LSD or psilocybin, and many users prefer silence to prevent overwhelming experiences.

Memory Suppression

Memory suppression is a reported cognitive effect of DMT.

Ego Death

DMT can induce ego death, a profound dissolution of the self.

Mindfulness

The cognitive effect of mindfulness tends to occur after the DMT experience has concluded, bringing an increased sense of presence, sensitivity to inner sensations, and awareness of the outer environment.

Multiple Thought Streams

During a DMT experience, individuals may encounter multiple thought streams in a chaotic fashion, often accompanied by a sense of cognitive overload.

Novelty Enhancement

Novelty enhancement is a cognitive effect associated with DMT use.

Personal Bias Suppression

DMT may suppress personal biases in cognition.

Rejuvenation

After the DMT experience concludes, a sense of rejuvenation is reported, particularly in Near-Death Experience (NDE) variants of a DMT experience.

Autonomous Voice Communication

Some users report autonomous voice communication as a cognitive effect of DMT.

Time Distortion

A prominent cognitive aspect of the DMT experience is time distortion. While the effects typically last under 15 minutes, users often subjectively feel as if the experience endured much longer, with reports of "many lifetimes" or even an "eternity." This effect is particularly notable in "breakthrough" experiences.

Visual Effects

Enhancements

DMT induces a spectrum of visual enhancements, altering perceptions and intensifying sensory experiences.

Colour Enhancement

Users may experience heightened perception of colors, enriching the visual landscape.

Pattern Recognition Enhancement

DMT enhances the ability to recognize intricate patterns, contributing to visual richness.

Visual Acuity Enhancement

Sharper visual acuity is a notable effect, enhancing the clarity of visual stimuli.

Magnification

Objects may appear magnified, intensifying their visual impact.

Distortions

Visual distortions, including melting, breathing, morphing, and flowing, are detailed, slow, smooth in motion, and static in appearance compared to other psychedelics.

Colour Replacement

The psychedelic experience may involve the replacement of colors, altering the visual palette.

Colour Shifting

Colors can shift and change dynamically, contributing to a dynamic visual experience.

Colour Tinting

Tints and hues may be added to the visual field, altering the overall color spectrum.

Tracers

Prolonged visual impressions or tracers may follow moving objects.

After Images

Retained images or afterimages can persist, influencing subsequent visual perceptions.

Recursion

Visual recursion, where patterns repeat within themselves, can be experienced.

Scenery Slicing

The visual field may exhibit slicing effects, creating distinct visual layers.

Symmetrical Texture Repetition

Symmetrical patterns and textures may repetitively unfold in the visual field.

Environmental Patterning

DMT may induce intricate patterns within the surrounding environment.

Geometry

The visual geometry associated with DMT resembles psilocin more than LSD. It is intricate, abstract, organic and digital, structured, brightly lit, multicolored, glossy, with sharp and soft edges, large, fast, smooth, and immersive. At higher doses, it tends to result in more complex states of visual geometry.

The smoked form of DMT is often considered to produce the most profound and intricate visual geometry in the psychedelic experience. In comparison to orally active DMT (ayahuasca), it exhibits a more digital appearance, akin to LSD in color, with a structured style reminiscent of a high dose of psilocin (4-HO-DMT).

Hallucinatory States

DMT induces a full spectrum of high-level hallucinatory states, consistently and reproducibly surpassing other psychedelics. These states include:

Machinescapes

Transformations

Internal Hallucination

DMT consistently produces high-level internal hallucinations, more reliably than other psychedelics. These can include lucid, interactive, novel, autonomous, geometry-based experiences, often with themes of personal, religious, spiritual, science-fiction, fantasy, surreal, nonsensical, or transcendental nature.

External Hallucination

External hallucinations, including autonomous entities, sceneries, landscapes, and perspective-based scenarios, are common, particularly in dark environments. They share characteristics of lucidity, interactivity, novelty, autonomy, geometry-based visuals, and thematic focus on personal, religious, spiritual, science-fiction, fantasy, surreal, nonsensical, or transcendental elements.

Auditory Effects

Enhancements

DMT is associated with enhancements in auditory acuity, with reports of heightened sensitivity often lingering post-experience, as noted in clinical studies with intravenously-administered DMT.

Distortions

Auditory distortions are part of the perceptual alterations induced by DMT.

Hallucinations

DMT produces auditory hallucinations, contributing to the multi-sensory richness of the experience.

Multi-sensory Effects

Synaesthesia

In its fullest manifestation, synaesthesia is a rare and non-reproducible effect associated with DMT. Increasing the dosage may elevate the likelihood of experiencing synaesthesia, particularly among individuals predisposed to synaesthetic states.

