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Table of Contents

• Introduction
• History and Cultural Context
• Chemical Structure
• Pharmacology
• Subjective Effects
• Safety and Toxicity

Introduction

4-Acetoxy-N,N-dimethyltryptamine (commonly referred to as 4-AcO-DMT, 4-acetoxy-DMT, O-acetylpsilocin, psilacetin, or "synthetic mushrooms") is a lesser-known psychedelic substance belonging to the tryptamine class. It is chemically related to psilocybin and psilocin, which are the active compounds found in psilocybin mushrooms, commonly known as "magic mushrooms." Although 4-AcO-DMT is believed to exert its psychedelic effects through binding to serotonin receptors in the brain, the exact mechanisms of action remain unclear.

History and Cultural Context

4-AcO-DMT was first synthesized in 1963 by chemists Albert Hofmann and Franz Troxler during a study aimed at exploring psilocin analogs. Despite its synthesis, the compound was not evaluated for its psychoactive properties at that time, and it remains unknown when it was first used in humans. In 1999, David E. Nichols suggested that 4-AcO-DMT could serve as a cost-effective alternative to psilocybin for pharmacological research. Following its introduction to the online research chemical market in the 2010s, reports of recreational use began to emerge, highlighting the compound's growing popularity among those interested in novel psychoactive substances.

Chemical Structure

4-AcO-DMT is a synthetic tryptamine characterized by a bicyclic indole heterocycle, which is connected to a terminal amino group via an ethyl side chain. In its structure, the compound features an acetoxy (-AcO) functional group at the R4 position of the indole heterocycle. Additionally, 4-AcO-DMT contains two methyl groups (CH₃) attached to the terminal amine nitrogen (RN) of the ethyl side chain.

This compound acts as the acetate ester analog of psilocin (4-HO-DMT) and is also the N-substituted methyl homolog of 4-AcO-MET. It represents the O-acetylated form of psilocin, contrasting with psilocybin, which is the O-phosphorylated form.

Pharmacology

Upon entering the body, 4-AcO-DMT, also known as O-acetylpsilocin, undergoes deacetylation to form psilocin, facilitated by deacetylases and acetyltransferases during first-pass metabolism in the liver. This conversion process indicates that 4-AcO-DMT retains psychoactive properties when ingested, as evidenced by its efficacy through various routes, including parenteral administration.

The psychedelic effects associated with 4-AcO-DMT are believed to arise from its activity as a partial agonist at the 5-HT2A serotonin receptor. However, ongoing scientific investigations continue to explore the complex role of these interactions and their contributions to the psychedelic experience.

User reports highlight subjective differences in the effects experienced between the acetylated and non-acetylated forms of psilocin. Some users claim that 4-AcO-DMT lasts slightly longer than psilocin, while others assert that it has a shorter duration. Furthermore, many individuals report experiencing less body load and nausea with 4-AcO-DMT compared to psilocin. Some users also suggest that the visual effects produced by 4-AcO-DMT are more akin to those of DMT rather than those of psilocybin or psilocin. These observations raise the possibility that 4-AcO-DMT may be psychoactive in its own right, rather than merely functioning as a prodrug. Nonetheless, no controlled clinical studies have yet been conducted to definitively distinguish the phenomenological effects of 4-AcO-DMT, psilocin, and psilocybin.

Subjective Effects

Users of 4-AcO-DMT typically report a range of subjective effects, including:

• Geometric Visual Effects: Many experience vivid, intricate geometric patterns and visuals.
• Time Distortion: Users often perceive changes in the passage of time, feeling as if it has slowed down or sped up.
• Enhanced Introspection: The compound frequently promotes deep self-reflection and introspective thoughts.
• Euphoria: Users report significant feelings of joy and well-being.
• Ego Loss: Some individuals experience a dissolution of the ego, fostering feelings of interconnectedness.

These effects are often considered similar to those induced by psilocybin, with some nuances that may differ between users.

Safety and Toxicity

Currently, there is a paucity of data regarding the pharmacology, metabolism, and toxicity of 4-AcO-DMT. Although it is generally believed that its toxicity profile mirrors that of psilocybin mushrooms, which are recognized as physiologically non-toxic, robust data to substantiate this assertion is lacking. Consequently, it is strongly advised for users to adopt harm reduction practices when considering the use of this substance, given the uncertainties surrounding its safety and long-term effects.

