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In recent years, synthetic cannabinoids have become an increasing source of worry due to their fast-expanding popularity and accompanying health hazards. These compounds imitate the effects of delta-9-tetrahydrocannabinol (THC), the psychoactive ingredient in cannabis. This article will cover three well-known synthetic cannabinoids: JWH-210, JWH-018, and JWH-250.
Description of JWH-210
JWH-210 is a potent cannabinoid agonist belonging to the naphthoylindole chemical family. This indicates that it binds to and stimulates CB1 and CB2 receptors, the same receptors that THC targets. JWH-210 is among the most effective 4-substituted naphthol derivatives in the naphthoylindole class, with a binding affinity of 0.46 nM at CB1 and 0.69 nM at CB2. Comparatively, its 4-methyl and 4-n-propyl homologues JWH-122 and JWH-182 exhibit a reduced binding affinity at CB1 (0.69 nM and 0.71 nM, respectively), as does its 4-methoxy homologue JWH-081 (CB1 Ki 1.2 nM).
Description of JWH-018
JWH-018 is a chemical molecule belonging to the naphthoylindole family that functions as a full agonist at both the CB1 and CB2 receptors, with modest selectivity for the CB2 receptor. It causes effects comparable to THC in animals, which has led to its inclusion in synthetic cannabis products sold legally as "incense mixes" in several countries. This substance has garnered notoriety due to its extensive usage in such items, which have been prohibited in several countries due to their health hazards.
Description of JWH-250
JWH-250 is a phenylacetylindole-based chemical molecule that functions as a cannabinoid agonist at both CB1 and CB2 receptors. JWH-250 is a representative member of a novel family of cannabinoid ligands, with binding affinities of 11 nM at CB1 and 33 nM at CB2. Unlike many of the earlier JWH family compounds, this molecule lacks a naphthalene ring and instead has a 2'-methoxy-phenylacetyl group at this position.
What are Synthetic Cannabinoids?
Synthetic cannabinoids are compounds that have been chemically produced to replicate the effects of THC. They are sprayed on plant matter and marketed as herbal smoking mixes or liquids for e-cigarettes or vaporizing devices. Initially advertised as a legal alternative to marijuana, synthetic cannabinoids have been linked to various harmful health consequences, including acute intoxication, renal failure, and death.
How Do Synthetic Cannabinoids Work?
Synthetic cannabinoids function by attaching to the same CB1 and CB2 brain receptors that THC targets. This binding has a variety of impacts, including changed perceptions, emotional changes, altered thought processes, and altered behaviour. These substances' strengths and adverse effects can vary widely, making them hazardous chemicals.