Transpersonal Effects

Spirituality Enhancement

DMT is known to enhance spirituality, fostering a profound connection to spiritual dimensions.

Existential Self-Realization

Users may undergo existential self-realization, gaining deep insights into their existence.

Near-Death Experience

DMT can induce an experience akin to a near-death experience, characterized by profound and transformative encounters.

Perception of Eternalism

Users may perceive a sense of eternalism, transcending the limitations of linear time.

Perception of Self-Design

The perception of self-design is a unique aspect of DMT experiences, offering insights into the nature of one's self.

Perceived Exposure to Inner Mechanics of Consciousness

DMT users may feel exposed to the inner mechanics of consciousness, gaining insights into the workings of the mind.

Unity and Interconnectedness

Experiences of unity and interconnectedness with the universe are common, fostering a deep sense of oneness.

For many individuals, these transpersonal effects are consistently more reproducible and powerful with smoked or vaporized DMT compared to other "classical psychedelics" like LSD or mescaline. This is likely attributed to DMT's intense yet relatively short-lived effects. These components are especially prevalent during "breakthrough" experiences as opposed to sub-breakthrough levels. The unique auditory symphony of DMT contributes to its reputation as a substance capable of unlocking profound and transcendent states of consciousness.

Progressive Stages

1. "Breaking Through"

When smoked or vaporized at moderate to heavy dosages, the DMT experience unfolds in a progressive sequence, beginning with the "Breaking Through" stage. This phase initiates with a distinctive come-up marked by heightened visual acuity and intensified color perception. Shortly after, a sudden onset of high-level 3 geometry envelops the external environment, often accompanied by auditory hallucinations like crackling sounds or extended high-pitched tones. Users may also experience physical sensations, such as the feeling of being pushed through a membrane or rapidly traversing space.

2. "The Waiting Room"

Following the breakthrough, individuals enter a transient phase known as "The Waiting Room" or "Loading Screen." This space, characterized by rapidly shifting and interlocking geometry, lasts approximately 10 to 20 seconds. It differs qualitatively from other stages of the experience, serving as a transitional state.

3. "The Other Side"

After the waiting period, users feel they have "broken through" to "The Other Side." Here, intense level 7 geometry and level 3-4 internal hallucinations unfold. Although experiences vary, DMT trips often follow common archetypes with scenarios, content, and plots. Users commonly describe visiting alternate realities containing autonomous entities, sceneries, landscapes, and themes of cosmic, transcendental, or transpersonal nature.

4. "Drifting Down"

The final stage involves the sensation of drifting away from the scenario until it fades, returning the user to reality. Accompanied by level 3-4 geometry, a sense of exhilaration and awe ensues. The moderate to mild geometry persists for another 10-15 minutes before dissipating, leaving behind a noticeable "body high" that lingers for up to an hour. This structured progression characterizes the profound and dynamic nature of the DMT experience, offering a glimpse into the intricate realms of consciousness.

Toxicity and Harm Potential

DMT, known for its intense psychedelic effects, is considered non-addictive and has an extremely low toxicity relative to dose. Extensive studies reveal few physical side effects associated with acute DMT exposure, indicating little to no negative cognitive, psychiatric, or physical consequences when used in reasonable doses in a controlled context.

Despite its apparent safety profile, caution is paramount, especially for individuals with underlying psychiatric conditions. Those with a personal or family history of mental illness are advised against using DMT without medical supervision.

Lethal Dosage

The median lethal dose (LD50) of DMT in humans remains unattainable, given its pharmacological properties. The substance's lack of dependence, abuse potential, and withdrawal symptoms contribute to its overall safety.

Dependence and Abuse Potential

DMT, like other serotonergic psychedelics, is considered non-addictive with low abuse potential. Animal studies demonstrate no successful attempts to induce self-administration of DMT, reinforcing its lack of dependence-inducing pharmacology. Tolerance to DMT effects is not observed, and cross-tolerance with other psychedelics is absent.

Dangerous Interactions

Caution is urged regarding potential dangerous interactions with other substances. Notably:

• Lithium: Combining DMT with lithium, prescribed for bipolar disorder, may increase the risk of psychosis and seizures.
• Cannabis: The synergy between cannabis and DMT can lead to unpredictable psychological reactions, emphasizing the need for caution in dosage and consumption intervals.
• Stimulants: Mixing DMT with stimulants like amphetamine or cocaine elevates the risk of anxiety, paranoia, panic attacks, and thought loops.
• Tramadol: Known to lower seizure thresholds, tramadol combined with psychedelics may trigger seizures in susceptible individuals.

