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Product Name: LSA
IUPAC Name: none
Other Names: LSA
Cas Number: none
Molecular Formula: none
Molar Mass: none g•mol-1
Effect: psychedelic, hallucinogen
Purity of the substance: 99.9%
Physical properties: liquid, blotters
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Table of Contents

  1. Introduction

    • Overview of Lysergic Acid Amide (LSA)
    • Historical Background
    • Chemical Similarities with LSD
  2. Chemistry

    • Molecular Structure of LSA
    • Chirality and Stereoisomers
    • Relationship with LSD and Use as a Precursor
  3. Pharmacology

    • 5-HT2A Receptor Interaction
    • Psychedelic Effects and Scientific Investigation
    • Challenges to LSA as the Primary Constituent
  4. Subjective Effects

    • Physical Effects
    • Cognitive Effects
    • Auditory and Transpersonal Effects
    • Visual Effects
    • Hallucinatory States
  5. Combination Effects

    • Cannabis
    • Dissociatives
    • Alcohol
    • Benzodiazepines
    • Psychedelics
  6. Natural Plant Sources

    • Morning Glory Seeds (MGS)
    • Hawaiian Baby Woodrose Seeds (HBWR)
    • Preparation Methods
  7. Toxicity and Harm Potential

    • Vasoconstriction
    • Dependence and Abuse Potential
  8. Dangerous Interactions

    • Lithium
    • Cannabis
    • Stimulants
    • Tramadol
    • SSRIs and MAOIs
    • Other Interactions
  9. Legal Status

    • Global Overview
  10. FAQ (Frequently Asked Questions)

    • Is LSA addictive?
    • What are the potential side effects?
    • How can users reduce nausea associated with LSA consumption?
    • What precautions should be taken when combining LSA with other substances?
    • How do LSA's legal status vary across different countries?


Lysergic acid amide (LSA), also known as ergine, d-lysergic acid amide, and d-lysergamide, stands as a naturally occurring psychedelic substance belonging to the lysergamide class. As an ergot alkaloid, LSA is the primary psychoactive element in morning glory seeds. With a chemical relation to LSD, LSA is reported to induce similar effects, albeit with some uncertainties. First described in 1932 during an investigation into ergot alkaloids, LSA was synthesized and tested for human activity in 1947 by Albert Hofmann. Today, it is commonly consumed through morning glory and Hawaiian baby woodrose seeds, with user reports emphasizing sedation, dream-like sensations, and mild to moderate psychedelia.


LSA, or d-lysergic acid amide, is an organic alkaloid featuring a lysergic acid core structure with an amine functional group bound to RN. Structurally similar to LSD, LSA lacks the diethyl substitution at RN, making it a chiral compound with an absolute configuration of (5R, 8R). It serves as a precursor to LSD and has two stereocenters at R5 and R8. The psychedelic effects of LSA are attributed to its partial agonism at the 5-HT2A receptor, yet the exact mechanism remains under scientific scrutiny.


Despite LSA's recognition as the primary psychedelic component in morning glory and Hawaiian baby woodrose seeds, the effects of isolated synthetic LSA are reported to be only mildly psychedelic. The possibility of a combination of lysergamide alkaloids, including iso-LSA and LSH, contributing to the overall experience has been proposed. The role of these interactions in producing the psychedelic experience remains a topic of scientific investigation.

Subjective Effects

Physical Effects:

  • Sedation: LSA is predominantly sedating, with settings influencing its stimulant or relaxing nature.
  • Spontaneous bodily sensations: A mild, pleasurable tingling sensation accompanied by waves of physical euphoria.
  • Perception of bodily heaviness.
  • Physical euphoria: More readily produced by LSA than LSD, but may be masked by nausea and vasoconstriction.
  • Motor control loss: More pronounced at higher doses.
  • Temperature regulation suppression.
  • Nausea: Potentially caused by other seed components, alleviated by extraction methods or ginger tea.
  • Vasoconstriction: Commonly reported, varying in intensity, causing joint and limb pains.
  • Increased heart rate.
  • Increased or decreased blood pressure: Alternating at different points in the experience.
  • Muscle contractions, relaxation, and spasms.
  • Dehydration, dizziness, headaches, appetite suppression, gustatory enhancement, orgasm suppression, excessive yawning, pupil dilation, photophobia, increased perspiration, difficulty urinating.