Subjective Effects

Users of 4-AcO-DMT often report experiences that are closely akin to those induced by psilocybin mushrooms. Descriptions of the experience include feelings of euphoria, warmth, and vibrant colors. Many users note that the visual effects can be brighter and more neon-like compared to those experienced with psilocybin, along with reduced nausea due to the absence of mushroom matter that needs to be digested.

Physical Effects

4-AcO-DMT can elicit a variety of physical sensations, including:

• Sedation: Often described as relaxing and mildly sedating, users frequently experience yawning and watery eyes.
• Perception of Bodily Heaviness: Users may feel a sense of heaviness in their body.
• Spontaneous Bodily Sensations: The substance can produce pleasurable, warm, and tingling sensations throughout the body.
• Tactile Enhancement: Users report heightened sensitivity to touch, though this is less intense compared to other psychedelics like LSD or 2C-B.
• Changes in Felt Bodily Form: Many users experience a sense of physical connection with objects around them, often described as comforting.
• Temperature Regulation Suppression: Users may experience fluctuations in body temperature, making a climate-controlled environment advisable.
• Nausea: This can often be minimized by taking the substance on an empty stomach or after a light meal.
• Muscle Relaxation and Contractions: Muscle contractions, if experienced, tend to be mild compared to other psychedelics.
• Increased Salivation and Pupil Dilation: Users may experience heightened salivation and dilated pupils.
• Watery Eyes and Frequent Urination: Common physiological responses during the experience.

Visual Effects

4-AcO-DMT produces a wide range of visual phenomena, including:

• Enhancements:

  • Visual Acuity and Color Enhancement: Colors appear more vivid and pronounced.
  • Pattern Recognition: Users may notice intricate patterns that emerge in their visual field.

• Distortions:

  • Drifting and Morphing: Visuals may appear to melt, flow, or breathe, characterized by slow and detailed movements.
  • Color Shifting and Tinting: Subtle changes in color perception occur.
  • Symmetrical Texture Repetition: Users may see patterns that repeat in symmetry throughout their visual field.

• Geometry: The geometric patterns experienced are often more reminiscent of those from psilocin and ayahuasca rather than those from LSD, featuring complex, organic forms that are brightly colored and softly edged.

• Hallucinatory States: High doses can lead to profound hallucinatory experiences that are interactive and personal in nature, often involving transformations or visions of landscapes and entities.

Cognitive Effects

The cognitive landscape of 4-AcO-DMT experiences is often described as:

• Relaxed and Profound: The experience is typically slower-paced compared to other psychedelics like LSD, fostering a state of clarity and introspection.
• Analysis and Novelty Enhancement: Users may find that their analytical thinking is enhanced, alongside a heightened appreciation for new experiences.
• Creativity Enhancement: The substance can foster an increase in creative thinking.
• Emotion Enhancement: Users often experience heightened emotional states, leading to feelings of compassion and connection.
• Language Suppression: A common effect, particularly in inexperienced users, where individuals may feel less inclined to articulate their thoughts verbally despite a clear internal narrative.
• Ego Death and Rejuvenation: Some users report feelings of ego dissolution, often accompanied by a rejuvenating sensation following challenging phases of the experience.

Legal Status

The legal standing of 4-AcO-DMT varies by country, existing in a gray area in many jurisdictions:

• Australia: Considered an analog of psilocin and classified as a Schedule 9 controlled substance.
• Belgium: Illegal to import.
• Brazil: Illegal to possess, produce, and sell.
• Germany: Controlled under the Narcotics Act, illegal without a license.
• Italy: Classified as illegal due to its relationship with other controlled substances.
• Japan: A controlled substance since July 29, 2015.
• Sweden: Classified as a Schedule I controlled substance.
• Switzerland: Could be considered illegal as an ester analog of psilocin.
• Turkey: Classified as a controlled substance, illegal to possess or produce.
• United Kingdom: Designated as a Class A drug.
• United States: Not specifically scheduled but could be treated as an analogue of psilocin, invoking potential legal repercussions under the Federal Analogue Act.

