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Introduction to 2'-Oxo-PCM

2'-Oxo-PCM, commonly known as deschloroketamine, O-PCM, DXE, and DCK, is a lesser-known novel dissociative substance within the arylcyclohexylamine class. This article aims to provide a detailed understanding of 2'-Oxo-PCM and its multifaceted properties.

Delving into Historical Origins

The historical accounts of 2'-Oxo-PCM's emergence have primarily centered around speculations regarding its potential antibacterial or immunosuppressant properties. If these speculations prove true, it raises concerns about the substance's prolonged use, which could potentially pose serious threats to one's health and immune system. This is why the misuse of this substance is strongly discouraged. Notably, ketamine exhibits similar properties.

2'-Oxo-PCM has become readily accessible through online research chemical vendors, marketed as a designer drug. Despite its availability, there remains a scarcity of data concerning its pharmacological attributes, metabolism, and toxicity. Given the limited understanding and its brief history of human usage, it is crucial for users to adopt stringent harm reduction practices if they choose to engage with this substance.

Unveiling the Chemical Composition

Deschloroketamine, also identified as 2-Phenyl-2-(methylamino)cyclohexanone, falls under the classification of arylcyclohexylamine drugs. These drugs are recognized for their structural features, comprising a cyclohexane ring bonded to an aromatic ring, in conjunction with an amine group. In the case of deschloroketamine, it encompasses a phenyl ring affixed to a cyclohexane ring substituted with an oxo group (cyclohexanone). Adjacent to the cyclohexanone ring, an amino methyl chain (-N-CH3) is attached to the alpha carbon (R2). Remarkably, the phenyl ring in deschloroketamine lacks the chlorine substitution found in ketamine, denoting its chemical distinction.

Peering into the World of Pharmacology

Due to the limited body of research dedicated to this substance, any discourse about its pharmacology relies primarily on structural attributes and perceived effects akin to other arylcyclohexylamine dissociatives like 3-MeO-PCP, PCP, and MXE. In light of these considerations, it is hypothesized that deschloroketamine functions as an NMDA receptor antagonist. NMDA receptors, a subtype of glutamate receptor, facilitate the passage of excitatory electrical signals between neurons in the brain and spinal column. To enable this signal transmission, the receptor must remain open. Dissociatives, however, obstruct the NMDA receptors by inducing their inactivation. This disruption leads to a loss of bodily sensation, motor coordination, memory retrieval, culminating in an experience reminiscent of a "k-hole."

Subjective Effects: A Work in Progress

Note: The following subjective effects section is currently under development, and it may contain incomplete or inaccurate information. Your contributions to expanding or refining this section are highly appreciated.

In terms of subjective effects, deschloroketamine exhibits closer similarities to ketamine and MXE compared to more stimulating, non-immobilizing compounds within the same class, such as 3-MeO-PCP, O-PCE, and PCP. Consequently, it has gained a reputation as a more suitable ketamine substitute among the various arylcyclohexylamines available in the realm of research chemicals. Nevertheless, users are strongly advised to exercise caution due to the potential health risks associated with its speculated antibacterial properties.

Physical Effects

• Pain Relief
• Spontaneous Physical Sensations
• Loss of Motor Control
• Muscle Relaxation
• Nausea
• Sedation
• Perception of Bodily Lightness
• Physical Autonomy (more prominent at lower doses)
• Physical Euphoria (even at low doses)
• Spatial Disorientation
• Dizziness
• Tactile Suppression
• Optical Sliding
• Decreased Libido
• Orgasm Suppression (though enhancement can also occur, even at higher doses)

Disconnective Effects

• Tactile Disconnection
• Visual Disconnection: Ultimately culminating in the well-known "k-hole" experience, featuring voids, spaces, and structures.
• Consciousness Disconnection

Auditory Effects

• Suppression
• Distortions
• Hallucinations

Multi-sensory Effects

• Synaesthesia

Transpersonal Effects

• Existential Self-Realization
• Unity and Interconnectedness

Cognitive Effects

• Anxiety Suppression
• Disinhibition
• Compulsive Redosing
• Conceptual Thinking
• Enhanced Creativity
• Déjà Vu
• Depersonalization
• Derealization
• Dream Potentiation
• Cognitive Euphoria
• Memory Suppression (including ego death and amnesia)
• Immersion Enhancement
• Increased Music Appreciation
• Suppression of Analysis
• Introspection
• Mania
• Time Distortion
• Thought Deceleration

Visual Effects

• Suppression
• Double Vision
• Frame Rate Suppression
• Pattern Recognition Suppression
• Visual Acuity Suppression
• Distortions: Including perspective distortions, environmental cubism, environmental orbism, and scenery slicing.
• Geometry
• Hallucinatory States: Encompassing internal hallucinations, autonomous entities, diverse settings, sceneries, landscapes, perspective hallucinations, and intricate scenarios.

Perils of Dangerous Interactions

It is vital to be aware that numerous psychoactive substances, which are relatively safe when used individually, can suddenly become perilous and potentially life-threatening when combined with certain other substances. To illustrate this point, here are some known hazardous interactions:

• Stimulants: The convergence of stimulants and dissociatives carries an elevated risk of adverse psychological reactions, including anxiety, mania, delusions, and psychosis. This risk becomes more pronounced when both substances are combined.

• Depressants: The simultaneous use of depressants can result in an increased risk of suddenly falling unconscious, leading to vomiting and choking, potentially resulting in suffocation. In the event of nausea or vomiting, individuals should aim to fall asleep in the recovery position, or a friend should assist them in assuming this position.

Legal Status

The legal classification of deschloroketamine varies from one region to another:

• Italy: Deschloroketamine is considered illegal in Italy.

• Latvia: In Latvia, deschloroketamine is illegal.

• Germany: Controlled under the NpSG (New Psychoactive Substances Act) since July 18, 2019, deschloroketamine is subject to penalties for production, import with the intent to distribute, administration to another person, and trading. Possession is illegal but not penalized.

• Switzerland: Deschloroketamine is categorized as a controlled substance, explicitly named under Verzeichnis E.

• United Kingdom: Classified as a class B drug in the UK, deschloroketamine is illegal to possess, produce, supply, or import. This classification stems from its status as an N-alkyl derivative of 2-Amino-2-phenylcyclohexanone, covered by the arylcyclohexylamine generic clause introduced by S.I. 2013/239, effective from February 26, 2013.

• Czech Republic: The substance is considered illegal in the Czech Republic.

• Austria: Deschloroketamine is illegal in Austria, regulated under the NPSV (Neue-Psychoaktive-Substanzen-Verordnung).

This comprehensive examination of 2'-Oxo-PCM, coupled with diligent harm reduction practices, is essential for individuals choosing to engage with this intriguing yet enigmatic substance.