Cognitive Effects:

  • Analysis enhancement: Introspection dominant.
  • Anxiety or anxiety suppression.
  • Conceptual thinking, cognitive euphoria.
  • Déjà vu, delusion, emotion enhancement.
  • Empathy, affection, and sociability enhancement.
  • Increased music appreciation.
  • Immersion enhancement.
  • Language suppression: Mild compared to classical psychedelics.
  • Increased sense of humor, laughter fits.
  • Memory suppression, ego death, mindfulness.
  • Novelty enhancement, rejuvenation.
  • Autonomous voice communication, thought acceleration, connectivity, loops.
  • Time distortion, wakefulness.

Auditory Effects:

  • Auditory enhancement, distortion, hallucinations.

Transpersonal Effects:

  • Spirituality enhancement.
  • Existential self-realization: Less common compared to classical psychedelics.
  • Unity and interconnectedness.

In conclusion, while LSA offers a unique psychedelic experience, users should be cautious due to potential adverse reactions. Harm reduction practices are highly recommended, especially for individuals predisposed to psychiatric disorders. Further research is essential to fully understand the pharmacology and subjective effects of LSA.

Physical Effects of LSA

Sedation and Stimulation

LSA is predominantly sedating, but its effects can vary based on the setting. In environments with stimuli or physical activities like walking or dancing, LSA can become stimulating and energetic. Conversely, in calm settings, it tends to induce relaxation and sedation.

Spontaneous Bodily Sensations

The "body high" of LSA is characterized by a mild, pleasurable, and soft tingling sensation. High doses accompany strong waves of physical euphoria, manifesting unpredictably throughout the trip and dominating the experience more than visual and cognitive effects, distinguishing it from LSD.

Perception of Bodily Heaviness

Users may experience a perception of bodily heaviness, contributing to the overall physical sensation associated with LSA consumption.

Physical Euphoria

Reportedly more readily produced by LSA than LSD, physical euphoria may be masked by nausea and vasoconstriction, especially when consuming LSA-containing seeds without prior extraction.

Motor Control Loss

At higher doses, motor control loss becomes pronounced, akin to the loss experienced with alcohol-induced inebriation. This effect is intensified by the perception of bodily heaviness.

Temperature Regulation Suppression

LSA may suppress temperature regulation, affecting how individuals perceive and respond to environmental temperatures.


Nausea associated with LSA is attributed to other seed components rather than LSA itself. Various extraction methods and anecdotal reports suggest remedies like ginger tea or cannabis to counteract nausea.


Commonly reported, LSA induces strong and pronounced vasoconstriction, potentially causing joint and limb pains. The discomfort level varies between individuals and is noted to be more intense compared to other psychedelics.

Cardiovascular Effects

LSA has been reported to influence heart rate and blood pressure, with instances of both increased and decreased blood pressure during different phases of the experience. The dependency on seed variations and alkaloid contents remains unclear.

Muscle Effects

Muscle contractions, relaxation, and spasms, along with potential dehydration, dizziness, headaches, and appetite suppression, are reported physical effects of LSA.

Sensory Effects

Gustatory enhancement, orgasm suppression, excessive yawning, pupil dilation, photophobia, increased perspiration, and difficulty urinating are additional sensory effects associated with LSA consumption.

Cognitive Effects of LSA

Relaxing Lucidity

Described as extremely relaxing yet lucid and clear-headed compared to other psychedelics, LSA may produce fast-paced bursts of thought and stimulation at random intervals despite its primarily sedating nature.

Subjective Cognitive Effects

LSA induces a range of psychedelic cognitive effects, including analysis enhancement, anxiety or anxiety suppression, conceptual thinking, cognitive euphoria, déjà vu, delusion, emotion enhancement, empathy, affection, sociability enhancement, and increased music appreciation.

Immersive Experiences

Users may undergo immersion enhancement, language suppression (mild compared to other psychedelics), increased sense of humor, laughter fits, memory suppression, ego death, mindfulness, novelty enhancement, rejuvenation, autonomous voice communication, thought acceleration, thought connectivity, thought loops, time distortion, and wakefulness.

