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Product Name: Nitrous oxide
IUPAC Name: Dinitrogen monoxide
Other Names: Nitrous Oxide, Laughing Gas, Nitrous, Hippy Crack, NOS, Nitro, N2O, Nangs
Molecular Formula: None
Molar Mass: 237.26 g·mol−1
Effect: stimulant, psychedelic
Purity of the substance: 99.9%
Physical properties: Crystals, Powder
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Table of Contents

  1. History and Culture
  2. Chemistry
  3. Dosage
  4. Physical Effects
  5. Visual Effects
  6. Cognitive Effects
  7. Auditory Effects
  8. Multi-sensory Effects
  9. Transpersonal Effects
  10. Combinational Effects
  11. Toxicity and Harm Potential
  12. Legal Status
  13. FAQ


Nitrous oxide, also known as laughing gas, nitrous, NOS, and informally as hippy-crack, is an atypical dissociative substance primarily found in the form of an inhalable gas. Commonly used in medical, recreational, and industrial settings, nitrous oxide has garnered various nicknames such as whippits, nangs, or bulbs, particularly when referring to whipped cream chargers/cartridges.

Historical Background

Nitrous oxide's discovery dates back to 1772 when the British chemist Joseph Priestly first identified it. However, it wasn't until the 19th century that its anesthetic properties were recognized, making it suitable for dental and surgical procedures. The British chemist Humphry Davy famously dubbed it "laughing gas" due to its exhilarating and laughter-inducing effects. Over time, nitrous oxide found its place in various domains, including medicine, motorsports, and industry.

Mechanism of Action

The exact mechanism of action of nitrous oxide remains elusive, but it is believed to interact with GABA and NMDA receptors in the brain. These interactions contribute to its sedative, analgesic, and dissociative effects, among others.

Uses and Applications

Medical and Dental

Nitrous oxide is widely utilized in surgery and dentistry for its anesthetic and analgesic properties. Its ability to induce sedation and pain relief makes it valuable in alleviating discomfort during various medical procedures.


In the realm of motorsports, nitrous oxide is prized for its performance-enhancing effects on internal combustion engines. By introducing nitrous oxide into the combustion chamber, an increased oxygen concentration facilitates more efficient fuel combustion, resulting in enhanced engine power.


Beyond medical and recreational use, nitrous oxide serves various industrial purposes. It is commonly employed in manufacturing processes, including the production of chemicals and pharmaceuticals.


In recreational settings, nitrous oxide is sought after for its euphoric and dissociative effects. Users report sensations of sedation, motor control loss, anxiety suppression, conceptual thinking, and euphoria.

Safety and Considerations

Nitrous oxide is generally considered to have low to moderate abuse potential and low toxicity when used in moderation. However, like any substance, excessive or irresponsible use can lead to adverse effects and health risks.

History and Culture

Early Discoveries and Recreational Use

Nitrous oxide gas, first synthesized in 1772 by English natural philosopher and chemist Joseph Priestley, marked the beginning of its intriguing history. Priestley documented his findings in the book Experiments and Observations on Different Kinds of Air (1775), detailing the gas's synthesis through the heating of iron filings dampened with nitric acid. However, it wasn't until 1800 that Humphry Davy, an assistant at the Pneumatic Institute, delved further into nitrous oxide's properties and potential applications. Davy noted its analgesic effects and coined the term "laughing gas," leading to its recreational use at "laughing gas parties" among the British upper class starting from 1799.

Medical Applications

Despite its recreational popularity, nitrous oxide's potential for medical use remained largely untapped until the 19th century. In 1844, American dentist Horace Wells observed its anesthetic properties during a tooth extraction, a discovery that revolutionized dental and surgical procedures. With the assistance of colleagues, including Gardner Quincy Colton and John Mankey Riggs, Wells demonstrated the gas's ability to induce insensitivity to pain. By 1863, Gardner Quincy Colton had administered nitrous oxide to over 25,000 patients in his dental clinics, paving the way for its widespread medical use.

