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Product Name: O-DSMT
IUPAC Name: 3-(2-((dimethylamino)methyl)-1-hydroxycyclohexyl)phenol
Other Names: O-Desmethyltramadol, desmetramadol
Cas Number: 73986-53-5
Molecular Formula: C15H24ClNO2
Molar Mass: 249.349 g/mol
Purity of the substance: ≥99.3%
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Desmetramadol, commonly known as O-desmethyltramadol (O-DSMT), is the principal active metabolite of tramadol and an opioid analgesic. It is a potent pain reliever commonly used to treat moderate to severe acute and chronic pain. Despite the possible therapeutic advantages of Desmetramadol, its usage is associated with many dangers, including addiction, overdose, and death.

What is Desmetramadol?

Desmetramadol is an opioid analgesic produced from the molecule of tramadol. The liver enzyme CYP2D6 metabolizes tramadol, and the bulk of its pain-relieving actions are due to the conversion to Desmetramadol. In contrast to other opioids, such as morphine and fentanyl, Desmetramadol has a low affinity for opioid receptors, making it a partial agonist instead of a complete agonist. This offers Desmetramadol a lesser overdose risk than full agonist opioids, but it also limits its therapeutic advantages to moderate pain therapy.

The Effects of Desmetramadol

Desmetramadol relieves pain by working on the central nervous system, which consists of the brain and spinal cord. Increased levels of the neurotransmitter dopamine in the brain result in the production of endorphins, which are the body's natural painkillers. Desmetramadol also influences the release of serotonin, which is believed to have a role in mood management and pain perception. Desmetramadol is associated with various adverse effects, including nausea, dizziness, sleepiness, and constipation, as a result of its effects on the central nervous system.

Desmetramadol and CYP2D6

The efficacy of desmetramadol is highly dependent on CYP2D6, the liver enzyme responsible for its metabolism. Due to the restricted conversion of tramadol to Desmetramadol, those with a less active type of CYP2D6, sometimes known as "low metabolizers," get less analgesic effects from Desmetramadol. Individuals with a more active version of CYP2D6 will have elevated Desmetramadol levels, which may result in increased adverse effects and an increased risk of overdose.

The Risks of Desmetramadol

The hazards connected with desmetramadol include addiction, overdose, and death. The Medication Enforcement Administration (DEA) classifies the drug as a Schedule III restricted narcotic due to its potential for misuse and dependency. Desmetramadol can also induce nausea, dizziness, sleepiness, constipation, and respiratory depression, among other side effects.

Desmetramadol and Tramadol: A Comparison

Desmetramadol and tramadol have comparable pain-relieving properties, although they differ in many ways. Due to its partial agonist characteristics and conversion to Desmetramadol, Tramadol has a decreased risk of overdose compared to other opioids. Tramadol is metabolized by CYP2D6, which may result in variable amounts of pain alleviation and adverse effects according to the CYP2D6 status of the individual.

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