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Introduction to 2-Fl-2'-Oxo-PCM

2-Fl-2'-Oxo-PCM, also known as 2-Fluorodeschloroketamine, 2-FDCK, and occasionally referred to as 2-Fluroketamine, Fluoroketamine, and 2-FK, is a novel and lesser-recognized dissociative substance belonging to the arylcyclohexylamine class. This comprehensive article aims to shed light on the intricate facets of 2-Fl-2'-Oxo-PCM.

Historical Origins

The precise origins of 2F-DCK remain largely unrecorded. It seemingly emerged within the online research chemical market in 2017, where it was marketed as a legal alternative to ketamine. Notably, its introduction followed the successful debut of a similar ketamine analog, deschloroketamine.

Chemistry Unveiled

2-Fluorodeschloroketamine, also identified as 2-(2-Fluorophenyl)-2-methylamino-cyclohexanone, falls into the category of arylcyclohexylamine drugs. This class of drugs is named for their distinctive structures, featuring a cyclohexane ring linked to an aromatic ring, accompanied by an amine group. In the case of 2-FDCK, it includes a phenyl ring bonded to a cyclohexane ring substituted with a ketone group (cyclohexanone). An amino methyl chain (-N-CH3) is attached to the adjacent alpha carbon (R2) of the cyclohexanone ring. Additionally, the phenyl ring is substituted at R2 with a fluorine group.

2-Fluorodescholoroketamine is a chiral molecule and is often produced as a racemate. The term 'des-' is a chemistry prefix indicating the absence of a specific functional group (in this instance, "chloro"). Therefore, 2-FDCK is named for its fluorine substitution at the phenyl ring rather than the chlorine found in ketamine.

Delving into Pharmacology

The limited research surrounding 2-FDCK necessitates basing discussions on its pharmacology on structural characteristics and the subjective effects observed, which bear resemblance to other arylcyclohexylamine dissociatives, such as DCK and ketamine. In this context, it is hypothesized that 2-Fluorodeschloroketamine operates as an NMDA receptor antagonist.

Physical Effects

• Pain Relief
• Spontaneous Physical Sensations
• Physical Euphoria
• Dizziness
• Loss of Motor Control
• Nausea
• Perception of Bodily Lightness
• Physical Autonomy
• Spatial Disorientation
• Tactile Suppression
• Orgasm Suppression

Disconnective Effects

• Tactile Disconnection
• Visual Disconnection: Leading to 2-Fluorodeschloroketamine's equivalent of the "k-hole," featuring spaces, voids, and structures.
• Consciousness Disconnection

Visual Effects

• Suppression
• Double Vision
• Frame Rate Suppression
• Pattern Recognition Suppression
• Visual Acuity Suppression
• Distortions
• Environmental Cubism
• Environmental Orbism
• Perspective Distortions
• Scenery Slicing
• Geometry
• Hallucinatory States
  • Internal Hallucination: Involving autonomous entities, settings, sceneries, landscapes, perspective hallucinations, scenarios, and plots

Cognitive Effects

2-FDCK's cognitive effects closely resemble those of ketamine, with some users noting nearly indistinguishable experiences. The 2-FDCK experience tends to proceed at a slower pace, accompanied by distinct psychedelic elements. However, it's essential to acknowledge that some users report a higher level of confusion and greater difficulty achieving a "hole" with higher doses. Nonetheless, 2-FDCK remains enjoyable and retains the antidepressant qualities of ketamine.

• Anxiety Suppression
• Compulsive Redosing
• Conceptual Thinking
• Enhanced Creativity
• Déjà Vu
• Depersonalization
• Derealization
• Disinhibition
• Dream Potentiation
• Cognitive Euphoria
• Enhanced Immersion
• Suppressed Analysis
• Introspection
• Memory Suppression
  • Ego Death
  • Amnesia
• Time Distortion
• Thought Deceleration
• Heightened Music Appreciation

Auditory Effects

• Distortions
• Hallucinations
• Suppression

Legal Status

The legal status of 2-Fluorodeschloroketamine varies from country to country:

• Austria: Illegal to possess, produce, and sell under the NPSG (Neue-Psychoaktive-Substanzen-Gesetz Österreich).
• Canada: Not specifically listed in the Controlled Drugs and Substances Act (CDSA) but could be considered controlled under schedule I due to structural similarity to ketamine.
• Germany: Controlled under the NpSG (New Psychoactive Substances Act) as of July 18, 2019, with specific legal provisions.
• Italy: Classified as a Schedule I (Tabella I) controlled substance.
• Latvia: Illegal in Latvia.
• Switzerland: Designated a controlled substance, specifically named under Verzeichnis E.
• Turkey: Classed as a drug and is illegal to possess, produce, supply, or import.
• United Kingdom: Classified as a class B drug, making it illegal to possess, produce, supply, or import, due to its structural similarity to ketamine.

2-Fl-2'-Oxo-PCM, with its intriguing characteristics and limited research, warrants careful and responsible use to ensure harm reduction.