Industrial and Continued Medical Use

While nitrous oxide proved inadequate as a standalone anesthetic for major surgeries, it found a valuable role as an initiator for stronger anesthetics like ether or chloroform. This technique, initiated by administering a mild flow of nitrous oxide followed by a stronger anesthetic, is still utilized in hospitals today. Nitrous oxide's versatility extends beyond medicine; it is listed on the World Health Organization's List of Essential Medicines, highlighting its importance in healthcare systems worldwide.


Nitrous oxide, also known as dinitrogen monoxide, can be synthesized by gently heating ammonium nitrate to decompose it into nitrous oxide. Structurally, nitrous oxide possesses a linear molecular structure, existing in two resonance structures due to the delocalization of electrons. It functions as an oxidizer in rocketry and motor racing, augmenting engine power output. At room temperature, nitrous oxide is a colorless, non-flammable gas with a slightly sweet odor and taste.


Nitrous oxide's pharmacological effects, including its anesthetic, hallucinogenic, and euphoriant properties, are primarily attributed to its role as an NMDA receptor antagonist. By blocking NMDA receptors, nitrous oxide disrupts neuronal communication, leading to sensations of dissociation and anesthesia. Additionally, it modulates various other receptors, contributing to its diverse range of effects.

Subjective Effects

Disclaimer: The effects listed below are based on anecdotal user reports and analyses, and caution should be exercised when interpreting them. Nitrous oxide's effects may vary unpredictably, with higher doses carrying increased risks of adverse effects, including addiction and injury.



  • 4 g: At this dosage level, the effects of nitrous oxide are just beginning to manifest.


  • 4 - 8 g (1/2 - 1 cartridges): Light doses of nitrous oxide typically involve the consumption of half to one cartridge. Users may experience subtle effects at this level.


  • 8 - 16 g (1 - 2 cartridges): Common doses of nitrous oxide range from one to two cartridges. This dosage level often induces noticeable effects, including mild euphoria and dissociation.


  • 16 - 40 g (2 - 5 cartridges): Strong doses of nitrous oxide, involving the consumption of two to five cartridges, can lead to intensified effects, including pronounced euphoria and dissociation.


  • 40 g + (>5 cartridges): Heavy doses of nitrous oxide, exceeding five cartridges, carry a significant risk of adverse effects and should be approached with caution. Users may experience intense euphoria and dissociation at this dosage level.

Physical Effects


  • Long-term or recurrent use of nitrous oxide can lead to serious neurological harm.

Spontaneous Physical Sensations

  • The nitrous oxide "body high" typically begins with a diverse mixture of cold, warm, sharp, and soft tingles, initially focusing on the head and face at lower dosages and spreading throughout the body at higher dosages.

Changes in Felt Bodily Form

  • Higher dosages may induce sensations of the body's physical form being stretched into infinity, compressed into a singularity, or split into two separate halves.


  • Although uncommon, some individuals may experience dizziness while under the influence of nitrous oxide.


  • Certain individuals may report headaches during the offset of nitrous oxide, though this occurrence is relatively uncommon.

Motor Control Loss

  • Nitrous oxide can cause a loss of gross and fine motor control, as well as impair balance and coordination, particularly at higher dosages. Users are advised to sit down to prevent falls and injuries.

Perception of Bodily Lightness

  • Users may experience a sensation of weightlessness, with the body feeling as though it is floating or drifting.

Physical Euphoria

  • Nitrous oxide can induce mild to intense feelings of pleasure and bliss, with anecdotal reports suggesting enhancement of sexual experiences and orgasm.

Tactile Suppression

  • Nitrous oxide partially to entirely suppresses the sense of touch, resulting in feelings of numbness in the extremities, contributing to its anesthetic properties.

Vitamin Deficiency

  • Repeated use of nitrous oxide may lead to vitamin B12 deficiency, although this can be prevented with B12 supplements.

