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Product Name: 4-Hydroxy-N-methyl-N-ethyltryptamine / 4-Hydroxy-N,N-methylethyltryptamine
IUPAC Name: 3-{2-[Ethyl(methyl)amino]ethyl}-1H-indol-4-ol
Other Names: 4-HO-MET, Metocin, Methylcybin, "Colour"
Cas Number: 77872-41-4
Molecular Formula: C13H18N2O
Molar Mass: 218,2948 g/mol
Effect: stimulant, psychedelic
Purity of the substance: 99.9%
Physical properties: Crystals, Powder
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Introduction: In the realm of psychoactive compounds, 4-HO-MET stands out as a captivating substance that has garnered the attention of researchers and enthusiasts alike. With its intriguing History, unique effects, and complex chemistry, 4-HO-MET offers a fascinating window into the world of psychedelic compounds. This article will delve into various aspects of 4-HO-MET, ranging from its origins and effects to its legal status and pharmacology.

What is 4-HO-MET: 

4-HO-MET is a synthetic psychedelic compound known for its hallucinogenic effects.

4-HO-MET, or 4-hydroxy-N-methyl-N-ethyltryptamine, belongs to the tryptamine class of compounds. Structurally, it is closely related to the psychedelic compound psilocin, the active metabolite of psilocybin found in magic mushrooms. 4-HO-MET is known for its psychoactive effects, including alterations in perception, mood, and cognition, which make it a sought-after substance among those interested in exploring altered states of consciousness.

The History of 4-HO-MET: 

The History of 4-HO-MET intertwines the broader exploration of psychedelic compounds. It was first synthesized by Alexander Shulgin, a renowned chemist and psychopharmacologist, in the 1960s. Shulgin's work focused on synthesizing and studying various psychoactive substances, including multiple tryptamines. The synthesis of 4-HO-MET led to its inclusion in Shulgin's book "TiHKAL" (Tryptamines I Have Known and Loved), where he detailed its chemical structure and effects.

Effects of 4-HO-MET: 

The impacts of 4-HO-MET are commonly described as psychedelic, marked by alterations in sensory perception, mood elevation, and changes in thought patterns. Users often report visual distortions, such as enhanced colors, geometric patterns, and heightened sensory experiences. Unlike other psychedelics, 4-HO-MET is often noted for its relatively mild and manageable psychological effects. This has contributed to its appeal among individuals new to psychedelic experiences or those seeking a more gentle journey.

Dosage of 4-HO-MET: 

The appropriate dosage of 4-HO-MET can vary significantly based on individual factors such as body weight, tolerance, and previous psychedelic experience. Generally, lower doses in the range of 10 to 20 milligrams can produce mild visual effects and a sense of euphoria akin to the effects of other psychedelics. Higher doses, around 20 to 40 milligrams, may intensify the visual and cognitive outcomes. However, exceeding these dosages can lead to unpredictable and potentially adverse reactions, underlining the importance of responsible use and careful dose titration.

Legal Status of 4-HO-MET: 

The lawful Status of 4-HO-MET varies by jurisdiction. In many countries, it is not approved for medical or recreational use and is often classified as a controlled substance. The legality of 4-HO-MET falls in a gray area, especially considering its Status as a research chemical. Individuals must research and understand the laws governing the possession, distribution, and use of 4-HO-MET in their regions.

Pharmacology of 4-HO-MET: 

The pharmacology of 4-HO-MET involves its interactions with serotonin receptors in the brain. Like other tryptamines, 4-HO-MET primarily affects the serotonin 5-HT2A receptor, leading to altered sensory perception and changes in cognition. The mechanisms through which 4-HO-MET produces its effects have yet to be fully understood and require further research. Its pharmacological profile contributes to the compound's psychoactive properties and potential therapeutic applications, though research in this area is limited.

Chemistry of 4-HO-MET: 

Chemically, 4-HO-MET is a tryptamine derivative. It features a substituted indole ring structure, a common motif in many psychedelic compounds. The "4-HO" prefix indicates the presence of a hydroxyl group (OH) attached to the 4th position of the indole ring. This structural modification is essential for its psychoactive effects, as it allows 4-HO-MET to interact with serotonin receptors in the brain. The compound's molecular structure also influences its pharmacokinetics and metabolism within the body.

Where to purchase 4-HO-MET:

4-HO-MET is classified as a research chemical and is not approved for medical or recreational use in most jurisdictions. Consequently, its availability can be limited, and acquiring it can present legal and safety concerns. Online sources selling research chemicals might offer 4-HO-MET, but potential buyers must exercise extreme caution, ensuring they understand and abide by local laws and regulations.


In the realm of psychoactive substances, 4-HO-MET offers a captivating journey into altered states of consciousness. Its unique effects, rich History, and complex chemistry make it a subject of scientific inquiry and personal exploration. However, it is essential to emphasize that using 4-HO-MET, like any psychedelic compound, should be approached with caution, respect, and a deep understanding of its potential risks and benefits. As research into its pharmacology and effects continues, 4-HO-MET promises to expand our knowledge of the intricate relationship between chemistry, brain function, and human consciousness.

Frequently Asked Questions

What are the effects of 4-HO-MET?

It induces visual and auditory hallucinations, altered perception, and mood changes, typically lasting 4-6 hours.

Is 4-HO-MET legal?

Legal status varies by country and region, so it's essential to research the laws in your location.

What are the risks associated with 4-HO-MET?

Possible risks include anxiety, confusion, and, in some cases, disturbing hallucinations. Responsible use and harm reduction are crucial.

How does 4-HO-MET affect the mind?

It alters thought processes, perception of time, and can lead to introspective experiences. Effects can be unpredictable.

Are there known interactions with other substances?

4-HO-MET may interact with various substances, including antidepressants and other psychedelics. Always research potential interactions.

What should I know before trying 4-HO-MET?

Understanding dosage, setting, and the importance of having a trusted sitter are essential. Start with a low dose if you're inexperienced.

What is the typical duration of a 4-HO-MET trip?

Trips usually last 4-6 hours, with effects peaking around 2-3 hours after ingestion.

Are there any medical considerations?

If you have underlying medical conditions, consult a healthcare professional before using 4-HO-MET. It can impact blood pressure and heart rate.

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