FAQ: 4-AcO-DMT

1. What is 4-AcO-DMT?

4-AcO-DMT, or 4-acetoxy-N,N-dimethyltryptamine, is a synthetic psychedelic compound that is chemically similar to psilocybin and psilocin, the active ingredients in magic mushrooms. It is known for producing effects similar to those of psilocybin.

2. How does 4-AcO-DMT work?

4-AcO-DMT primarily interacts with serotonin receptors in the brain, particularly the 5-HT2A receptor, which is thought to mediate its psychedelic effects.

3. What are the effects of 4-AcO-DMT?

Users typically report a range of effects, including euphoria, enhanced sensory perception, vivid visual hallucinations, and altered thought processes. The experience can also include physical sensations like body heaviness and tactile enhancement.

4. How long do the effects of 4-AcO-DMT last?

The effects of 4-AcO-DMT usually last between 4 to 6 hours, with the peak effects occurring around 2 to 3 hours after ingestion.

5. How is 4-AcO-DMT consumed?

4-AcO-DMT can be consumed orally, often in the form of powder, capsules, or blotter paper. It can also be ingested as a solution.

6. Is 4-AcO-DMT safe?

While many users report positive experiences, the safety of 4-AcO-DMT has not been extensively studied in clinical settings. Like all psychedelics, it carries potential risks, especially in individuals with a history of mental health issues.

7. What are the side effects of 4-AcO-DMT?

Common side effects may include nausea, vomiting, headaches, anxiety, and muscle contractions. Some users also experience excessive yawning, watery eyes, and changes in body temperature.

8. Can 4-AcO-DMT cause addiction?

There is currently no evidence to suggest that 4-AcO-DMT is physically addictive. However, it can lead to psychological dependence in some individuals.

9. What is the legal status of 4-AcO-DMT?

4-AcO-DMT exists in a legal gray area in many countries. It is not classified under international drug schedules but may be considered an analogue of psilocin in some jurisdictions, which could lead to legal consequences.

10. Can you overdose on 4-AcO-DMT?

While there are no widely reported cases of fatal overdose specifically from 4-AcO-DMT, high doses can lead to intense and potentially overwhelming experiences that may be psychologically distressing.

11. What are the differences between 4-AcO-DMT and psilocybin?

4-AcO-DMT is chemically similar to psilocybin and is thought to produce similar effects. However, some users report that 4-AcO-DMT has a more synthetic feel and less nausea than traditional psilocybin mushrooms.

12. Is 4-AcO-DMT legal in my country?

The legal status of 4-AcO-DMT varies widely by country. It’s essential to check local laws to determine if it is legal to possess, use, or sell in your area.

13. What is the recommended dose for 4-AcO-DMT?

Dosing can vary depending on individual tolerance, but common doses range from 10 mg to 30 mg for most users. Beginners should start with a lower dose to gauge their sensitivity.

14. Can 4-AcO-DMT cause long-term psychological effects?

While many users report positive long-term changes in perspective and emotional well-being, there is also the potential for negative psychological effects, especially in individuals predisposed to mental health issues.

15. What is the best environment for taking 4-AcO-DMT?

A safe, comfortable, and controlled environment is crucial for a positive experience. Users often recommend a quiet, familiar space with minimal distractions and access to calming music or visuals.

16. How does 4-AcO-DMT compare to other psychedelics?

4-AcO-DMT is often compared to psilocybin, LSD, and DMT. Each substance has its unique effects, durations, and experiences, but 4-AcO-DMT is typically noted for its euphoric and introspective qualities.

17. What should I do if I have a bad trip?

If experiencing a bad trip, it's essential to remain calm. Deep breathing, grounding techniques, and having a trusted friend present can help. In severe cases, professional help may be necessary.

18. Can 4-AcO-DMT be used for therapeutic purposes?

There is ongoing research into the therapeutic potential of psychedelics, including 4-AcO-DMT. While anecdotal evidence suggests potential benefits for mental health, more rigorous studies are needed.

19. Is there a risk of drug interactions with 4-AcO-DMT?

4-AcO-DMT may interact with other substances, especially other psychedelics, stimulants, or drugs that affect serotonin levels. Always consult a healthcare professional before combining substances.

20. How can I prepare for a 4-AcO-DMT experience?

Preparation is key. It is advisable to educate yourself about the substance, set intentions for your experience, ensure a supportive environment, and consider having a sober sitter present for safety.