Visual Effects


  • Nitrous oxide can cause various visual suppressions, including blurred vision leading to blindness, frame rate suppression, and double vision, particularly at moderate dosages.


  • At higher dosages, users may experience static geometric patterns that appear in front of their vision, often accompanied by a sensation of merging with the patterns.

Hallucinatory States

  • Hallucinations are rare but possible at high dosages, manifesting as both external and internal experiences, often delirious in believability.

Cognitive Effects


  • High dosages of nitrous oxide may result in amnesia and memory loss following the experience, particularly alongside ego death.

Anxiety Suppression

  • Nitrous oxide can suppress feelings of anxiety, promoting a sense of relaxation and calmness.

Compulsive Redosing

  • Users may feel compelled to repeatedly consume nitrous oxide, increasing the risk of adverse effects.

Depersonalization and Derealization

  • Nitrous oxide may induce feelings of depersonalization and derealization, leading to a sense of detachment from oneself and the surrounding environment.

Déjà Vu

  • Some individuals may experience strong feelings of déjà vu under the influence of nitrous oxide, although this occurrence is uncommon and inconsistent.

Cognitive Euphoria

  • Users may experience mild to intense feelings of happiness and positivity.

Analysis Suppression

  • Nitrous oxide can suppress cognitive analysis and rational thinking, leading to a more fluid and immersive experience.

Increased Sense of Humor

  • The substance often enhances the perception of humor, leading to laughter fits and intense giggling.

Memory Suppression

  • Higher dosages may result in level 3 ego death, characterized by the rapid disintegration and re-stacking of one's sense of self and long-term memory.

Suggestibility Enhancement

  • Users may become more suggestible under the influence of nitrous oxide, leading to altered perceptions and behaviors.

Thought Deceleration

  • Nitrous oxide can slow down thought processes, resulting in a sense of mental relaxation and clarity.

Vivid Dreams

  • Some individuals may experience vivid and immersive dream-like experiences while under the influence of nitrous oxide.

Auditory Effects


  • Nitrous oxide can cause powerful distortions in auditory perception, including changes in volume, pitch, and tone, as well as the introduction of phasers, white noise, and echo effects.


  • External sounds may be muffled and indistinct under the influence of nitrous oxide, appearing distant and unclear.

Multi-sensory Effects


  • Some users may experience synaesthesia, where auditory stimuli are perceived as visual sensations, particularly within closed-eye visuals.

Transpersonal Effects

Unity and Interconnectedness

  • During high-dosage states of ego death, users may experience a sense of unity and interconnectedness with the greater whole.

Perception of Interdependent Opposites

  • Nitrous oxide may provide insights into conflicting ideas and concepts, leading to a perception of natural balance and harmony.

Combinational Effects

  • Nitrous oxide is often combined with other hallucinogens, such as psychedelics, dissociatives, cannabis, or alcohol, to potentiate their effects and create unique experiences.

oxicity and Harm Potential

The exact toxic dosage of nitrous oxide remains unknown, but potential problems associated with its use include:

Vitamin B12 Depletion

  • Nitrous oxide temporarily inhibits methionine synthase, a B12-dependent enzyme crucial for various bodily functions. Heavy and frequent long-term use can deplete vitamin B12 levels, leading to serious neurological problems. Symptoms may include numbness and tingling in the extremities, lips, and toes, progressing to numbness in all extremities in severe cases. Ceasing nitrous oxide use and seeking medical attention if symptoms persist is advised. Taking B12 supplements, especially in combination with multivitamins and complete amino acid supplements, may alleviate this issue.

Mistaken Identity with Nitric Oxide

  • Nitrous oxide is occasionally mistaken for nitric oxide, a toxic industrial gas. Inhaling nitric oxide can cause permanent lung damage or be fatal. Users should exercise caution and ensure they are inhaling the correct substance.

Harm Reduction Practices

  • It is strongly recommended to practice harm reduction when using nitrous oxide to minimize risks associated with its use.