Auditory Effects and Transpersonal Experiences

Auditory Effects

Auditory enhancement, distortion, and hallucinations are reported auditory effects associated with LSA consumption.

Transpersonal Experiences

LSA induces spirituality enhancement, and existential self-realization, although less common compared to classical psychedelics like LSD, psilocybin mushrooms, and mescaline. Unity and interconnectedness are also reported transpersonal effects.

Visual Effects of LSA

Mild Visual Effects

Visual effects of LSA are primarily present at large doses, but they are proportionally milder compared to its cognitive and physical effects. Enhancements such as color enhancement, pattern recognition enhancement, visual acuity enhancement, and frame rate enhancement are reported.

Visual Distortions

Visual distortions in LSA are simpler than those found with other psychedelics. Depth perception distortions, drifting, color shifting, tracers, scenery slicing, and symmetrical texture repetition are noted visual distortions.

Visual Geometry

LSA's visual geometry is intricate, abstract, organic, unstructured, dimly lit, multicolored, glossy, soft-edged, small-sized, slow in speed, smooth in motion, rounded in corners, non-immersive, and consistent in intensity. Higher doses are more likely to produce 8B geometry over 8A geometry.

Hallucinatory States

Large doses of LSA can induce high-level hallucinatory states, including transformations, internal hallucinations (autonomous entities, settings, sceneries, landscapes, and perspective hallucinations), and external hallucinations (rare, but lucid and autonomous). Peripheral information misinterpretation is also reported as an effect of LSA.

Combination Effects with LSA


Cannabis can significantly enhance both the sensory and cognitive effects of LSA. However, extreme caution is advised when combining these substances, as it may substantially increase the likelihood of negative psychological reactions such as anxiety, confusion, and psychosis. Users opting for this combination are recommended to start with only a fraction of their usual cannabis dose and take extended breaks between hits to minimize the risk of adverse reactions.


Dissociatives amplify the cognitive, visual, and general hallucinatory effects of LSA. The combination may result in vivid visuals, intense internal hallucinations, and an elevated risk of confusion, delusions, and psychosis. Users should approach this combination with caution due to the potential for heightened effects.


Alcohol, with its central depressant effects, can be used to alleviate anxiety and tension induced by LSA. However, caution is urged as alcohol may contribute to dehydration, nausea, and physical fatigue, potentially worsening the overall experience. If alcohol is used, moderation is key, and only a fraction of the usual amount is advised.


Benzodiazepines, depending on the dose, can partially or completely diminish the intensity of cognitive, physical, and visual effects during an LSA trip. While effective in halting "bad trips," caution is essential due to the potential for abuse. Acquiring benzodiazepines for this purpose requires careful consideration.


Combining LSA with other psychedelics intensifies the physical, cognitive, and visual effects synergistically. The unpredictable nature of this synergy generally discourages such combinations. If users choose to combine psychedelics, it is strongly recommended to start with significantly lower dosages than those taken for each substance individually.

Natural Plant Sources

Morning Glory Seeds (MGS)

Although LSA is illegal in some regions, various seeds containing it are available in gardening stores. Seeds from commercial sources often have coatings or fungicides that can lead to extreme nausea, discomfort, or neurological damage if ingested. Cleaning or de-coating methods may be ineffective, making it crucial to purchase untreated seeds from reliable vendors. Heavy metal testing kits are recommended to assess mercury content before ingestion.

Typical Oral Doses:

  • Threshold: 20 - 50 seeds / 1.5 g
  • Light: 50 - 100 seeds / 1.5 - 3 g
  • Common: 100 - 250 seeds / 3 - 6 g
  • Strong: 250 - 400 seeds / 6 - 10 g
  • Heavy: 400 seeds + / 10 g +

Hawaiian Baby Woodrose Seeds (HBWR)

Hawaiian baby woodrose, a climbing vine native to the Indian subcontinent, contains lysergamide alkaloids like LSA. Typical oral doses for HBWR seeds are provided below:

Typical Oral Doses:

  • Threshold: 1 - 3 seeds
  • Light: 3 - 5 seeds
  • Common: 5 - 7 seeds
  • Strong: 7 - 12 seeds
  • Heavy: 12 seeds +

Preparation Methods

LSA-containing seeds can be prepared using various methods, including simple extraction, tincture of extracted LSA, and low-dose cold water extraction (CWE). Detailed methods are available in the tutorial index.

