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O-Acetylpsilocin, also known as 4-acetoxy-DMT, 4-AcO-DMT, psilocin, or synthetic shrooms, is a semi-synthetic hallucinogenic substance recognized as a possible alternative to psilocybin for pharmacological investigations. This chemical is considered a prodrug of psilocin, similar to psilocybin, and David Nichols has indicated that it would be valuable for such research. However, some users say that the subjective effects of O-acetyl psilocin differ from those of psilocybin and psilocin, which has led to its appeal among a restricted set of users.

Chemical Structure and Classification

O-Acetylpsilocin is a semi-synthetic drug produced by the acetylation of psilocin, a hallucinogenic chemical found naturally in magic mushrooms. This substance is categorized as psychedelic and shares structural similarities with psilocybin and psilocin.

Differences between Psilocybin and Psilocin

While structurally related to psilocybin and psilocin, O-Acetylpsilocin is considered to have distinct subjective effects. Some users claim that the effects of O-Acetylpsilocin are more powerful and stay longer than those of psilocybin, while others claim that it is less intense and provides a more relaxed, euphoric state.

Discovery and Early Use

O-Acetylpsilocin was initially synthesized in the middle of the 20th century and has subsequently been utilized for various uses. However, its potential as a replacement for psilocybin in pharmacological research was not identified until recently.

Recent Developments

In recent years, O-Acetylpsilocin has acquired appeal as a designer drug, particularly in Europe. Some users prefer 4-AcO-DMT over real psilocybin mushrooms because they have fewer undesirable side effects, such as nausea and bodily heaviness, which are more commonly reported in natural mushroom experiences.

Short-Term Effects

The short-term effects of O-Acetylpsilocin vary according to the individual, the amount consumed, and the mode of administration. Common side effects include hallucinations, altered perceptions of time and space, elevated heart rate and blood pressure, and exhilaration and enthusiasm.

Long-Term Effects

O-Acetylpsilocin usage can result in physical and mental health issues, including anxiety, sadness, and hallucinations. In addition, the medicine can cause substance misuse and dependency.