Risks of Whipped-Cream Chargers Compared to Medical Nitrous Oxide

Vapor Pressure

  • Whipped-Cream Chargers: Direct inhalation from a tank or whippet can freeze the lips and throat due to the very cold temperatures of the gas. Releasing the gas into a balloon first allows it to warm before administration.
  • Medical Nitrous Oxide: Administered slowly to prevent adverse effects.


  • Whipped-Cream Chargers: Contains no oxygen, posing a risk of oxygen deprivation and suffocation if continuously inhaled without adequate oxygen intake.
  • Medical Nitrous Oxide: Typically administered in combination with oxygen to prevent hypoxia.


  • Whipped-Cream Chargers: May contain impurities such as industrial grease and steel particles from manufacturing. Filtering through cloth or regular cleaning of dispensing devices can reduce harm.
  • Medical Nitrous Oxide: Medical-grade quality, ensuring purity and safety.

Dependence and Abuse Potential

  • Nitrous oxide, like other dissociatives, can be mildly addictive with a moderate potential for abuse. Tolerance to its effects develops with prolonged use, leading to increased dosage requirements to achieve the same effects. Nitrous oxide does not produce cross-tolerance with other dissociatives.

Dangerous Interactions

  • Combining nitrous oxide with certain substances, such as alcohol, GHB, opioids, or tramadol, can potentiate sedation and ataxia, increasing the risk of loss of consciousness, aspiration, and memory blackouts. Users should conduct independent research to ensure safe consumption.

Legal Status


  • Nitrous oxide is legal for medical use but prohibited for recreational purposes.


  • Available for medical anesthesia purposes with regulations on gas cylinder transfer.

New Zealand

  • Requires a prescription for possession or sale under the Medicines Act.

United Kingdom

  • Illegal for recreational use under the Psychoactive Substances Act 2016, but "cream chargers" are legally sold.

United States

  • Legal under federal law but regulated by the FDA. State laws vary, with some prohibiting possession for recreational use and others regulating sale and distribution.


Nitrous oxide, with its intriguing history and multifaceted applications, remains a substance of significant interest across various fields. From its pivotal role in modern medicine to its recreational and industrial uses, understanding its effects and potential is crucial for ensuring safe and responsible utilization.


Q: What is nitrous oxide?

A: Nitrous oxide, also known as laughing gas, is an inhalable gas with dissociative properties. It was first synthesized in 1772 and has since been used for various purposes, including anesthesia and recreational use.

Q: How does nitrous oxide affect the body?

A: Nitrous oxide affects the body by temporarily inhibiting certain enzymes, leading to effects such as euphoria, numbness, and altered perception.

Q: What are the potential risks of using nitrous oxide?

A: Long-term or frequent use of nitrous oxide can deplete vitamin B12 levels, leading to neurological problems. Inhaling nitric oxide, often mistaken for nitrous oxide, can cause lung damage or be fatal. Additionally, misuse of nitrous oxide can lead to oxygen deprivation and suffocation.

Q: How can users minimize the risks associated with nitrous oxide use?

A: Users can minimize risks by practicing harm reduction techniques, such as using the substance in a safe environment, avoiding continuous inhalation without oxygen intake, and ensuring they are inhaling the correct substance.

Q: Is nitrous oxide addictive?

A: Nitrous oxide can be mildly addictive with a moderate potential for abuse. Tolerance to its effects develops with prolonged use, requiring increased dosage to achieve the same effects.

Q: What are some dangerous interactions associated with nitrous oxide?

A: Combining nitrous oxide with substances such as alcohol, opioids, or GHB can potentiate sedation and ataxia, increasing the risk of loss of consciousness and memory blackouts.

Q: What is the legal status of nitrous oxide?

A: The legal status of nitrous oxide varies by country. In some countries, it is legal for medical use but prohibited for recreational purposes, while in others, possession and sale may be regulated or prohibited altogether for recreational use.

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