Toxicity and Harm Potential

The toxicity and long-term health effects of recreational LSA use remain unstudied in a scientific context, and the exact toxic dose is unknown. Anecdotal evidence suggests minimal negative effects at low to moderate doses. Independent research is crucial to ensure safety when combining substances, and harm reduction practices are strongly recommended.


Regular, prolonged use of LSA can lead to increased vasoconstriction effects with weaker psychoactive effects. Recognizable signs include painful or uncomfortable legs, indicating reduced blood flow to muscles. Abstaining from LSA for up to three days is reported to return vasoconstriction to baseline.

Dependence and Abuse Potential

LSA is considered non-addictive with low abuse potential. There are no reports of successful attempts to train animals to self-administer LSA, indicating a lack of necessary pharmacology for dependence. Tolerance forms immediately after ingestion, taking about seven days to return to baseline.

Dangerous Interactions


Combining lithium, commonly prescribed for bipolar disorder, with psychedelics, including LSA, significantly increases the risk of psychosis and seizures, making this combination strongly discouraged.


Cannabis may unpredictably enhance the effects of LSA, leading to adverse psychological reactions. Caution is advised, and users are recommended to start with a fraction of their normal cannabis dose and take long breaks between hits to avoid unintentional overdose.


Stimulants like amphetamine, cocaine, or methylphenidate, when combined with LSA, can heighten the risk of anxiety, paranoia, panic attacks, and thought loops. There may also be an increased risk of mania and psychosis.


Tramadol, known to lower the seizure threshold, combined with psychedelics like LSA, may trigger seizures in susceptible individuals.

Other Interactions


Selective serotonin reuptake inhibitors (SSRIs) suppress the visual and cognitive effects of LSA, while MAO inhibitors potentiate visual and introspective effects. Caution is advised when combining MAOIs with psychedelics due to the increased risk of a bad trip and potential dangerous interactions with other substances.

Legal Status

The legal status of LSA varies worldwide:

  • Australia: Illegal
  • Austria: Not regulated
  • Germany: Controlled under NpSG
  • Latvia: LSA itself is controlled; status of LSA-containing seeds unclear
  • The Netherlands: LSA is illegal; morning glory and Hawaiian baby woodrose seeds are legal
  • New Zealand: Illegal
  • Sweden: Being researched; future illegality possible
  • Switzerland: Legal for scientific or industrial use; plant matter is not illegal
  • Türkiye: Illegal
  • United Kingdom: Class A controlled substance

United States: DEA Schedule III controlled substance; seeds containing LSA legal for purchase.

FAQ (Frequently Asked Questions)

Is LSA addictive?

No, LSA is considered non-addictive with a low abuse potential. There are no reported instances of successful attempts to train animals to self-administer LSA, indicating a lack of pharmacology for dependence.

What are the potential side effects?

While LSA is not considered addictive, users may experience adverse reactions such as severe anxiety, paranoia, and psychosis, especially among individuals predisposed to psychiatric disorders. Users may also encounter nausea and bodily discomfort, commonly referred to as "body load."

How can users reduce nausea associated with LSA consumption?

Various extraction methods can be employed to significantly reduce or eliminate nausea caused by LSA-containing seeds. Anecdotal reports also suggest that ginger tea or cannabis may help counteract nausea.

What precautions should be taken when combining LSA with other substances?

Combining LSA with substances like cannabis, dissociatives, alcohol, benzodiazepines, or other psychedelics requires caution. Users are advised to start with lower doses and take breaks to avoid negative psychological reactions.

How do LSA's legal status vary across different countries?

LSA's legal status varies globally. While some countries strictly regulate or prohibit its use, others may allow certain plant sources containing LSA. Users should be aware of and comply with the specific legal regulations in their respective regions.

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