Legal Status

Internationally, DMT is classified as a Schedule I controlled substance under the United Nations 1971 Convention on Psychotropic Substances. This classification implies close monitoring of international trade and restriction to scientific research and medical use. However, natural sources containing DMT, such as ayahuasca, are not regulated under this convention.

Country-specific Legal Status

Australia

DMT is a Schedule 9 controlled substance, strictly regulated for medical or scientific research purposes. Possession, sale, or use without approval is prohibited under the Misuse of Drugs Act 1981.

Austria

DMT is illegal to possess, produce, and sell under the Suchtmittelgesetz Österreich.

Belgium

DMT is illegal for possession, sale, purchase, and import.

Brazil

DMT is illegal for possession, production, and sale under Portaria SVS/MS nº 344, with relaxed rules for religious use.

Canada

DMT is listed in Schedule III of the Controlled Drugs and Substances Act.

Denmark

DMT is a Category B controlled substance.

Estonia

DMT is a Schedule I controlled substance.

France

DMT is classified as a narcotic.

Hungary

DMT is illegal for possession, production, and sale.

Germany

DMT is controlled under Anlage I BtMG (Narcotics Act, Schedule I).

Ireland

DMT is a Schedule 1 controlled substance under the Misuse of Drugs Acts.

Israel

DMT is an illegal substance, prosecuted as a crime for production, trade, and possession.

India

DMT is illegal to produce, transport, trade, or possess.

Italy

DMT is a Schedule I controlled substance.

Latvia

DMT is a Schedule I controlled substance.

The Netherlands

DMT is classified as a Lijst 1 (List I) controlled substance under the Opiumwet (Opium Law).

New Zealand

DMT is a Class A controlled substance under the Misuse of Drugs Act 1975.

Norway

DMT is a Schedule I controlled substance.

Russia

DMT is a список I (List I) controlled substance, illegal for possession, production, and sale.

Serbia

DMT is a List 4 controlled substance.

Sweden

DMT is controlled under Förteckning I (Schedule 1), with specific legal considerations regarding possession of processed plant material.

Switzerland

DMT is a controlled substance specifically named under Verzeichnis D.

United Kingdom

DMT is a Class A controlled substance.

United States

DMT is a Schedule I controlled substance, with rules relaxed for religious use. Recent DEA efforts focus on restricting internet sales of the bark containing DMT.

Czech Republic

DMT is a Schedule I controlled substance.

This detailed overview encompasses the toxicity, harm potential, and legal status of DMT, offering valuable insights for those navigating the intriguing landscape of psychedelic substances.

FAQ (Frequently Asked Questions)

Q1: Is DMT addictive?

DMT is considered non-addictive with a low abuse potential. Tolerance does not develop, and withdrawal symptoms are virtually non-existent.

Q2: What are the potential dangers of using DMT?

While DMT itself has low toxicity, it can act as a trigger for individuals with underlying psychiatric conditions. Adverse reactions, including severe anxiety and psychosis, are possible, particularly for those predisposed to mental disorders.

Q3: Can DMT be lethal?

The median lethal dose (LD50) of DMT in humans has not been reached, making it exceptionally low in toxicity relative to dose.

Q4: Are there dangerous interactions with other substances?

Yes, combining DMT with certain substances like lithium, cannabis, stimulants, or tramadol can lead to dangerous and potentially life-threatening interactions. Caution and independent research are essential.

Q5: What is the legal status of DMT?

Internationally, DMT is classified as a Schedule I controlled substance. However, regulations vary by country, with some allowing for religious or medicinal use.

Q6: What are the progressive stages of a DMT experience?

The DMT experience typically progresses through breaking through, entering a waiting room, reaching the other side, and finally drifting down to reality. Each stage involves distinct visual and sensory phenomena.

Q7: How long do the effects of DMT last?

The effects of smoked or vaporized DMT are intense but short-lived, typically lasting under 15 minutes. However, users may experience a lingering "body high" for up to an hour.

Q8: Can DMT be used for therapeutic purposes?

Research on the therapeutic potential of DMT is ongoing, with some studies exploring its role in treating mental health conditions. However, caution and medical supervision are advised.

Q9: How should DMT be approached for a safe experience?

Extreme caution and harm reduction practices are recommended when using DMT. Individuals with a history of mental illness or those in physically taxing conditions should avoid its use.

Q10: Are there religious exemptions for DMT use?

Some countries allow religious or ceremonial use of DMT, but regulations vary. It is crucial to be aware of and adhere to local laws regarding the substance's use.